SAGE Publications
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The NR3B Subgroup: An Overrview
SAGE Publications - Tập 5 Số 1 - Trang nrs.05009 - 2007
Members of the NR3B group of the nuclear receptor superfamily, known as the
estrogen-related receptors (ERRs), were the first orphan receptors to be
identified two decades ago. Despite the fact that a natural ligand has yet to be
associated with the ERRs, considerable knowledge about their mode of action and
biological functions has emerged through extensive biochemical, genetic and
functional gen...
PPARα: Energy Combustion, Hypolipidemia, Inflammation and Cancer
SAGE Publications - Tập 8 Số 1 - Trang nrs.08002 - 2010
The peroxisome proliferator-activated receptor α (PPARα, or NR1C1) is a nuclear
hormone receptor activated by a structurally diverse array of synthetic
chemicals known as peroxisome proliferators. Endogenous activation of PPARα in
liver has also been observed in certain gene knockout mouse models of lipid
metabolism, implying the existence of enzymes that either generate (synthesize)
or degrade en...
Retinoid-Related Orphan Receptors (RORs): Critical Roles in Development, Immunity, Circadian Rhythm, and Cellular Metabolism
SAGE Publications - Tập 7 Số 1 - 2009
The last few years have witnessed a rapid increase in our knowledge of the
retinoid-related orphan receptors RORα, -β, and -γ (NR1F1-3), their mechanism of
action, physiological functions, and their potential role in several
pathologies. The characterization of ROR-deficient mice and gene expression
profiling in particular have provided great insights into the critical functions
of RORs in the reg...
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