Medical Molecular Morphology
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Molecular status of pituitary carcinoma and atypical adenoma that contributes the effectiveness of temozolomide
Medical Molecular Morphology - Tập 47 - Trang 1-7 - 2013
There have been several reports of temozolomide (TMZ) treatment of pituitary carcinomas and atypical adenomas. O6-methyl-guanine-DNA methyltransferase is not the sole molecule determining the sensitivity to TMZ in pituitary carcinomas and atypical adenomas. The Japan Society of Hypothalamic and Pituitary Tumors study suggests that MSH6, one of mismatch repair pathway enzyme, fulfills a contributor......
Correction to: Upregulation of complement C1q reflects mucosal regeneration in a mouse model of colitis
Medical Molecular Morphology - Tập 54 Số 3 - Trang 301-301 - 2021
Formation of large vacuoles induced by cooperative effects of oncostatin M and dexamethasone in human fetal liver cells
Medical Molecular Morphology - Tập 41 - Trang 53-58 - 2008
The morphology of human fetal liver cells treated with both oncostatin M and dexamethasone was strikingly different from those of cells treated with either oncostatin M or dexamethasone alone. Cotreatment with oncostatin M and dexamethasone resulted in the appearance of numerous large vacuoles. The size of the vacuoles varied among individual cells, ranging from 0.05 to 20 μm depending on the cell......
A case of “ETV6-FISH-negative” secretory carcinoma of the parotid gland: immunohistochemical study
Medical Molecular Morphology - Tập 54 - Trang 296-300 - 2021
Secretory carcinoma of the salivary glands is a relatively new disease concept, and is characterized by “morphological resemblance to mammary secretory carcinoma and ETV6–NTRK3 gene fusion.” Herein we describe a confusing case and briefly discuss practical diagnostic problems. The patient was a 71-year-old Japanese man who had a tumor consistent with secretory carcinoma at the microscopic and immu......
Usefulness of immunohistochemistry to distinguish between secretory carcinoma and acinic cell carcinoma in the salivary gland
Medical Molecular Morphology - Tập 54 - Trang 23-30 - 2020
Secretory carcinoma (SC) of the salivary gland is a relatively newly described disease, separate from acinic cell carcinoma (ACC), which frequently displays ETV6-NTRK3 gene fusion. However, the differences between SC and ACC remain unclear. Here, histological reevaluation of 12 formerly diagnosed ACC cases was performed, which yielded a new diagnosis of SC in four cases due to a lack of obvious ac......
Mechanism of atopic cataract caused by eosinophil granule major basic protein
Medical Molecular Morphology - Tập 53 - Trang 94-103 - 2019
Atopic cataracts develop under the ages of 40 years, after which visual acuity rapidly declines. However, the mechanism underlying the development of atopic cataracts is not yet clear. We focused on the eosinophil granule major basic protein (MBP), which was detected in the aqueous humor of atopic cataracts previously, and which was cytotoxic. Specifically, we investigated its origin in this fluid......
Various copper and iron overload patterns in the livers of patients with Wilson disease and idiopathic copper toxicosis
Medical Molecular Morphology - Tập 46 - Trang 133-140 - 2013
Wilson disease (WD) is a major type of primary copper toxicosis associated with hypoceruloplasminemia, while idiopathic copper toxicosis (ICT) is a minor type characterized by normoceruloplasminemia. Because ceruloplasmin is the major circulating ferroxidase, iron metabolism may be affected in patients with WD. Biopsied liver specimens obtained from patients with primary copper toxicosis were fixe......
Medical molecular morphology with imaging mass spectrometry
Medical Molecular Morphology - Tập 42 - Trang 133-137 - 2009
Imaging mass spectrometry (IMS) is a two-dimensional mass spectrometry to visualize the spatial distribution of biomolecules that does not need either separation or purification of target molecules and enables us to monitor not only the identification of unknown molecules but also the localization of numerous molecules simultaneously. Among the ionization techniques, matrix-assisted laser desorpti......
Downregulation of miR-23a-3p improves cognitive function in rats after subarachnoid hemorrhage by targeting VCAN
Medical Molecular Morphology - Tập 55 - Trang 146-157 - 2022
Subarachnoid hemorrhage (SAH) is a complicated and deadly disorder. Dysregulation of miRNAs in SAH has been widely reported. This investigation elucidated the function of miR-23a-3p in the in vivo and in vitro models of SAH. The miR-23a-3p and VCAN levels in SAH rats and sham controls were detected by RT-qPCR. The SAH rats were intracerebrally administrated with miR-23a-3p antagomir. Morphological......
IL-32 production from lung adenocarcinoma cells is potentially involved in immunosuppressive microenvironment
Medical Molecular Morphology -
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