Medical Molecular Morphology

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Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide
Medical Molecular Morphology - Tập 47 - Trang 1-7 - 2013
Akira Matsuno, Mineko Murakami, Katsumi Hoya, Shoko M. Yamada, Shinya Miyamoto, So Yamada, Jae-Hyun Son, Hajime Nishido, Fuyuaki Ide, Hiroshi Nagashima, Mutsumi Sugaya, Toshio Hirohata, Akiko Mizutani, Hiroko Okinaga, Yudo Ishii, Shigeyuki Tahara, Akira Teramoto, R. Yoshiyuki Osamura
There have been several reports of temozolomide (TMZ) treatment of pituitary carcinomas and atypical adenomas. O6-methyl-guanine-DNA methyltransferase is not the sole molecule determining the sensitivity to TMZ in pituitary carcinomas and atypical adenomas. The Japan Society of Hypothalamic and Pituitary Tumors study suggests that MSH6, one of mismatch repair pathway enzyme, fulfills a contributor... hiện toàn bộ
Clinicopathological heterogeneity in ovarian clear cell adenocarcinoma: a study on individual therapy practice
Medical Molecular Morphology - Tập 48 - Trang 146-154 - 2014
Yuji Matsuo, Hironori Tashiro, Hiroyuki Yanai, Takuya Moriya, Hidetaka Katabuchi
Ovarian clear cell adenocarcinoma (CCA) has been believed to be a lethal histological subtype of an epithelial ovarian adenocarcinoma (EOA); its precursor has been assumed to be endometriosis. However, it has been reported that CCAs occasionally exhibit different clinical behaviors, suggesting that CCAs might not belong to a single category. We focused on CCAs combined with other histological type... hiện toàn bộ
Multistep mouse mammary tumorigenesis through preneoplasia to neoplasia and acquisition of metastatic potential
Medical Molecular Morphology - Tập 40 - Trang 9-17 - 2007
Airo Tsubura, Katsuhiko Yoshizawa, Norihisa Uehara, Takashi Yuri, Yoichiro Matsuoka
Human breast tissue can give rise to hyperplasias, atypical hyperplasias, and in situ carcinomas originating in a terminal duct-lobular unit (TDLU). These entities are associated with increased risk of subsequent development of invasive carcinoma. Human breast carcinomas arise via intermediate steps known as precursor or premalignant lesions. However, it is difficult to perform stepwise observatio... hiện toàn bộ
Heparin prevents oxidative stress-induced apoptosis in human decidualized endometrial stromal cells
Medical Molecular Morphology - Tập 52 Số 4 - Trang 209-216 - 2019
Shunsuke Tamaru, Takeshi Kajihara, Yumi Mizuno, Natsuko Takano, Hideno Tochigi, Tomomi Satō, Osamu Ishihara
KL-6 is another useful marker in assessing a micropapillary pattern in carcinomas of the breast and urinary bladder, but not the colon
Medical Molecular Morphology - Tập 42 - Trang 123-127 - 2009
Yuji Ohtsuki, Naoto Kuroda, Tatsuo Umeoka, Ryohei Watanabe, Kenji Ochi, Yuhei Okada, Gang-Hong Lee, Mutsuo Furihata
To evaluate the peculiar “inside-out” pattern in micropapillary (MP) carcinoma, we investigated the usefulness of KL-6 antibody in the assessment of the MP pattern of cancers, in comparison with antibodies to epithelial membrane antigen (EMA), MUC1 (CD227), and CD 10. Immunohistochemical investigation was performed on specimens exhibiting an MP pattern obtained from 12 persons with cancer: 4 with ... hiện toàn bộ
Correction to: Upregulation of complement C1q reflects mucosal regeneration in a mouse model of colitis
Medical Molecular Morphology - Tập 54 Số 3 - Trang 301-301 - 2021
Naohiko Gunji, Kyoko Katakura, Kazumichi Abe, Kazumasa Kawashima, Tatsuo Fujiwara, Michio Onizawa, Atsushi Takahashi, Hiromasa Ohira
Differences in autoimmune hepatitis based on inflammation localization
Medical Molecular Morphology - Tập 54 - Trang 8-13 - 2020
Atsushi Takahashi, Hiromasa Ohira, Kazumichi Abe, Mikio Zeniya, Masanori Abe, Teruko Arinaga-Hino, Takuji Torimura, Kaname Yoshizawa, Akinobu Takaki, Jong-Hon Kang, Yoshiyuki Suzuki, Nobuhiro Nakamoto, Ayano Inui, Atsushi Tanaka, Hajime Takikawa
Histopathology is essential for the diagnosis and evaluation of disease activity of autoimmune hepatitis (AIH). We aimed to elucidate the characteristics of AIH from the localization of inflammation. We re-evaluated a nationwide survey that was performed in Japan in 2018 of AIH patients diagnosed between 2014 and 2017. A total of 303 patients were enrolled, and the clinical and treatment character... hiện toàn bộ
Formation of large vacuoles induced by cooperative effects of oncostatin M and dexamethasone in human fetal liver cells
Medical Molecular Morphology - Tập 41 - Trang 53-58 - 2008
Tamihide Matsunaga, Mie Toba, Tsuyoshi Teramoto, Mitsue Mizuya, Kaori Aikawa, Shigeru Ohmori
The morphology of human fetal liver cells treated with both oncostatin M and dexamethasone was strikingly different from those of cells treated with either oncostatin M or dexamethasone alone. Cotreatment with oncostatin M and dexamethasone resulted in the appearance of numerous large vacuoles. The size of the vacuoles varied among individual cells, ranging from 0.05 to 20 μm depending on the cell... hiện toàn bộ
A case of “ETV6-FISH-negative” secretory carcinoma of the parotid gland: immunohistochemical study
Medical Molecular Morphology - Tập 54 - Trang 296-300 - 2021
Hiroshi Harada, Koji Irie, Shin-ichi Nakatsuka, Takakazu Sasaguri, Keiichiro Honma, Akira Kurose
Secretory carcinoma of the salivary glands is a relatively new disease concept, and is characterized by “morphological resemblance to mammary secretory carcinoma and ETV6–NTRK3 gene fusion.” Herein we describe a confusing case and briefly discuss practical diagnostic problems. The patient was a 71-year-old Japanese man who had a tumor consistent with secretory carcinoma at the microscopic and immu... hiện toàn bộ
Significance of the association between early embryonic development and endocytosis
Medical Molecular Morphology - - 2022
Akihito Morita, Yuhkoh Satouh, Ken Sato, Akira Iwase
Tổng số: 473   
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