Protein & Cell

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Extracellular signal regulated kinase 5 promotes cell migration, invasion and lung metastasis in a FAK-dependent manner
Protein & Cell - Tập 11 - Trang 825-845 - 2020
Weiwei Jiang, Fangfang Cai, Huangru Xu, Yanyan Lu, Jia Chen, Jia Liu, Nini Cao, Xiangyu Zhang, Xiao Chen, Qilai Huang, Hongqin Zhuang, Zi-Chun Hua
This study was designed to evaluate ERK5 expression in lung cancer and malignant melanoma progression and to ascertain the involvement of ERK5 signaling in lung cancer and melanoma. We show that ERK5 expression is abundant in human lung cancer samples, and elevated ERK5 expression in lung cancer was linked to the acquisition of increased metastatic and invasive potential. Importantly, we observed ...... hiện toàn bộ
The exploration of N6-deoxyadenosine methylation in mammalian genomes
Protein & Cell - - 2021
Xuwen Li, Zijian Zhang, Xinlong Luo, Jacob Schrier, Andrew D. Yang, Tao P. Wu
N6-methyladenine (N6-mA, m6dA, or 6mA), a prevalent DNA modification in prokaryotes, has recently been identified in higher eukaryotes, including mammals. Although 6mA has been well-studied in prokaryotes, the function and regulatory mechanism of 6mA in eukaryotes are still poorly understood. Recent studies indicate that 6mA can serve as an epigenetic mark and play critical roles in various biolog...... hiện toàn bộ
I-GSEA4GWAS v2: a web server for functional analysis of SNPs in trait-associated pathways identified from genome-wide association study
Protein & Cell - Tập 6 - Trang 221-224 - 2014
Kunlin Zhang, Suhua Chang, Liyuan Guo, Jing Wang
Correction of β-thalassemia mutant by base editor in human embryos
Protein & Cell - - 2017
Puping Liang, Chenhui Ding, Hongwei Sun, Xiaowei Xie, Yanwen Xu, Xiya Zhang, Yu Sun, Yuanyan Xiong, Wenbin Ma, Yongxiang Liu, Yali Wang, Jian-Pei Fang, Dan Liú, Zhou Songyang, Canquan Zhou, Junjiu Huang
Exosomes from antler stem cells alleviate mesenchymal stem cell senescence and osteoarthritis
Protein & Cell - Tập 13 Số 3 - Trang 220-226 - 2022
Jinghui Lei, Xiaoyu Jiang, Wei Li, Jie Ren, Datao Wang, Zhejun Ji, Zeming Wu, Fang Cheng, Yusheng Cai, Zhengrong Yu, Juan Carlos Izpisúa Belmonte, Chunyi Li, Guang‐Hui Liu, Weiqi Zhang, Jing Qu, Si Wang
Nucleotide bias of DCL and AGO in plant anti-virus gene silencing
Protein & Cell - Tập 1 - Trang 847-858 - 2011
Thien Ho, Liang Wang, Linfeng Huang, Zhigang Li, Denise W. Pallett, Tamas Dalmay, Kazusato Ohshima, John A. Walsh, Hui Wang
Plant Dicer-like (DCL) and Argonaute (AGO) are the key enzymes involved in anti-virus post-transcriptional gene silencing (AV-PTGS). Here we show that AV-PTGS exhibited nucleotide preference by calculating a relative AV-PTGS efficiency on processing viral RNA substrates. In comparison with genome sequences of dicot-infecting Turnip mosaic virus (TuMV) and monocot-infecting Cocksfoot streak virus (...... hiện toàn bộ
Equilibria between the K+ binding and cation vacancy conformations of potassium channels
Protein & Cell - - 2019
Yao He, Bo Zhang, Hao Dong, Penglin Xu, Xiaoying Cai, Ting Zhou, Yu Mu, Jun Liang, Xiao Zheng, Changlin Tian
Correction to: Rescue of premature aging defects in Cockayne syndrome stem cells by CRISPR/Cas9-mediated gene correction
Protein & Cell - Tập 13 - Trang 623-625 - 2022
Si Wang, Zheying Min, Qianzhao Ji, Lingling Geng, Yao Su, Zunpeng Liu, Huifang Hu, Lixia Wang, Weiqi Zhang, Keiichiro Suzuiki, Yu Huang, Puyao Zhang, Tie-Shan Tang, Jing Qu, Yang Yu, Guang-Hui Liu, Jie Qiao
Programmed cell death may act as a surveillance mechanism to safeguard male gametophyte development in Arabidopsis
Protein & Cell - - 2011
Jian Zhang, Chong Teng, Yan Liang
Therapeutic silencing miR-146b-5p improves cardiac remodeling in a porcine model of myocardial infarction by modulating the wound reparative phenotype
Protein & Cell - Tập 12 Số 3 - Trang 194-212 - 2021
Yiteng Liao, Hao Li, Hao Cao, Yun Dong, Lei Gao, Zhongmin Liu, Junbo Ge, Hongming Zhu
AbstractFibrotic remodeling is an adverse consequence of immune response-driven phenotypic modulation of cardiac cells following myocardial infarction (MI). MicroRNA-146b (miR-146b) is an active regulator of immunomodulation, but its function in the cardiac inflammatory cascade and its clinical implication in fibrotic remodeling following MI remain largely unknown....... hiện toàn bộ
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