NeuroMolecular Medicine
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Biochemical features of ceruloplasmin gene mutations linked to aceruloplasminemia
NeuroMolecular Medicine - Tập 8 - Trang 361-373 - 2006
Aceruloplasminemia is a neurodegenerative disease characterized by parenchymal iron accumulation owing to mutations in the ceruloplasmin gene. Ceruloplasmin is expressed in the central nervous system in which most of the ceruloplasmin is located on the surface of astrocytes in a glycosylphosphatidy linositol (GPI)-anchored form. We herein describe the biochemical features of wild-type and mutant G...... hiện toàn bộ
Phytochemicals in Ischemic Stroke
NeuroMolecular Medicine - - 2016
Stroke is the second foremost cause of mortality worldwide and a major cause of long-term disability. Due to changes in lifestyle and an aging population, the incidence of stroke continues to increase and stroke mortality predicted to exceed 12 % by the year 2030. However, the development of pharmacological treatments for stroke has failed to progress much in over 20 years since the introduction o...... hiện toàn bộ
The Role of lncRNA TUG1 in the Parkinson Disease and Its Effect on Microglial Inflammatory Response
NeuroMolecular Medicine - Tập 23 - Trang 327-334 - 2020
Parkinson’s disease (PD) is a common neurodegenerative disease in the middle-aged and elderly populations. The purpose of this study was to investigate the clinical value of lncRNA TUG1 in PD and its effect on the microglial inflammatory response. A total of 181 subjects were recruited for the study, including 97 patients with PD (male/female 50/47) and 84 healthy individuals (male/female 41/43). ...... hiện toàn bộ
Family-based association study of the serotonin-2A receptor gene (5-HT2A) and bipolar disorder
NeuroMolecular Medicine - Tập 2 - Trang 251-259 - 2002
Objectives: The serotonin 2A receptor gene (5-HT2A) is of great interest for research in neuropsychiatric disorders based on the observation that various neuroleptic agents and antidepressants bind with relatively high affinity at 5-HT2A receptors, and the fact that the receptor density in platelets tends to increase in depression. To test for the presence of association between 5-HT2A and bipolar...... hiện toàn bộ
Withania somnifera as a Potential Anxiolytic and Anti-inflammatory Candidate Against Systemic Lipopolysaccharide-Induced Neuroinflammation
NeuroMolecular Medicine - - 2018
Reactive gliosis, microgliosis, and subsequent secretion of various inflammatory mediators like cytokines, proteases, reactive oxygen, and nitrogen species are the suggested key players associated with systemic inflammation-driven neuroinflammation and cognitive impairments in various neurological disorders. Conventionally, non-steroidal anti-inflammatory drugs are prescribed to suppress inflammat...... hiện toàn bộ
Alpinia oxyphylla–Schisandra chinensis Herb Pair Alleviates Amyloid-β Induced Cognitive Deficits via PI3K/Akt/Gsk-3β/CREB Pathway
NeuroMolecular Medicine - Tập 22 - Trang 370-383 - 2020
Alzheimer’s disease (AD), one of the most common neurodegenerative diseases, threatens people’s health. Based on the theory of traditional Chinese medicine (TCM) efficacy and treatment theory, we first proposed the Alpinia oxyphylla–Schisandra chinensis herb pair (ASHP) for finding a candidate of AD treatment. This study aimed at exploring the effects of ASHP on improving the cognitive function an...... hiện toàn bộ
Models for Studying Myelination, Demyelination and Remyelination
NeuroMolecular Medicine - Tập 19 Số 2 - Trang 181-192 - 2017
One of the most widely studied demyelinating diseases is multiple sclerosis, which is characterised by the appearance of demyelinating plaques, followed by myelin regeneration. Nevertheless, with disease progression, remyelination tends to fail, increasing the characteristic neurodegeneration of the disease. It is essential to understand the mechanisms that operate in the processes of myelination,...... hiện toàn bộ
Gene-targeting technologies for the study of neurological disorders
NeuroMolecular Medicine - Tập 6 - Trang 13-30 - 2004
Studies using genetic manipulations have proven invaluable in the research of neurological disorders. In the forefront of these approaches is the knockout technology that engineers a targeted gene mutation in mice resulting in inactivation of gene expression. In many cases, important roles of a particular gene in embryonic development have precluded the in vivo study of its function in the adult b...... hiện toàn bộ
The Promising Epigenetic Regulators for Refractory Epilepsy: An Adventurous Road Ahead
NeuroMolecular Medicine - Tập 25 - Trang 145-162 - 2022
The attribution of seizure freedom is yet to be achieved for patients suffering from refractory epilepsy, e.g. Dravet Syndrome (DS). The confined ability of mono-chemical entity-based antiseizure drugs (ASDs) to act directly at genomic level is one of the factors, combined with undetermined seizure triggers lead to recurrent seizure (RS) in DS, abominably affecting the sub-genomic architecture of ...... hiện toàn bộ
Withania somnifera and Its Withanolides Attenuate Oxidative and Inflammatory Responses and Up-Regulate Antioxidant Responses in BV-2 Microglial Cells
NeuroMolecular Medicine - Tập 18 - Trang 241-252 - 2016
Withania somnifera (L.) Dunal, commonly known as Ashwagandha, has been used in Ayurvedic medicine for promoting health and quality of life. Recent clinical trials together with experimental studies indicated significant neuroprotective effects of Ashwagandha and its constituents. This study is aimed to investigate anti-inflammatory and anti-oxidative properties of this bot...... hiện toàn bộ
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