NeuroMolecular Medicine
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Resveratrol Improves Neuroimmune Dysregulation Through the Inhibition of Neuronal Toll-Like Receptors and COX-2 Signaling in BTBR T+ Itpr3tf/J Mice
NeuroMolecular Medicine - Tập 20 - Trang 133-146 - 2018
Autism is a neurodevelopmental disorder characterized by deficits in qualitative impairments in communication, repetitive and social interaction, restricted, and stereotyped patterns of behavior. Resveratrol has been extensively studied pharmacologically and biologically and has anti-inflammatory, antioxidant, and neuroprotective effects on neuronal damage in neurodegenerative disorders. The BTBR ......
Aberrant DNA Methylation of Blood in Schizophrenia by Adjusting for Estimated Cellular Proportions
NeuroMolecular Medicine - - 2014
Global MicroRNA Expression Profiling Reveals Differential Expression of Target Genes in 6-Hydroxydopamine-injured MN9D Cells
NeuroMolecular Medicine - Tập 15 - Trang 593-604 - 2013
Recent evidence indicates that microRNAs (miRNAs) play a key role in neurodegenerative diseases. However, little is known about how these small RNAs contribute to dopaminergic neuronal apoptosis. Here, we profiled the expression of miRNAs in MN9D cells with and without 6-hydroxydopamine (6-OHDA) treatment by miRCURY™ LNA microRNA arrays. We identified six miRNAs (miR-668-3p, let-7d-3p, miR-3077-3p......
Hypoxia Markers are Expressed in Interneurons Exposed to Recurrent Seizures
NeuroMolecular Medicine - Tập 15 - Trang 133-146 - 2012
An early but transient decrease in oxygen availability occurs during experimentally induced seizures. Using pimonidazole, which probes hypoxic insults, we found that by increasing the duration of pilocarpine-induced status epilepticus (SE) from 30 to 120 min, counts of pimonidazole-immunoreactive neurons also increased (P < 0.01, 120 vs 60 and 30 min). All the animals exposed to SE were immunoposi......
Transcriptomic Heterogeneity of Alzheimer’s Disease Associated with Lipid Genetic Risk
NeuroMolecular Medicine - Tập 22 - Trang 534-541 - 2020
Alzheimer’s disease (AD) is a multifactorial disease that affects more than 5 million Americans. Multiple pathways might be involved in the AD pathogenesis. The implication of lipid genetic susceptibility on brain gene expression is yet to be investigated. The current study included 192 brain samples from AD patients who were enrolled in the ROSMAP study. The samples were genotyped and imputed to ......
Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease
NeuroMolecular Medicine - Tập 8 Số 1 - Trang 217-241 - 2006
We review the putative functions and malfunctions of proteins encoded by genes mutated in Charcot-Marie-Tooth disease (CMT; inherited motor and sensory neuropathies) in normal and affected peripheral nerves. Some proteins implicated in demyelinating CMT, peripheral myelin protein 22, protein zero (P0), and connexin32 (Cx32/GJB1) are crucial components of myelin. Periaxin is involved in connecting ......
Revealing the Modular Similarities and Differences Among Alzheimer’s Disease, Vascular Dementia, and Parkinson’s Disease in Genomic Networks
NeuroMolecular Medicine - Tập 24 - Trang 125-138 - 2021
Alzheimer’s disease (AD), vascular dementia (VD), and Parkinson’s disease (PD) exert increasingly lethal or disabling effects on humans, but the associations among these diseases at the molecular level remain unclear. In our research, lists of genes related to these three diseases were acquired from public databases. We constructed gene–gene networks of the lists of disease-related genes using the......
Tau protein in familial and sporadic diseases
NeuroMolecular Medicine - Tập 4 - Trang 37-48 - 2003
Abnormal protein aggregation is a common characteristic of many neurodegenerative diseases of the brain. Filamentous deposits made of the microtubule-associated protein tau constitute a major defining characteristic of several neurodegenerative diseases known as tauopathies. The role of tau in neurodegeneration has been clarified by the identification of genetic mutations in the tau gene in cases ......
GWAS-Supported CRP Gene Polymorphisms and Functional Outcome of Large Artery Atherosclerotic Stroke in Han Chinese
NeuroMolecular Medicine - Tập 20 - Trang 225-232 - 2018
Elevated C-reactive protein (CRP) levels increase the risk of poor functional disability in patients with ischemic stroke (IS). This study aimed to investigate the association between CRP gene polymorphisms and 3-month functional disability of large artery atherosclerotic (LAA) stroke in Han Chinese. Patients with first-ever LAA IS were prospectively enrolled in Nanjing Stroke Registry Program bet......
AMPA Receptor Properties are Modulated in the Early Stages Following Pilocarpine-induced Status Epilepticus
NeuroMolecular Medicine - Tập 15 - Trang 324-338 - 2013
Glutamate over-activation and the consequent neuronal excitotoxicity have been identified as crucial players in brain dysfunctions such as status epilepticus (SE). Owing to the central function of 2-amino-3-(hydroxyl-5-methylisoxazole-4-yl) propionic acid receptors (AMPARs) in fast excitatory neurotransmission, these receptors have been recognized to play a prominent role in the development and ge......
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