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Lipid-Based Drug Carriers for Prodrugs to Enhance Drug Delivery
Springer Science and Business Media LLC - - 2015
Jennica L. Zaro
Epigenetic CpG Demethylation of the Promoter and Reactivation of the Expression of Neurog1 by Curcumin in Prostate LNCaP Cells
Springer Science and Business Media LLC - Tập 13 - Trang 606-614 - 2011
Limin Shu, Tin Oo Khor, Jong-Hun Lee, Sarandeep S. S. Boyanapalli, Ying Huang, Tien-Yuan Wu, Constance L.-L. Saw, Ka-Lung Cheung, Ah-Ng Tony Kong
Curcumin (CUR), a major bioactive polyphenolic component from turmeric curry, Curcuma longa, has been shown to be a potent anti-cancer phytochemical with well-established anti-inflammatory and anti-oxidative stress effects. Chromatin remodeling-related epigenetic regulation has emerged as an important mechanism of carcinogenesis, chemoprevention, and chemotherapy. CUR has been found to inhibit his...... hiện toàn bộ
Oral Drug Product Administration via Enteral Feeding Tubes: In Vitro Testing
Springer Science and Business Media LLC - - 2024
Selina Wilson, Julianne Farabaugh, Yemin Liu, Zhao Liu, Rachel Meyers, Matthew Santangelo, Karen Thompson
Medication administration via enteral feeding tubes (EFT) is a necessary practice for patients unable to swallow oral dosage forms due to a medical condition or treatment that affects the ability to swallow or the function of the gastrointestinal tract. Off-label administration of oral drug products via EFT raises concerns for pharmaceutical sponsors, regulators, and healthcare practitioners (HCPs...... hiện toàn bộ
Mutant glycosyltransferases assist in the development of a targeted drug delivery system and contrast agents for MRI
Springer Science and Business Media LLC - Tập 8 - Trang E190-E195 - 2006
Pradman K. Qasba, Boopathy Ramakrishnan, Elizabeth Boeggeman
The availability of structural information on glycosyltransferases is beginning to make structure-based reengineering of these enzymes possible. Mutant glycosyltransferases have been generated that can transfer a sugar residue with a chemically reactive unique functional group to a sugar moiety of glycoproteins, glycolipids, and proteoglycans (glyco-conjugates). The presence of modified sugar moie...... hiện toàn bộ
Discovery pharmaceutics—Challenges and opportunities
Springer Science and Business Media LLC - Tập 8 - Trang E402-E408 - 2006
Xue-Qing Chen, Melissa D. Antman, Christoph Gesenberg, Olafur S. Gudmundsson
Most pharmaceutical companies are now evaluating compounds for druglike properties early in the discovery process. The data generated at these early stages allow upfront identification of potential development challenges and thus selection of the best candidates for lead nomination. Most often, lead nomination candidates are selected based on pharmacological and toxicological data. However, many d...... hiện toàn bộ
Covariates in Pharmacometric Repeated Time-to-Event Models: Old and New (Pre)Selection Tools
Springer Science and Business Media LLC - Tập 21 - Trang 1-8 - 2018
Sebastiaan C. Goulooze, Elke H. J. Krekels, Thomas Hankemeier, Catherijne A. J. Knibbe
During covariate modeling in pharmacometrics, computational time can be reduced by using a fast preselection tool to identify a subset of promising covariates that are to be tested with the more computationally demanding likelihood ratio test (LRT), which is considered to be the standard for covariate selection. There is however a lack of knowledge on best practices for covariate (pre)selection in...... hiện toàn bộ
Challenges in Development of Targeted Liposomal Therapeutics
Springer Science and Business Media LLC - - 2012
Rupa R. Sawant, Vladimir P. Torchilin
Assessing Food Effects on Oral Drug Absorption Based on the Degree of Renal Excretion
Springer Science and Business Media LLC - Tập 23 - Trang 1-11 - 2021
Tao Zhang, Peng Zou
Food intake influences the pharmacokinetics of orally administered drugs by altering drug absorption, metabolism, and excretion. A drug which is mainly excreted into urine as parent drug is usually highly water-soluble and metabolically stable. Food intake is not expected to significantly affect its extent of oral absorption, metabolism, and excretion. Therefore, we hypothesize that an orally admi...... hiện toàn bộ
A Mathematical Model of the Effect of Immunogenicity on Therapeutic Protein Pharmacokinetics
Springer Science and Business Media LLC - Tập 15 - Trang 1141-1154 - 2013
Xiaoying Chen, Timothy Hickling, Eugenia Kraynov, Bing Kuang, Chuenlei Parng, Paolo Vicini
A mathematical pharmacokinetic/anti-drug-antibody (PK/ADA) model was constructed for quantitatively assessing immunogenicity for therapeutic proteins. The model is inspired by traditional pharmacokinetic/pharmacodynamic (PK/PD) models, and is based on the observed impact of ADA on protein drug clearance. The hypothesis for this work is that altered drug PK contains information about the extent and...... hiện toàn bộ
Integrated Multi-stakeholder Systems Thinking Strategy: Decision-making with Biopharmaceutics Risk Assessment Roadmap (BioRAM) to Optimize Clinical Performance of Drug Products
Springer Science and Business Media LLC - Tập 22 Số 5 - 2020
Arzu Selen, Anette Müllertz, Filippos Kesisoglou, Rodney J. Y. Ho, Jack Cook, Paul Dickinson, Talia Flanagan
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