Effects of Chronic Administration of Sarpogrelate on Systolic Blood Pressure of Spontaneously Hypertensive Rats: Comparison with QuinaprilPharmacology - Tập 64 Số 2 - Trang 71-75 - 2002
Yuki Setoguchi, Toshio Ohnuki, Mamunur Rashid, Takashi Nakamura, Kaoru Hattori, Takafumi Nagatomo, Kenichi Watanabe, Akio Mitomi, Mikio Nakazawa
Effects of long-term sarpogrelate (5-HT<sub>2</sub> antagonist) administration on the systolic blood pressure of Wistar-Kyoto normotensive rats (WKYs) and spontaneously hypertensive rats (SHRs) were studied and compared with those of quinapril (ACE-I). Sarpogrelate and quinapril were administered orally for 12 weeks and body and heart weights, systolic blood pressure and the re...... hiện toàn bộ
Heme Oxygenase Inhibitors Transiently Increase Serum Ferritin Concentrations without Altering Other Acute-Phase Reactants in ManPharmacology - Tập 59 Số 1 - Trang 51-56 - 1999
Lars Berglund, Richard A. Galbraith, Lennart Emtestam, George I. Drummond, Bo Angelin, Attallah Kappas
Sn protoporphyrin (SnPP) and Sn mesoporphyrin (SnMP), potent inhibitors of heme oxygenase (HO), significantly suppress bilirubin production, lower serum and biliary bilirubin levels and increase biliary heme output in animals and man. In this study, 20 healthy volunteers, 7 patients with primary biliary cirrhosis and 4 patients with idiopathic hemochromatosis were treated with SnPP and 4 h...... hiện toàn bộ