RNA
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Convergence of natural and artificial evolution on an RNA loop–loop interaction: The HIV-1 dimerization initiation site
RNA - Tập 6 Số 9 - Trang 1267-1276 - 2000
A dynamic bulge in the U6 RNA internal stem–loop functions in spliceosome assembly and activationThe highly conserved internal stem–loop (ISL) of U6 spliceosomal RNA is unwound for U4/U6 complex formation during spliceosome assembly and reformed upon U4 release during spliceosome activation. The U6 ISL is structurally similar to Domain 5 of group II self-splicing introns, and contains a dynamic bulge that coordinates a Mg++ ion essential for the first catalytic st... ...
RNA - Tập 13 Số 12 - Trang 2252-2265 - 2007
The interaction between DCL1 and HYL1 is important for efficient and precise processing of pri-miRNA in plant microRNA biogenesisIt has been reported that some double-stranded RNA (dsRNA) binding proteins interact with small RNA biogenesis-related RNase III enzymes. However, their biological significance is poorly understood. Here we examine the relationship between the Arabidopsis microRNA- (miRNA) producing enzyme DCL1 and the dsRNA binding protein HYL1. In the hyl1-2...
RNA - Tập 12 Số 2 - Trang 206-212 - 2006
Contribution of the intercalated adenosine at the helical junction to the stability of the gag-pro frameshifting pseudoknot from mouse mammary tumor virus
RNA - Tập 6 Số 3 - Trang 409-421 - 2000
Rational design of artificial riboswitches based on ligand-dependent modulation of internal ribosome entry in wheat germ extract and their applications as label-free biosensorsRiboswitches are RNA elements in mRNA that control gene expression in cis in response to their specific ligands. Because artificial riboswitches make it possible to regulate any gene with an arbitrary molecule, they are expected to function as biosensors, in which the output is easily detectable protein expression. I report herein a fully rational design strategy... ...
RNA - Tập 17 Số 3 - Trang 478-488 - 2011
The pseudouridine synthase RluD is required for normal ribosome assembly and function in Escherichia coliRluD is the pseudouridine synthase responsible for the formation of Ψ1911, Ψ1915, and Ψ1917 in Escherichia coli 23S rRNA. Previous work from our laboratory demonstrated that disruption of the rluD gene and/or loss of the pseudouridine residues for which it is responsible resulted in a severe growth phenotype. In the current work we have... ...
RNA - Tập 11 Số 7 - Trang 1141-1152 - 2005
Exon repression by polypyrimidine tract binding proteinPolypyrimidine tract binding protein (PTB) is known to silence the splicing of many alternative exons. However, exons repressed by PTB are affected by other RNA regulatory elements and proteins. This makes it difficult to dissect the structure of the pre-mRNP complexes that silence splicing, and to understand the role of PTB in this process. We determined the minimal requirements for PTB-m... ...
RNA - Tập 11 Số 5 - Trang 699-716 - 2005
Human ribosomal protein L13a is dispensable for canonical ribosome function but indispensable for efficient rRNA methylationPreviously, we demonstrated that treatment of monocytic cells with IFN-γ causes release of ribosomal protein L13a from the 60S ribosome and subsequent translational silencing of Ceruloplasmin (Cp) mRNA. Here, evidence using cultured cells demonstrates that Cp mRNA silencing is dependent on L13a and that L13a-deficient ribosomes are competent for global translational activity. Human monocyt... ...
RNA - Tập 13 Số 12 - Trang 2224-2237 - 2007
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