Lipids in Health and Disease

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4-cholesten-3-one decreases breast cancer cell viability and alters membrane raft-localized EGFR expression by reducing lipogenesis and enhancing LXR-dependent cholesterol transporters
Lipids in Health and Disease - Tập 18 - Trang 1-15 - 2019
Josiane Elia, Delphine Carbonnelle, Cédric Logé, Lucie Ory, Jean-Michel Huvelin, Mona Tannoury, Mona Diab-Assaf, Karina Petit, Hassan Nazih
The alteration of lipid metabolism in cancer cells is recognized as one of the most important metabolic hallmarks of cancer. Membrane rafts defined as plasma membrane microdomains enriched in cholesterol and sphingolipids serve as platforms for signaling regulation in cancer. The main purpose of this study was to evaluate the effect of the cholesterol metabolite, 4-cholesten-3-one, on lipid metabo...... hiện toàn bộ
Plasmalogens and Alzheimer’s disease: a review
Lipids in Health and Disease - - 2019
Xiao Q. Su, Junming Wang, Andrew J. Sinclair
Growing evidence suggests that ethanolamine plasmalogens (PlsEtns), a subtype of phospholipids, have a close association with Alzheimer’s disease (AD). Decreased levels of PlsEtns have been commonly found in AD patients, and were correlated with cognition deficit and severity of disease. Limited studies showed positive therapeutic outcomes with plasmalogens interventions in AD subjects and in rode...... hiện toàn bộ
DL- and PO-phosphatidylcholines as a promising learning and memory enhancer
Lipids in Health and Disease - Tập 10 - Trang 1-5 - 2011
Tetsu Nagata, Takahiro Yaguchi, Tomoyuki Nishizaki
In the water maze test, oral administration with 1,2-dilynoleoyl-sn-glycero-3-phosphocholine (DLPhtCho)(5 mg/kg) alone or DLPhtCho (5 mg/kg) plus 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPhtCho)(5 mg/kg) significantly shortened the prolonged acquisition latency for rats intraperitoneally injected with scopolamine, with more efficient effect than (POPhtCho)(5 mg/kg) alone, arachidonic ac...... hiện toàn bộ
Associations of lipid measures with total occlusion in patients with established coronary artery disease: a cross-sectional study
Lipids in Health and Disease - Tập 21 - Trang 1-12 - 2022
Tianyu Li, Deshan Yuan, Peizhi Wang, Sida Jia, Ce Zhang, Pei Zhu, Ying Song, Xiaofang Tang, Xueyan Zhao, Zhan Gao, Yuejin Yang, Runlin Gao, Bo Xu, Jinqing Yuan
Total occlusion is the most severe coronary lesion, indicating heavy ischemic burden and poor prognosis. The lipid profile is central to the development of atherosclerotic coronary lesions. Evidence on the optimal lipid measure to be monitored and managed in patients with established coronary artery disease (CAD) is inconclusive. Total cholesterol (TC), total triglyceride (TG), low-density lipopro...... hiện toàn bộ
Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A2 (Lp-PLA2 ): a review
Lipids in Health and Disease - Tập 10 - Trang 1-10 - 2011
Isis T Silva, Ana PQ Mello, Nágila RT Damasceno
The association of cardiovascular events with Lp-PLA2 has been studied continuously today. The enzyme has been strongly associated with several cardiovascular risk markers and events. Its discovery was directly related to the hydrolysis of the platelet-activating factor and oxidized phospholipids, which are considered protective functions. However, the hydrolysis of bioactive lipids generates lyso...... hiện toàn bộ
Fructose impairs glucose-induced hepatic triglyceride synthesis
Lipids in Health and Disease - Tập 10 - Trang 1-10 - 2011
Danshan Huang, Tania Dhawan, Stephen Young, William H Yong, Laszlo G Boros, Anthony P Heaney
Obesity, type 2 diabetes and hyperlipidemia frequently coexist and are associated with significantly increased morbidity and mortality. Consumption of refined carbohydrate and particularly fructose has increased significantly in recent years and has paralled the increased incidence of obesity and diabetes. Human and animal studies have demonstrated that high dietary fructose intake positively corr...... hiện toàn bộ
Retinol-binding protein 4 in combination with lipids to predict the regression phenomenon of autism spectrum disorders
Lipids in Health and Disease - Tập 20 - Trang 1-8 - 2021
Jianling Chen, Jing Chen, Yun Xu, Peipei Cheng, Shunying Yu, Yingmei Fu, Yasong Du
About 20–40 % of autistic people experience a phenomenon of regression. Retinol binding protein 4 (RBP4) plays an important role as an inflammatory neurotrophic adipokine and is a promising mediator of the fat-brain axis. Abnormal fatty acid metabolism and lipid mediators have been reported to be related to the etiological mechanism in autism, and amelioration of impaired lipid metabolism can be r...... hiện toàn bộ
Renoprotective, anti-oxidative and anti-apoptotic effects of oral low-dose quercetin in the C57BL/6J model of diabetic nephropathy
Lipids in Health and Disease - Tập 13 - Trang 1-10 - 2014
Isabele BS Gomes, Marcella L Porto, Maria Carmen LFS Santos, Bianca P Campagnaro, Thiago MC Pereira, Silvana S Meyrelles, Elisardo C Vasquez
Diabetic nephropathy (DN) is one of the major causes of end-stage renal disease in diabetic patients. Increasing evidence from studies in the rodents has suggested that this disease is associated with increased oxidative stress due to hyperglycemia. In the present study, we evaluated the renoprotective, anti-oxidative and anti-apoptotic effects of the flavonoid quercetin in C57BL/6J model of DN. D...... hiện toàn bộ
Caloric restriction in C57BL/6J mice mimics therapeutic fasting in humans
Lipids in Health and Disease - - 2006
Lisa B. Mahoney, Christine A. Denny, Thomas N. Seyfried
Abstract Background Caloric restriction (CR) has long been recognized as a dietary therapy that improves health and increases longevity. Little is known about the persistent effects of CR on plasma biomarkers (glucose, ketone bodies, and lipids) following re-feeding in mice. It is also unclear ho...... hiện toàn bộ
Effect of immunization against ox-LDL with two different antigens on formation and development of atherosclerosis
Lipids in Health and Disease - Tập 6 Số 1 - Trang 32 - 2007
S. Asgary, Shadan Saberi, Shirin Azampanah
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