Oxford University Press (OUP)
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Hormonal Predictors of Bone Loss in Elderly Women: A Prospective Study
Oxford University Press (OUP) - Tập 13 Số 7 - Trang 1167-1174 - 1998
Abstract To test the hypotheses that baseline concentrations of sex steroids,
sex hormone binding globulin (SHBG), and calciotropic hormones predict rates of
bone loss in elderly women, sera were stored at −190°C, and calcaneal bone
mineral density (BMD) was measured in 9704 community-dwelling white women aged
65 and over (1986–1988). Hip BMD was measured 2 years later (1990). Repeat
measurements ...
Biochemical Markers of Bone Turnover and Prediction of Hip Bone Loss in Older Women: The Study of Osteoporotic Fractures
Oxford University Press (OUP) - Tập 14 Số 8 - Trang 1404-1410 - 1999
Abstract To examine the ability of commercially available biochemical markers of
bone formation and resorption to predict hip bone loss, we prospectively
obtained serum and timed 2-h urine specimens from 295 women age 67 years or
older who were not receiving estrogen replacement therapy. Serum was assayed for
two markers of bone formation: osteocalcin (OC) and bone-specific alkaline
phosphatase (B...
The Roles of Osteoprotegerin and Osteoprotegerin Ligand in the Paracrine Regulation of Bone Resorption
Oxford University Press (OUP) - Tập 15 Số 1 - Trang 2-12 - 2000
Abstract Although multiple hormones and cytokines regulate various aspects of
osteoclast formation, the final two effectors are osteoprotegerin ligand
(OPG-L)/osteoclast differentiation factor (ODF), a recently cloned member of the
tumor necrosis factor superfamily, and macrophage colony–stimulating factor.
OPG-L/ODF is produced by osteoblast lineage cells and exerts its biological
effects through...
Serum Estradiol and Sex Hormone-Binding Globulin and the Risk of Hip Fracture in Elderly Women: The EPIDOS Study
Oxford University Press (OUP) - Tập 15 Số 9 - Trang 1835-1841 - 2000
Abstract It has been suggested that low serum 17β-estradiol (E2) and sex
hormone-binding globulin (SHBG) may predict hip fracture in postmenopausal
women. We have investigated the predictive value of serum E2 and SHBG
concentrations and urinary deoxypyridinoline (D-Pyr) and type I collagen
breakdown products (CTX) in a large prospective cohort of 7598 healthy elderly
ambulatory women (EPIDOS study...
Static and tetracycline-based bone histomorphometric data from 34 normal postmenopausal females
Oxford University Press (OUP) - Tập 3 Số 2 - Trang 133-144 - 1988
Abstract Transilial bone biopsies were obtained from 34 healthy postmenopausal
women following in vivo fluorochrome labeling. Stained and unstained
undecalcified sections were evaluated using a Merz grid. Standard
histomorphometric data from cancellous bone tissue were collected and the
results were evaluated and presented as variables commonly used in bone
histomorphometry. The normal ranges, med...
Tỷ Lệ Xuất Hiện và Gánh Nặng Kinh Tế của Các Chấn Thương Liên Quan Đến Loãng Xương Tại Hoa Kỳ, 2005–2025 Dịch bởi AI
Oxford University Press (OUP) - Tập 22 Số 3 - Trang 465-475 - 2007
Tóm tắt Nghiên cứu này dự đoán gánh nặng của các chấn thương liên quan đến loãng
xương và chi phí tại Hoa Kỳ, phân theo giới tính, nhóm tuổi, chủng tộc/dân tộc
và loại chấn thương, từ năm 2005 đến 2025. Tổng số chấn thương vượt quá 2 triệu,
với chi phí gần 17 tỷ USD vào năm 2005. Nam giới chiếm hơn 25% gánh nặng. Sự gia
tăng nhanh chóng trong gánh nặng bệnh tật được dự đoán ở các nhóm không phải
n...
Growing C57Bl/6 Mice Increase Whole Bone Mechanical Properties by Increasing Geometric and Material Properties
Oxford University Press (OUP) - Tập 14 Số 12 - Trang 2159-2166 - 1999
Abstract In vivo murine models are becoming increasingly important in bone
research. To establish baseline data for researchers using these models, we
studied the long bones from C57BL/6 female mice, a strain that is widely used in
bone research. We determined the femoral structural and material properties in
both torsion and four-point bending for mice at ages 4–24 weeks. Measurements of
femoral ...
Isolation and characterization of a cDNA for osteopontin-k: A kidney cell adhesion molecule with high homology to osteopontins
Oxford University Press (OUP) - Tập 7 Số 6 - Trang 693-699 - 1992
Abstract Screening of a bovine renal cDNA library with MAbs(1) resulted in the
isolation of a 1447 bp cDNA. This cDNA (pBk2.1) was sequenced and shown to
contain an open reading frame with a putative protein of 261 amino acids, with a
molecular weight of 29,573 (minute leader sequence) and a hydrophobic leader
sequence of 16 amino acids. pBk2.1 was shown to share a high level of nucleic
acid seque...
Enhanced Expression of the Inorganic Phosphate Transporter Pit-1 Is Involved in BMP-2–Induced Matrix Mineralization in Osteoblast-Like Cells
Oxford University Press (OUP) - Tập 21 Số 5 - Trang 674-683 - 2006
Abstract Pi handling by osteogenic cells is important for bone mineralization.
The role of Pi transport in BMP-2–induced matrix calcification was studied.
BMP-2 enhances Pit-1 Pi transporters in osteogenic cells. Experimental analysis
suggest that this response is required for bone matrix calcification.
Introduction: Bone morphogenetic proteins (BMPs) are produced by osteogenic
cells and play an i...
Disturbances in Bone Largely Predict Aortic Calcification in an Alternative Rat Model Developed to Study Both Vascular and Bone Pathology in Chronic Kidney Disease
Oxford University Press (OUP) - Tập 30 Số 12 - Trang 2313-2324 - 2015
ABSTRACT Because current rat models used to study chronic kidney disease
(CKD)-related vascular calcification show consistent but excessive vascular
calcification and chaotic, immeasurable, bone mineralization due to excessive
bone turnover, they are not suited to study the bone-vascular axis in one and
the same animal. Because vascular calcification and bone mineralization are
closely related t...
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