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Immunotherapies Targeting Amyloid and Tau Protein in Alzheimer’s Disease: Should We Move Away from Diseases and Focus on Biological Targets? A Systematic Review and Expert Opinion
Springer Science and Business Media LLC - Tập 12 - Trang 1883-1907 - 2023
Arthur Esquer, Frédéric Blanc, Nicolas Collongues
Alzheimer’s disease (AD) is the most common cause of dementia worldwide, making it a major public health issue. Anti-amyloid and anti-tau antibodies are the most advanced therapeutic approach at present. Three drugs (lecanemab, donanemab and aducanumab) are on track to be marketed in the coming months. In this systematic review, we review all Phase 2 and Phase 3 clinical trials conducted in this i...... hiện toàn bộ
The Effect of Dimethyl Fumarate on Cerebral Gray Matter Atrophy in Multiple Sclerosis
Springer Science and Business Media LLC - Tập 5 - Trang 215-229 - 2016
Sheena L. Dupuy, Shahamat Tauhid, Shelley Hurwitz, Renxin Chu, Fawad Yousuf, Rohit Bakshi
The objective of this pilot study was to compare cerebral gray matter (GM) atrophy over 1 year in patients starting dimethyl fumarate (DMF) for multiple sclerosis (MS) to that of patients on no disease-modifying treatment (noDMT). DMF is an established therapy for relapsing–remitting (RR) MS. We retrospectively analyzed 20 patients with RRMS at the start of DMF [age (mean ± SD) 46.1 ± 10.2 years,...... hiện toàn bộ
Practical Evidence-Based Recommendations for Patients with Multiple Sclerosis Who Want to Have Children
Springer Science and Business Media LLC - Tập 7 - Trang 207-232 - 2018
Yara Dadalti Fragoso, Tarso Adoni, Joseph B. Bidin Brooks, Alessandro Finkelsztejn, Paulo Diniz da Gama, Anderson K. Grzesiuk, Vanessa Daccach Marques, Monica Fiuza K. Parolin, Henry K. Sato, Daniel Lima Varela, Claudia Cristina F. Vasconcelos
Multiple sclerosis (MS) management presently aims to reach a state of no (or minimal) evidence of disease activity. The development and commercialization of new drugs has led to a renewed interest in family planning, since patients with MS may face a future with reduced (or no) disease-related neurological disability. The advice of neurologists is often sought by patients who want to have children...... hiện toàn bộ
Cost Per Relapse Avoided for Ozanimod Versus Other Selected Disease-Modifying Therapies for Relapsing–Remitting Multiple Sclerosis in the United States
Springer Science and Business Media LLC - Tập 12 Số 3 - Trang 849-861 - 2023
Daniel Kantor, Timothy Pham, Oscar Patterson-Lomba, Elyse Swallow, Akanksha Dua, Komal Gupte-Singh
Integrative Analyses Identify KCNJ15 as a Candidate Gene in Patients with Epilepsy
Springer Science and Business Media LLC - Tập 11 Số 4 - Trang 1767-1776 - 2022
Shitao Wang, Zongyou Li, Xiaoqing Ding, Zongyou Zhao, Mengen Zhang, Hui Xu, Junfeng Lu, Lili Dai
Efficacy of Dimethyl Fumarate in Young Adults with Relapsing-Remitting Multiple Sclerosis: Analysis of the DEFINE, CONFIRM, and ENDORSE Studies
Springer Science and Business Media LLC - - 2023
Lilyana Amezcua, Yang Mao-Draayer, Wendy S. Vargas, Rebecca Farber, Sara Schaefer, Filipe Branco, Sarah M. England, Nicholas Belviso, James B. Lewin, Jason P. Mendoza, Sai L. Shankar
Dimethyl fumarate (DMF) showed favorable benefit-risk in patients with relapsing-remitting multiple sclerosis (MS) in phase 3 DEFINE and CONFIRM trials and in the ENDORSE extension study. Disease activity can differ in younger patients with MS compared with the overall population. Randomized patients received DMF 240 mg twice daily or placebo (PBO; years 0–2 DEFINE/CONFIRM), then DMF (years 3–10; ...... hiện toàn bộ
The Early Diagnosis of Alzheimer’s Disease: A Patient-Centred Conversation with the Care Team
Springer Science and Business Media LLC - Tập 12 - Trang 11-23 - 2022
Ziad Nasreddine, Valentina Garibotto, Simon Kyaga, Alessandro Padovani
Alzheimer’s disease (AD) is a neurodegenerative disorder which accounts for 60–80% of dementia cases, affecting approximately 10 million people in Europe. Neuroimaging techniques and cerebrospinal fluid biomarkers used in combination with cognitive assessment tools open the door to early diagnosis of AD. However, these tools present some challenges that need to be overcome, such as low sensitivity...... hiện toàn bộ
Abstracts from the 5th International Porto Congress of Multiple Sclerosis
Springer Science and Business Media LLC - Tập 8 - Trang 1-31 - 2019
Maria José Sá
Migraine and Ischemic Stroke: A Mendelian Randomization Study
Springer Science and Business Media LLC - Tập 11 - Trang 237-246 - 2021
Mei-Jun Shu, Jia-Rui Li, Yi-Cheng Zhu, Hang Shen
Previous epidemiological studies have found an increased risk for ischemic stroke in patients with migraine; however, the evidence for a causal relationship between migraine and ischemic stroke is scarce. This study aims to explore the potential causal relationship between migraine and ischemic stroke and its subtypes [including large artery stroke (LAS), small vessel stroke (SVS), and cardioembo...... hiện toàn bộ
The Humanistic and Economic Burden of Alzheimer's Disease
Springer Science and Business Media LLC - Tập 11 - Trang 525-551 - 2022
Amir Abbas Tahami Monfared, Michael J. Byrnes, Leigh Ann White, Quanwu Zhang
Alzheimer’s disease (AD) is the leading cause of cognitive impairment and dementia in older individuals (aged ≥ 65 years) throughout the world. As a result of these progressive deficits in cognitive, emotional, and physical function, AD dementia can cause functional disability and loss of independence. To gain a deeper understanding of the recent literature on the burden of AD, including that of m...... hiện toàn bộ
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