Molecular Cancer
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Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma
Molecular Cancer - - 2015
Regulatory cells and the effect of cancer immunotherapy
Molecular Cancer - Tập 22 - Trang 1-15 - 2023
Several mechanisms and cell types are involved in the regulation of the immune
response. These include mostly regulatory T cells (Tregs), regulatory
macrophages (Mregs), myeloid suppressor cells (MDSCs) and other regulatory cell
types such as tolerogenic dendritic cells (tolDCs), regulatory B cells (Bregs),
and mesenchymal stem cells (MSCs). These regulatory cells, known for their
ability to suppr...
RASSF1A promoter methylation and expression analysis in normal and neoplastic kidney indicates a role in early tumorigenesis
Molecular Cancer - Tập 6 - Trang 1-9 - 2007
Epigenetic silencing of the RAS association domain family 1A (RASSF1A) tumor
suppressor gene promoter has been demonstrated in renal cell carcinoma (RCC) as
a result of promoter hypermethylation. Contradictory results have been reported
for RASSF1A methylation in normal kidney, thus it is not clear whether a
significant difference between RASSF1A methylation in normal and tumor cells of
the kidney...
Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profiling
Molecular Cancer - Tập 14 - Trang 1-18 - 2015
Monolayer cultures of immortalised cell lines are a popular screening tool for
novel anti-cancer therapeutics, but these methods can be a poor surrogate for
disease states, and there is a need for drug screening platforms which are more
predictive of clinical outcome. In this study, we describe a phenotypic antibody
screen using three-dimensional cultures of primary cells, and image-based
multi-pa...
Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanoma
Molecular Cancer - Tập 13 Số 1 - Trang 1-14 - 2014
The clinical use of BRAF inhibitors for treatment of metastatic melanoma is
limited by the development of drug resistance. In this study we investigated
whether co-targeting the MAPK and the PI3K-AKT pathway can prevent emergence of
resistance or provide additional growth inhibitory effects in vitro. Anti-tumor
effects of the combination of the BRAF inhibitor (BRAFi) dabrafenib and
GSK2141795B (AK...
Cancer stem cell metabolism: a potential target for cancer therapy
Molecular Cancer - Tập 15 - Trang 1-10 - 2016
Cancer Stem cells (CSCs) are a unipotent cell population present within the
tumour cell mass. CSCs are known to be highly chemo-resistant, and in recent
years, they have gained intense interest as key tumour initiating cells that may
also play an integral role in tumour recurrence following chemotherapy. Cancer
cells have the ability to alter their metabolism in order to fulfil
bio-energetic and b...
Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGH
Molecular Cancer - Tập 4 - Trang 1-12 - 2005
Amplification of the q21-q23 region on chromosome 1 is frequently found in
sarcomas and a variety of other solid tumours. Previous analyses of sarcomas
have indicated the presence of at least two separate amplicons within this
region, one located in 1q21 and one located near the apolipoprotein A-II (APOA2)
gene in 1q23. In this study we have mapped and characterized the amplicon in
1q23 in more de...
A novel approach to identify driver genes involved in androgen-independent prostate cancer
Molecular Cancer - Tập 13 - Trang 1-12 - 2014
Insertional mutagenesis screens have been used with great success to identify
oncogenes and tumor suppressor genes. Typically, these screens use
gammaretroviruses (γRV) or transposons as insertional mutagens. However,
insertional mutations from replication-competent γRVs or transposons that occur
later during oncogenesis can produce passenger mutations that do not drive
cancer progression. Here, w...
Role of the dynamic tumor microenvironment in controversies regarding immune checkpoint inhibitors for the treatment of non-small cell lung cancer (NSCLC) with EGFR mutations
Molecular Cancer - Tập 18 - Trang 1-18 - 2019
Immunotherapy has been incorporated into the first- and second-line treatment
strategies for non-small cell lung cancer (NSCLC), profoundly ushering in a new
treatment landscape. However, both adaptive signaling and oncogenic (epidermal
growth factor receptor (EGFR)-driven) signaling may induce PD-L1 upregulation in
NSCLC. Nevertheless, the superiority of immune checkpoint inhibitors (ICIs) in
adv...
Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis
Molecular Cancer - Tập 21 Số 1
Abstract Background Pancreatic cancer is one of the most lethal cancers
worldwide. The IAPs function as E3 ubiquitin ligases and contribute to
pancreatic cancer initiation, progression, and metastasis. Although IAP-targeted
therapies have been developed and shown anticancer efficacy in preclinical
settings, none of them has been approved yet. Methods Transcriptome data from
public datasets were us...
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