NeuroRX
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Animal models of head trauma
NeuroRX - Tập 2 - Trang 410-422 - 2005
Animal models of traumatic brain injury (TBI) are used to elucidate primary and secondary sequelae underlying human head injury in an effort to identify potential neuroprotective therapies for developing and adult brains. The choice of experimental model depends upon both the research goal and underlying objectives. The intrinsic ability to study injury-induced changes in behavior, physiology, met...... hiện toàn bộ
Hypoxic preconditioning protects against ischemic brain injury
NeuroRX - Tập 1 - Trang 26-35 - 2004
Animals exposed to brief periods of moderate hypoxia (8% to 10% oxygen for 3 hours) are protected against cerebral and cardiac ischemia between 1 and 2 days later. This hypoxia preconditioning requires new RNA and protein synthesis. The mechanism of this hypoxia-induced tolerance correlates with the induction of the hypoxia-inducible factor (HIF), a transcription factor heterodimeric complex compo...... hiện toàn bộ
Therapy of X-linked adrenoleukodystrophy
NeuroRX - Tập 3 - Trang 246-253 - 2012
Current therapies for X-linked adrenoleukodystrophy (X-ALD) include replacement therapy with adrenal steroids, which is mandatory for all patients with impaired adrenal function but does not alter neurological progression significantly; dietary therapy with “Lorenzo’s Oil,” which appears to have a preventive effect in asymptomatic boys whose brain MRI is normal; and hematopoietic stem cell transpl...... hiện toàn bộ
The cognitive phenotype of Down syndrome: Insights from intracellular network analysis
NeuroRX - Tập 3 - Trang 396-406 - 2012
Down syndrome (DS) is caused by trisomy of chromosome 21. All individuals with DS exhibit some level of cognitive dysfunction. It is generally accepted that these abnormalities are a result of the upregulation of genes encoded by chromosome 21. Many chromosome 21 proteins are known or predicted to function in critical neurological processes, but typically they function as modulators of these proce...... hiện toàn bộ
Localization of brain endothelial luminal and abluminal transporters with immunogold electron microscopy
NeuroRX - Tập 2 - Trang 27-43 - 2005
Immunogold electron microscopy has identified a variety of blood-brain barrier (BBB) proteins with transporter and regulatory functions. For example, isoforms of the glucose transporter, protein kinase C (PKC), and caveolin-1 are BBB specific. Isoform 1 of the facilitative glucose transporter family (GLUT1) is expressed solely in endothelial (and pericyte) domains, and ∼75% of the protein is membr...... hiện toàn bộ
Translational research in central nervous system drug discovery
NeuroRX - Tập 2 - Trang 671-682 - 2005
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