Neuroscience Bulletin
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Increased globulin and its association with hemorrhagic transformation in patients receiving intra-arterial thrombolysis therapy
Neuroscience Bulletin - Tập 30 - Trang 469-476 - 2014
Previous studies have identified a diverse set of predisposing factors for the occurrence of hemorrhagic transformation (HT), but the independent clinical predictors of HT after intraarterial thrombolysis have not been determined. In this retrospective study, we investigated the characteristics of patients with or without HT who had received intra-arterial thrombolysis therapy, using biochemical a......
Pro-protein convertase-2/carboxypeptidase-E mediated neuropeptide processing of RGC-5 cell after in vitro ischemia
Neuroscience Bulletin - Tập 25 Số 3 - Trang 165-165 - 2009
Dlg1 Knockout Inhibits Microglial Activation and Alleviates Lipopolysaccharide-Induced Depression-Like Behavior in Mice
Neuroscience Bulletin - Tập 37 - Trang 1671-1682 - 2021
Microglia-mediated neuroinflammation is widely perceived as a contributor to numerous neurological diseases and mental disorders including depression. Discs large homolog 1 (Dlg1), an adaptor protein, regulates cell polarization and the function of K+ channels, which are reported to regulate the activation of microglia. However, little is known about the role of Dlg1 in microglia and the maintenan......
Projections from Infralimbic Cortex to Paraventricular Thalamus Mediate Fear Extinction Retrieval
Neuroscience Bulletin - Tập 37 - Trang 229-241 - 2020
The paraventricular nucleus of the thalamus (PVT), which serves as a hub, receives dense projections from the medial prefrontal cortex (mPFC) and projects to the lateral division of central amygdala (CeL). The infralimbic (IL) cortex plays a crucial role in encoding and recalling fear extinction memory. Here, we found that neurons in the PVT and IL were strongly activated during fear extinction re......
Biphasic Cholinergic Modulation of Reverberatory Activity in Neuronal NetworksAbstract Acetylcholine (ACh) is an important neuromodulator in various cognitive functions. However, it is unclear how ACh influences neural circuit dynamics by altering cellular properties. Here, we investigated how ACh influences reverberatory activity in cultured neuronal networks. We found that ACh suppressed the occurrence of evoked reverberation at low to mode... ...
Neuroscience Bulletin - Tập 39 Số 5 - Trang 731-744 - 2023
More than Scratching the Surface: Recent Progress in Brain Mechanisms Underlying Itch and Scratch
Neuroscience Bulletin - Tập 36 - Trang 85-88 - 2019
Internal States Influence the Representation and Modulation of Food Intake by Subthalamic Neurons
Neuroscience Bulletin - Tập 36 - Trang 1355-1368 - 2020
Deep brain stimulation of the subthalamic nucleus (STN) is an effective therapy for motor deficits in Parkinson’s disease (PD), but commonly causes weight gain in late-phase PD patients probably by increasing feeding motivation. It is unclear how STN neurons represent and modulate feeding behavior in different internal states. In the present study, we found that feeding caused a robust activation ......
UNC13A Gene Brings New Hope for ALS Disease-Modifying Drugs
Neuroscience Bulletin - Tập 38 - Trang 1431-1434 - 2022
Pathogenesis of Parkinson’s disease: oxidative stress, environmental impact factors and inflammatory processes
Neuroscience Bulletin - Tập 23 - Trang 125-130 - 2008
Current hypothesis of neuronal degeneration in Parkinson’s disease (PD) have been proposed, including formation of free radicals and oxidative stress, mitochondrial dysfunction, excitotoxicity, trophic factor deficiency, inflammatory processes, genetic factors, environmental impact factors, toxic action of nitric oxide, apoptosis, and so on. This review mainly discussed oxidative stress, environme......
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