Rheumatology
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Sắp xếp:
Oral corticosteroids and fracture risk: relationship to daily and cumulative doses
Rheumatology - Tập 39 Số 12 - Trang 1383-1389 - 2000
Diagnostic performance and validation of autoantibody testing in myositis by a commercial line blot assay
Rheumatology - Tập 49 Số 12 - Trang 2370-2374 - 2010
Anti-signal recognition particle autoantibody ELISA validation and clinical associations
Rheumatology - Tập 54 Số 7 - Trang 1194-1199 - 2015
The heart in dermatomyositis and polymyositis
Rheumatology - Tập 45 Số suppl_4 - Trang iv18-iv21 - 2006
Heart involvement in systemic lupus erythematosus, anti-phospholipid syndrome and neonatal lupus
Rheumatology - Tập 45 Số suppl_4 - Trang iv8-iv13 - 2006
Spanish Rheumatology Society and Hospital Pharmacy Society Consensus on recommendations for biologics optimization in patients with rheumatoid arthritis, ankylosing spondylitis and psoriatic arthritis
Rheumatology - Tập 54 Số 7 - Trang 1200-1209 - 2015
Microcirculation dynamics in systemic vasculitis: evidence of impaired microvascular response regardless of cardiovascular risk factors Abstract
Objectives
Systemic vasculitides (SVs) are a highly inflammatory group of diseases characterized by significant cardiovascular (CV) mortality. Microvascular damage closely linked with accelerated atherosclerosis and thrombosis represents a core pathophysiological mechanism contributing to the excess CV risk of patients with SVs. Skin represents an easily accessible tissue facilitating non-invasive microvascular study. In this study we aimed to investigate microcirculation dynamics and associate them with disease-related factors in patients with SVs.
Methods
We assessed skin microcirculation using laser speckle contrast imaging (LSCI) and vascular reactivity by the post-occlusive reactive hyperaemia (PORH) protocol in a meticulously selected group of patients with SVs without CV disease and compared them to controls, matched for age, sex, BMI and smoking status.
Results
Sixty individuals were included in the study, 30 patients and 30 controls. Patients with SVs presented a lower peak magnitude during reperfusion phase (median [interquartile range] 207 [60.1] vs 143.7 [41.0] laser speckle perfusion units, P < 0.001) and lower percentage cutaneous vascular conductance increase (mean (s.d.) 190.0 [49.6]% vs 149.6 [48.9]%, P = 0.002) as compared with controls. Importantly, microvascular damage was correlated with disease duration (P < 0.001, r = −0.563 and P < 0.001, r = 0.442, respectively).
Conclusion
For the first time we have shown that patients with SVs exhibit impaired microvascular function and blunted reactivity after occlusion, as this was demonstrated by the LSCI technique. Therefore, skin microcirculation may be a useful, non-invasive method in patients with SVs for the early detection of microvascular dysfunction, which is closely related to the high CV risk that these patients bear.
Rheumatology - Tập 62 Số 7 - Trang 2510-2516 - 2023
Skin microvascular dysfunction in systemic lupus erythematosus patients with and without cardiovascular risk factors Abstract
Objectives
Patients with SLE have increased cardiovascular mortality. Alterations in both macro- and micro-circulation have been associated with cardiovascular disease. We sought to assess skin microvascular function by using laser speckle contrast analysis (LASCA) in patients with SLE, with and without cardiovascular disease and risk factors.
Methods
Continuous blood flow was recorded using a LASCA device during baseline, a 5-min arterial occlusion and a 5-min reperfusion period.
Results
Thirty-five patients with SLE (85.7% women) with a median disease duration 12.0 (6.5–17.5) years and a mean age of 46.3 (8.6) years and 31 controls matched for age, sex and BMI were enrolled. During reperfusion, SLE patients exhibited a smaller peak magnitude compared with controls (161.0 (47.1) vs 197.2 (41.4)%, respectively, P =0.002). Results remained unchanged among 24 SLE patients without cardiovascular disease compared with the control group (169.2 (48.1) vs 195.6 (34.0)%, respectively, P =0.002).
Conclusion
Our study shows, for the first time, that patients with SLE, even without overt cardiovascular disease or risk factors, exhibit a blunted microvascular reactivity during reperfusion compared with controls. These results show that skin microvascular dysfunction is present in SLE independently of the CV burden that these patients bear and may represent an early sign of vascular damage.
Rheumatology - Tập 60 Số 6 - Trang 2834-2841 - 2021
Increased expression of interleukin-22 in patients with giant cell arteritis
Rheumatology - Tập 57 Số 1 - Trang 64-72 - 2018
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