Neurological Research and Practice

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A mobile battery-powered brain perfusion ultrasound (BPU) device designed for prehospital stroke diagnosis: correlation to perfusion MRI in healthy volunteers
Neurological Research and Practice - - 2022
Mustafa Kilic, Fabien Scalzo, Chandler Lyle, Dobri Baldaranov, Maximilian Dirnbacher, Tristan Honda, David S. Liebeskind, Felix Schlachetzki
Early prehospital stroke identification is crucial for goal directed hospital admission especially in rural areas. However, clinical prehospital stroke scales are designed to identify any stroke but cannot sufficiently differentiate hemorrhagic from ischemic stroke, including large vessel occlusion (LVO) amenable to mechanical thrombectomy. We report on a novel small, portable and battery driven p...... hiện toàn bộ
Early vigabatrin augmenting GABA-ergic pathways in post-anoxic status epilepticus (VIGAB-STAT) phase IIa clinical trial study protocol
Neurological Research and Practice - Tập 4 - Trang 1-9 - 2022
Carolina B. Maciel, Fernanda J. P. Teixeira, Katie J. Dickinson, Jessica C. Spana, Lisa H. Merck, Alejandro A. Rabinstein, Robert Sergott, Guogen Shan, Guanhong Miao, Charles A. Peloquin, Katharina M. Busl, Lawrence J. Hirsch
Nearly one in three unconscious cardiac arrest survivors experience post-anoxic status epilepticus (PASE). Historically, PASE has been deemed untreatable resulting in its exclusion from status epilepticus clinical trials. However, emerging reports of survivors achieving functional independence following early and aggressive treatment of PASE challenged this widespread therapeutic nihilism. In the ...... hiện toàn bộ
Key design elements of successful acute ischemic stroke treatment trials
Neurological Research and Practice - Tập 5 Số 1
Laetitia Yperzeele, Ashkan Shoamanesh, Y. Vishnu Venugopalan, Sherita Chapman, Michael V. Mazya, Marina Charalambous, Valeria Caso, Werner Hacke, Philip M Bath, Ivan Koltsov
Abstract Purpose We review key design elements of positive randomized controlled trials (RCTs) in acute ischemic stroke (AIS) treatment and summarize their main characteristics. Method We s...... hiện toàn bộ
A look back at 3 years of neurological research and practice (NRP)
Neurological Research and Practice - Tập 4 - Trang 1-4 - 2022
Werner Hacke
Video-EEG monitoring as a valuable tool for antiseizure medication withdrawal in patients with epilepsy: implications for clinical practice and public health policies
Neurological Research and Practice - Tập 5 - Trang 1-2 - 2023
Obed Okwoli Apochi
This letter to the editor discusses “the use of video-EEG monitoring to guide antiseizure medication (ASM) withdrawal in patients with epilepsy” [1]. The author highlights the potential benefits of this approach, including reduced risk of seizure recurrence and improved patient outcomes. The author also notes the need for further research to refine the criteria for identifying patients who are goo...... hiện toàn bộ
Bridging therapy is associated with improved cognitive function after large vessel occlusion stroke – an analysis of the German Stroke Registry
Neurological Research and Practice - Tập 2 - Trang 1-9 - 2020
Philipp Ettelt, Ilko L. Maier, Marlena Schnieder, Mathias Bähr, Daniel Behme, Marios-Nikos Psychogios, Jan Liman
The targeted use of endovascular therapy (EVT), with or without intravenous thrombolysis (IVT) in acute large cerebral vessel occlusion stroke (LVOS) has been proven to be superior compared to IVT alone. Despite favorable functional outcome, many patients complain about cognitive decline after EVT. If IVT in addition to EVT has positive effects on cognitive function is unclear. We analyzed data fr...... hiện toàn bộ
Autoimmune encephalitis in children and adolescents
Neurological Research and Practice - Tập 2 - Trang 1-8 - 2020
C. G. Bien, C. I. Bien
Autoimmune encephalitides with neural and glial antibodies have become an attractive field in neurology because the antibodies are syndrome-specific, explain the pathogenesis, indicate the likelihood of an underlying tumor, and often predict a good response to immunotherapy. The relevance and the management of antibody-associated encephalitides in the pediatric age group are to be discussed. Subac...... hiện toàn bộ
COX2 expression is associated with preoperative tumor volume but not with volumetric tumor growth in vestibular schwannoma
Neurological Research and Practice - Tập 3 - Trang 1-7 - 2021
Felix Behling, Elisa Suhm, Vanessa Ries, Vítor Moura Gonçalves, Ghazaleh Tabatabai, Marcos Tatagiba, Jens Schittenhelm
Vestibular schwannomas (VS) are benign slow growing tumors arising from the vestibular nerve. The role of cyclooxygenase 2 (COX2) in tumor development of growth has been addressed in a few studies with contradictory results and suggestions. We recently analyzed the immunohistochemical expression of COX2 in 1044 VS samples and described an association of higher COX2 expression with proliferation bu...... hiện toàn bộ
Quality assurance data for regional drip-and-ship strategies- gearing up the transfer process
Neurological Research and Practice - Tập 3 - Trang 1-8 - 2021
Erendira G. Boss, Ferdinand O. Bohmann, Björn Misselwitz, Manfred Kaps, Tobias Neumann-Haefelin, Waltraud Pfeilschifter, Natalia Kurka
Stroke patients with large vessel occlusion (LVO) require endovascular therapy (EVT) provided by comprehensive stroke centers (CSC). One strategy to achieve fast stroke symptom ‘onset to treatment’ times (OTT) is the preclinical selection of patients with severe stroke for direct transport to CSC. Another is the optimization of interhospital transfer workflow. Our aim was to investigate the dynami...... hiện toàn bộ
HDMTX-based induction therapy followed by consolidation with conventional systemic chemotherapy and intraventricular therapy (modified Bonn protocol) in primary CNS lymphoma: a monocentric retrospective analysis
Neurological Research and Practice - Tập 1 - Trang 1-9 - 2019
Sabine Seidel, Agnieszka Korfel, Thomas Kowalski, Michelle Margold, Fatme Ismail, Roland Schroers, Alexander Baraniskin, Hendrik Pels, Peter Martus, Uwe Schlegel
To evaluate outcome and toxicity of High-dose methotrexate (HDMTX)-based induction therapy followed by consolidation with conventional systemic chemotherapy and facultative intraventricular therapy (modified Bonn protocol) in patients with primary CNS lymphoma (PCNSL). Between 01/2005 and 12/2013 113 patients with newly diagnosed PCNSL presented at our center; 98 of those qualified for HDMTX based...... hiện toàn bộ
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