Molecular Cancer

Công bố khoa học tiêu biểu

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RNA vòng: chuyển hóa, chức năng và tương tác với protein Dịch bởi AI
Molecular Cancer - - 2020
Wei‐Yi Zhou, Zerong Cai, Jia Liu, De-Shen Wang, Huai-Qiang Ju, Rui‐Hua Xu
Tóm tắtRNA vòng (CircRNAs) là các phân tử RNA đơn chuỗi, được đóng kín một cách đồng hóa trị và hiện diện phổ biến ở nhiều loài, từ virus đến động vật có vú. Những tiến bộ quan trọng đã được ghi nhận trong sinh tổng hợp, điều hòa, vị trí, phân hủy và sửa đổi của circRNAs. CircRNAs thực hiện các chức năng sinh học bằng cách đóng vai trò là các bộ điều chỉnh phiên mã...... hiện toàn bộ
mRNA vaccine for cancer immunotherapy
Molecular Cancer - Tập 20 - Trang 1-23 - 2021
Lei Miao, Yu Zhang, Leaf Huang
mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor antigens in antigen-presenting cells (APCs), facilitate APC activation and innate/adaptive immune stimulation. mRNA cancer vaccine precedes other conventional vaccine platforms due to high potency, safe administration, rapid development potent...... hiện toàn bộ
SMC3 knockdown triggers genomic instability and p53-dependent apoptosis in human and zebrafish cells
Molecular Cancer - - 2006
Giancarlo Ghiselli
The structural maintenance of chromosome 3 (SMC3) protein is a constituent of a number of nuclear multimeric protein complexes that are involved in DNA recombination and repair in addition to chromosomal segregation. Overexpression of SMC3 activates a tumorigenic cascade through which mammalian cells acquire a transformed phenotype. This has led us to examine in depth how SMC3 level affects cell g...... hiện toàn bộ
Nerve growth factor promotes breast cancer angiogenesis by activating multiple pathways
Molecular Cancer - Tập 9 - Trang 1-13 - 2010
Rodrigue Romon, Eric Adriaenssens, Chann Lagadec, Emmanuelle Germain, Hubert Hondermarck, Xuefen Le Bourhis
Although several anti-angiogenic therapies have been approved in the treatment of cancer, the survival benefits of such therapies are relatively modest. Discovering new molecules and/or better understating signaling pathways of angiogenesis is therefore essential for therapeutic improvements. The objective of the present study was to determine the involvement of nerve growth factor (NGF) in breast...... hiện toàn bộ
RETRACTED ARTICLE: α-santalol inhibits the angiogenesis and growth of human prostate tumor growth by targeting vascular endothelial growth factor receptor 2-mediated AKT/mTOR/P70S6K signaling pathway
Molecular Cancer - Tập 12 - Trang 1-18 - 2013
Sarita Saraswati, Shakti Kumar, Abdulqader A Alhaider
VEGF receptor 2 (VEGFR2) inhibitors, as efficient antiangiogenesis agents, have been applied in the cancer treatment. However, recently, most of these anticancer drugs have some adverse effects. Discovery of novel VEGFR2 inhibitors as anticancer drug candidates is still needed. We used α-santalol and analyzed its inhibitory effects on human umbilical vein endothelial cells (HUVECs) and Prostate tu...... hiện toàn bộ
E2F1 renders prostate cancer cell resistant to ICAM-1 mediated antitumor immunity by NF-κB modulation
Molecular Cancer - Tập 13 - Trang 1-13 - 2014
Zijia Ren, Wenyao Kang, Lihua Wang, Baoliang Sun, Jiajia Ma, Chaogu Zheng, Jie Sun, Zhigang Tian, Xiaoyi Yang, Weihua Xiao
E2F1 is the gatekeeper of the cell cycle controlling an analogous balance between proliferation and cell death. E2F1 expression is elevated in advanced prostate cancer. However, it is still unclear that the roles and mechanisms of E2F1 on prostate cancers. Targeted knockdown by interferon RNA was applied on two prostate cancer and Hela cell lines to examine the inverse correlation expression of E2...... hiện toàn bộ
Tumors: Too sweet to remember?
Molecular Cancer - Tập 6 - Trang 1-5 - 2007
H Peter Vollmers, Stephanie Brändlein
Immunity, based on a natural and an educated system, is responsible for recognition and elimination of infectious particles, cellular waste, modified self and transformed cells. This dual system guarantees that dangerous particles are removed immediately after appearance and that a memory with maturated weapons exists, if the organism is re-infected by the same particle. For malignant cells, howev...... hiện toàn bộ
mRNA vaccine: a potential therapeutic strategy
Molecular Cancer - Tập 20 - Trang 1-23 - 2021
Yang Wang, Ziqi Zhang, Jingwen Luo, Xuejiao Han, Yuquan Wei, Xiawei Wei
mRNA vaccines have tremendous potential to fight against cancer and viral diseases due to superiorities in safety, efficacy and industrial production. In recent decades, we have witnessed the development of different kinds of mRNAs by sequence optimization to overcome the disadvantage of excessive mRNA immunogenicity, instability and inefficiency. Based on the immunological study, mRNA vaccines ar...... hiện toàn bộ
Function and mechanism of tumor suppressor gene LRRC4/NGL-2
Molecular Cancer - Tập 13 - Trang 1-7 - 2014
Peiyao Li, Gang Xu, Guiyuan Li, Minghua Wu
LRRC4/NGL-2 (Leucine rich repeat containing 4/Netrin-G ligand-2), a relatively specific expressed gene in brain tissue, is a member of the LRRC4/ NGL (netrin-G ligand) family and belongs to the superfamily of LRR proteins. LRRC4/NGL-2 regulates neurite outgrowth and lamina-specific dendritic segmentation, suggesting that LRRC4/NGL-2 is important for the development of the nervous system. In additi...... hiện toàn bộ
Genome-scale CRISPR-Cas9 knockout screening in gastrointestinal stromal tumor with Imatinib resistance
Molecular Cancer - Tập 17 Số 1 - 2018
Jie Cao, Jianchang Wei, Ping Yang, Tong Zhang, Zhuanpeng Chen, Feng He, Wei Fang, Huacui Chen, Hong He, Junbin Zhong, Zhi Yang, Wei Cai, Wanglin Li, Qiang Wang
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