Neurochemical Research

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Oxidative and Inflammatory Pathways in Parkinson’s Disease
Neurochemical Research - Tập 34 Số 1 - Trang 55-65 - 2009
Rebecca M. Chamberlin, Marilyn James-Kracke, Grace Y. Sun, Albert Y. Sun
L-364,718 Potentiates Electroacupuncture Analgesia Through Cck-A Receptor of Pain-Related Neurons in the Nucleus Parafascicularis
Neurochemical Research - Tập 36 Số 1 - Trang 129-138 - 2011
Shi, T. F., Yang, C. X., Yang, D. X., Gao, H. R., Zhang, G. W., Zhang, D., Jiao, R. S., Xu, M. Y., Qiao, H. Q.
Electroacupuncture (EA) has been successfully used to alleviate pain produced by various noxious stimulus. Cholecystokinin-8 (CCK-8) is a neuropeptide involved in the mediation of pain. We have previously shown that CCK-8 could antagonize the analgesic effects of EA on pain-excited neurons (PENs) and pain-inhibited neurons (PINs) in the nucleus parafascicularis (nPf). However, its mechanism of act...... hiện toàn bộ
Analysis of individual CNS protein synthesis
Neurochemical Research - Tập 17 - Trang 809-815 - 1992
Susana E. Blau, Thomas M. Smith, George C. Stone
A procedure for labeling rat CNS proteins in vivo which is useful for behavioral and pharmacological studies has been developed. Intraventricular administration of35S-methionine through bilateral indwelling cannulae provided reproducible and highly specific radiolabeling of proteins from frontal cortex (FC), parietal cortex (PC), occipital cortex (OC), striatum (ST), septal nuclei (SN), amygdala (...... hiện toàn bộ
The Effect of Aging on Mitochondrial Complex I and the Extent of Oxidative Stress in the Rat Brain Cortex
Neurochemical Research - Tập 41 - Trang 2160-2172 - 2016
Zuzana Tatarkova, Maria Kovalska, Veronika Timkova, Peter Racay, Jan Lehotsky, Peter Kaplan
One of the characteristic features of the aging is dysfunction of mitochondria. Its role in the regulation of metabolism and apoptosis suggests a possible link between these cellular processes. This study investigates the relationship of respiratory complex I with aging-related oxidative stress in the cerebral mitochondria. Deterioration of complex I seen in senescent (26-months old) mitochondria ...... hiện toàn bộ
Study on Antidepressant Effect and Mechanism of Crocin Mediated by the mTOR Signaling Pathway
Neurochemical Research - Tập 47 - Trang 3126-3136 - 2022
Yan Wang, Sixu Zhou, Xujiao Song, Shanshan Ding, Baogui Wang, Jiangfeng Wen, Chunlin Chen
Crocin is a monomer of Chinese traditional herbs extracted from saffron, relieving depression-like behavior. However, its underlying mechanism of action remains unclear. Herein, we explored whether crocin's antidepressant effect depended on the mammalian target of the rapamycin (mTOR) signaling pathway. The model of PC12 cells injury was established by corticosterone, the changes in cell survival ...... hiện toàn bộ
Lack of interaction between α2 and dopamine D2-receptors in mediating their inhibitory effects on [3H]dopamine release from rat nucleus accumbens slices
Neurochemical Research - Tập 18 - Trang 285-289 - 1993
V. A. Russell, M. C. L. Lamm, J. J. F. Taljaard
The α2-adrenoceptor agonist, UK14304, dose-dependently inhibited the electrically stimulated release of dopamine (DA) from rat nucleus accumbens slices. This effect was antagonized by idazoxan, confirming that it was an α2-adrenoceptor mediated effect. There was no evidence of endogenous activation of noradrenergic receptors suggesting that the α2-adrenoceptor agonist was not acting presynapticall...... hiện toàn bộ
Differential effects of 4-aminopyridine on acetylcholine release triggered by K+ depolarization, veratridine, or A23187 in rat cerebral cortical synaptosomes
Neurochemical Research - Tập 14 - Trang 157-160 - 1989
Edwin M. Meyer, Deborah H. Otero
The effect of 4-aminopyridine on [3H]acetylcholine release was studied in rat cerebral cortical synaptosomes in the presence of a several secretagogues that have different mechanisms of action. As found previously, 4-aminopyridine increased [3H]acetylcholine release in a concentration-dependent manner (5–10 mM); a high concentration (10 mM) also elevated [3H]choline efflux. However, the 35 mM K+ i...... hiện toàn bộ
Nuclear Ca++-influx, Ca++/Calmodulin-Dependent Protein Kinase IV Activity and CREB Protein Phosphorylation during Post-Hypoxic Reoxygenation in Neuronal Nuclei of Newborn Piglets: The Role of Nitric Oxide
Neurochemical Research - Tập 31 - Trang 1463-1471 - 2006
Om Prakash Mishra, Alan B. Zubrow, Qazi M. Ashraf, Maria Delivoria-Papadopoulos
The present study tests the hypothesis that post-hypoxic reoxygenation results in an nitric oxide (NO)-mediated increase in nuclear Ca++-influx, increased calmodulin kinase (CaM kinase) IV activity, and increased Ser133 phosphorylation of cyclic AMP response element binding (CREB) protein in neuronal nuclei of the cerebral cortex of newborn piglets. Piglets were divided into normoxic (Nx), hypoxic...... hiện toàn bộ
Ethylcholine mustard aziridinium ion lesions of the rat cortex result in retrograde degeneration of basal forebrain cholinergic neurons: Implications for animal models of neurodegenerative disease
Neurochemical Research - Tập 12 - Trang 613-618 - 1987
P. H. Stephens, Philip Tagari, A. C. Cuello
Multiple injections of 2 nmols of cyclised ethylcholine mustard aziridinium ion (ECMA), a putative cholinergic neurotoxin, were made (unilaterally) into the cortical terminal field of cholinergic neurons projecting from the nucleus basalis of Meynert (NBM) in the rat basal forebrain. After 30 days, choline acetyltransferase enzymatic activity, a marker for cholinergic function, was significantly l...... hiện toàn bộ
Changes in Purines Concentration in the Cerebrospinal Fluid of Pregnant Women Experiencing Pain During Active Labor
Neurochemical Research - Tập 40 - Trang 2262-2269 - 2015
André P. Schmidt, Ana E. Böhmer, Gisele Hansel, Félix A. Soares, Jean P. Oses, Alex T. Giordani, Irimar P. Posso, José Otávio C. Auler, Florentino F. Mendes, Elaine A. Félix, Luís V. Portela, Diogo O. Souza
Labor pain has been reported as a severe pain and can be considered as a model of acute visceral pain. It is well known that extracellular purines have an important role in pain signaling in the central nervous system. This study analyzes the relationship between extracellular purines and pain perception during active labor. A prospective observational study was performed. Cerebrospinal fluid (CSF...... hiện toàn bộ
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