Molecular and Cellular Biology
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Characterization of a β-Actin mRNA Zipcode-Binding Protein
Molecular and Cellular Biology - Tập 17 Số 4 - Trang 2158-2165 - 1997
Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function. The NF1 gene, which is altered in patients with type 1 neurofibromatosis, has been postulated to function as a tumor suppressor gene. The NF1 protein product neurofibromin stimulates the intrinsic GTPase activity of active GTP-bound Ras, thereby inactivating it. Consistent with a tumor suppressor function, we have found that the introduction of NF1 in melanoma cell lines that are deficient in neurofibromin inhibited their growth and induced their differentiation. In addition, overexpression of neurofibromin in NIH 3T3 cells was growth inhibitory but did not alter the level of GTP.Ras in the cells. Transformation by v-ras, whose protein product is resistant to GTPase stimulation by neurofibromin, was inhibited in a cell line overexpressing neurofibromin, while transformation by v-raf was not altered. The results demonstrate that NF1 is a tumor suppressor gene that can inhibit Ras-dependent growth by a regulatory mechanism that is independent of neurofibromin's ability to stimulate Ras GTPase.
Molecular and Cellular Biology - Tập 14 Số 1 - Trang 641-645 - 1994
HOXA5-Induced Apoptosis in Breast Cancer Cells Is Mediated by Caspases 2 and 8
Molecular and Cellular Biology - Tập 24 Số 2 - Trang 924-935 - 2004
Amber Suppression in Mammalian Cells Dependent upon Expression of an <i>Escherichia coli</i> Aminoacyl-tRNA Synthetase Gene
Molecular and Cellular Biology - Tập 16 Số 3 - Trang 907-913 - 1996
Coactivator-Dependent Acetylation Stabilizes Members of the SREBP Family of Transcription Factors
Molecular and Cellular Biology - Tập 23 Số 7 - Trang 2587-2599 - 2003
GATA Factors and Androgen Receptor Collaborate To Transcriptionally Activate the<i>Rhox5</i>Homeobox Gene in Sertoli Cells
Molecular and Cellular Biology - Tập 28 Số 7 - Trang 2138-2153 - 2008
Role of Phosphoinositide 3-Kinase in Activation of Ras and Mitogen-Activated Protein Kinase by Epidermal Growth Factor
Molecular and Cellular Biology - Tập 19 Số 6 - Trang 4279-4288 - 1999
Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae. Saccharomyces cerevisiae contains two genes which encode cyclic AMP (cAMP) phosphodiesterase. We previously isolated and characterized PDE2, which encodes a high-affinity cAMP phosphodiesterase. We have now isolated the PDE1 gene of S. cerevisiae, which encodes a low-affinity cAMP phosphodiesterase. These two genes represent highly divergent branches in the evolution of phosphodiesterases. High-copy-number plasmids containing either PDE1 or PDE2 can reverse the growth arrest defects of yeast cells carrying the RAS2(Val-19) mutation. PDE1 and PDE2 appear to account for the aggregate cAMP phosphodiesterase activity of S. cerevisiae. Disruption of both PDE genes results in a phenotype which resembles that induced by the RAS2(Val-19) mutation. pde1- pde2- ras1- ras2- cells are viable.
Molecular and Cellular Biology - Tập 7 Số 10 - Trang 3629-3636 - 1987
MicroRNA 329 Suppresses Angiogenesis by Targeting CD146
Molecular and Cellular Biology - Tập 33 Số 18 - Trang 3689-3699 - 2013
Yeast Upf Proteins Required for RNA Surveillance Affect Global Expression of the Yeast Transcriptome
Molecular and Cellular Biology - Tập 19 Số 10 - Trang 6710-6719 - 1999
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