Springer Science and Business Media LLC
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Sắp xếp:
A Multimorbidity-Based, Risk-Stratified Reanalysis of the Atrial Fibrillation Follow-Up Investigation of Rhythm Management (AFFIRM) Trial
Springer Science and Business Media LLC - - 2020
Safety of Antithrombotic Agents in Elderly Patients with Acute Coronary Syndromes
Springer Science and Business Media LLC - Tập 33 - Trang 233-248 - 2016
There are unique challenges in the treatment and prevention of acute coronary syndromes (ACS) with antithrombotics in elderly patients: elderly patients usually require multiple drugs due to comorbidities, are highly susceptible to adverse drug reactions and drug–drug interactions, may have cognitive problems affecting compliance and complications, are especially exposed to the risk of falls and, ...... hiện toàn bộ
Inhaled Corticosteroids, Bone Mineral Density and Fracture in Older People
Springer Science and Business Media LLC - Tập 21 - Trang 631-638 - 2012
The efficacy of inhaled corticosteroids in the treatment of asthma has been firmly established in a variety of settings. The majority of asthma management plans now recommend the use of inhaled corticosteroids at an early stage. This means that most patients with asthma will be prescribed an inhaled corticosteroid at some point in time and many patients with asthma will use these drugs for several...... hiện toàn bộ
Safety of Simultaneous Pneumococcal and Influenza Vaccination in Elderly Patients in Brazil
Springer Science and Business Media LLC - Tập 15 - Trang 43-45 - 2012
Should High Lipid Levels in Very Old Patients Be Lowered?
Springer Science and Business Media LLC - Tập 6 - Trang 85-90 - 2012
Twelve-Month Treatment of Overactive Bladder
Springer Science and Business Media LLC - Tập 18 - Trang 551-560 - 2012
Context: Tolterodine is a bladder-selective antimuscarinic agent designed for the treatment of overactive bladder. Traditional antimuscarinic therapies are poorly tolerated due to a high incidence of anticholinergic adverse events and consequently few patients remain on long term therapy.
Objective: To evaluate the long term efficacy and tolerability of tolterodin...... hiện toàn bộ
Aspiring to Reasonableness in Accelerated Approval: Anticipating and Avoiding the Next Aducanumab
Springer Science and Business Media LLC - Tập 39 - Trang 389-400 - 2022
The US Food and Drug Administration’s decisions about drug approval—though guided by science, as well as relevant statutes, regulations, and guidance documents—reflect normative judgments about how the agency should exercise its discretion. This is particularly true in the context of the “accelerated approval” pathway, where the agency must balance speeding to market drugs for patients with unmet ...... hiện toàn bộ
Optimal Dosages for Melatonin Supplementation Therapy in Older Adults: A Systematic Review of Current Literature
Springer Science and Business Media LLC - Tập 31 - Trang 441-451 - 2014
Melatonin is a hormone that regulates circadian rhythm, and its levels decline with age. As melatonin levels decrease, older adults are prone to develop disorders related to an altered circadian rhythm. The effective dose of melatonin supplementation in these disorders remains unclear. Our objective was to define the optimal dosage of exogenous melatonin administration in disorders related to alte...... hiện toàn bộ
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