NeuroRX

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Failures and successes of NMDA receptor antagonists: Molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults
NeuroRX - Tập 1 - Trang 101-110 - 2004
Stuart A. Lipton
Excitotoxicity, defined as excessive exposure to the neurotransmitter glutamate or overstimulation of its membrane receptors, has been implicated as one of the key factors contributing to neuronal injury and death in a wide range of both acute and chronic neurologic disorders. Excitotoxic cell death is due, at least in part, to excessive activation ofN-methyl-d-aspartate (NMDA)-type glutamate rece...... hiện toàn bộ
Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer’s disease
NeuroRX - Tập 2 - Trang 612-626 - 2005
J. Steven Jacobsen, Peter Reinhart, Menelas N. Pangalos
Alzheimer’s disease is a progressive neurodegenerative disorder and the leading cause of dementia in the Western world. Postmortem, it is characterized neuropathologically by the presence of amyloid plaques, neurofibrillary tangles, and a profound gray matter loss. Neurofibrillary tangles are composed of an abnormally hyperphosphorylated intracellular protein called tau, tightly wound into paired ...... hiện toàn bộ
Speaker abstracts from ASENT 2004 Annual Meeting March 11–13, 2004
NeuroRX - - 2004
Floyd E. Bloom, Richard Chappell, Mark Corrigan, Alfred L. Goldberg, J. Timothy Greenamyre, Jeffrey Martin, Dale Schenk, A. Jon Stoessl, Robert J. Temple
Biomarkers of Alzheimer disease in plasma
NeuroRX - Tập 1 - Trang 226-234 - 2004
Michael C. Irizarry
Plasma and serum biochemical markers proposed for Alzheimer disease (AD) are based on pathophysiologic processes such as amyloid plaque formation [amyloid β-protein (Aβ), Aβ autoantibodies, platelet amyloid precursor protein (APP) isoforms], inflammation (cytokines), oxidative stress (vitamin E, isoprostanes), lipid metabolism (apolipoprotein E, 24S-hydroxycholesterol), and vascular disease [homoc...... hiện toàn bộ
Spinal muscular atrophy: A test case for drug development in orphan diseases
NeuroRX - Tập 3 - Trang 535-539 - 2012
Lisa J. Bain
Hypothermic neuroprotection
NeuroRX - Tập 3 - Trang 154-169 - 2012
A. J. Gunn, M. Thoresen
The possibility that hypothermia during or after resuscitation from asphyxia at birth, or cardiac arrest in adults, might reduce evolving damage has tantalized clinicians for a very long time. It is now known that severe hypoxia-ischemia may not necessarily cause immediate cell death, but can precipitate a complex biochemical cascade leading to the delayed neuronal loss. Clinically and experimenta...... hiện toàn bộ
Active efflux across the blood-brain barrier: Role of the solute carrier family
NeuroRX - Tập 2 - Trang 73-85 - 2005
Hiroyuki Kusuhara, Yuichi Sugiyama
Drug development in critical times
NeuroRX - Tập 3 Số 4 - Trang 540-543 - 2006
Lisa J. Bain
Mechanisms of neural cell death: Implications for development of neuroprotective treatment strategies
NeuroRX - Tập 1 Số 1 - Trang 5-16 - 2004
Alexander G. Yakovlev, Alan I. Faden
Characterization of Soluble Fas Receptor as a Neuroprotective Agent following Acute Spinal Cord Injury
NeuroRX - Tập 3 - Trang 412 - 2006
S. Robins, M. Fehlings
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