O-GlcNAc Integrates the Proteasome and Transcriptome To Regulate Nuclear Hormone ReceptorsMolecular and Cellular Biology - Tập 26 Số 22 - Trang 8539-8550 - 2006
Damon B. Bowe, Andrea Sadlonova, Clifford A. Toleman, Zdeněk Novák, Yong Hu, Ping Huang, Soumendu Sundar Mukherjee, Timothy G. Whitsett, Andra R. Frost, Andrew J. Paterson, Jeffrey E. Kudlow
Different structural alterations upregulate in vitro tyrosine kinase activity and transforming potency of the erbB-2 gene.Molecular and Cellular Biology - Tập 8 Số 12 - Trang 5570-5574 - 1988
Oreste Segatto, C. Richter King, Jacalyn H. Pierce, Pier Paolo Di Fiore, S A Aaronson
Compared with normal erbB-2 gp185, mutant erbB-2 proteins generated by mutations either in the transmembrane domain or by NH2-terminal deletion are able to transform NIH 3T3 cells at a 10- to 100-fold greater efficiency. Mutant proteins of both classes show increased tyrosine kinase activity, suggesting that an abnormal level of receptor-associated tyrosine kinase activity is a major deter...... hiện toàn bộ