Neurochemical Research
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Knockdown of ZFAS1 Inhibits Hippocampal Neurons Apoptosis and Autophagy by Activating the PI3K/AKT Pathway via Up-regulating miR-421 in Epilepsy
Neurochemical Research - Tập 45 - Trang 2433-2441 - 2020
Epilepsy is a common neurological disease. The dysregulated long noncoding RNAs (lncRNAs) are implicated in epileptogenesis. The aim of this research is to explore the role and mechanism of lncRNA zinc finger antisense 1 (ZFAS1) in status epilepticus (SE)-induced hippocampal neurons injury. SE mice model was established and primary hippocampal neurons were isolated. The expression levels of ZFAS1 ...... hiện toàn bộ
Interaction of [125I]β nerve growth factor with acidic proteins
Neurochemical Research - Tập 6 - Trang 287-300 - 1981
We have demonstrated that the β nerve growth factor will interact with various acidic proteins apparently nonspecifically. When125I-labeled β nerve growth factor at a concentration of 3.8×10−10 M is incubated with an acidic protein at 2 mg/ml (4.5×10−6–4.4×10−5 M), a complex is formed. This complex changes the isoelectric point of the125I-labeled β nerve growth factor sufficiently so that the125I-...... hiện toàn bộ
δ andk opiate receptors in primary astroglial cultures part II: Receptor sets in cultures from various brain regions and interactions with ß-receptor activated cyclic AMP
Neurochemical Research - Tập 17 - Trang 545-551 - 1992
In a previous paper, δ and κ opiate receptors were shown to be co-localized on the same cell in enriched primary cultures of astroglia from neonatal rat cerebral cortex. Activation of the receptors inhibited adenylate cyclase. In this work, the presence of opiate receptors was investigated in astroglial primary cultures from neonatal rat striatum and brain stem. Cyclic adenosine 3′, 5′-monophospha...... hiện toàn bộ
The Neuroprotective Effects of Decursin Isolated from Angelica gigas Nakai Against Amyloid β-Protein-Induced Apoptosis in PC 12 Cells via a Mitochondria-Related Caspase Pathway
Neurochemical Research - Tập 40 - Trang 1555-1562 - 2015
Decursin, purified from Angelica gigas Nakai, has been proven to exert neuroprotective property. Previous study revealed decursin protected the PC12 cells from Aβ25–35-induced oxidative cytotoxicity. The present study aimed to investigate whether decursin could protect PC12 cells from apoptosis caused by Aβ. Our results indicated that pretreatment of PC12 cells with decursin significantly inhibite...... hiện toàn bộ
Macromolecular synthesis in mitochondria isolated from different regions of developing rat brain
Neurochemical Research - Tập 4 - Trang 25-35 - 1979
DNA, RNA, and protein synthesis in mitochondria isolated from cerebral hemispheres, brain stem, and cerebellum of 10- and 30-day-old rats was measured. Synthesis of different macromolecules was affected by the respective mitochondrial specific inhibitors, showing a good level of purity of mitochondrial preparations. DNA and protein synthesis in 10-day-old rats was about 70% higher than in 30-day-o...... hiện toàn bộ
Metabolism of cerebrosides and sulfatides in the nervous system ofXenopus tadpole during metamorphosis
Neurochemical Research - Tập 11 - Trang 557-565 - 1986
Xenopus laevis tadpoles undergoing metamorphosis were used to study the turnover of cerebrosides and sulfatides in the nervous system of the frog. Tadpoles at the beginning of metamorphosis were treated by intraperitoneal injection with [U-14C]glucose and radioactivity incorporated into galactosphingolipids of brain and tail was measured after various times. The specific activity of brain cerebro...... hiện toàn bộ
Effect of repeated convulsive seizures on brain GABA levels
Neurochemical Research - Tập 6 - Trang 267-273 - 1981
Repeated audiogenic seizures (4 times a day for 14 days), in genetically selected sensitive mice, induce a significant decrease in GABA level in the following brain areas: nucleus caudatus, posterior colliculus, occipital and frontal cortex, cerebellum, substantia nigra, hippocampus, amygdala, and temporal cortex. No variations were observed in olfactory bulbs, pons medulla, hypothalamus, thalamus...... hiện toàn bộ
Lithium Treatment Prevents Apoptosis in Neonatal Rat Hippocampus Resulting from Sevoflurane Exposure
Neurochemical Research - Tập 41 - Trang 1993-2005 - 2016
We aimed to observe the therapeutic effects of lithium on inhalational anesthetic sevoflurane-induced apoptosis in immature brain hippocampus. From postnatal day 5 (P5) to P28, male Sprague–Dawley pups were intraperitoneally injected with lithium chloride or 0.9 % sodium chloride. On P7 after the injection, pups were exposed to 2.3 % sevoflurane or air for 6 h. Brain tissues were harvested 12 h an...... hiện toàn bộ
Developmental dissociation of myelin synthesis and “myelin-associated” enzyme activities in the shiverer mouse
Neurochemical Research - Tập 5 - Trang 885-895 - 1980
Developmental changes in three enzymes associated with myelin lipids were studied in the shiverer mouse, a murine mutant showing a severe deficiency of CNS myelin. Age-related changes in cerebroside sulfotransferase (measured in brain) and arylsulfatase A and cerebroside B-galactosidase (measured in brain and liver) were the same for shiverer and control mice. The shiverer mouse, therefore, demons...... hiện toàn bộ
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