Journal of Physiology

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Protons activate a cation conductance in a sub‐population of rat dorsal root ganglion neurones.
Journal of Physiology - Tập 433 Số 1 - Trang 145-161 - 1991
Stuart Bevan, J.C. Yeats
1. The responses of adult and neonatal rat dorsal root ganglion (DRG) neurones to buffered acidic solutions were studied with both voltage clamp and radioactive ion flux techniques. Electrophysiological experiments were made on acutely isolated neurones and ion flux experiments were made on cells that had been in culture for 3‐6 days. 2. Acid solutions of pH < 6.2 evoked a sustained, sl...... hiện toàn bộ
Selective phototoxic destruction of rat Merkel cells abolishes responses of slowly adapting type I mechanoreceptor units.
Journal of Physiology - Tập 479 Số 2 - Trang 247-256 - 1994
Isamu Ikeda, Yoshiro Yamashita, Tsunehiko Ono, Hisashi Ogawa
1. The fluorescent dye quinacrine which accumulates in Merkel cells in touch domes was administered to rats and the effects of excitation light irradiation on the mechanical responses of slowly adapting (SA) type I units innervating the touch domes were investigated. 2. Histological examination showed that after 10 min of irradiation degeneration was specifically localized to Merkel cells ...... hiện toàn bộ
Relationship of substance P to afferent characteristics of dorsal root ganglion neurones in guinea‐pig
Journal of Physiology - Tập 505 Số 1 - Trang 177-191 - 1997
Sally N. Lawson, B. A. Crepps, Edward R. Perl
The relationship between the afferent properties and substance P‐like immunoreactivity (SP‐LI) of L6 and SI dorsal root ganglion (DRG) neuronal somata was examined in anaesthetized guinea‐pigs. Glass pipette microelectrodes filled with fluorescent dyes were used to make intracellular recordings and to label DRG somata. The dor...... hiện toàn bộ
Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations.
Journal of Physiology - Tập 307 Số 1 - Trang 413-428 - 1980
Brian Ault, Richard H. Evans, A.A. Francis, Diana Johnson Oakes, J.C. Watkins
1. The depressant actions of Mg2+ and a range of other divalent ions on synaptic excitation and on responses produced by excitatory amino acids and other putative transmitters have been investigated in hemisected isolated spinal cords of frogs and neonatal rats. Some comparative studies were also made using the rat isolated superior cervical ganglion. 2. At concentrations above 10 microM, ...... hiện toàn bộ
Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.
Journal of Physiology - Tập 334 Số 1 - Trang 33-46 - 1983
G L Collingridge, Steven J. Kehl, H. McLennan
1. The effects of excitatory amino acids and some antagonists applied by ionophoresis to stratum radiatum in the CA1 region of rat hippocampal slices were examined on the locally recorded field e.p.s.p. evoked by stimulation of the Schaffer collateral‐commissural projection. 2. L‐glutamate, L‐aspartate and the more potent and selective excitatory amino acids quisqualate, kainate and N‐meth...... hiện toàn bộ
A Phase Response Curve to Single Bright Light Pulses in Human Subjects
Journal of Physiology - Tập 549 Số 3 - Trang 945-952 - 2003
Sat Bir S. Khalsa, Megan E. Jewett, Christian Cajochen, Charles A. Czeisler
The circadian pacemaker is differentially sensitive to the resetting effects of retinal light exposure, depending upon the circadian phase at which the light exposure occurs. Previously reported human phase response curves (PRCs) to single bright light exposures have employed small sample sizes, and were often based on relatively imprecise estimates of circadian phase and phase resetting. ...... hiện toàn bộ
Human phase response curve to a 1 h pulse of bright white light
Journal of Physiology - Tập 590 Số 13 - Trang 3035-3045 - 2012
Melissa A. St. Hilaire, Joshua J. Gooley, Sat Bir S. Khalsa, Richard E. Kronauer, Charles A. Czeisler, Steven W. Lockley
Key points The human circadian pacemaker generates near‐24‐h rhythms that set the timing of many physiological, metabolic and behavioural body rhythms, and is synchronized to environmental time primarily by the 24 h light–dark cycle. The magnitude and dir...... hiện toàn bộ
Human responses to bright light of different durations
Journal of Physiology - Tập 590 Số 13 - Trang 3103-3112 - 2012
Anne‐Marie Chang, Nayantara Santhi, Melissa St. Hilaire, Claude Gronfier, Dayna S. Bradstreet, Jeanne F. Duffy, Steven W. Lockley, Richard E. Kronauer, Charles A. Czeisler
Key points Light is the strongest time cue for entrainment and phase resetting of the circadian clock. In humans, exposure to long‐duration light (6.5 h) in the late evening/early night causes phase delays, suppresses melatonin and increases alertness.... hiện toàn bộ
The pattern of gastric emptying: a new view of old results
Journal of Physiology - Tập 182 Số 1 - Trang 144-149 - 1966
Anthony Hopkins
1. Gastric emptying has until now been regarded as exponential in form, but this pattern does not account for all phases of a meal.2. A pattern of emptying in which the square root of the volume of meal remaining declines linearly with time has been shown to account for the experimental results with less error.
Ca2+ transients associated with openings of inositol trisphosphate‐gated channels in Xenopus oocytes.
Journal of Physiology - Tập 491 Số 3 - Trang 663-668 - 1996
Ian Parker, Yong Yao
1. The mechanisms underlying inositol 1,4,5‐trisphosphate (InsP3)‐induced Ca2+ liberation were studied in Xenopus oocytes by using scanning and stationary‐point confocal fluorescence microscopy to record Ca2+ signals evoked by photorelease of InsP3 from a caged precursor. 2. Fluorescence measurements from confocal images showed that increasing [InsP3] evoked three distinct modes of Ca2+ li...... hiện toàn bộ
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