Evaluation of Cytotoxic Properties of N,N'-bis[(1-aryl-3-heteroaryl)propylidene]-hydrazine dihydrochloridesPharmaceutical Chemistry Journal - Tập 54 - Trang 784-787 - 2020
K. Kucukoglu, H. I. Gul, H. Sakagami
N,N'-bis[(1-aryl-3-heteroaryl)propylidene]hydrazine dihydrochlorides, P1, P4 – P8, and R1 – R7, were assayed against human oral squamous cell carcinoma (HSC-2, HSC-3, HSC-4), human promyelocytic leukemia cell line (HL-60), and human normal oral cells (HGF, HPC, and HPLF) as non-tumor cells to evaluate their cytotoxic properties. Peplomycin was used as a reference compound. It was found that P- and...... hiện toàn bộ
HPLC Analysis of a New Granulated Preparation Containing Isoniazid and Pyridoxine HydrochloridePharmaceutical Chemistry Journal - Tập 39 - Trang 441-443 - 2005
E. V. Kompantseva, A. V. Khalata, L. P. Ovcharenko, L. N. Dukkardt, N. V. Blagorazumnaya
A new ready-to-use medicinal form — granules containing isoniazid and pyridoxine hydrochloride (0.15 and 0.015 g per gram of granules, respectively) — has been recently developed. An HPLC technique for the qualitative and quantitative analysis of the new preparation is described. The analyses are carried out using a Millihrom-2 chromatograph equipped with a UV detector and a KAKh 4-64-3 column fil...... hiện toàn bộ
Modification of the Antitumor Action of Cytostatic Drugs Using a Copolymer of N-Vinylpyrrolidone and 2-Methyl-5-VinylpyridinePharmaceutical Chemistry Journal - Tập 51 - Trang 523-527 - 2017
A. V. Panov, Yu. V. Kochkina, E. I. Yartsev, D. V. Eremin, T. A. Yakovleva, S. A. Kedik
Simultaneous administration of a copolymer of N-vinylpyrrolidone and 2-methyl-5-vinylpyridine and cytostatic agents to mice with a variety of implanted tumors was found to increase treatment efficacy, promoting increases in survival time. This effect is of interest for further studies of the possible use of copolymer as an immunomodulator in chemotherapy.
Synthesis, physicochemical characteristics, and biocidal activity of some transition metal mixed-ligand complexes with bidentate (NO and NN) Schiff basesPharmaceutical Chemistry Journal - Tập 41 - Trang 78-81 - 2007
N. H. Patel, H. M. Parekh, M. N. Patel
Mixed-ligand complexes of the type [M(SB)2acphen], where M = Mn(II), Co(II), Ni(II), Cu(II), and Cd(II), HSB = 3,5-dibromosalicylideneaniline, and acphen = bis(acetophenone)ethylenediamine, have been prepared and characterized on the basis of elemental analyses, magnetic measurements, thermogravimetry, and infrared and electronic absorption spectroscopy. All the mixed-ligand complexes exhibit an o...... hiện toàn bộ