Microbiome
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Community genomic analyses constrain the distribution of metabolic traits across the Chloroflexi phylum and indicate roles in sediment carbon cycling
Microbiome - Tập 1 - Trang 1-17 - 2013
Sediments are massive reservoirs of carbon compounds and host a large fraction
of microbial life. Microorganisms within terrestrial aquifer sediments control
buried organic carbon turnover, degrade organic contaminants, and impact
drinking water quality. Recent 16S rRNA gene profiling indicates that members of
the bacterial phylum Chloroflexi are common in sediment. Only the role of the
class Deha...
Evidence for an association of gut microbial Clostridia with brain functional connectivity and gastrointestinal sensorimotor function in patients with irritable bowel syndrome, based on tripartite network analysis
Microbiome - Tập 7 - Trang 1-15 - 2019
Evidence from preclinical and clinical studies suggests that interactions among
the brain, gut, and microbiota may affect the pathophysiology of irritable bowel
syndrome (IBS). As disruptions in central and peripheral serotonergic signaling
pathways have been found in patients with IBS, we explored the hypothesis that
the abundance of serotonin-modulating microbes of the order Clostridiales is
ass...
Understanding the “individual drug reaction” from the perspective of the interaction between probiotics and lovastatin in vitro and in vivo
Microbiome - Tập 11 - Trang 1-16 - 2023
The existence of the gut microbiota produces an “individual drug reaction.” As
members of the intestinal microbiota, probiotics, although they have prebiotic
functions, may accelerate the degradation of drugs, thereby affecting drug
efficacy. Lovastatin is one of the well-recognized lipid-lowering drugs. Its
main action site is the liver. Therefore, if it is degraded in advance by
gastrointestinal...
Placental TLR recognition of salivary and subgingival microbiota is associated with pregnancy complications
Microbiome - Tập 12 Số 1
Abstract Background Pre-term birth, the leading cause of neonatal mortality, has
been associated with maternal periodontal disease and the presence of oral
pathogens in the placenta. However, the mechanisms that underpin this link are
not known. This investigation aimed to identify the origins of placental
microbiota and to interrogate the association between parturition complications
and immune r...
Interactions between rootstocks and compost influence the active rhizosphere bacterial communities in citrus
Microbiome - Tập 11 Số 1 - Trang 1-16 - 2023
While the rootstock genotype (belowground part of a plant) can impact
rhizosphere microbial communities, few studies have examined the relationships
between rootstock genotype-based recruitment of active rhizosphere bacterial
communities and the availability of root nutrients for plant uptake. Rootstocks
are developed to provide resistance to disease or tolerance of abiotic stresses,
and compost a...
BioMiCo: a supervised Bayesian model for inference of microbial community structure
Microbiome - Tập 3 - Trang 1-15 - 2015
Microbiome samples often represent mixtures of communities, where each community
is composed of overlapping assemblages of species. Such mixtures are complex,
the number of species is huge and abundance information for many species is
often sparse. Classical methods have a limited value for identifying complex
features within such data. Here, we describe a novel hierarchical model for
Bayesian inf...
Vertical transmission of the gut microbiota influences glucose metabolism in offspring of mice with hyperglycaemia in pregnancy
Microbiome - Tập 10 - Trang 1-19 - 2022
Hyperglycaemia in pregnancy (HIP) is a common metabolic disorder that not only
poses risks to maternal health but also associates with an increased risk of
diabetes among offspring. Vertical transmission of microbiota may influence the
offspring microbiome and subsequent glucose metabolism. However, the mechanism
by which maternal gut microbiota may influence glucose metabolism of the
offspring re...
Repeatability and reproducibility assessment in a large-scale population-based microbiota study: case study on human milk microbiota
Microbiome - Tập 9 - Trang 1-10 - 2021
Quality control including assessment of batch variabilities and confirmation of
repeatability and reproducibility are integral component of high throughput
omics studies including microbiome research. Batch effects can mask true
biological results and/or result in irreproducible conclusions and
interpretations. Low biomass samples in microbiome research are prone to reagent
contamination; yet, qua...
Arms race in a cell: genomic, transcriptomic, and proteomic insights into intracellular phage–bacteria interplay in deep-sea snail holobionts
Microbiome - Tập 9 - Trang 1-13 - 2021
Deep-sea animals in hydrothermal vents often form endosymbioses with
chemosynthetic bacteria. Endosymbionts serve essential biochemical and
ecological functions, but the prokaryotic viruses (phages) that determine their
fate are unknown. We conducted metagenomic analysis of a deep-sea vent snail. We
assembled four genome bins for Caudovirales phages that had developed dual
endosymbiosis with sulph...
Mapping the early life gut microbiome in neonates with critical congenital heart disease: multiomics insights and implications for host metabolic and immunological health
Microbiome - Tập 10 Số 1
Abstract Background The early life gut microbiome is crucial in maintaining host
metabolic and immune homeostasis. Though neonates with critical congenital heart
disease (CCHD) are at substantial risks of malnutrition and immune imbalance,
the microbial links to CCHD pathophysiology remain poorly understood. In this
study, we aimed to investigate the gut microbiome in neonates with CCHD in
associa...
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