Pharmacological Reports
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Immunosuppressants attenuate HMGB1 expression and release from primary astrocyte cultures exposed to combined oxygen-glucose deprivation
Pharmacological Reports - Tập 61 - Trang 353-353 - 2009
Interleukin-13-induced activation of signal transducer and activator of transcription 6 is mediated by an activation of Janus kinase 1 in cultured human bronchial smooth muscle cells
Pharmacological Reports - Tập 64 - Trang 454-458 - 2012
The current study was carried out to identify the JAK molecule(s) that is involved in the IL-13-induced activation of STAT6 in cultured human bronchial smooth muscle cells (hBSMCs). Cultured hBSMCs were stimulated with IL-13 in the absence and presence of JAK inhibitor-I (a nonspecific JAKs inhibitor), tyrphostin-AG490 (a specific JAK2 inhibitor), WHI-P131 (a specific JAK3 inhibitor), or tyrphosti......
Therapeutic potential of melatonin in targeting molecular pathways of organ fibrosis
Pharmacological Reports - - 2024
Pioglitazone, an anti-diabetic drug requires sustained MAPK activation for its anti-tumor activity in MCF7 breast cancer cells, independent of PPAR-γ pathway
Pharmacological Reports - Tập 68 - Trang 144-154 - 2016
Flowers for Algernon: steroid dysgenesis, epigenetics and brain disorders
Pharmacological Reports - Tập 64 Số 6 - Trang 1285-1290 - 2012
Blockade of fructose transporter protein GLUT5 inhibits proliferation of colon cancer cells: proof of concept for a new class of anti-tumor therapeutics
Pharmacological Reports - Tập 73 - Trang 939-945 - 2021
Despite the fact that colorectal cancer (CRC) is one of the most commonly diagnosed cancers in men and women, its current treatment remains unsatisfactory and therefore novel studies proposing new approaches are necessary. A high sugar diet is believed to promote carcinogenesis. Fructose is absorbed from the gastrointestinal tract by members of the glucose transporter family—GLUT. The aim of the s......
Nitrate tolerance as a model of vascular dysfunction: Roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress
Pharmacological Reports - Tập 61 - Trang 33-48 - 2009
Organic nitrates are a group of very effective anti-ischemic drugs. They are used for the treatment of patients with stable angina, acute myocardial infarction and chronic congestive heart failure. Amajor therapeutic limitation inherent to organic nitrates is the development of tolerance, which occurs during chronic treatment with these agents. The mechanisms underlying nitrate tolerance remain in......
Antinociceptive effect of the new cyclic dermorphin/deltorphin tetrapeptide analogue in animal models of pain
Pharmacological Reports - Tập 65 - Trang 28-29 - 2013
The decreased achievement of therapeutic goal in lipid lowering therapy in obese and diabetic patients in Poland
Pharmacological Reports - Tập 69 - Trang 6-12 - 2017
Một khuôn mẫu mới cho sự sinh ra các loài phản ứng được xúc tác bởi XOR trong nội mô Dịch bởi AI
Pharmacological Reports - Tập 67 - Trang 669-674 - 2015
Một loạt bệnh lý mạch máu liên quan đến viêm, trạng thái thiếu oxy và tỷ lệ tạo ra các loài phản ứng gia tăng. Một nguồn chính của các loài phản ứng này là enzym phân giải purine xanthine oxidoreductase (XOR) khi nhiều báo cáo trong 30 năm qua đã chứng minh rằng sự ức chế XOR có tác dụng tích cực. Mặc dù có sự liên hệ lâu dài giữa hoạt động XOR mạch máu gia tăng và các kết quả lâm sàng tiêu cực, c......
Tổng số: 2,984
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