Protein & Cell
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Memory T cells: strategies for optimizing tumor immunotherapy
Protein & Cell - Tập 11 - Trang 549-564 - 2020
Several studies have demonstrated that memory T cells including stem cell memory (Tscm) T cells and central memory (Tcm) T cells show superior persistence and antitumor immunity compared with effector memory T (Tem) cells and effector T (Teff) cells. Furthermore, the Tcm/Teff ratio has been reported to be a predictive biomarker of immune responses against some tumors. Thus, a system-level understa......
Structures of the N- and C-terminal domains of MHV-A59 nucleocapsid protein corroborate a conserved RNA-protein binding mechanism in coronavirus
Protein & Cell - - 2010
Crystal structure of the African swine fever virus structural protein p35 reveals its role for core shell assembly
Protein & Cell - Tập 11 - Trang 600-605 - 2020
Structural studies on MRG701 chromodomain reveal a novel dimerization interface of MRG proteins in green plants
Protein & Cell - Tập 7 - Trang 792-803 - 2016
MRG proteins are conserved during evolution in fungi, flies, mammals and plants, and they can exhibit diversified functions. The animal MRGs were found to form various complexes to activate gene expression. Plant MRG1/2 and MRG702 were reported to be involved in the regulation of flowering time via binding to H3K36me3-marked flowering genes. Herein, we determined the crystal structure of MRG701 ch......
Correction to: Glycosylation of dentin matrix protein 1 is a novel key element for astrocyte maturation and BBB integrity
Protein & Cell - - 2018
In the original publication, the label of Fig. 2C should be read as “GFAP/lectin/DAPI” not “DMP1/GFAP/lectin/DAPI”.
The role of Pbx1 in T cells
Protein & Cell - Tập 2 - Trang 946-949 - 2012
Tissue and organ differentiation is tightly controlled to ensure proper development and function of the growing embryo as well as cells such as lymphocytes that differentiate throughout the adult stage. Therefore it is vital that the genes and the protein they encode that are involved in these processes function accurately. Hence, any mutation or error that occurs along the way can result in exten......
Debao Wang, the founder of nucleic acid biology and industry in People’s Republic of China
Protein & Cell - Tập 12 - Trang 237-239 - 2020
Hepatitis B virus is degraded by autophagosome-lysosome fusion mediated by Rab7 and related components
Protein & Cell - Tập 10 Số 1 - Trang 60-66 - 2019
Proteomic identification and functional characterization of MYH9, Hsc70, and DNAJA1 as novel substrates of HDAC6 deacetylase activity
Protein & Cell - Tập 6 - Trang 42-54 - 2014
Histone deacetylase 6 (HDAC6), a predominantly cytoplasmic protein deacetylase, participates in a wide range of cellular processes through its deacetylase activity. However, the diverse functions of HDAC6 cannot be fully elucidated with its known substrates. In an attempt to explore the substrate diversity of HDAC6, we performed quantitative proteomic analyses to monitor changes in the abundance o......
Formation and regulation of Yersinia biofilms
Protein & Cell - Tập 2 - Trang 173-179 - 2011
Flea-borne transmission is a recent evolutionary adaptation that distinguishes the deadly Yersinia pestis from its progenitor Y. Pseudotuberculosis, a mild pathogen transmitted via the food-borne route. Y. Pestis synthesizes biofilms in the flea gut, which is important for fleaborne transmission. Yersinia biofilms are bacterial colonies surrounded by extracellular matrix primarily containing a hom......
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