Regulatory cells and the effect of cancer immunotherapyMolecular Cancer - Tập 22 - Trang 1-15 - 2023
María Iglesias-Escudero, Noelia Arias-González, Eva Martínez-Cáceres
Several mechanisms and cell types are involved in the regulation of the immune response. These include mostly regulatory T cells (Tregs), regulatory macrophages (Mregs), myeloid suppressor cells (MDSCs) and other regulatory cell types such as tolerogenic dendritic cells (tolDCs), regulatory B cells (Bregs), and mesenchymal stem cells (MSCs). These regulatory cells, known for their ability to suppr...... hiện toàn bộ
RASSF1A promoter methylation and expression analysis in normal and neoplastic kidney indicates a role in early tumorigenesisMolecular Cancer - Tập 6 - Trang 1-9 - 2007
Inga Peters, Kristina Rehmet, Nadine Wilke, Markus A Kuczyk, Jörg Hennenlotter, Tyark Eilers, Stefan Machtens, Udo Jonas, Jürgen Serth
Epigenetic silencing of the RAS association domain family 1A (RASSF1A) tumor suppressor gene promoter has been demonstrated in renal cell carcinoma (RCC) as a result of promoter hypermethylation. Contradictory results have been reported for RASSF1A methylation in normal kidney, thus it is not clear whether a significant difference between RASSF1A methylation in normal and tumor cells of the kidney...... hiện toàn bộ
Identification of anti-tumour biologics using primary tumour models, 3-D phenotypic screening and image-based multi-parametric profilingMolecular Cancer - Tập 14 - Trang 1-18 - 2015
Alan M. Sandercock, Steven Rust, Sandrine Guillard, Kris F. Sachsenmeier, Nick Holoweckyj, Carl Hay, Matt Flynn, Qihui Huang, Kuan Yan, Bram Herpers, Leo S. Price, Jo Soden, Jim Freeth, Lutz Jermutus, Robert Hollingsworth, Ralph Minter
Monolayer cultures of immortalised cell lines are a popular screening tool for novel anti-cancer therapeutics, but these methods can be a poor surrogate for disease states, and there is a need for drug screening platforms which are more predictive of clinical outcome. In this study, we describe a phenotypic antibody screen using three-dimensional cultures of primary cells, and image-based multi-pa...... hiện toàn bộ
Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanomaMolecular Cancer - Tập 13 Số 1 - Trang 1-14 - 2014
Lassen, Amanda, Atefi, Mohammad, Robert, Lidia, Wong, Deborah JL, Cerniglia, Michael, Comin-Anduix, Begonya, Ribas, Antoni
The clinical use of BRAF inhibitors for treatment of metastatic melanoma is limited by the development of drug resistance. In this study we investigated whether co-targeting the MAPK and the PI3K-AKT pathway can prevent emergence of resistance or provide additional growth inhibitory effects in vitro. Anti-tumor effects of the combination of the BRAF inhibitor (BRAFi) dabrafenib and GSK2141795B (AK...... hiện toàn bộ
Cancer stem cell metabolism: a potential target for cancer therapyMolecular Cancer - Tập 15 - Trang 1-10 - 2016
Abhijeet Deshmukh, Kedar Deshpande, Frank Arfuso, Philip Newsholme, Arun Dharmarajan
Cancer Stem cells (CSCs) are a unipotent cell population present within the tumour cell mass. CSCs are known to be highly chemo-resistant, and in recent years, they have gained intense interest as key tumour initiating cells that may also play an integral role in tumour recurrence following chemotherapy. Cancer cells have the ability to alter their metabolism in order to fulfil bio-energetic and b...... hiện toàn bộ
Mapping and characterization of the amplicon near APOA2 in 1q23 in human sarcomas by FISH and array CGHMolecular Cancer - Tập 4 - Trang 1-12 - 2005
Stine H Kresse, Jeanne-Marie Berner, Leonardo A Meza-Zepeda, Simon G Gregory, Wen-Lin Kuo, Joe W Gray, Anne Forus, Ola Myklebost
Amplification of the q21-q23 region on chromosome 1 is frequently found in sarcomas and a variety of other solid tumours. Previous analyses of sarcomas have indicated the presence of at least two separate amplicons within this region, one located in 1q21 and one located near the apolipoprotein A-II (APOA2) gene in 1q23. In this study we have mapped and characterized the amplicon in 1q23 in more de...... hiện toàn bộ
A novel approach to identify driver genes involved in androgen-independent prostate cancerMolecular Cancer - Tập 13 - Trang 1-12 - 2014
Ellyn N Schinke, Victor Bii, Arun Nalla, Dustin T Rae, Laura Tedrick, Gary G Meadows, Grant D Trobridge
Insertional mutagenesis screens have been used with great success to identify oncogenes and tumor suppressor genes. Typically, these screens use gammaretroviruses (γRV) or transposons as insertional mutagens. However, insertional mutations from replication-competent γRVs or transposons that occur later during oncogenesis can produce passenger mutations that do not drive cancer progression. Here, w...... hiện toàn bộ
Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasisMolecular Cancer - Tập 21 Số 1
Simin Qi, Xiaoqing Guan, Jia Zhang, Dehua Yu, Xiaoduo Yu, Qinglin Li, Wenjuan Yin, Xiangdong Cheng, Weidong Zhang, Jiang‐Jiang Qin
Abstract
Background
Pancreatic cancer is one of the most lethal cancers worldwide. The IAPs function as E3 ubiquitin ligases and contribute to pancreatic cancer initiation, progression, and metastasis. Although IAP-targeted therapies have been developed and shown anticancer efficacy in preclinical s...... hiện toàn bộ