Reproductive Medicine and Biology

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Histone acetylation in reproductive organs: Significance of histone deacetylase inhibitors in gene transcription
Reproductive Medicine and Biology - - 2005
Hiroshi Uchida, Tetsuo Maruyama, Toru Arase, Masanori Ono, Takashi Nagashima, H. Masuda, Hironori Asada, Yasunori Yoshimura
Acetylation of histones is cooperatively regulated by two groups of enzymes, histone acetyltransferases and histone deacetylases. Histone acetylation status plays a fundamental role in the level of gene transcription; numerous studies have demonstrated that histone deacetylase inhibitors cause cell growth arrest, apoptosis, and differentiation in various cells including human mammary gland...... hiện toàn bộ
Role of reactive oxygen species in gynecologic diseases
Reproductive Medicine and Biology - Tập 3 - Trang 177-199 - 2004
Rakesh K. Sharma, Ashok Agarwal
Free radicals derived from molecular oxygen and nitrogen are highly reactive metabolites called reactive oxygen species (ROS). Cells continuously produce free radicals and ROS as part of the metabolic process. They are involved in the various functions of the reproductive system. Antioxidants are enzymes or compounds that scavenge and reduce the presence of free radicals. Normally, a balance exist...... hiện toàn bộ
Mild stimulation with clomiphene citrate in combination with recombinant follicle-stimulating hormone and gonadotropin-releasing hormone antagonist and its influence on serum estradiol level and pregnancy rate
Reproductive Medicine and Biology - Tập 7 - Trang 85-89 - 2008
Atsushi Yanaihara, Takeshi Yorimitsu, Hiroshi Motoyama, Motohiro Ohara, Toshihiro Kawamura
The mild ovarian stimulation protocol for in vitro fertilization (IVF) is carried out to minimize adverse side-effects as well as cost. While performing mild ovarian stimulation with a gonadotropin-releasing hormone (GnRH) antagonist, the pregnancy rate was examined in cases that exhibited a serum estradiol (E2) drop down. In this study, 174 patients who requested mild ovarian stimulation for IVF ...... hiện toàn bộ
Age-associated events in bovine oocytes and possible countermeasures
Reproductive Medicine and Biology - Tập 15 Số 3 - Trang 155-164 - 2016
Iwata, Hisataka
Maternal aging profoundly affects oocyte quality. This has become common knowledge in industrialized countries and extensive studies addressing the causes and possible countermeasures against age-associated deterioration of oocytes suggest that mitochondrial dysfunction is a causal factor in infertility. However, almost all studies addressing age-associated events in oocytes have used mice as an a...... hiện toàn bộ
Heterotopic autotransplantation of vitrified mouse ovary
Reproductive Medicine and Biology - Tập 10 - Trang 267-275 - 2011
Hussein Eimani, Arash Behbahanian, Bahman Zeinali, Mojtaba Rezazade Valoujerdi, Poopak Eftekhari, Abdulhussein Shahverdi, Hamid Gourabi, Afsaneh Golkar-Narenji
The aim of this study was to investigate the survival and development of premature follicles and oocytes from a vitrified-transplanted ovary in a murine experimental model. The 14-day-old mice were unilaterally ovariectomized and the separated ovaries were vitrified by cryotop. After 2 weeks the ovaries were warmed and autotransplanted into the gluteus superfiscialis muscle. After 3 weeks, these o...... hiện toàn bộ
Nuclear reprogramming of sperm and somatic nuclei in eggs and oocytes
Reproductive Medicine and Biology - - 2013
Marta Teperek, Kazuaki Miyamoto
AbstractEggs and oocytes have a prominent ability to reprogram sperm nuclei for ensuring embryonic development. The reprogramming activity that eggs/oocytes intrinsically have towards sperm is utilised to reprogram somatic nuclei injected into eggs/oocytes in nuclear transfer (NT) embryos. NT embryos of various species can give rise to cloned animals, demonstrating...... hiện toàn bộ
Human sperm motility in a microgravity environment
Reproductive Medicine and Biology - Tập 4 - Trang 161-167 - 2005
Takahito Ikeuchi, Shoichi Sasaki, Yukihiro Umemoto, Yasue Kubota, Hiroki Kubota, Tomoyoshi Kaneko, Kenjiro Kohri
We carried out clinostat and parabolic flight experiments to examine the effects of a microgravity (,uG) environment on human sperm motility. Semen samples were obtained manually from 18 healthy men (aged 27.4 ± 5.4 years) who had given their informed consent. In dinostat experiments, samples that were left stationary were used as a stationary control. Samples rotated vertically and horizontally w...... hiện toàn bộ
Diagnosis and treatment methods for recurrent miscarriage cases
Reproductive Medicine and Biology - Tập 8 Số 4 - Trang 141-144 - 2009
Sugiura-Ogasawara, Mayumi, Ozaki, Yasuhiko, Kitaori, Tamao
Recurrent miscarriage is classically defined as three or more consecutive pregnancy losses. Established causes of recurrent miscarriage are antiphospholipid antibodies, uterine anomalies and abnormal chromosomes in either partner, particularly translocations. Embryonic aneuploidy is the most important cause of miscarriage before 10 weeks’ gestation. It can be speculated that about 51% of pati...... hiện toàn bộ
Selected single blastocyst transfers maintained pregnancy outcome and eliminated multiple pregnancies
Reproductive Medicine and Biology - Tập 3 - Trang 13-18 - 2004
Takeshi Kuramoto, Arief Boediono, Akiyoshi Egashira, Mutsuro Motoishi, Michiyo Sugioka, Kimiko Fukuda, Toki Higashijima, Naomi Yoshioka, Rajadurai Raiamahendran
Transfer of more than one embryo followingin vitro fertilization/intracytoplasmic sperm injection cycles have increased pregnancy rate at the cost of increasing the incidence of triplets and twins. It has been proposed that prolonged culture to the blastocyst stage would automatically result in the selection of good quality embryos for transfer and minimize the incidence of triplets and twins. The...... hiện toàn bộ
Referees
Reproductive Medicine and Biology - Tập 6 - Trang 241-242 - 2007
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