Oxford University Press (OUP)

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Hormonal Predictors of Bone Loss in Elderly Women: A Prospective Study
Oxford University Press (OUP) - Tập 13 Số 7 - Trang 1167-1174 - 1998
Katie Stone, Douglas C. Bauer, Dennis M. Black, Peter M. Sklarin, Kristine E. Ensrud, S. R. Cummings
Abstract To test the hypotheses that baseline concentrations of sex steroids, sex hormone binding globulin (SHBG), and calciotropic hormones predict rates of bone loss in elderly women, sera were stored at −190°C, and calcaneal bone mineral density (BMD) was measured in 9704 community-dwelling white women aged 65 and over (1986–1988). Hip BMD was mea...... hiện toàn bộ
Biochemical Markers of Bone Turnover and Prediction of Hip Bone Loss in Older Women: The Study of Osteoporotic Fractures
Oxford University Press (OUP) - Tập 14 Số 8 - Trang 1404-1410 - 1999
Douglas C. Bauer, Peter M. Sklarin, Katie Stone, Dennis M. Black, Michael C. Nevitt, Kristine E. Ensrud, Claude D. Arnaud, Harry K. Genant, Patrick Garnero, P. D. Delmas, Henrik Lawaetz, S. R. Cummings
Abstract To examine the ability of commercially available biochemical markers of bone formation and resorption to predict hip bone loss, we prospectively obtained serum and timed 2-h urine specimens from 295 women age 67 years or older who were not receiving estrogen replacement therapy. Serum was assayed for two markers of bone formation: osteocalci...... hiện toàn bộ
Enhanced Expression of the Inorganic Phosphate Transporter Pit-1 Is Involved in BMP-2–Induced Matrix Mineralization in Osteoblast-Like Cells
Oxford University Press (OUP) - Tập 21 Số 5 - Trang 674-683 - 2006
Atsushi Suzuki, Chafik Ghayor, Jérôme Guicheux, David Magne, S. Quillard, Ayako Kakita, Yuka Ono, Yoshitaka Miura, Yutaka Oiso, Mitsuyasu Itoh, Joseph Caverzasio
Abstract Pi handling by osteogenic cells is important for bone mineralization. The role of Pi transport in BMP-2–induced matrix calcification was studied. BMP-2 enhances Pit-1 Pi transporters in osteogenic cells. Experimental analysis suggest that this response is required for bone matrix calcification. Introduction: B...... hiện toàn bộ
Femoral Neck Bone Loss Predicts Fracture Risk Independent of Baseline BMD
Oxford University Press (OUP) - Tập 20 Số 7 - Trang 1195-1201 - 2005
Tuan V. Nguyen, Jacqueline R. Center, John A. Eisman
Abstract Whereas low BMD is known to be a risk factor for fracture, it is not clear whether loss of BMD is also a risk factor. In elderly women, greater loss of BMD at the femoral neck was associated with increased risk of fracture, independent of baseline BMD and age. Introduction: Baseline measurement of BMD predicts...... hiện toàn bộ
Regulation of 1,25-dihydroxyvitamin d3 by calcium in the parathyroidectomized, parathyroid hormone-replete rat
Oxford University Press (OUP) - Tập 4 Số 6 - Trang 929-935 - 1989
Eduardo Slatopolsky, Murray J. Favus, Craig B. Langman, David A. Bushinsky
AbstractParathyroid hormone (PTH) is a major stimulus for the renal production of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. Elevated arterial blood ionized calcium ([Ca2+]) depresses serum 1,25-(OH)2D3 in nonparathyroidectomized rats even when serum PTH is maintained at high levels by infusion. However, suppression by [Ca2+] of endogenous PTH, causing the fall in 1,...... hiện toàn bộ
Medium Perfusion Enhances Osteogenesis by Murine Osteosarcoma Cells in Three-Dimensional Collagen Sponges
Oxford University Press (OUP) - Tập 14 Số 12 - Trang 2118-2126 - 1999
Stefan M. Mueller, Shuichi Mizuno, Louis C. Gerstenfeld, Julie Glowacki
Abstract In this study, we examined in vitro histogenesis by murine K8 osteosarcoma cells maintained in three-dimensional (3D) collagen sponges. We tested the hypothesis that perfusion of medium enhances cell viability and their biosynthetic activity as assessed by expression of the osteoblastic phenotype and mineral deposition. At intervals, samples...... hiện toàn bộ
Cortical and Trabecular Load Sharing in the Human Vertebral Body
Oxford University Press (OUP) - Tập 21 Số 2 - Trang 307-314 - 2006
Senthil Kumar Eswaran, Atul Gupta, Mark F. Adams, Tony M. Keaveny
Abstract The biomechanical role of the vertebral cortical shell remains poorly understood. Using high-resolution finite element modeling of a cohort of elderly vertebrae, we found that the biomechanical role of the shell can be substantial and that the load sharing between the cortical and trabecular bone is complex. As a result, a more integrative m...... hiện toàn bộ
Osteocyte kỳ diệu Dịch bởi AI
Oxford University Press (OUP) - Tập 26 Số 2 - Trang 229-238 - 2011
Lynda F. Bonewald
Tóm tắt Thập kỷ qua đã cung cấp một lượng dữ liệu khổng lồ về sinh học phân tử và chức năng của tế bào xương (osteocyte). Khác xa với hình ảnh “vị trí tạm bợ trong xương”, tế bào này đã được phát hiện có nhiều chức năng, như là một người điều phối quá trình tái cấu trúc xương thông qua việc điều chỉnh hoạt động của cả tế bào hủy xương (osteoclast) và...... hiện toàn bộ
Anabolic or Catabolic Responses of MC3T3-E1 Osteoblastic Cells to Parathyroid Hormone Depend on Time and Duration of Treatment
Oxford University Press (OUP) - Tập 14 Số 9 - Trang 1504-1512 - 1999
Paul C. Schiller, Gianluca D’Ippolito, Bernard A. Roos, G. A. Howard
Abstract We have investigated signaling (cAMP) and anabolic responses (mineralization of extracellular matrix [ECM]) to parathyroid hormone (PTH) in long-term (30 days) cultures of MC3T3-E1 cells, a murine model of osteoblast differentiation. Expression of PTH/PTH–related peptide receptor (PTH1R) mRNA is detected early and remains relatively constant...... hiện toàn bộ
Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee
Oxford University Press (OUP) - Tập 28 Số 1 - Trang 2-17 - 2013
David W. Dempster, Juliet Compston, Marc K. Drezner, Francis H. Glorieux, John А. Kanis, Hartmut H. Malluche, Jean Sibilia, Susan M. Ott, Robert R. Recker, A. M. Parfitt
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