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The activity of ciprofloxacin against Pseudomonas aeruginosa in normal and granulocytopenic mice
Springer Science and Business Media LLC - - 1987
Some adaptations in the method of the ‘Pharmacopoeia Helvetica Editio Sixta’ for the determination of total alkaloids in Strychnos seeds
Springer Science and Business Media LLC - Tập 9 Số 6 - Trang 324-325 - 1987
Health-related quality of life assessments in osteoarthritis during NSAID treatment
Springer Science and Business Media LLC - Tập 18 - Trang 130-136 - 1996
There is some evidence that nabumetone (1000 mg once daily) in comparison with piroxicam (20 mg once daily) in patients with OA in general practice is associated with a lower incidence and less severe occurrence of stomach pain but with more withdrawals due to lack of efficacy. The aim of this analysis was to investigate whether these differences are reflected in health-related quality of life ass...... hiện toàn bộ
Pharmacokinetic interactions between indomethacin and paracetamol in the rat
Springer Science and Business Media LLC - Tập 7 Số 1 - Trang 15-19 - 1985
The influence of concurrent administration of paracetamol with indomethacin on the plasma concentrations of these drugs was studied in rats. Orally administered paracetamol reduced the plasma levels of indomethacin during the first 2 hours after oral administration. Later, 16 and 24 hours after administration of indomethacin, the plasma levels exceeded the control values due to the concurrent oral...... hiện toàn bộ
Direct-to-consumer communication on prescription only medicines via the Internet in the Netherlands, a pilot study Opinion of the pharmaceutical industry, patient associations and support groups
Springer Science and Business Media LLC - Tập 26 - Trang 169-172 - 2004
Objective: Investigation of the current application of direct-to-consumer (DTC) communication on prescription only medicines via the Internet in the Netherlands. Method: Questionnaires were sent by e-mail to 43 Dutch innovative pharmaceutical industries and 130 Patient Association and Support Groups (PASGs). Results: In this pilot study, the response of the pharmaceutical industry was rather low b...... hiện toàn bộ
Influence of protein binding and severity of illness on renal elimination of four cephalosporin drugs in intensive-care patients
Springer Science and Business Media LLC - Tập 9 - Trang 98-103 - 1987
A pharmacokinetic study after a single dose of ceftriaxone, cefoxitin, cefuroxime and ceftazidime was performed to investigate the influence of protein binding and severity of disease on the renal elimination. In intensive-care patients drug-protein binding was substantially less compared to that in volunteers and patients with less complicated diseases. This did not result in increased eliminatio...... hiện toàn bộ
Allosteric properties of the oxyphenbutazone-human serum albumin complex
Springer Science and Business Media LLC - Tập 5 - Trang 228-233 - 1983
The conformational change of albumin which occurs around physiological pH, the so-called N-B transition, has been studied by measuring the induced circular dichroic signal of the oxyphenbutazone-albumin complex. This N-B transition has been characterized by a set of parameters according to the two-state model of Monod, Wyman and Changeux. The influence of calcium ions on the N-B transition has bee...... hiện toàn bộ
Rapid assay for thein vitro chemosensitivity testing of human breast tumours
Springer Science and Business Media LLC - Tập 11 Số 6 - Trang 244-244 - 1989
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