Liver Transplantation
1527-6465
Cơ quản chủ quản: WILEY , LIPPINCOTT WILLIAMS & WILKINS , John Wiley and Sons Ltd
Lĩnh vực:
SurgeryHepatologyTransplantation
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Các bài báo tiêu biểu
Clostridium difficile infection in hospitalized liver transplant patients: A nationwide analysis
Tập 18 Số 8 - Trang 972-978 - 2012
Recipient aging accelerates acquired transthyretin amyloidosis after domino liver transplantation Domino liver transplantation (DLT) with liver grafts from patients with hereditary transthyretin (TTR) amyloidosis has been performed throughout the world because of a severe liver graft shortage. Reports of acquired systemic TTR amyloidosis in domino liver recipients have been increasing; however, the precise pathogenesis and clinical course of acquired TTR amyloidosis remains unclear. We analyzed the relationship between the occurrence of acquired amyloidosis and clinical features in 22 consecutive domino liver donors with hereditary TTR amyloidosis (10 males and 12 females; mean age at DLT: 37.2 years; TTR mutations: V30M [n = 19], Y114C [n = 1], L55P [n = 1], and S50I [n = 1]) and 22 liver recipients (16 males and 6 females; mean age at DLT, 46.2 years). The mean times from DLT to amyloid first appearance and transplant recipient symptom onset were 8.2 years and 9.9 years, respectively. Kaplan‐Meier analysis and quantification of the amyloid deposition revealed aging of recipients correlated with early de novo amyloid deposition. The sex of donors and recipients and the age, disease duration, and disease severity of donors had no significant effect on the latency of de novo amyloid deposition. In conclusion, our results demonstrate that recipient aging is associated with the early onset de novo amyloidosis. Because acquired amyloidosis will likely increase, careful follow‐up for early amyloidosis detection and new treatments, including TTR stabilizers and gene‐silencing therapies, are required. Liver Transplantation 22 656‐664 2016 AASLD.
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Posttransplantation dialysis-associated infections: Morbidity and impact on outcome in liver transplant recipients
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Role of gender and race mismatch and graft failure in patients undergoing liver transplantation
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Risk factors for renal dysfunction in the postoperative course of liver transplant
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Impact of donor gender on male rat recipients of small-for-size liver grafts
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Pretransplant MELD score and post liver transplantation survival in the UK and Ireland
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Outcome of foreign residents undergoing deceased donor liver transplantation in China: A single-center experience in Taiwan
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