Pharmacotherapy

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Bevacizumab Use and the Risk of Arterial and Venous Thromboembolism in Patients with High‐Grade Gliomas: A Nested Case‐Control Study
Pharmacotherapy - Tập 39 Số 9 - Trang 921-928 - 2019
In-Young Lee, Sruthi Adimadhyam, Edith A. Nutescu, Jifang Zhou, Alemseged Ayele Asfaw, Karen Sweiss, Pritesh Patel, Gregory S. Calip
Study ObjectiveBevacizumab is used in the treatment of recurrent glioblastoma, but evidence is limited on the incidence of thromboembolic complications regarding the use of this drug in real‐world settings. We evaluated the risk of arterial thromboembolism (ATE) and venous thromboembolism (... hiện toàn bộ
Evaluation of Carvedilol for the Treatment of Portal Hypertension
Pharmacotherapy - Tập 24 Số 1 - Trang 94-104 - 2004
Brian A. Hemstreet
Development of bleeding gastroesophageal varices is a serious consequence of portal hypertension secondary to cirrhosis. Nonselective β‐blockers have been used to reduce portal pressures and prevent primary and secondary bleeding episodes. However, up to two thirds of patients may not respond appropriately to these agents. Nonselective β‐blockers combined with vasodilatory drugs result in ...... hiện toàn bộ
Midazolam: Benzodiazepin Tan Trong Nước Đầu Tiên; Dược Lý Học, Dược Động Học và Hiệu Quả Điều Trị Mất Ngủ và Gây Mê Dịch bởi AI
Pharmacotherapy - Tập 5 Số 3 - Trang 138-155 - 1985
J Kanto
Midazolam là một dẫn xuất của 1,4-benzodiazepin với cấu trúc hóa học độc đáo: tùy thuộc vào pH môi trường, thuốc có thể tạo ra muối dễ tan trong nước (pH < 4) hoặc tồn tại ở dạng vòng diazepin ưu béo (pH > 4). Tính chất này góp phần vào sự khởi phát nhanh chóng của tác dụng và sự dung nạp tốt tại vị trí cục bộ sau khi tiêm parenteral. Sau khi uống và tiêm parenteral, midazolam có tốc...... hiện toàn bộ
#benzodiazepin #dược lý học #dược động học #midazolam #gây mê #mất ngủ #tác dụng an thần #amnesia #ổn định tim mạch #khởi phát nhanh #dung nạp tại chỗ
Successful Interventions for Gram‐Negative Resistance to Extended‐Spectrum β‐Lactam Antibiotics
Pharmacotherapy - Tập 19 Số 8P2 - 1999
Louis B. Rice
Antibiotic resistance among nosocomial pathogens in this country's hospitals adds significantly to patient morbidity and mortality and the cost of health care. Optimism for identifying antimicrobial agents that would “solve the problem” of resistance has been replaced by a much more guarded and realistic view of the battle between humans and pathogenic microorganisms. Efforts now are more ...... hiện toàn bộ
Cisplatin‐induced nephrotoxicity in an outpatient setting
Pharmacotherapy - Tập 41 Số 2 - Trang 184-190 - 2021
Carly V. Burns, Stephanie B. Edwin, Susan Szpunar, Jason Forman
AbstractBackgroundThe use of cisplatin is limited by the development of nephrotoxicity, with an incidence approaching 30%. It is unclear if a risk prediction score can effectively predict the development of nephrotoxicity throughout all cycles of cisplatin therapy among outpatients.Methods...... hiện toàn bộ
Evaluation of Warfarin Management with International Normalized Ratio Self‐Testing and Online Remote Monitoring and Management Plus Low‐Dose Vitamin K with Genomic Considerations: A Pilot Study
Pharmacotherapy - Tập 33 Số 11 - Trang 1136-1146 - 2013
Henry I. Bussey, Marie Bussey, Kristin L. Bussey‐Smith, Christopher R. Frei
Study ObjectivesAs better international normalized ratio (INR) control and self‐testing reduce events in warfarin‐treated patients, and vitamin K supplementation may improve INR... hiện toàn bộ
Reduction in Warfarin Adverse Events Requiring Patient Hospitalization After Implementation of a Pharmacist-Managed Anticoagulation Service
Pharmacotherapy - Tập 25 Số 5 - Trang 685-689 - 2005
Christy Locke, Susan L. Ravnan, Rajul A. Patel, James A. Uchizono
Outpatient Self‐Management of Warfarin Therapy: A Pilot Study
Pharmacotherapy - Tập 19 Số 6 - Trang 787-793 - 1999
Rubina Sunderji, Lara M Campbell, Karen Shalansky, Anthony Fung, Cedric Carter, Kenneth Gin
Self‐testing and adjusting of warfarin dosages by patients is an evolving strategy for management of oral anticoagulation. We performed this open, prospective, 3‐month pilot study to assess the feasibility of conducting a large, randomized trial comparing self‐managed with physician‐managed anticoagulation. Ten competent patients with planned anticoagulation for at least 3 months were prov...... hiện toàn bộ
Fluoroquinolone‐Associated Tendinopathy: Does Levofloxacin Pose the Greatest Risk?
Pharmacotherapy - Tập 36 Số 6 - Trang 679-693 - 2016
Monique R. Bidell, Thomas P. Lodise
Fluoroquinolone antibiotics recently have gained increased national attention due to safety concerns. A well‐described and serious adverse event associated with receipt of fluoroquinolones is tendinitis and tendon rupture. These tendon injuries can result in long‐term sequelae, including chronic pain and mobility restrictions, and may warrant surgery. Due to the severity of these adverse e...... hiện toàn bộ
Risperidone‐Associated Diabetes Mellitus: A Pharmacovigilance Study
Pharmacotherapy - Tập 23 Số 6 - Trang 735-744 - 2003
Elizabeth A. Koller, James T. Cross, P. Murali Doraiswamy, B Schneider
Study Objective. To explore the clinical characteristics of hyperglycemia in patients treated with risperidone.Design. Pharmacovigilance survey of spontaneously reported adverse events in risperidone‐treated patients, with reports of haloperidol‐associated hyperglycemia used as a control.Setting.... hiện toàn bộ
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