Journal of Physiology
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Protons activate a cation conductance in a sub‐population of rat dorsal root ganglion neurones.
Journal of Physiology - Tập 433 Số 1 - Trang 145-161 - 1991
1. The responses of adult and neonatal rat dorsal root ganglion (DRG) neurones
to buffered acidic solutions were studied with both voltage clamp and
radioactive ion flux techniques. Electrophysiological experiments were made on
acutely isolated neurones and ion flux experiments were made on cells that had
been in culture for 3‐6 days. 2. Acid solutions of pH < 6.2 evoked a sustained,
slowly inacti...
Selective phototoxic destruction of rat Merkel cells abolishes responses of slowly adapting type I mechanoreceptor units.
Journal of Physiology - Tập 479 Số 2 - Trang 247-256 - 1994
1. The fluorescent dye quinacrine which accumulates in Merkel cells in touch
domes was administered to rats and the effects of excitation light irradiation
on the mechanical responses of slowly adapting (SA) type I units innervating the
touch domes were investigated. 2. Histological examination showed that after 10
min of irradiation degeneration was specifically localized to Merkel cells
loaded w...
Relationship of substance P to afferent characteristics of dorsal root ganglion neurones in guinea‐pig
Journal of Physiology - Tập 505 Số 1 - Trang 177-191 - 1997
The relationship between the afferent properties and substance P‐like
immunoreactivity (SP‐LI) of L6 and SI dorsal root ganglion (DRG) neuronal somata
was examined in anaesthetized guinea‐pigs. Glass pipette microelectrodes filled
with fluorescent dyes were used to make intracellular recordings and to label
DRG somata. The dorsal root conduction velocity (CV) and the afferent receptive
properties ...
Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations.
Journal of Physiology - Tập 307 Số 1 - Trang 413-428 - 1980
1. The depressant actions of Mg2+ and a range of other divalent ions on synaptic
excitation and on responses produced by excitatory amino acids and other
putative transmitters have been investigated in hemisected isolated spinal cords
of frogs and neonatal rats. Some comparative studies were also made using the
rat isolated superior cervical ganglion. 2. At concentrations above 10 microM,
Mg2+ sel...
Excitatory amino acids in synaptic transmission in the Schaffer collateral‐commissural pathway of the rat hippocampus.
Journal of Physiology - Tập 334 Số 1 - Trang 33-46 - 1983
1. The effects of excitatory amino acids and some antagonists applied by
ionophoresis to stratum radiatum in the CA1 region of rat hippocampal slices
were examined on the locally recorded field e.p.s.p. evoked by stimulation of
the Schaffer collateral‐commissural projection. 2. L‐glutamate, L‐aspartate and
the more potent and selective excitatory amino acids quisqualate, kainate and
N‐methyl‐DL‐as...
A Phase Response Curve to Single Bright Light Pulses in Human Subjects
Journal of Physiology - Tập 549 Số 3 - Trang 945-952 - 2003
The circadian pacemaker is differentially sensitive to the resetting effects of
retinal light exposure, depending upon the circadian phase at which the light
exposure occurs. Previously reported human phase response curves (PRCs) to
single bright light exposures have employed small sample sizes, and were often
based on relatively imprecise estimates of circadian phase and phase resetting.
In the p...
Human phase response curve to a 1 h pulse of bright white light
Journal of Physiology - Tập 590 Số 13 - Trang 3035-3045 - 2012
Key points The human circadian pacemaker generates near‐24‐h rhythms that set
the timing of many physiological, metabolic and behavioural body rhythms, and is
synchronized to environmental time primarily by the 24 h light–dark cycle. The
magnitude and direction of the resetting response of the pacemaker to light
depends on the time of day of exposure, and the change in responses over the day
is su...
Human responses to bright light of different durations
Journal of Physiology - Tập 590 Số 13 - Trang 3103-3112 - 2012
Key points Light is the strongest time cue for entrainment and phase resetting
of the circadian clock. In humans, exposure to long‐duration light (6.5 h) in
the late evening/early night causes phase delays, suppresses melatonin and
increases alertness. Here we studied the effects of different durations of
exposure to a single high‐intensity (∼10,000 lux) light pulse (0.2 h, 1 h, 2.5 h
and 4.0 h) o...
The pattern of gastric emptying: a new view of old results
Journal of Physiology - Tập 182 Số 1 - Trang 144-149 - 1966
1. Gastric emptying has until now been regarded as exponential in form, but this
pattern does not account for all phases of a meal.2. A pattern of emptying in
which the square root of the volume of meal remaining declines linearly with
time has been shown to account for the experimental results with less error.
Ca2+ transients associated with openings of inositol trisphosphate‐gated channels in Xenopus oocytes.
Journal of Physiology - Tập 491 Số 3 - Trang 663-668 - 1996
1. The mechanisms underlying inositol 1,4,5‐trisphosphate (InsP3)‐induced Ca2+
liberation were studied in Xenopus oocytes by using scanning and
stationary‐point confocal fluorescence microscopy to record Ca2+ signals evoked
by photorelease of InsP3 from a caged precursor. 2. Fluorescence measurements
from confocal images showed that increasing [InsP3] evoked three distinct modes
of Ca2+ liberation...
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