Oxford University Press (OUP)

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Hormonal Predictors of Bone Loss in Elderly Women: A Prospective Study
Oxford University Press (OUP) - Tập 13 Số 7 - Trang 1167-1174 - 1998
Katie Stone, Douglas C. Bauer, Dennis M. Black, Peter M. Sklarin, Kristine E. Ensrud, S. R. Cummings
Abstract To test the hypotheses that baseline concentrations of sex steroids, sex hormone binding globulin (SHBG), and calciotropic hormones predict rates of bone loss in elderly women, sera were stored at −190°C, and calcaneal bone mineral density (BMD) was measured in 9704 community-dwelling white women aged 65 and over (1986–1988). Hip BMD was mea...... hiện toàn bộ
The Roles of Osteoprotegerin and Osteoprotegerin Ligand in the Paracrine Regulation of Bone Resorption
Oxford University Press (OUP) - Tập 15 Số 1 - Trang 2-12 - 2000
Lorenz C. Hofbauer, Sundeep Khosla, Colin R. Dunstan, David L. Lacey, William J. Boyle, B. Lawrence Riggs
Abstract Although multiple hormones and cytokines regulate various aspects of osteoclast formation, the final two effectors are osteoprotegerin ligand (OPG-L)/osteoclast differentiation factor (ODF), a recently cloned member of the tumor necrosis factor superfamily, and macrophage colony–stimulating factor. OPG-L/ODF is produced by osteoblast lineage...... hiện toàn bộ
Biochemical Markers of Bone Turnover and Prediction of Hip Bone Loss in Older Women: The Study of Osteoporotic Fractures
Oxford University Press (OUP) - Tập 14 Số 8 - Trang 1404-1410 - 1999
Douglas C. Bauer, Peter M. Sklarin, Katie Stone, Dennis M. Black, Michael C. Nevitt, Kristine E. Ensrud, Claude D. Arnaud, Harry K. Genant, Patrick Garnero, P. D. Delmas, Henrik Lawaetz, S. R. Cummings
Abstract To examine the ability of commercially available biochemical markers of bone formation and resorption to predict hip bone loss, we prospectively obtained serum and timed 2-h urine specimens from 295 women age 67 years or older who were not receiving estrogen replacement therapy. Serum was assayed for two markers of bone formation: osteocalci...... hiện toàn bộ
Serum Estradiol and Sex Hormone-Binding Globulin and the Risk of Hip Fracture in Elderly Women: The EPIDOS Study
Oxford University Press (OUP) - Tập 15 Số 9 - Trang 1835-1841 - 2000
Roland Chapurlat, Patrick Garnero, Gérard Bréart, Pierre J. Meunier, Pierre D. Delmas
Abstract It has been suggested that low serum 17β-estradiol (E2) and sex hormone-binding globulin (SHBG) may predict hip fracture in postmenopausal women. We have investigated the predictive value of serum E2 and SHBG concentrations and urinary deoxypyridinoline (D-Pyr) and type I collagen breakdown products (CTX) in a large prospective cohort of 759...... hiện toàn bộ
Static and tetracycline-based bone histomorphometric data from 34 normal postmenopausal females
Oxford University Press (OUP) - Tập 3 Số 2 - Trang 133-144 - 1988
Robert R. Recker, Donald B. Kimmel, Michael A. Parfitt, Michael K. Davies, N.M. Keshawarz, Sharilyn M. Hinders
Abstract Transilial bone biopsies were obtained from 34 healthy postmenopausal women following in vivo fluorochrome labeling. Stained and unstained undecalcified sections were evaluated using a Merz grid. Standard histomorphometric data from cancellous bone tissue were collected and the results were evaluated and presented as variables commonly used ...... hiện toàn bộ
Enhanced Expression of the Inorganic Phosphate Transporter Pit-1 Is Involved in BMP-2–Induced Matrix Mineralization in Osteoblast-Like Cells
Oxford University Press (OUP) - Tập 21 Số 5 - Trang 674-683 - 2006
Atsushi Suzuki, Chafik Ghayor, Jérôme Guicheux, David Magne, S. Quillard, Ayako Kakita, Yuka Ono, Yoshitaka Miura, Yutaka Oiso, Mitsuyasu Itoh, Joseph Caverzasio
Abstract Pi handling by osteogenic cells is important for bone mineralization. The role of Pi transport in BMP-2–induced matrix calcification was studied. BMP-2 enhances Pit-1 Pi transporters in osteogenic cells. Experimental analysis suggest that this response is required for bone matrix calcification. Introduction: B...... hiện toàn bộ
Skeletal Unloading Causes Resistance of Osteoprogenitor Cells to Parathyroid Hormone and to Insulin-like Growth Factor-I
Oxford University Press (OUP) - Tập 14 Số 1 - Trang 21-31 - 1999
Paul J. Kostenuik, J. Harris, Bernard P. Halloran, Russell T. Turner, Emily Morey‐Holton, Daniel D. Bikle
Abstract Skeletal unloading decreases bone formation and osteoblast number in vivo and decreases the number and proliferation of bone marrow osteoprogenitor (BMOp) cells in vitro. We tested the ability of parathyroid hormone (PTH) to stimulate BMOp cells in vivo by treating Sprague Dawley rats (n = 32) with intermittent PTH(1–34) (1 h/day at 8 μ g/10...... hiện toàn bộ
Development and characterization of a conditionally immortalized human fetal osteoblastic cell line
Oxford University Press (OUP) - Tập 10 Số 2 - Trang 178-186 - 1995
Steven A. Harris, Robert J. Enger, Lawrence B. Riggs, Thomas C. Spelsberg
Abstract We report the establishment of a human fetal osteoblast cell line derived from biopsies obtained from a spontaneous miscarriage. Primary cultures isolated from fetal tissue were transfected with a gene coding for a temperature-sensitive mutant (tsA58) of SV40 large T antigen along with a gene coding for neomycin (G418) resistance. Individual...... hiện toàn bộ
Vitamin D Receptor–Dependent 1α,25(OH)2 Vitamin D3–Induced Anti-Apoptotic PI3K/AKT Signaling in Osteoblasts
Oxford University Press (OUP) - Tập 23 Số 8 - Trang 1238-1248 - 2008
Xiaoyu Zhang, Laura P. Zanello
Abstract Osteoblast apoptosis plays a crucial role in bone remodeling. Physiological doses of 1α,25(OH)2-vitamin D3 (1,25D) protect osteoblasts against apoptosis by means of mechanisms only partially understood. We studied activation of an Akt survival cascade downstream of 1,25D nongenomic stimulation of phosphatidylinositide-3′-kinase (PI3K) in ost...... hiện toàn bộ
Long-Term Aminobisphosphonate Treatment of Fibrous Dysplasia: Spectacular Increase in Bone Density
Oxford University Press (OUP) - Tập 12 Số 8 - Trang 1314-1315 - 1997
Robert S. Weinstein
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