Neurochemical Research
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The Effect of Aging on Mitochondrial Complex I and the Extent of Oxidative Stress in the Rat Brain Cortex
Neurochemical Research - Tập 41 - Trang 2160-2172 - 2016
One of the characteristic features of the aging is dysfunction of mitochondria. Its role in the regulation of metabolism and apoptosis suggests a possible link between these cellular processes. This study investigates the relationship of respiratory complex I with aging-related oxidative stress in the cerebral mitochondria. Deterioration of complex I seen in senescent (26-months old) mitochondria ......
Neuroprotective Effect Of Peptide Fractions from Chia (Salvia hispanica) on H2O2-Induced Oxidative Stress-Mediated Neuronal Damage on N1E-115 Cell Line
Neurochemical Research - Tập 45 - Trang 2278-2285 - 2020
Neurodegenerative diseases (ND) affect around a billion people worldwide. Oxidative stress plays a critical role in the activation of neuronal death mechanisms, implicated in the ND etiology. In the present research, the neuroprotective effect of the S. hispanica protein derivatives is evaluated, on neuronal cells N1E-115, after the damage induction with H2O2. From the protein-rich fraction of S. ......
Early Differences in Dorsal Hippocampal Metabolite Levels in Males But Not Females in a Transgenic Rat Model of Alzheimer’s Disease
Neurochemical Research - Tập 39 - Trang 305-312 - 2013
McGill-R-Thy1-APP rats express the human amyloid precursor protein carrying the Swedish and Indiana mutations. We examined the neurochemical content of the dorsal hippocampus in three-months-old male and female transgenic rats and healthy age- and gender-matched controls using in vivo 1H MRS in order to assess early metabolite alterations and whether these were similar for both genders. Whereas ma......
Perinatal Treatments with the Dopamine D2-Receptor Agonist Quinpirole Produces Permanent D2-Receptor Supersensitization: a Model of Schizophrenia
Neurochemical Research - Tập 41 - Trang 183-192 - 2015
Repeated daily treatments of perinatal rats with the dopamine D2-receptor (D2-R) agonist quinpirole for a week or more produces the phenomenon of ‘priming’—gradual but long-term sensitization of D2-R. In fact a daily dose of quinpirole as low as 50 µg/kg/day is adequate for sensitizing D2-R. Primed rats as neonates and in adolescence, when acutely treated with quinpirole display enhanced eating/gn......
Giải mã cơ chế gây dị tật ống thần kinh do thuốc điều trị lâm sàng dựa trên phân tích dược lý mạng và mô hình docking phân tử Dịch bởi AI
Neurochemical Research - Tập 47 - Trang 3709-3722 - 2022
Các tác nhân hóa trị như methotrexate (MTX), raltitrexed (RTX), 5-fluorouracil (5-FU), hydroxyurea (HU), axit retinoic (RA) và axit valproic (VPA), một loại thuốc chống động kinh, đều có thể gây ra những dị dạng trong hệ thần kinh trung ương (CNS) đang phát triển, như dị tật ống thần kinh (NTDs). Tuy nhiên, các cơ chế gây bệnh chung vẫn chưa được làm sáng tỏ. Nghiên cứu này nhằm khám phá các cơ ch......
#dị tật ống thần kinh #thuốc hóa trị #dược lý mạng #phân tích docking phân tử #cơ chế gây bệnh
The activity of neutral ribonucleases in nuclei of rat sympathetic ganglia and effects of nerve injury
Neurochemical Research - Tập 12 - Trang 541-549 - 1987
Nuclei were isolated from homogenates of rat superior cervical ganglion by a conventional differential centrifugation technique with approximately 60% recovery. Ribonuclease activity at pH 7.1 (neutral ribonuclease) was associated with the “nuclei fraction” and represented 19% of the overall activity in normal ganglia. Ribonuclease in the “nuclei fraction” was stimulated variably by the sulfhydryl......
Clinical Relevance of Serum Aquaporin-4 Antibody Levels in Neuromyelitis Optica
Neurochemical Research - Tập 38 - Trang 997-1001 - 2013
Neuromyelitis optica (NMO) is an inflammatory disease that selectively affects the optic nerves and spinal cord. The discovery of NMO-IgG targeting aquaporin-4 (AQP4) in NMO patients suggested that NMO is a distinct entity, with a fundamentally different etiology from that of multiple sclerosis (MS). Although NMO usually leads to grave disability because of the more severe tissue destruction compa......
Muscarinic receptor subtypes in bovine adrenal medulla
Neurochemical Research - Tập 17 - Trang 1235-1239 - 1992
Catecholamine secretion in the bovine adrenal medulla is evoked largely by nicotinic receptor activation. However, bovine adrenal medulla also contain muscarinic receptors that mediate several cell responses. To understand the physiological role of muscarinic receptors in the bovine adrenal medulla it is important to identify the pharmacological subtypes present in this tissue. For this, we analyz......
Effect of Acute and Chronic Administration of l-Tyrosine on Nerve Growth Factor Levels in Rat Brain
Neurochemical Research - Tập 38 - Trang 1742-1746 - 2013
Most inborn errors of tyrosine catabolism produce hypertyrosinemia. Neurological manifestations are variable and some patients are developmentally normal, while others show different degrees of developmental retardation. Considering that current data do not eliminate the possibility that elevated levels of tyrosine and/or its derivatives may have noxious effects on central nervous system developme......
Amino acid uptake systems in lizard and chick brain cells
Neurochemical Research - Tập 16 Số 7 - Trang 731-736 - 1991
The uptake of seven amino acids, α-aminoisobutyric acid (AIB), cyclo-leucine (cyclo-Leu), γ-aminobutyric acid (GABA), glycine (Gly), glutamic acid (Glu), lysine (Lys), and taurine (Tau), representatives of different amino acid transport systems, was studied in slices of brain from Tokay lizards and White Leghorn chicks. In descending order, the rate of the initial uptake of the amino acids in both......
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