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Low Arid1a Expression Correlates with Poor Prognosis and Promotes Cell Proliferation and Metastasis in Osteosarcoma
Springer Science and Business Media LLC - Tập 25 - Trang 875-881 - 2017
Ning Xu, Lili Wang, Ping Sun, Suyang Xu, Shiping Fu, Zhihua Sun
AT-rich interactive domain-containing protein 1A (ARID1A) has been shown to function as a tumour suppressor in various malignancies. However, the biological role of ARID1A in osteosarcoma is not clear. The present study aimed to investigate the expression pattern, prognostic value and the biological role of ARID1A in human osteosarcoma. ARID1A expression in 53 osteosarcoma surgical specimens was e...... hiện toàn bộ
Expression of Matrilin-2 in Liver Cirrhosis and Hepatocellular Carcinoma
Springer Science and Business Media LLC - Tập 14 - Trang 15-22 - 2008
Erzsébet Szabó, Éva Korpos, Enkhjargal Batmunkh, Gábor Lotz, Ágnes Holczbauer, Ilona Kovalszky, Ferenc Deák, Ibolya Kiss, Zsuzsa Schaff, András Kiss
The recently described matrilin protein family is part of the extracellular matrix, their pathophysiological role as well as distribution in liver diseases, however, have not yet been studied. Considering that matrilins have been found to play role in cell growth and tissue remodeling, their possible involvement in carcinogenesis has been raised. The main objective of this study was to investigate...... hiện toàn bộ
IDH Mutation Analysis in Glioma Patients by CADMA Compared with SNaPshot Assay and two Immunohistochemical Methods
Springer Science and Business Media LLC - Tập 25 - Trang 971-978 - 2018
Irena Urbanovska, Magdalena Houdova Megova, Zachary Dwight, Ondrej Kalita, Magdalena Uvirova, Jarmila Simova, Lucie Tuckova, Petr Buzrla, Tomas Palecek, Marian Hajduch, Jana Dvorackova, Jiri Drabek
Mutations in IDH1/2 genes are a marker of good prognosis for glioma patients, associated with low grade gliomas and secondary glioblastomas. Immunohistochemistry and Sanger sequencing are current standards for IDH1/2 genotyping while many other methods exist. The aim of this study was to validate Competitive amplification of differentially melting amplicons (CADMA) PCR for IDH genotyping by compar...... hiện toàn bộ
Ribosomal Protein S6 Phosphorylation is Associated with Epithelial Dysplasia and Squamous Cell Carcinoma of the Oral Cavity
Springer Science and Business Media LLC - Tập 19 - Trang 189-193 - 2012
Somsri Rojanawatsirivej, Risa Chaisuparat, Somchai Yodsanga
Ribosomal protein S6 (RPS6), a downstream effector of the mammalian target of rapamycin pathway (mTOR), is activated in many cancers including oral squamous cell carcinoma (OSCC). However, the role of RPS6 in the progression of potentially malignant disorders (or premalignant lesions) to OSCC is unknown. The purpose of this study was to examine the expression of RPS6 in epithelial dysplasia and OS...... hiện toàn bộ
Clusterin as a Diagnostic and Prognostic Marker for Transitional Cell Carcinoma of the Bladder
Springer Science and Business Media LLC - Tập 16 - Trang 101-109 - 2009
Sahar M. Hazzaa, Osama M. Elashry, Ibtesam K. Afifi
We investigated the feasibility of profiling and measuring the concentration of clusterin in urine and serum for individuals with transitional cell carcinoma (TCC) of the bladder and comparing it with nontumor controls. In addition, we analyzed the correlation of expression of clusterin in specimens of TCC to various clinicopathologic parameters and prognosis of bladder cancer. Blood and urine sam...... hiện toàn bộ
Detection and isolation of MUC1 mucin from larynx squamous cell carcinoma
Springer Science and Business Media LLC - Tập 6 - Trang 93-99 - 2000
María V. Croce, Mike R. Price, Amada Segal-Eiras
The progression from uncontrolled cell proliferation to invasion and metastasis of epithelial tumors is partially understood. Alteration of epithelial mucin expression have been described in different malignant localizations but only few attempts have been made to identify mucin expression in malignant laryngeal tumors. In the present report, results are shown of studies on the expression of mucin...... hiện toàn bộ
ADRA2A Germline Gene Polymorphism is Associated to the Severity, but not to the Risk, of Breast Cancer
Springer Science and Business Media LLC - Tập 22 - Trang 357-365 - 2015
Batoul Kaabi, Ghania Belaaloui, Wassila Benbrahim, Kamel Hamizi, Mourad Sadelaoud, Wided Toumi, Hocine Bounecer
Breast cancer (BC) prognosis and risk were associated to obesity, metabolic syndrome and type 2 diabetes mellitus. Two Single Nucleotide Polymorphisms (SNPs) of the adrenergic receptor-2a gene (ADRA2A): rs1800544 and rs553668, have been associated to these metabolic disorders. We investigated these SNPs in BC risk and prognosis. A total of 102 BC patients and 102 healthy controls were included. Th...... hiện toàn bộ
Accuracy and Reproducibility of HER2 Status in Breast Cancer Using Immunohistochemistry: A Quality Control Study in Tuscany Evaluating the Impact of Updated 2013 ASCO/CAP Recommendations
Springer Science and Business Media LLC - Tập 21 - Trang 477-485 - 2014
S. Bianchi, S. Caini, M. Paglierani, C. Saieva, V. Vezzosi, G. Baroni, A. Simoni, D. Palli
The correct identification of HER2-positive cases is a key point to provide the most appropriate therapy to breast cancer (BC) patients. We aimed at investigating the reproducibility and accuracy of HER2 expression by immunohistochemistry (IHC) in a selected series of 35 invasive BC cases across the pathological anatomy laboratories in Tuscany, Italy. Unstained sections of each BC case were sent t...... hiện toàn bộ
Stereologic Analysis of Tissue Compartments of Gunshot-injured and Blunt-injured Spleen
Springer Science and Business Media LLC - Tập 16 - Trang 69-73 - 2009
Novica M. Milićević, Jasna B. Trbojević-Stanković, Cinthia B. Drachenberg, Živana Milićević
The spleen is composed of several tissue compartments and the respective histoquantitative data are essential for complete understanding of immune or pathological processes in this organ. The aim of our study was to determine and compare the stereologic parameters of all tissue compartments of the gunshot-injured and blunt-injured human spleen. The model-based stereology with point-counting method...... hiện toàn bộ
Lewis x is highly expressed in normal tissues: A comparative immunohistochemical study and literature revision
Springer Science and Business Media LLC - Tập 13 Số 2 - Trang 130-138 - 2007
María Virginia Croce, M. Isla-Larrain, Martín Enrique Rabassa, Sandra O. Demichelis, A. Colussi, M. Praena Crespo, Ezequiel Lacunza, Amada Segal‐Eiras
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