Multisystem Inflammatory Syndrome in Children During the Coronavirus 2019 Pandemic: A Case Series Tập 9 Số 3 - Trang 393-398 - 2020
Kathleen Chiotos, Hamid Bassiri, Edward M. Behrens, Allison M. Blatz, Joyce C. Chang, Caroline Diorio, Julie C. Fitzgerald, Alexis A. Topjian, Audrey R. Odom John
Abstract We present a series of 6 critically ill children with multisystem
inflammatory syndrome in children. Key findings of this syndrome include fever,
diarrhea, shock, and variable presence of rash, conjunctivitis, extremity edema,
and mucous membrane changes.
COVID-19–Associated Pediatric Multisystem Inflammatory Syndrome Tập 9 Số 3 - Trang 407-408 - 2020
Maria Deza Leon, Ajla Redzepi, Eric McGrath, Nahed Abdel‐Haq, Ahmed Shawaqfeh, Usha Sethuraman, Bradley Tilford, Teena Chopra, Harbir Arora, Jocelyn Y. Ang, Basim I. Asmar
Multicenter Interim Guidance on Use of Antivirals for Children With Coronavirus Disease 2019/Severe Acute Respiratory Syndrome Coronavirus 2 Tập 10 Số 1 - Trang 34-48 - 2021
Kathleen Chiotos, Molly Hayes, David W. Kimberlin, Sarah Bruyn Jones, Scott H. James, Swetha Pinninti, April Yarbrough, Mark J. Abzug, Taiju Miyagami, Vijaya L. Soma, Daniel E. Dulek, Surabhi B Vora, Alpana Waghmare, Joshua Wolf, Rosemary Olivero, Steven P Grapentine, Rachel L Wattier, Laura L. Bio, Shane J. Cross, Nicholas O. Dillman, Kevin J. Downes, Carlos R. Oliveira, Kathryn Timberlake, Jennifer L. Young, Rachel C. Orscheln, Pranita D. Tamma, Hayden T. Schwenk, Philip Zachariah, Margaret Aldrich, David L. Goldman, Helen Groves, Nipunie Rajapakse, Gabriella S Lamb, Alison C. Tribble, Adam L. Hersh, Emily A. Thorell, Mark R. Denison, Adam J. Ratner, Jason G. Newland, Mari Nakamura
AbstractBackgroundAlthough coronavirus disease 2019 (COVID-19) is a mild
infection in most children, a small proportion develop severe or critical
illness. Data describing agents with potential antiviral activity continue to
expand such that updated guidance is needed regarding use of these agents in
children.MethodsA panel of pediatric infectious diseases physicians and
pharmacists from 20 geogra... hiện toàn bộ
Guillain-Barré Syndrome Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Detection and Coronavirus Disease 2019 in a Child Tập 9 Số 4 - Trang 510-513 - 2020
Maher Ben Khalifa, Fairouz Zakaria, Yasser Ragab, Ahmed Saad, Ahmed K. Bamaga, Yasser Emad, Johannes J. Rasker
Abstract Coronavirus disease (COVID-19) is caused by infection with severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). Physicians in China reported
what is believed to be the first adult case of a SARS-CoV-2 infection associated
with acute Guillain-Barré syndrome (GBS), followed by 5 adult Italian patients
and another case in the United States. In the current report, we present one of
... hiện toàn bộ
Multidisciplinary Guidance Regarding the Use of Immunomodulatory Therapies for Acute Coronavirus Disease 2019 in Pediatric Patients Tập 9 Số 6 - Trang 716-737 - 2020
Daniel E. Dulek, Robert C. Fuhlbrigge, Alison C. Tribble, James A. Connelly, Michele Loi, Hassan El Chebib, Shanmuganathan Chandrakasan, W Otto, Caroline Diorio, Garrett Keim, Kelly Walkovich, Preeti Jaggi, Jennifer E Girotto, April Yarbrough, Edward M. Behrens, Randy Q. Cron, Hamid Bassiri
AbstractBackgroundImmune-mediated lung injury and systemic hyperinflammation are
characteristic of severe and critical coronavirus disease 2019 (COVID-19) in
adults. Although the majority of severe acute respiratory syndrome coronavirus 2
infections in pediatric populations result in minimal or mild COVID-19 in the
acute phase of infection, a small subset of children develop severe and even
critic... hiện toàn bộ
Pharmacokinetics of First-Line Drugs Among Children With Tuberculosis in Rural Tanzania Tập 9 Số 1 - Trang 14-20 - 2020
Museveni Justine, Anita Yeconia, Ingi Nicodemu, Domitila Augustino, Jean Gratz, Estomih Mduma, Scott K. Heysell, Sokoine Kivuyo, Sayoki Mfinanga, Charles A. Peloquin, Theodore Zagurski, Gibson Kibiki, Blandina T. Mmbaga, Eric R. Houpt, Tania A. Thomas
AbstractBackgroundDosing recommendations for treating childhood tuberculosis
(TB) were revised by the World Health Organization, yet so far, pharmacokinetic
studies that have evaluated these changes are relatively limited. We evaluated
plasma drug concentrations of rifampicin (RIF), isoniazid (INH), pyrazinamide
(PZA), and ethambutol (EMB) among children undergoing TB treatment in Tanzania
when th... hiện toàn bộ
A Multicenter Consortium to Define the Epidemiology and Outcomes of Pediatric Solid Organ Transplant Recipients With Inpatient Respiratory Virus Infection Tập 8 Số 3 - Trang 197-204 - 2019
Lara Danziger‐Isakov, William J. Steinbach, Grant Paulsen, Flor M. Muñoz, Leigh R. Sweet, Michael Green, Marian G. Michaels, Janet A. Englund, Alastair Murray, Natasha Halasa, Daniel E. Dulek, Rebecca Pellett Madan, Betsy C. Herold, Brian T. Fisher
Abstract Background Respiratory virus infection (RVI) in pediatric solid organ
transplant (SOT) recipients poses a significant risk; however, the epidemiology
and effects of an RVI after pediatric SOT in the era of current molecular
diagnostic assays are unclear. Methods A retrospective observational cohort of
pediatric SOT recipients (January 2010 to June 2013) was assembled from 9 US
pediatric t... hiện toàn bộ
Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients Tập 9 Số 5 - Trang 622-625 - 2020
Peter Lang, Thomas Eichholz, Tamam Bakchoul, Monika Streiter, Maurice Petrasch, Hans Bösmüller, Reinhild Klein, Armin Rabsteyn, Annemarie Lang, Constantin Adams, Karin Klingel, Michaela Geßner, Peter Rosenberger, Peter Ruef, Rupert Handgretinger
AbstractThe pediatric inflammatory multisystem syndrome temporally associated
with severe acute respiratory syndrome coronavirus 2 infection is a severe
complication of coronavirus disease 2019. Since impaired coagulation and
thrombosis/endotheliitis are suspected pathomechanisms, we treated 2 patients
with defibrotide, a profibrinolytic, antithrombotic, antiinflammatory
oligonucleotide. Symptoms ... hiện toàn bộ