Medical Oncology

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DNA promoter and histone H3 methylation downregulate NGX6 in gastric cancer cells
Medical Oncology - Tập 31 - Trang 1-9 - 2013
Jian Liu, Xinjiang Zhu, Xiaoyang Xu, Dongqiu Dai
Nasopharyngeal carcinoma-associated gene 6 (NGX6) is a novel candidate tumor metastasis suppressor gene. Our study was to determine whether DNA hypermethylation and histone modification at the NGX6 gene promoter play important roles in silencing NGX6 expression in gastric cancer. NGX6 expression was downregulated in all gastric cancer cells and 76.19 % tissues. In three GC cell lines, hypermethyla... hiện toàn bộ
Telomere shortening occurs early during gastrocarcinogenesis
Medical Oncology - Tập 29 - Trang 893-898 - 2011
Yunchuan Mu, Qing Zhang, Linhang Mei, Xiaosun Liu, Weili Yang, Jiren Yu
When telomeres are shortened to a critical length, they will initiate chromosomal instability (CIN) and may finally cause tumorigenesis. The purpose of the present study was to evaluate the shortened telomere as a potential biomarker for tumorigenesis in gastric carcinoma. The telomeres in matched cancer and adjacent noncancer mucosa samples from 86 gastric carcinoma patients were measured by real... hiện toàn bộ
Lung cancer as a cardiotoxic state: a review
Medical Oncology - Tập 34 - Trang 1-17 - 2017
David Pérez-Callejo, María Torrente, María Auxiliadora Brenes, Beatriz Núñez, Mariano Provencio
As the overall survival of patients with lung cancer continues to increase, more cancer survivors are faced with the risk of developing treatment-related cardiovascular toxicities. The increased knowledge of the molecular biology of non-small cell lung cancer has led to new and more personalized treatments. Nevertheless, the usual chemotherapy schemes and radiation therapy induce cardiac toxicitie... hiện toàn bộ
HBsAg is an independent prognostic factor in diffuse large B cell lymphoma patients in rituximab era: result from a multicenter retrospective analysis in China
Medical Oncology - - 2014
Zheng Wei, Shanhua Zou, Feng Li, Zhigang Cheng, Junmin Li, Jianmin Wang, Chun Wang, Fangyuan Chen, Junning Cao, Yunfeng Cheng
Estrogen upregulates the IGF-1 signaling pathway in lung cancer through estrogen receptor-β
Medical Oncology - - 2012
Huiping Tang, Yongde Liao, Guang Chen, Liqiang Xu, Chao Zhang, Sheng Hong Ju, Sheng Zhou
Serum semicarbazide-sensitive amine oxidase (SSAO) activity correlates with VEGF in non-small-cell lung cancer patients
Medical Oncology - Tập 21 - Trang 241-250 - 2004
Håkan Garpenstrand, Michael Bergqvist, Daniel Brattström, Anders Larsson, Lars Oreland, Patrik Hesselius, Gunnar Wagenius
Semicarbazide-sensitive amine oxidase (SSAO) is an enzyme associated with vascular systems in mammals. SSAO catalyzes the deamination of primary monoamines and has been suggested to be a risk factor in vascular disorders, e.g., diabetic vascular complications. The primary aim of the present study was to investigate if serum SSAO activity is associated with clinical parameters in non-small cell lun... hiện toàn bộ
Prognostic evaluation of microRNA-210 expression in pediatric osteosarcoma
Medical Oncology - Tập 30 - Trang 1-6 - 2013
Haiqing Cai, Lijun Lin, Haikang Cai, Mingjie Tang, Zhigang Wang
MicroRNA-210 (miR-210) plays important roles in the regulation of cell growth, angiogenesis, and apoptosis in different cancer type. Previous study of miRNA expression profiling found that miR-210 was significantly elevated in osteosarcoma samples. However, its roles in this disease have not been fully elucidated. Thus, the aim of this study was to investigate the association of miR-210 expression... hiện toàn bộ
Tumor lysis syndrome after treatment with gemcitabine for metastatic transitional cell carcinoma
Medical Oncology - Tập 24 - Trang 455-457 - 2007
Cheng-Jui Lin, Ken-Hong Lim, Yi-Chou Cheng, Han-Hsiang Chen, Chih-Jen Wu
Tumor lysis syndrome is a set of life threatening complication that can arise from treatment of high tumor burden, drug sensitive, and rapidly proliferating neoplasm particularly of hematological origin. It is rarely described in patients with solid tumors. We report the first case of tumor lysis syndrome in a man with metastatic renal pelvic transitional cell carcinoma after gemcitabine treatment... hiện toàn bộ
Zoledronic acid inhibits proliferation and impairs migration and invasion through downregulating VEGF and MMPs expression in human nasopharyngeal carcinoma cells
Medical Oncology - Tập 29 - Trang 714-720 - 2011
Xu-yuan Li, Ying-cheng Lin, Wan-lan Huang, Chao-qun Hong, Jiong-yu Chen, Yan-jie You, Wei-bing Li
To demonstrate the effect of zoledronic acid in proliferation, invasion, and migration of human nasopharyngeal carcinoma cell HNE-1 and explore the potential role of VEGF, MMP-2, and MMP-9 proteins in vitro. Human nasopharyngeal carcinoma cell HNE-1 was exposed to various concentrations (0–40 μmol/l) of zoledronic acid. Zoledronic acid inhibited proliferation of HNE-1 cells though not in a dose-de... hiện toàn bộ
Nitrative and oxidative DNA damage as potential survival biomarkers for nasopharyngeal carcinoma
Medical Oncology - Tập 28 - Trang 377-384 - 2010
Yuan-Jiao Huang, Bei-Bei Zhang, Ning Ma, Mariko Murata, An-zhou Tang, Guang-Wu Huang
Currently, there are no satisfactory biomarkers available to screen for nasopharyngeal carcinoma (NPC). Nitric oxide (NO), produced by inducible nitric oxide synthase (iNOS), has been suggested to cause nitrative and oxidative stress, leading to the accumulation of 8-nitroguanine (8-NitroG) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) and the subsequent transversion mutation of DNA. The aim of this st... hiện toàn bộ
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