Potentially Inappropriate Drug Prescriptions and Risk of Hospitalization among Older, Italian, Nursing Home ResidentsSpringer Science and Business Media LLC - Tập 27 - Trang 747-758 - 2012
Carmelinda Ruggiero, Giuseppina Dell’Aquila, Beatrice Gasperini, Graziano Onder, Fabrizia Lattanzio, Stefano Volpato, Andrea Corsonello, Cinzia Maraldi, Roberto Bernabei, Antonio Cherubini
Background Potentially inappropriate medications in older patients increase the risk of adverse drug events, which are an important cause of hospital admission and death among hospitalized patients. Little information is available about the prevalence of potentially inappropriate drug prescriptions (PIDPs) and the related health adverse outcomes among nursing home (NH) residents. ...... hiện toàn bộ
Treatment Strategies in Alzheimer’s Disease with a Focus on Early Pharmacological InterventionsSpringer Science and Business Media LLC - Tập 21 - Trang 415-426 - 2012
Josef Marksteiner, Reinhold Schmidt
Complex interactive effects of genetic predisposition, neurochemical changes and disease comorbidity have been elucidated in the genesis of dementia syndromes. Alzheimer’s disease is the most prevalent type of dementia in developed Western countries. In Alzheimer’s disease, pharmacological treatment aims at symptomatic relief, disease modification or disease prevention. Cholinesterase inhibitors a...... hiện toàn bộ
Pharmacokinetic Optimisation of Drug Therapy in Elderly PatientsSpringer Science and Business Media LLC - Tập 7 - Trang 10-18 - 2012
Beverly M. Parker, Barry J. Cusack, Robert E. Vestal
With increasing age, there are a number of physiological changes that affect the handling of drugs in the human body. Increases in body fat percentage as well as decreases in lean body mass, hepatic metabolism and renal elimination capacity are of particular clinical significance. It is important to take these changes into account when choosing drug therapy for older patients in order to minimise ...... hiện toàn bộ
TrazodoneSpringer Science and Business Media LLC - Tập 4 - Trang 331-355 - 2012
Malini Haria, Andrew Fitton, Donna McTavish
Trazodone is a triazolopyridine derivative, chemically and pharmacologically unrelated to other currently available antidepressants. It possesses antidepressant, and also some anxiolytic and hypnotic activity. Results from a small number of short term (4 to 6 weeks) comparative studies in a total of 320 evaluable elderly patients with major depression, suggest that trazodone at therapeutic doses i...... hiện toàn bộ
Effects of a Medication Review on Delirium in Older Hospitalised Patients: A Comparative Retrospective Cohort StudySpringer Science and Business Media LLC - Tập 35 - Trang 153-161 - 2018
Eveline L. van Velthuijsen, Sandra M. G. Zwakhalen, Evelien Pijpers, Liesbeth I. van de Ven, Ton Ambergen, Wubbo J. Mulder, Frans R. J. Verhey, Gertrudis I. J. M. Kempen
Delirium in older hospitalised patients is a common and serious disorder. Polypharmacy and certain medications are risk factors for developing delirium. A medication review could benefit older hospitalised patients with delirium. (1) Evaluate the effects of medication review on length of delirium, length of hospital stay, mortality, and discharge destination; and (2) describe and analyse the propo...... hiện toàn bộ