Protein & Cell
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Memory T cells: strategies for optimizing tumor immunotherapy
Protein & Cell - Tập 11 - Trang 549-564 - 2020
Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells. Furthermore, the Tcm/Teff ratio has been reported to be a predictive biomarker of immune responses against some tumors. Thus, a system-level understa......
Structural studies on MRG701 chromodomain reveal a novel dimerization interface of MRG proteins in green plants
Protein & Cell - Tập 7 - Trang 792-803 - 2016
MRG proteins are conserved during evolution in fungi, flies, mammals and plants, and they can exhibit diversified functions. The animal MRGs were found to form various complexes to activate gene expression. Plant MRG1/2 and MRG702 were reported to be involved in the regulation of flowering time via binding to H3K36me3-marked flowering genes. Herein, we determined the crystal structure of MRG701 ch......
The role of Pbx1 in T cells
Protein & Cell - Tập 2 - Trang 946-949 - 2012
Tissue and organ differentiation is tightly controlled to ensure proper development and function of the growing embryo as well as cells such as lymphocytes that differentiate throughout the adult stage. Therefore it is vital that the genes and the protein they encode that are involved in these processes function accurately. Hence, any mutation or error that occurs along the way can result in exten......
Debao Wang, the founder of nucleic acid biology and industry in People’s Republic of China
Protein & Cell - Tập 12 - Trang 237-239 - 2020
Hepatitis B virus is degraded by autophagosome-lysosome fusion mediated by Rab7 and related components
Protein & Cell - Tập 10 Số 1 - Trang 60-66 - 2019
Formation and regulation of Yersinia biofilms
Protein & Cell - Tập 2 - Trang 173-179 - 2011
Flea-borne transmission is a recent evolutionary adaptation that distinguishes the deadly Yersinia pestis from its progenitor Y. Pseudotuberculosis, a mild pathogen transmitted via the food-borne route. Y. Pestis synthesizes biofilms in the flea gut, which is important for fleaborne transmission. Yersinia biofilms are bacterial colonies surrounded by extracellular matrix primarily containing a hom......
Correction to: Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers
Protein & Cell - Tập 10 - Trang 927-928 - 2019
In the original publication the labels in figure 4C and D are incorrectly published. The correct labels for figure 4C and D is provided in this correction.
Histone deacetylase 6 and cytoplasmic linker protein 170 function together to regulate the motility of pancreatic cancer cells
Protein & Cell - Tập 5 - Trang 214-223 - 2014
Pancreatic cancer is a devastating disease with the worst prognosis among all the major human malignancies. The propensity to rapidly metastasize contributes significantly to the highly aggressive feature of pancreatic cancer. The molecular mechanisms underlying this remain elusive, and proteins involved in the control of pancreatic cancer cell motility are not fully characterized. In this study, ......
TCF-1 deficiency influences the composition of intestinal microbiota and enhances susceptibility to colonic inflammation
Protein & Cell - Tập 11 - Trang 380-386 - 2020
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