Molecular Cancer

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Regulatory cells and the effect of cancer immunotherapy
Molecular Cancer - Tập 22 - Trang 1-15 - 2023
María Iglesias-Escudero, Noelia Arias-González, Eva Martínez-Cáceres
Several mechanisms and cell types are involved in the regulation of the immune response. These include mostly regulatory T cells (Tregs), regulatory macrophages (Mregs), myeloid suppressor cells (MDSCs) and other regulatory cell types such as tolerogenic dendritic cells (tolDCs), regulatory B cells (Bregs), and mesenchymal stem cells (MSCs). These regulatory cells, known for their ability to suppr...... hiện toàn bộ
Effects of AKT inhibitor therapy in response and resistance to BRAF inhibition in melanoma
Molecular Cancer - Tập 13 Số 1 - Trang 1-14 - 2014
Lassen, Amanda, Atefi, Mohammad, Robert, Lidia, Wong, Deborah JL, Cerniglia, Michael, Comin-Anduix, Begonya, Ribas, Antoni
The clinical use of BRAF inhibitors for treatment of metastatic melanoma is limited by the development of drug resistance. In this study we investigated whether co-targeting the MAPK and the PI3K-AKT pathway can prevent emergence of resistance or provide additional growth inhibitory effects in vitro. Anti-tumor effects of the combination of the BRAF inhibitor (BRAFi) dabrafenib and GSK2141795B (AK...... hiện toàn bộ
Cancer stem cell metabolism: a potential target for cancer therapy
Molecular Cancer - Tập 15 - Trang 1-10 - 2016
Abhijeet Deshmukh, Kedar Deshpande, Frank Arfuso, Philip Newsholme, Arun Dharmarajan
Cancer Stem cells (CSCs) are a unipotent cell population present within the tumour cell mass. CSCs are known to be highly chemo-resistant, and in recent years, they have gained intense interest as key tumour initiating cells that may also play an integral role in tumour recurrence following chemotherapy. Cancer cells have the ability to alter their metabolism in order to fulfil bio-energetic and b...... hiện toàn bộ
Role of the dynamic tumor microenvironment in controversies regarding immune checkpoint inhibitors for the treatment of non-small cell lung cancer (NSCLC) with EGFR mutations
Molecular Cancer - Tập 18 - Trang 1-18 - 2019
Anqi Lin, Ting Wei, Hui Meng, Peng Luo, Jian Zhang
Immunotherapy has been incorporated into the first- and second-line treatment strategies for non-small cell lung cancer (NSCLC), profoundly ushering in a new treatment landscape. However, both adaptive signaling and oncogenic (epidermal growth factor receptor (EGFR)-driven) signaling may induce PD-L1 upregulation in NSCLC. Nevertheless, the superiority of immune checkpoint inhibitors (ICIs) in adv...... hiện toàn bộ
Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis
Molecular Cancer - Tập 21 Số 1
Simin Qi, Xiaoqing Guan, Jia Zhang, Dehua Yu, Xiaoduo Yu, Qinglin Li, Wenjuan Yin, Xiangdong Cheng, Weidong Zhang, Jiang‐Jiang Qin
Abstract Background Pancreatic cancer is one of the most lethal cancers worldwide. The IAPs function as E3 ubiquitin ligases and contribute to pancreatic cancer initiation, progression, and metastasis. Although IAP-targeted therapies have been developed and shown anticancer efficacy in preclinical s...... hiện toàn bộ
Phenylbutyrate interferes with the Fanconi anemia and BRCA pathway and sensitizes head and neck cancer cells to cisplatin
Molecular Cancer - Tập 7 - Trang 1-9 - 2008
Kyunghee Burkitt, Mats Ljungman
Cisplatin has been widely used to treat head and neck cancer. One of the clinical limitations with this treatment, however, is that tumors that are initially responsive to cisplatin later acquire resistance. We have recently shown that a subset of head and neck cancer cell lines has a defective Fanconi anemia DNA damage response pathway and this defect correlates to cisplatin sensitivity. We have ...... hiện toàn bộ
A urine extracellular vesicle circRNA classifier for detection of high-grade prostate cancer in patients with prostate-specific antigen 2–10 ng/mL at initial biopsy
Molecular Cancer - Tập 20 - Trang 1-6 - 2021
Ya-Di He, Wen Tao, Tao He, Bang-Yu Wang, Xiu-Mei Tang, Liang-Ming Zhang, Zhen-Quan Wu, Wei-Ming Deng, Ling-Xiao Zhang, Chun-Kui Shao, Jing Zhou, Li-Min Rong, Xin Gao, Liao-Yuan Li
The aim of this study was to identify a urine extracellular vesicle circular RNA (circRNA) classifier that could detect high-grade prostate cancer (PCa) of Grade Group (GG) 2 or greater. For this purpose, we used RNA sequencing to identify candidate circRNAs from urinary extracellular vesicles from 11 patients with high-grade PCa and 11 case-matched patients with benign prostatic hyperplasia. Usin...... hiện toàn bộ
Circulating tumor DNA landscape and prognostic impact of acquired resistance to targeted therapies in cancer patients: a national center for precision medicine (PRISM) study
Molecular Cancer -
Arnaud Bayle, Laïla Belcaid, Lola‐Jade Palmieri, Diego Teysonneau, Sophie Cousin, Mariella Spalato Ceruso, Mihaela Aldea, Damien Vasseur, Mélissa Alamé, Laura Blouin, Isabelle Soubeyran, Claudio Nicotra, Maud Ngo-Camus, Antoine Hollebecque, Yohann Loriot, Benjamin Besse, Ludovic Lacroix, Etienne Rouleau, Fabrice Barlési, Fabrice André, Antoîne Italiano
Abstract Background Despite the effectiveness of the various targeted therapies currently approved for solid tumors, acquired resistance remains a persistent problem that limits the ultimate effectiveness of these treatments. Polyclonal resistance to targeted therapy has been described in multiple s...... hiện toàn bộ
Geographical mapping of a multifocal thyroid tumour using genetic alteration analysis & miRNA profiling
Molecular Cancer - Tập 7 Số 1 - 2008
Sinéad Aherne, Paul Smyth, Richard Flavin, Susan M. Russell, Karen Denning, Jing Huan Li, Simone M Guenther, John O’Leary, Orla Sheils
Abstract Background Papillary thyroid carcinoma (PTC) frequently presents as multiple tumour-foci within a single thyroid gland or pluriform, with synchronous tumours comprising different histological variants, raising questions regarding its clonality. Among the genetic aberrations described in ...... hiện toàn bộ
The lncRNA CASC15 regulates SOX4 expression in RUNX1-rearranged acute leukemia
Molecular Cancer - Tập 16 - Trang 1-15 - 2017
Thilini R. Fernando, Jorge R. Contreras, Matteo Zampini, Norma I. Rodriguez-Malave, Michael O. Alberti, Jaime Anguiano, Tiffany M. Tran, Jayanth K. Palanichamy, Jasmine Gajeton, Nolan M. Ung, Cody J. Aros, Ella V. Waters, David Casero, Giuseppe Basso, Martina Pigazzi, Dinesh S. Rao
Long non-coding RNAs (lncRNAs) play a variety of cellular roles, including regulation of transcription and translation, leading to alterations in gene expression. Some lncRNAs modulate the expression of chromosomally adjacent genes. Here, we assess the roles of the lncRNA CASC15 in regulation of a chromosomally nearby gene, SOX4, and its function in RUNX1/AML translocated leukemia. ...... hiện toàn bộ
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