Neuroscience Bulletin
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Virus-Mediated Overexpression of ETS-1 in the Ventral Hippocampus Counteracts Depression-Like Behaviors in Rats
Neuroscience Bulletin - Tập 35 - Trang 1035-1044 - 2019
ETS-1 is a transcription factor that is a member of the E26 transformation-specific (ETS) family. Galanin receptor 2 (GalR2), a subtype of receptors of the neuropeptide galanin, has been shown to have an antidepressant-like effect after activation in rodents. Our previous study has shown that overexpression of ETS-1 increases the expression of GalR2 in PC12 phaeochromocytoma cells. However, whethe...... hiện toàn bộ
The role and the mechanism of γ-aminobutyric acid during central nervous system development
Neuroscience Bulletin - Tập 24 - Trang 195-200 - 2008
γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter in adult mammalian central nervous system (CNS). During CNS development, the role of GABA is switched from an excitatory transmitter to an inhibitory transmitter, which is caused by an inhibition of calcium influx into postsynaptic neuron derived from release of GABA. The switch is influenced by the neuronal chloride concentration. When ...... hiện toàn bộ
Paroxysmal Kinesigenic Dyskinesia: Genetics and Pathophysiological Mechanisms
Neuroscience Bulletin - - Trang 1-11 - 2023
Paroxysmal kinesigenic dyskinesia (PKD), the most common type of paroxysmal movement disorder, is characterized by sudden and brief attacks of choreoathetosis or dystonia triggered by sudden voluntary movements. PKD is mainly caused by mutations in the PRRT2 or TMEM151A gene. The exact pathophysiological mechanisms of PKD remain unclear, although the function of PRRT2 protein has been well charact...... hiện toàn bộ
CRH Neurons in the Laterodorsal Tegmentum Mediate Acute Stress-induced Anxiety
Neuroscience Bulletin - Tập 37 - Trang 999-1004 - 2021
Genomic Mosaicism of the Brain: Origin, Impact, and Utility
Neuroscience Bulletin - - Trang 1-18 - 2023
Genomic mosaicism describes the phenomenon where some but not all cells within a tissue harbor unique genetic mutations. Traditionally, research focused on the impact of genomic mosaicism on clinical phenotype—motivated by its involvement in cancers and overgrowth syndromes. More recently, we increasingly shifted towards the plethora of neutral mosaic variants that can act as recorders of cellular...... hiện toàn bộ
Autophagy is involved in oral rAAV/Aβ vaccine-induced Aβ clearance in APP/PS1 transgenic mice
Neuroscience Bulletin - Tập 31 - Trang 491-504 - 2015
The imbalance between ß-amyloid (Aß) generation and clearance plays a fundamental role in the pathogenesis of Alzheimer’s disease (AD). The sporadic form of AD is characterized by an overall impairment in Aß clearance. Immunotherapy targeting Aß clearance is believed to be a promising approach and is under active clinical investigation. Autophagy is a conserved pathway for degrading abnormal prote...... hiện toàn bộ
Mutant Huntingtin Causes a Selective Decrease in the Expression of Synaptic Vesicle Protein 2C
Neuroscience Bulletin - Tập 34 - Trang 747-758 - 2018
Huntington’s disease (HD) is a neurodegenerative disease caused by a polyglutamine expansion in the huntingtin (Htt) protein. Mutant Htt causes synaptic transmission dysfunctions by interfering in the expression of synaptic proteins, leading to early HD symptoms. Synaptic vesicle proteins 2 (SV2s), a family of synaptic vesicle proteins including 3 members, SV2A, SV2B, and SV2C, plays important rol...... hiện toàn bộ
Is Alzheimer’s Disease Transmissible in Humans?
Neuroscience Bulletin - Tập 35 Số 6 - Trang 1113-1115 - 2019
Construction and functional activity of a recombinant vector expressing rat glutamic acid decarboxylase 65
Neuroscience Bulletin - Tập 27 - Trang 430-435 - 2011
Glutamic acid decarboxylase 2 (GAD65) is a gamma-aminobutyric acid (GABA) synthetase. This study aimed to construct a recombinant lentivirus-rGAD65 (rLV-rGAD65) vector containing the cDNA of rat GAD65 (rGAD65) and assess its functional activity in vitro and in vivo. cDNA of rGAD65 was amplified by RT-PCR and subcloned into the LV vector, forming the rLV-GFP-rGAD65 plasmid. The recombinant lentivir...... hiện toàn bộ
A Neural Circuit Controlling Virgin Female Aggression Induced by Mating-related Cues in Drosophila
Neuroscience Bulletin - Tập 39 - Trang 1396-1410 - 2023
Females increase aggression for mating opportunities and for acquiring reproductive resources. Although the close relationship between female aggression and mating status is widely appreciated, whether and how female aggression is regulated by mating-related cues remains poorly understood. Here we report an interesting observation that Drosophila virgin females initiate high-frequency attacks towa...... hiện toàn bộ
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