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A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients: Are We Overdosing Older Patients?
Springer Science and Business Media LLC - Tập 33 - Trang 737-746 - 2016
Shamsuddin Akhtar, Joseph Heng, Feng Dai, Robert B. Schonberger, Mathew M. Burg
Despite guidelines suggesting a 25–50 % reduction in induction doses of intravenous anesthetic agents in the elderly (≥65 years), we hypothesized that practitioners were not sufficiently correcting drug administration for age, contributing to an increased incidence of hypotension in older patients undergoing general anesthesia. We conducted a retrospective, observational study in a tertiary-care a...... hiện toàn bộ
Aspirin and Heparin in Acute Ischaemic Stroke in Older Patients
Springer Science and Business Media LLC - Tập 15 - Trang 29-36 - 2012
Gordon J. Gubitz, Peter A. G. Sandercock
Over four-fifths of all strokes are due to thrombotic or embolic occlusion of cerebral arteries. There is a strong rationale for considering antithrombotic therapy for the treatment of patients with acute ischaemic stroke. Antiplatelet therapy with 150 to 300mg of aspirin (acetylsalicylic acid) started within the first 48 hours of an ischaemic stroke improves patient outcome in the short and long ...... hiện toàn bộ
Novel Treatments for Multiple Myeloma: What Role Do They Have in Older Adults?
Springer Science and Business Media LLC - Tập 35 - Trang 289-302 - 2018
Hira S. Mian, Tanya M. Wildes
Multiple myeloma is a malignant plasma cell disease, which typically affects older patients, with a median age at diagnosis of 70 years. The recent introduction of novel drugs and ongoing improvements in supportive care have significantly contributed to overall better management and outcomes for patients with multiple myeloma. Autologous stem-cell transplantation has been a standard part of therap...... hiện toàn bộ
Vaccination in the Elderly: What Can Be Recommended?
Springer Science and Business Media LLC - Tập 31 - Trang 581-599 - 2014
Pierre-Olivier Lang, Richard Aspinall
The age-associated increased susceptibility to infectious disease would suggest that vaccination should be a route to promote healthy aging and keep our seniors autonomous and independent. While vaccination represents a cost-effective and efficient strategy at community level, the ability of the immune system to mount a protective immune response is still unpredictable at the level of the individu...... hiện toàn bộ
α1-Antitrypsin
Springer Science and Business Media LLC - Tập 12 - Trang 429-440 - 2012
Martin Schwaiblmair, Claus Vogelmeier
α1-Antitrypsin (α1AT) deficiency is the most common genetic cause of liver disease in children and emphysema in adults. Therapy for pulmonary disease attributable to α1AT deficiency includes α1AT augmentation therapy along with supportive measures. The α1AT preparation that is currently used for therapy is derived from fractionated plasma. The results of clinical trials suggest that augmentation t...... hiện toàn bộ
Frailty Risks of Prescription Analgesics and Sedatives across Frailty Models: the Health and Retirement Study
Springer Science and Business Media LLC - Tập 39 - Trang 377-387 - 2022
Andrew W. Bergen, Gulcan Cil, Lana J. Sargent, Chintan V. Dave
Limited evidence for incident frailty risks associated with prescription analgesics and sedatives in older (≥ 65 years) community-living adults prompted a more comprehensive investigation. We used data from older Health and Retirement Study respondents and three frailty models (frailty index, functional domain, frailty phenotype with 8803, 10,470, and 6850 non-frail individuals, respectively) and ...... hiện toàn bộ
Diagnostic and Management Strategies for Patients with Chronic Prostatitis and Chronic Pelvic Pain Syndrome
Springer Science and Business Media LLC - Tập 38 - Trang 845-886 - 2021
Vanessa N. Pena, Noah Engel, Andrew T. Gabrielson, Matthew J. Rabinowitz, Amin S. Herati
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a common and often heterogenous condition that can have severe consequences on patient quality of life. In this review, we describe the pathophysiology, diagnostic work-up, and treatment of patients with CP/CPPS incorporating the most recent literature. Studies have demonstrated that CP/CPPS involves a complex pathophysiology, including...... hiện toàn bộ
Functional Outcomes of Drug Treatment in Alzheimer’s Disease
Springer Science and Business Media LLC - Tập 24 - Trang 155-167 - 2012
Richard A. Hansen, Gerald Gartlehner, Kathleen N. Lohr, Daniel I. Kaufer
Patient functioning is an important outcome in Alzheimer’s disease, but treatment-related improvements in patient function are difficult to quantify because a number of different scales are used in its measurement. To evaluate systematically the evidence relating to patient functioning as an outcome measure in the drug treatment of Alzheimer’s disease. Data were obtained by searching MEDLINE®, EMB...... hiện toàn bộ
Pharmacological Treatments for Persistent Non-Malignant Pain in Older Persons
Springer Science and Business Media LLC - Tập 21 - Trang 19-41 - 2012
Thorsten Nikolaus, Andrej Zeyfang
Persistent non-malignant pain is common, often neglected and under-treated among older persons. Some older adults do not complain because they consider chronic pain to be a characteristic of normal aging. Physicians have concerns regarding adverse effects of pharmacological treatment. The model of the World Health Organization for treatment of cancer pain is generally accepted and also recommended...... hiện toàn bộ
Laxatives as a Risk Factor for Iatrogenic Falls in Elderly Subjects
Springer Science and Business Media LLC - Tập 27 Số 11 - Trang 895-901 - 2010
Bloch, Frédéric, Thibaud, Marie, Dugué, Benoit, Brèque, Cyril, Rigaud, Anne-Sophie, Kemoun, Gilles
Background The multifactorial nature of falls is well known, and several studies on falls in the elderly have reported that laxatives can be a risk factor, but without attempting to discuss possible mechanisms to explain this role. Objective We aimed to isolate studies in which the risk factors for falls in the elderly related to laxatives have been evaluated and to carry out a meta-analysis combi...... hiện toàn bộ
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