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Các bài báo tiêu biểu
The Effect of Bacterial Biofilms on Post-sinus Surgical Outcomes
Tập 22 Số 1 - Trang 1-6 - 2008
Background Although the existence of biofilms on the sinus mucosa of patients
with chronic rhinosinusitis (CRS) is now well established, the role that these
structures play remains unclear. It is thought that biofilms may contribute to
the recalcitrant and persistent nature that characterizes CRS, but little
research exists documenting the effect that they have on postoperative mucosal
outcomes. T...
Endoscopic Resection of Malignant Tumors of the Nose and Sinuses
Tập 21 Số 1 - Trang 89-94 - 2007
Background Since the introduction of endoscopic surgery, its role has been
gradually extended to encompass a range of pathologies, including sinonasal
tumors, facilitated by the ability to repair significant skull-base defects.
However, the rarity and long natural history of malignant tumors make it
difficult to accrue cohorts comparable with the established gold standard of
craniofacial resection...
Prevalence of Biofilm-forming Bacteria in Chronic Rhinosinusitis
Tập 22 Số 3 - Trang 239-245 - 2008
Background Recently, biofilms have been implicated in the pathogenesis of
recalcitrant chronic rhinosinusitis (CRS). We sought to determine the prevalence
of biofilm-forming cultures obtained from patients with CRS and clinical factors
that may contribute to biofilm formation. Methods Endoscopically guided
sinonasal cultures were obtained in duplicate from CRS patients with evidence of
mucopurulen...
Demonstration of Biofilm in Human Bacterial Chronic Rhinosinusitis
Tập 19 Số 5 - Trang 452-457 - 2005
Background Bacterial biofilms may explain why some patients with bacterial
chronic rhinosinusitis (CRS) improve while on antibiotics but relapse after
completion of the antibiotic. In the human host, biofilms exist as a community
of bacteria surrounded by a glycocalyx that is adherent to a foreign body or a
mucosal surface with impaired host defense. Biofilms generate planktonic,
nonadherent bacte...
Effectiveness of Topical Antibiotics on Staphylococcus Aureus Biofilm in Vitro
Tập 21 Số 2 - Trang 149-153 - 2007
Background In vitro biofilm-producing capacity in isolates of Staphylococcus
aureus and Pseudomonas aeruginosa collected from the sinus cavities after
endoscopic sinus surgery (ESS) are associated with a poor outcome in patients
with chronic rhinosinusitis (CRS). However, conventional oral antibiotic therapy
is frequently ineffective in eradicating bacteria in the biofilm form.
Increasing the conc...
Topical Application of Mitomycin-C in Endoscopic Dacryocystorhinostomy
Tập 14 Số 3 - Trang 205-208 - 2000
Endoscopic dacryocystorhinostomy (DCR) is a well-established alternative to
external DCR for treatment of obstruction of the lacrimal pathway and has a
success rate of up to 95% in primary cases. Despite the benefits of using an
endoscopic approach, including enhanced intranasal access to the lacrimal
drainage system, there still exists a significant failure rate, particularly in
revision procedur...
A Scanning Electron Microscopic Study of Smoking and Age-Related Changes in Human Nasal Epithelium
Tập 6 Số 5 - Trang 185-190 - 1992
The nose is known to undergo dysfunctional changes as people age, probably due
to exposure to agents such as smoking, environmental pollutants, and microbes. A
morphologic expression of these insults might be a change in the number of
ciliated cells present in the nasal mucosa. This study revealed that smoking and
age were not related to a reduction in the number of ciliated cells of the
inferior ...