Medical Molecular Morphology

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Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide
Medical Molecular Morphology - Tập 47 - Trang 1-7 - 2013
Akira Matsuno, Mineko Murakami, Katsumi Hoya, Shoko M. Yamada, Shinya Miyamoto, So Yamada, Jae-Hyun Son, Hajime Nishido, Fuyuaki Ide, Hiroshi Nagashima, Mutsumi Sugaya, Toshio Hirohata, Akiko Mizutani, Hiroko Okinaga, Yudo Ishii, Shigeyuki Tahara, Akira Teramoto, R. Yoshiyuki Osamura
There have been several reports of temozolomide (TMZ) treatment of pituitary carcinomas and atypical adenomas. O6-methyl-guanine-DNA methyltransferase is not the sole molecule determining the sensitivity to TMZ in pituitary carcinomas and atypical adenomas. The Japan Society of Hypothalamic and Pituitary Tumors study suggests that MSH6, one of mismatch repair pathway enzyme, fulfills a contributor...... hiện toàn bộ
Correction to: Upregulation of complement C1q reflects mucosal regeneration in a mouse model of colitis
Medical Molecular Morphology - Tập 54 Số 3 - Trang 301-301 - 2021
Naohiko Gunji, Kyoko Katakura, Kazumichi Abe, Kazumasa Kawashima, Tatsuo Fujiwara, Michio Onizawa, Atsushi Takahashi, Hiromasa Ohira
Formation of large vacuoles induced by cooperative effects of oncostatin M and dexamethasone in human fetal liver cells
Medical Molecular Morphology - Tập 41 - Trang 53-58 - 2008
Tamihide Matsunaga, Mie Toba, Tsuyoshi Teramoto, Mitsue Mizuya, Kaori Aikawa, Shigeru Ohmori
The morphology of human fetal liver cells treated with both oncostatin M and dexamethasone was strikingly different from those of cells treated with either oncostatin M or dexamethasone alone. Cotreatment with oncostatin M and dexamethasone resulted in the appearance of numerous large vacuoles. The size of the vacuoles varied among individual cells, ranging from 0.05 to 20 μm depending on the cell...... hiện toàn bộ
A case of “ETV6-FISH-negative” secretory carcinoma of the parotid gland: immunohistochemical study
Medical Molecular Morphology - Tập 54 - Trang 296-300 - 2021
Hiroshi Harada, Koji Irie, Shin-ichi Nakatsuka, Takakazu Sasaguri, Keiichiro Honma, Akira Kurose
Secretory carcinoma of the salivary glands is a relatively new disease concept, and is characterized by “morphological resemblance to mammary secretory carcinoma and ETV6–NTRK3 gene fusion.” Herein we describe a confusing case and briefly discuss practical diagnostic problems. The patient was a 71-year-old Japanese man who had a tumor consistent with secretory carcinoma at the microscopic and immu...... hiện toàn bộ
Squamous cell carcinoma with rhabdoid features of the gingiva: a case report with unusual histology
Medical Molecular Morphology - Tập 47 - Trang 240-245 - 2013
Kimihide Kusafuka, Tetsuro Onitsuka, Tomoko Miki, Chika Murai, Toshihito Suda, Tomohito Fuke, Tomoyuki Kamijo, Yoshiyuki Iida, Takashi Nakajima
Squamous cell carcinoma (SCC) with rhabdoid features (SCCRF) is extremely rare in the oral cavity. We report herein a case of oral SCCRF. The patient was a 69-year-old Japanese woman who had been suffering from a mass in the right lower gingiva. Right hemi-mandibulectomy was performed. The gingival tumor was composed of pleomorphic, non-cohesive ovoid tumor cells with abundant cytoplasm and eccen...... hiện toàn bộ
Effects of moderate exercise on biochemical, morphological, and physiological parameters of the pancreas of female mice with estrogen deprivation and dyslipidemia
Medical Molecular Morphology - Tập 51 - Trang 118-127 - 2018
Aparecida Gabriela Bexiga Veloso, Nathalia Edviges Alves Lima, Elisabete de Marco Ornelas, Clever Gomes Cardoso, Mara Rubia Marques, Beatriz da Costa Aguiar Alves Reis, Fernando Luiz Affonso Fonseca, Laura Beatriz Mesiano Maifrino
Menopausal women are at high risk of developing heart disease. However, physical exercise practice can reverse this scenario. We evaluated the biochemical, morphological, and physiological effects of moderate aerobic physical exercise on the pancreas of knockout mice for LDL receptor with estrogen deprivation by ovariectomy. Animals were divided into six groups (n = 5): sedentary non-ovariectomize...... hiện toàn bộ
CD7 aberrant expression led to a lineage switch at relapsed childhood acute pre-B lymphoblastic leukemia
Medical Molecular Morphology - - 2016
Vahid Fallah Azad, Amir Abbas Hedayati Asl, Maryam Tashvighi, Naghmeh Niktoreh Mofrad, Mansoureh Haghighi, Azim Mehrvar
Usefulness of immunohistochemistry to distinguish between secretory carcinoma and acinic cell carcinoma in the salivary gland
Medical Molecular Morphology - Tập 54 - Trang 23-30 - 2020
Yuichiro Hamamoto, Hiroshi Harada, Masaharu Kohara, Keiichiro Honma, Shin-ichi Nakatsuka, Eiichi Morii
Secretory carcinoma (SC) of the salivary gland is a relatively newly described disease, separate from acinic cell carcinoma (ACC), which frequently displays ETV6-NTRK3 gene fusion. However, the differences between SC and ACC remain unclear. Here, histological reevaluation of 12 formerly diagnosed ACC cases was performed, which yielded a new diagnosis of SC in four cases due to a lack of obvious ac...... hiện toàn bộ
Mechanism of atopic cataract caused by eosinophil granule major basic protein
Medical Molecular Morphology - Tập 53 - Trang 94-103 - 2019
Naoki Yamamoto, Noriko Hiramatsu, Sumito Isogai, Masashi Kondo, Kazuyoshi Imaizumi, Masayuki Horiguchi
Atopic cataracts develop under the ages of 40 years, after which visual acuity rapidly declines. However, the mechanism underlying the development of atopic cataracts is not yet clear. We focused on the eosinophil granule major basic protein (MBP), which was detected in the aqueous humor of atopic cataracts previously, and which was cytotoxic. Specifically, we investigated its origin in this fluid...... hiện toàn bộ
Various copper and iron overload patterns in the livers of patients with Wilson disease and idiopathic copper toxicosis
Medical Molecular Morphology - Tập 46 - Trang 133-140 - 2013
Hisao Hayashi, Ai Hattori, Yasuaki Tatsumi, Kazuhiko Hayashi, Yoshiaki Katano, Jun Ueyama, Shinya Wakusawa, Motoyoshi Yano, Hidemi Goto
Wilson disease (WD) is a major type of primary copper toxicosis associated with hypoceruloplasminemia, while idiopathic copper toxicosis (ICT) is a minor type characterized by normoceruloplasminemia. Because ceruloplasmin is the major circulating ferroxidase, iron metabolism may be affected in patients with WD. Biopsied liver specimens obtained from patients with primary copper toxicosis were fixe...... hiện toàn bộ
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