Lipids in Health and Disease
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Mouse models of atherosclerosis: a historical perspective and recent advances
Lipids in Health and Disease - Tập 16 - Trang 1-11 - 2017
Atherosclerosis represents a significant cause of morbidity and mortality in both the developed and developing countries. Animal models of atherosclerosis have served as valuable tools for providing insights on its aetiology, pathophysiology and complications. They can be used for invasive interrogation of physiological function and provide a platform for testing the efficacy and safety of differe......
Genome-wide identification and characterization of long non-coding RNAs during postnatal development of rabbit adipose tissue
Lipids in Health and Disease - - 2018
Depot-specific differences in perilipin and hormone-sensitive lipase expression in lean and obese
Lipids in Health and Disease - Tập 8 - Trang 1-10 - 2009
Mainly dependent on hormone-sensitive lipase, lipolysis is differently impaired between fat depots in human obesity. Perilipin A expression is a critical element in adipocyte lipolysis. The present study aimed at comparing expression and subcellular distribution of perilipin and hormone-sensitive lipase in two abdominal adipose tissues of lean and obese women. We examined whether regional differen......
4-cholesten-3-one decreases breast cancer cell viability and alters membrane raft-localized EGFR expression by reducing lipogenesis and enhancing LXR-dependent cholesterol transporters
Lipids in Health and Disease - Tập 18 - Trang 1-15 - 2019
The alteration of lipid metabolism in cancer cells is recognized as one of the most important metabolic hallmarks of cancer. Membrane rafts defined as plasma membrane microdomains enriched in cholesterol and sphingolipids serve as platforms for signaling regulation in cancer. The main purpose of this study was to evaluate the effect of the cholesterol metabolite, 4-cholesten-3-one, on lipid metabo......
High prevalence of dyslipidemia and associated risk factors among rural Chinese adults
Lipids in Health and Disease - Tập 13 - Trang 1-11 - 2014
Dyslipidemia is a key independent modifiable risk factor for Cardiovascular Disease, which is a leading contributor to morbidity and mortality in most developed and developing countries. This study was designed to investigate the current epidemiological features of dyslipidemia among adults in rural China. Between January 2013 and August 2013, we conducted a cross-sectional study involving 11,956 ......
Association of long-term consumption of repeatedly heated mix vegetable oils in different doses and hepatic toxicity through fat accumulation
Lipids in Health and Disease - Tập 19 - Trang 1-9 - 2020
Hepatic diseases are one of the chief reasons for worldwide morbidity and mortality. The increased incidence in Asian countries is driving researchers to explore preventive ways from nature. It is more practical to go with healthy routine edibles like vegetable oils to avoid environmental and chemical hepatic injuries. With the use of thermally oxidized oils overproduction of reactive oxygen speci......
Plasmalogens and Alzheimer’s disease: a review
Lipids in Health and Disease - - 2019
Growing evidence suggests that ethanolamine plasmalogens (PlsEtns), a subtype of phospholipids, have a close association with Alzheimer’s disease (AD). Decreased levels of PlsEtns have been commonly found in AD patients, and were correlated with cognition deficit and severity of disease. Limited studies showed positive therapeutic outcomes with plasmalogens interventions in AD subjects and in rode......
DL- and PO-phosphatidylcholines as a promising learning and memory enhancer
Lipids in Health and Disease - Tập 10 - Trang 1-5 - 2011
In the water maze test, oral administration with 1,2-dilynoleoyl-sn-glycero-3-phosphocholine (DLPhtCho)(5 mg/kg) alone or DLPhtCho (5 mg/kg) plus 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPhtCho)(5 mg/kg) significantly shortened the prolonged acquisition latency for rats intraperitoneally injected with scopolamine, with more efficient effect than (POPhtCho)(5 mg/kg) alone, arachidonic ac......
Associations of lipid measures with total occlusion in patients with established coronary artery disease: a cross-sectional study
Lipids in Health and Disease - Tập 21 - Trang 1-12 - 2022
Total occlusion is the most severe coronary lesion, indicating heavy ischemic burden and poor prognosis. The lipid profile is central to the development of atherosclerotic coronary lesions. Evidence on the optimal lipid measure to be monitored and managed in patients with established coronary artery disease (CAD) is inconclusive. Total cholesterol (TC), total triglyceride (TG), low-density lipopro......
Antioxidant and inflammatory aspects of lipoprotein-associated phospholipase A2 (Lp-PLA2 ): a review
Lipids in Health and Disease - Tập 10 - Trang 1-10 - 2011
The association of cardiovascular events with Lp-PLA2 has been studied continuously today. The enzyme has been strongly associated with several cardiovascular risk markers and events. Its discovery was directly related to the hydrolysis of the platelet-activating factor and oxidized phospholipids, which are considered protective functions. However, the hydrolysis of bioactive lipids generates lyso......
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