Neurochemical Research

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Acetylcholine synthesis in human CSF: Implications for study of central cholinergic metabolism
Neurochemical Research - Tập 14 - Trang 191-196 - 1989
Steven T. DeKosky, Stephen W. Scheff, Carter G. Hackney
Investigation of neurological diseases involving central cholinergic dysfunction has led to numerous studies seeking a peripheral marker of cholinergic activity in brain. The main objective of these studies was to determine whether the ACh synthesizing activity present in human CSF was due to the presence of the enzyme choline acetyltransferase (ChAT; 68kDa). When CSF was fractionated into low and...... hiện toàn bộ
The subcellular distribution of a membrane-bound calmodulin-stimulated protein kinase
Neurochemical Research - Tập 11 - Trang 253-268 - 1986
J. A. P. Rostas, V. A. Brent, J. W. Heath, R. L. B. Neame, D. A. Powis, R. P. Weinberger, P. R. Dunkley
Incubation of subcellular fractions isolated from rat cerebral cortex with [γ-32P]ATP results in the phosphorylation of a number of proteins including two with apparent molecular weights of approximately 50,000 and 60,000 daltons. These phosphoproteins were shown to be the autophosphorylated subunits of a calmodulin-stimulated protein kinase by a number of physicochemical criteria, including their...... hiện toàn bộ
Oxidative and Inflammatory Pathways in Parkinson’s Disease
Neurochemical Research - Tập 34 Số 1 - Trang 55-65 - 2009
Rebecca M. Chamberlin, Marilyn James-Kracke, Grace Y. Sun, Albert Y. Sun
MiR-508-5p Inhibits the Progression of Glioma by Targeting Glycoprotein Non-metastatic Melanoma B
Neurochemical Research - Tập 41 - Trang 1684-1690 - 2016
Gang Bao, Ning Wang, Ruichun Li, Gaofeng Xu, Peijun Liu, Baixiang He
Glioma is a severe and highly lethal brain cancer, a malignancy largely stemming from growing in a relatively restrained area of the brain. Hence, the understanding of the molecular regulation of the growth of glioma is critical for improving its treatment. MicroRNA has become a hotspot in research on diseases, especially in the initiation and progression of different types of cancer. However, the...... hiện toàn bộ
L-364,718 Potentiates Electroacupuncture Analgesia Through Cck-A Receptor of Pain-Related Neurons in the Nucleus Parafascicularis
Neurochemical Research - Tập 36 Số 1 - Trang 129-138 - 2011
Shi, T. F., Yang, C. X., Yang, D. X., Gao, H. R., Zhang, G. W., Zhang, D., Jiao, R. S., Xu, M. Y., Qiao, H. Q.
Electroacupuncture (EA) has been successfully used to alleviate pain produced by various noxious stimulus. Cholecystokinin-8 (CCK-8) is a neuropeptide involved in the mediation of pain. We have previously shown that CCK-8 could antagonize the analgesic effects of EA on pain-excited neurons (PENs) and pain-inhibited neurons (PINs) in the nucleus parafascicularis (nPf). However, its mechanism of act...... hiện toàn bộ
Cytochalasin B inhibits phosphoinositide hydrolysis in rat hippocampal slices
Neurochemical Research - Tập 18 - Trang 225-229 - 1993
Jun-ichi Kitanaka, Sadaaki Maeda, Akemichi Baba
The effect of cytochalasin B on phosphoinositide (PI) hydrolysis was examined in rat hippocampal slices. Pretreatment of the slices with cytochalasin B caused a significant decrease in PI hydrolysis elicited by carbachol, norepinephrine, or by high K+. This effect was cytochalasin B dose- and time-dependent and was not mimicked by cytochalasin D, vinblastine, colchicine, or phloretin. In contrast,...... hiện toàn bộ
The Place of Choline Acetyltransferase Activity Measurement in the “Cholinergic Hypothesis” of Neurodegenerative Diseases
Neurochemical Research - Tập 33 - Trang 318-327 - 2007
Antonio Contestabile, Elisabetta Ciani, Andrea Contestabile
The so-called “cholinergic hypothesis” assumes that degenerative dysfunction of the cholinergic system originating in the basal forebrain and innervating several cortical regions and the hippocampus, is related to memory impairment and neurodegeneration found in several forms of dementia and in brain aging. Biochemical methods measuring the activity of the key enzyme for acetylcholine synthesis, c...... hiện toàn bộ
Analysis of individual CNS protein synthesis
Neurochemical Research - Tập 17 - Trang 809-815 - 1992
Susana E. Blau, Thomas M. Smith, George C. Stone
A procedure for labeling rat CNS proteins in vivo which is useful for behavioral and pharmacological studies has been developed. Intraventricular administration of35S-methionine through bilateral indwelling cannulae provided reproducible and highly specific radiolabeling of proteins from frontal cortex (FC), parietal cortex (PC), occipital cortex (OC), striatum (ST), septal nuclei (SN), amygdala (...... hiện toàn bộ
A Synopsis of Multitarget Potential Therapeutic Effects of Huperzine A in Diverse Pathologies–Emphasis on Alzheimer’s Disease Pathogenesis
Neurochemical Research - Tập 47 - Trang 1166-1182 - 2022
Mayuri Shukla, Prapimpun Wongchitrat, Piyarat Govitrapong
Numerous challenges are confronted when it comes to the recognition of therapeutic agents for treating complex neurodegenerative diseases like Alzheimer’s disease (AD). The perplexing pathogenicity of AD embodies cholinergic dysfunction, amyloid beta (Aβ) aggregation, neurofibrillary tangle formation, neuroinflammation, mitochondrial disruption along with vicious production of reactive oxygen spec...... hiện toàn bộ
GD3 Expression in CHO-K1 Cells Increases Growth Rate, Induces Morphological Changes, and Affects Cell-Substrate Interactions
Neurochemical Research - Tập 27 - Trang 1421-1429 - 2002
Jose L. Daniotti, Adolfo R. Zurita, Vera M. T. Trindade, Hugo J. F. Maccioni
We have generated a panel of CHO-K1 cell clones with different glycolipid compositions by stable transfection of appropriate glycosyltransferases and studied the morphological and growth phenotype of a clone stably expressing Sial-T2. Compared with the GM3 expressing parental cells, Sial-T2 transfectants show low expression of GM3 and neo expression of GD3 and GT3. These cells show about 60% reduc...... hiện toàn bộ
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