NeuroRX
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Liquid chromatography with tandem mass spectrometry-based proteomic discovery in aging and Alzheimer’s disease
NeuroRX - Tập 3 - Trang 336-343 - 2006
Pharmacological treatments that facilitate extinction of fear: Relevance to psychotherapy
NeuroRX - Tập 3 - Trang 82-96 - 2006
RNA interference and nonviral targeted gene therapy of experimental brain cancer
NeuroRX - Tập 2 - Trang 139-150 - 2005
The human epidermal growth factor receptor (EGFR) plays an oncogenic role in solid cancer, including brain primary and metastatic cancers. Transvascular nonviral gene therapy in combination with EGFR-RNA interference (RNAi) represents a new therapeutic approach to silencing oncogenic genes in solid cancers. This is achieved with pegylated immunoliposomes (PIL) carrying short hairpin RNA expression......
Neurorestorative treatment of stroke: Cell and pharmacological approaches
NeuroRX - Tập 3 - Trang 466-473 - 2006
Evidence from cost-effectiveness research
NeuroRX - Tập 1 - Trang 348-355 - 2004
Economic evaluations are a set of outcomes and health services research methods to inform the debate about the rising cost of health care and include cost-of-illness studies and cost-effectiveness research. Cost-effectiveness research is the comparative analysis of two or more alternative interventions in terms of their health and economic consequences, whose results are expressed as an incrementa......
Failures and successes of NMDA receptor antagonists: Molecular basis for the use of open-channel blockers like memantine in the treatment of acute and chronic neurologic insults
NeuroRX - Tập 1 - Trang 101-110 - 2004
Excitotoxicity, defined as excessive exposure to the neurotransmitter glutamate or overstimulation of its membrane receptors, has been implicated as one of the key factors contributing to neuronal injury and death in a wide range of both acute and chronic neurologic disorders. Excitotoxic cell death is due, at least in part, to excessive activation ofN-methyl-d-aspartate (NMDA)-type glutamate rece......
The congenital disorders of glycosylation: A multifaceted group of syndromes
NeuroRX - Tập 3 - Trang 254-263 - 2012
The congenital disorders of glycosylation (CDG) are a rapidly expanding group of metabolic syndromes with a wide symptomatology and severity. They all stem from deficient N-glycosylation of proteins. To date the group contains 18 different subtypes: 12 of Type I (disrupted synthesis of the lipid-linked oligosaccharide precursor) and 6 of Type II (malfunctioning trimming/processing of the protein-b......
Current concepts in therapeutic strategies targeting cognitive decline and disease modification in Alzheimer’s disease
NeuroRX - Tập 2 - Trang 612-626 - 2005
Alzheimer’s disease is a progressive neurodegenerative disorder and the leading cause of dementia in the Western world. Postmortem, it is characterized neuropathologically by the presence of amyloid plaques, neurofibrillary tangles, and a profound gray matter loss. Neurofibrillary tangles are composed of an abnormally hyperphosphorylated intracellular protein called tau, tightly wound into paired ......
Translating therapies for Huntington’s disease from genetic animal models to clinical trials
NeuroRX - Tập 1 - Trang 298-306 - 2004
Genetic animal models of inherited neurological diseases provide an opportunity to test potential treatments and explore their promise for translation to humans experiencing these diseases. Therapeutic trials conducted in mouse models of Huntington’s disease have identified a growing number of potential therapies that are candidates for clinical trials. Although it is very exciting to have these c......
Therapeutic approaches and advances in pediatric stroke
NeuroRX - Tập 3 - Trang 133-142 - 2012
Evidence-based therapeutic interventions for pediatric ischemic cerebrovascular disease are beginning to emerge. The primary therapeutic target is usually the pathological prothrombotic disturbance that underlies the majority of pediatric stroke. A battle between anticoagulation and anti-platelet therapies continues to provide controversy and is the inspiration for upcoming randomized trials. Supp......
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