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Lipid-Based Drug Carriers for Prodrugs to Enhance Drug Delivery
Springer Science and Business Media LLC - - 2015
Jennica L. Zaro
Gene-Directed Enzyme Prodrug Therapy
Springer Science and Business Media LLC - - 2015
Jin Zhang, Vijay Kale, Mingnan Chen
Epigenetic CpG Demethylation of the Promoter and Reactivation of the Expression of Neurog1 by Curcumin in Prostate LNCaP Cells
Springer Science and Business Media LLC - Tập 13 - Trang 606-614 - 2011
Limin Shu, Tin Oo Khor, Jong-Hun Lee, Sarandeep S. S. Boyanapalli, Ying Huang, Tien-Yuan Wu, Constance L.-L. Saw, Ka-Lung Cheung, Ah-Ng Tony Kong
Curcumin (CUR), a major bioactive polyphenolic component from turmeric curry, Curcuma longa, has been shown to be a potent anti-cancer phytochemical with well-established anti-inflammatory and anti-oxidative stress effects. Chromatin remodeling-related epigenetic regulation has emerged as an important mechanism of carcinogenesis, chemoprevention, and chemotherapy. CUR has been found to inhibit his... hiện toàn bộ
Development of a New Inhaler for High-Efficiency Dispersion of Spray-Dried Powders Using Computational Fluid Dynamics (CFD) Modeling
Springer Science and Business Media LLC - Tập 21 - Trang 1-15 - 2019
Worth Longest, Dale Farkas
Computational fluid dynamics (CFD) modeling offers a powerful tool for the development of drug delivery devices using a first principles approach but has been underutilized in the development of pharmaceutical inhalers. The objective of this study was to develop quantitative correlations for predicting the aerosolization behavior of a newly proposed dry powder inhaler (DPI). The dose aerosolizatio... hiện toàn bộ
Oral Drug Product Administration via Enteral Feeding Tubes: In Vitro Testing
Springer Science and Business Media LLC - - 2024
Selina Wilson, Julianne Farabaugh, Yemin Liu, Zhao Liu, Rachel Meyers, Matthew Santangelo, Karen Thompson
Medication administration via enteral feeding tubes (EFT) is a necessary practice for patients unable to swallow oral dosage forms due to a medical condition or treatment that affects the ability to swallow or the function of the gastrointestinal tract. Off-label administration of oral drug products via EFT raises concerns for pharmaceutical sponsors, regulators, and healthcare practitioners (HCPs... hiện toàn bộ
Mutant glycosyltransferases assist in the development of a targeted drug delivery system and contrast agents for MRI
Springer Science and Business Media LLC - Tập 8 - Trang E190-E195 - 2006
Pradman K. Qasba, Boopathy Ramakrishnan, Elizabeth Boeggeman
The availability of structural information on glycosyltransferases is beginning to make structure-based reengineering of these enzymes possible. Mutant glycosyltransferases have been generated that can transfer a sugar residue with a chemically reactive unique functional group to a sugar moiety of glycoproteins, glycolipids, and proteoglycans (glyco-conjugates). The presence of modified sugar moie... hiện toàn bộ
Các chiến lược kiểm tra ổn định dựa trên khoa học và rủi ro - Một trường hợp thử nghiệm về việc triển khai toàn cầu và tiếp nhận quy định Dịch bởi AI
Springer Science and Business Media LLC - Tập 22 - Trang 1-11 - 2020
Dorys Argelia Diaz, Michael Lynch, Megan McMahon, Raquel Oblessuc, Stephen T. Colgan
Việc triển khai và chấp nhận toàn cầu về các chiến lược ổn định dựa trên khoa học và rủi ro (SRB) nhằm tạo ra sản phẩm dược phẩm ổn định được xem xét. Chiến lược ổn định này cũng có thể được gọi là “ổn định tinh gọn” vì nó bao gồm việc giảm thiểu số lượng các thử nghiệm và thời điểm so với những gì thường được áp dụng. Một mở rộng dòng sản phẩm (dạng chế phẩm rắn mới) cho một sản phẩm đã được hiểu... hiện toàn bộ
#Ổn định; Chiến lược dựa trên khoa học; Đánh giá rủi ro; Giao thức; Quy định toàn cầu
Discovery pharmaceutics—Challenges and opportunities
Springer Science and Business Media LLC - Tập 8 - Trang E402-E408 - 2006
Xue-Qing Chen, Melissa D. Antman, Christoph Gesenberg, Olafur S. Gudmundsson
Most pharmaceutical companies are now evaluating compounds for druglike properties early in the discovery process. The data generated at these early stages allow upfront identification of potential development challenges and thus selection of the best candidates for lead nomination. Most often, lead nomination candidates are selected based on pharmacological and toxicological data. However, many d... hiện toàn bộ
Activation of Protein Kinase A Stimulates SUMOylation, Expression, and Transport Activity of Organic Anion Transporter 3
Springer Science and Business Media LLC - Tập 21 - Trang 1-11 - 2019
Haoxun Wang, Jinghui Zhang, Guofeng You
Organic anion transporter 3 (OAT3) plays a vital role in removing a broad variety of anionic drugs from kidney, thus avoiding their possible toxicity in the body. We earlier established that activation of protein kinase C (PKC) enhances OAT3 ubiquitination, which promotes OAT3 internalization from the cell plasma membrane to intracellular endosomes and consequent degradation. As a result, OAT3 exp... hiện toàn bộ
Drug Repurposing: Far Beyond New Targets for Old Drugs
Springer Science and Business Media LLC - Tập 14 Số 4 - Trang 759-763 - 2012
Tudor I. Oprea, Jordi Mestres
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