Journal of the Egyptian National Cancer Institute

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Gene co-expression network construction and analysis for identification of genetic biomarkers associated with glioblastoma multiforme using topological findings
Journal of the Egyptian National Cancer Institute - Tập 35 - Trang 1-11 - 2023
Seema Sandeep Redekar, Satishkumar L. Varma, Atanu Bhattacharjee
Glioblastoma multiforme (GBM) is one of the most malignant types of central nervous system tumors. GBM patients usually have a poor prognosis. Identification of genes associated with the progression of the disease is essential to explain the mechanisms or improve the prognosis of GBM by catering to targeted therapy. It is crucial to develop a methodology for constructing a biological network and a... hiện toàn bộ
Impact of changing PI-RADS cutoff on prostate cancer detection by MRI cognitive fusion biopsy in biopsy-naïve patients
Journal of the Egyptian National Cancer Institute - Tập 35 - Trang 1-5 - 2023
Hesham Abdel-Azim El-Helaly, Asem Abdel-Aziz Mahmoud, Ahmed Mohamed Magdy, Abdelwahab Hasehem, Hamdy Mohamed Ibrahim, Khaled Moheyelden Mohamed, Mohamed Hamdy Ismail
Multi-parametric magnetic resonance imaging may improve the detection of prostate cancer. The aim of this work is to compare between PI-RADS 3–5 and PI-RADS 4–5 as a threshold for targeted prostatic biopsy. This is a prospective clinical study that included 40 biopsy-naïve patients referred for prostate biopsy. Patients underwent prebiopsy multi-parametric (mp-MRI), followed by 12-core transrectal... hiện toàn bộ
Detection of activating mutations in liquid biopsy of Egyptian breast cancer patients using targeted next-generation sequencing: a pilot study
Journal of the Egyptian National Cancer Institute - Tập 33 - Trang 1-11 - 2021
Neemat Kassem, Hebatallah Kassem, Loay Kassem, Mohamed Hassan
Breast cancer (BC) is the 2nd most prevalent malignancy worldwide and is the most prevalent cancer among Egyptian women. The number of newly described cancer-associated genes has grown exponentially since the emergence of next-generation sequencing (NGS) technology. We aim to identify activating mutations in liquid biopsy of Egyptian breast cancer patients using targeted NGS technology. We also de... hiện toàn bộ
Potential role of microRNAs in pancreatic cancer manifestation: a review
Journal of the Egyptian National Cancer Institute - Tập 34 - Trang 1-9 - 2022
Lisa Kabiraj, Atreyee Kundu
Cancer cells are different from normal cells in regard to phenotypic and functional expression. Cancer is the outcome of aberrant gene expression affecting various cellular signaling pathways. MicroRNAs (MiRs) are small, non-coding RNAs regulating the expression of various protein-coding genes post-transcriptionally and are known to play critical roles in the complicated cellular pathways leading ... hiện toàn bộ
Predictors of peritoneal metastasis of gastric origin
Journal of the Egyptian National Cancer Institute - Tập 34 - Trang 1-5 - 2022
Mohamed Atef ElKordy, Rady Mansour Soliman, Mahitab Ibrahim ElTohamy, Dalia Negm Eldin Mohamed, Ahmed Morsi Mustafa
Gastric adenocarcinoma is one of the most aggressive forms of cancer. Despite marked advancements in radiological techniques, peritoneal deposits are still only discovered during laparotomies in a significant number of cases. The role of surgery in the management of metastatic gastric cancer is very limited, reducing the value of conducting laparotomies. In addition, conducting laparoscopies for t... hiện toàn bộ
Aberrant expression of multiple T cell markers on diffuse large B cell lymphoma: a case report
Journal of the Egyptian National Cancer Institute - Tập 33 - Trang 1-5 - 2021
Anurag Mehta, Prerna Chadha, Poojan Agarwal, Sunil Pasricha
Aberrant T cell antigen expression has been well documented in diffuse large B cell lymphomas. However, co-expression of multiple T cell antigens including CD3, which has been considered a specific marker for T cells is extremely rare. Awareness about such aberrant expression is important so as not to misdiagnose or wrongly classify a lymphoma. The aim of this article is to report such a case. A 6... hiện toàn bộ
Osteosarcoma subtypes: Magnetic resonance and quantitative diffusion weighted imaging criteria
Journal of the Egyptian National Cancer Institute - Tập 30 - Trang 39-44 - 2018
Rania Zeitoun, Ahmed M. Shokry, Sahar Ahmed Khaleel, Shaimaa M. Mogahed
Implications of the 21-gene recurrence score assay (Oncotype DX) on adjuvant treatment decisions in ER-positive early-stage breast cancer patients: experience of Kuwait Cancer Control Center
Journal of the Egyptian National Cancer Institute - Tập 32 - Trang 1-7 - 2020
Salah Fayaz, Heba El-Sayed Eissa, Gerges Attia Demian
The Oncotype DX is a quantitative assay of the expression of 16 tumor-related genes and 5 reference genes that predicts the potential of adjuvant chemotherapy benefit in estrogen receptor (ER)-positive early breast cancer patients. The study aims to evaluate the impact of Oncotype DX as a tool for adjuvant treatment decision of ER-positive, HER2-negative, N0/N1 early-stage breast cancer patients a... hiện toàn bộ
Basal cell hyperplasia (BCH) versus high grade prostatic intraepithelial neoplasia (HGPIN) in tiny prostatic needle biopsies: Unusual diagnostic dilemma
Journal of the Egyptian National Cancer Institute - Tập 26 - Trang 15-22 - 2014
Fatma El-Zahraa Salah El-Deen Yassin, Eman M.S. Muhammad, Mohammed Zaki, Mohammed Dyaa Saleem, Rabab Ahmed Ahmed Mohammed
Retrosternal goiter: The need for thoracic approach based on CT findings: Surgeon’s view
Journal of the Egyptian National Cancer Institute - Tập 24 - Trang 85-90 - 2012
Mostafa A. Sakkary, Abdelrahman M. Abdelrahman, Ahmed M. Mostafa, Ahmed A. Abbas, Mohamed H. Zedan
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