NeuroMolecular Medicine

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Global MicroRNA Expression Profiling Reveals Differential Expression of Target Genes in 6-Hydroxydopamine-injured MN9D Cells
NeuroMolecular Medicine - Tập 15 - Trang 593-604 - 2013
Li Li, Hui-Zhen Chen, Fang-Fang Chen, Feng Li, Meng Wang, Li Wang, Yun-Qing Li, Dian-Shuai Gao
Recent evidence indicates that microRNAs (miRNAs) play a key role in neurodegenerative diseases. However, little is known about how these small RNAs contribute to dopaminergic neuronal apoptosis. Here, we profiled the expression of miRNAs in MN9D cells with and without 6-hydroxydopamine (6-OHDA) treatment by miRCURY™ LNA microRNA arrays. We identified six miRNAs (miR-668-3p, let-7d-3p, miR-3077-3p...... hiện toàn bộ
Hypoxia Markers are Expressed in Interneurons Exposed to Recurrent Seizures
NeuroMolecular Medicine - Tập 15 - Trang 133-146 - 2012
Fabio Gualtieri, Carla Marinelli, Daniela Longo, Matteo Pugnaghi, Paolo F. Nichelli, Stefano Meletti, Giuseppe Biagini
An early but transient decrease in oxygen availability occurs during experimentally induced seizures. Using pimonidazole, which probes hypoxic insults, we found that by increasing the duration of pilocarpine-induced status epilepticus (SE) from 30 to 120 min, counts of pimonidazole-immunoreactive neurons also increased (P < 0.01, 120 vs 60 and 30 min). All the animals exposed to SE were immunoposi...... hiện toàn bộ
Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease
NeuroMolecular Medicine - Tập 8 Số 1 - Trang 217-241 - 2006
Niemann, Axel, Berger, Philipp, Suter, Ueli
We review the putative functions and malfunctions of proteins encoded by genes mutated in Charcot-Marie-Tooth disease (CMT; inherited motor and sensory neuropathies) in normal and affected peripheral nerves. Some proteins implicated in demyelinating CMT, peripheral myelin protein 22, protein zero (P0), and connexin32 (Cx32/GJB1) are crucial components of myelin. Periaxin is involved in connecting ...... hiện toàn bộ
Gastrodin Attenuates Lipopolysaccharide-Induced Inflammatory Response and Migration via the Notch-1 Signaling Pathway in Activated Microglia
NeuroMolecular Medicine - Tập 24 - Trang 139-154 - 2021
Yue-yi Yao, Run Li, Yan-ji Guo, Yu Zhao, Jia-zhi Guo, Qing-long Ai, Lian-mei Zhong, Di Lu
Microglia-mediated neuroinflammation is known to play a pivotal role in the pathogenesis of different neurological diseases. Gastrodin, a phenolic glucoside, has been reported to exert anti-inflammatory effects in activated microglia challenged with lipopolysaccharide (LPS); however, the underlying mechanism has remained obscure. The present study aimed to ascertain if Gastrodin would regulate the...... hiện toàn bộ
Monitoring of Neuronal Loss in the Hippocampus of Aβ-Injected Rat: Autophagy, Mitophagy, and Mitochondrial Biogenesis Stand Against Apoptosis
NeuroMolecular Medicine - Tập 16 Số 1 - Trang 175-190 - 2014
Fatemeh Shaerzadeh, Fereshteh Motamedi, Dariush Minai‐Tehrani, Fariba Khodagholi
Interleukin-1 Mediates Ischemic Brain Injury via Induction of IL-17A in γδ T Cells and CXCL1 in Astrocytes
NeuroMolecular Medicine - Tập 24 - Trang 437-451 - 2022
Ines Sophie Schädlich, Jonas Heinrich Vienhues, Alina Jander, Marius Piepke, Tim Magnus, Kate Lykke Lambertsen, Bettina Hjelm Clausen, Mathias Gelderblom
As a prototypical proinflammatory cytokine, interleukin-1 (IL-1) exacerbates the early post-stroke inflammation, whereas its neutralization is protective. To further investigate the underlying cell-type-specific IL-1 effects, we subjected IL-1 (α/β) knockout (Il1−/−) and wildtype (WT) littermate mice to permanent middle cerebral artery occlusion (pMCAO) and assessed immune cell infiltration and cy...... hiện toàn bộ
Role for the ubiquitin-proteasome system in Parkinson’s disease and other neurodegenerative brain amyloidoses
NeuroMolecular Medicine - Tập 4 - Trang 95-108 - 2003
Darren J. Moore, Valina L. Dawson, Ted M. Dawson
Many neurodegenerative brain amyloidoses, including Alzheimer’s and Parkinson’s disease, are characterized by selective neuronal loss together with the appearance of intraneuronal ubiquitin-positive proteinaceous aggregates or inclusion bodies. These features usually result from the abnormal accumulation and processing of mutant, misfolded, or damaged intracellular proteins. It has recently become...... hiện toàn bộ
No Association Between NRG1 and ErbB4 Genes and Psychopathological Symptoms of Schizophrenia
NeuroMolecular Medicine - - 2014
Sarah Tosato, Martina Zanoni, Chiara Bonetto, Federica Tozzi, Clyde Francks, Elisa Ira, Simona Tomassi, Mariaelena Bertani, Dan Rujescu, Ina Giegling, David St Clair, Michele Tansella, Mirella Ruggeri, Pierandrea Muglia
Kernicterus and the molecular mechanisms of bilirubin-induced CNS injury in newborns
NeuroMolecular Medicine - Tập 8 - Trang 513-529 - 2006
Jon F. Watchko
Kernicterus is a devastating, chronic disabling neurological disorder whose central nervous system (CNS) sequelae reflect both a predilection of bilirubin toxicity for neurons (rather than glial cells) and the regional topography of bilirubin-induced neuronal injury that is characterized by prominent basal ganglia, cochlear, and oculomotor nuclei involvement. The molecular pathogenesis of bilirubi...... hiện toàn bộ
Energy Restriction Negates NMDA Receptor Antagonist Efficacy in Ischemic Stroke
NeuroMolecular Medicine - Tập 13 Số 3 - Trang 175-178 - 2011
Jeong Seon Yoon, Mohamed R. Mughal, Mark P. Mattson
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