Journal of Physiology

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Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations.
Journal of Physiology - Tập 307 Số 1 - Trang 413-428 - 1980
Brian Ault, Richard H. Evans, A.A. Francis, Diana Johnson Oakes, J.C. Watkins
1. The depressant actions of Mg2+ and a range of other divalent ions on synaptic excitation and on responses produced by excitatory amino acids and other putative transmitters have been investigated in hemisected isolated spinal cords of frogs and neonatal rats. Some comparative studies were also made using the rat isolated superior cervical ganglion. 2. At concentrations above 10 microM, ...... hiện toàn bộ
A Phase Response Curve to Single Bright Light Pulses in Human Subjects
Journal of Physiology - Tập 549 Số 3 - Trang 945-952 - 2003
Sat Bir S. Khalsa, Megan E. Jewett, Christian Cajochen, Charles A. Czeisler
The circadian pacemaker is differentially sensitive to the resetting effects of retinal light exposure, depending upon the circadian phase at which the light exposure occurs. Previously reported human phase response curves (PRCs) to single bright light exposures have employed small sample sizes, and were often based on relatively imprecise estimates of circadian phase and phase resetting. ...... hiện toàn bộ
Ca2+ transients associated with openings of inositol trisphosphate‐gated channels in Xenopus oocytes.
Journal of Physiology - Tập 491 Số 3 - Trang 663-668 - 1996
Ian Parker, Yong Yao
1. The mechanisms underlying inositol 1,4,5‐trisphosphate (InsP3)‐induced Ca2+ liberation were studied in Xenopus oocytes by using scanning and stationary‐point confocal fluorescence microscopy to record Ca2+ signals evoked by photorelease of InsP3 from a caged precursor. 2. Fluorescence measurements from confocal images showed that increasing [InsP3] evoked three distinct modes of Ca2+ li...... hiện toàn bộ
Somatostatin Receptor type 2 Mediates Bombesin‐Induced Inhibition of Gastric Acid Secretion in Mice
Journal of Physiology - Tập 549 Số 3 - Trang 889-901 - 2003
Laura Piqueras, Yvette Taché, Vicente Martı́nez
Studies in isolated mouse stomach showed that bombesin releases somatostatin. We characterized the effects of exogenous bombesin on gastric acid secretion in mice and determined the involvement of somatostatin and somatostatin receptor type 2 (SSTR2) by using somatostatin immunoneutralization, the SSTR2 antagonist, PRL‐2903, and SSTR2 knockout mice. Gastric acid secretion was monitored und...... hiện toàn bộ
Amplitude‐ and instruction‐dependent modulation of movement‐related electromyogram activity in humans.
Journal of Physiology - Tập 316 Số 1 - Trang 97-107 - 1981
S.H. Brown, J.D. Cooke
1. Studies were made of the electromyogram (EMG) patterns associated with the performance of visually guided, step‐tracking arm movements by normal humans. Subjects were instructed to make movement either ‘accurately', ‘as fast as possible’ or ‘fast and accurately'. Movements of 16, 32, 48 and 64 deg of arc were made with each instruction. Movements had durations of approximately 250‐600 m...... hiện toàn bộ
A surgical approach to the superior cervical ganglion and related structures in the sheep
Journal of Physiology - Tập 135 Số 1 - Trang 52-57 - 1957
A. B. Appleton, G. M. H. Waites
Analysis of some central actions of nicotine injected into the cerebral ventricles of cats
Journal of Physiology - Tập 185 Số 2 - Trang 400-417 - 1966
Geoffrey Hall, E. Reit
1. In unanaesthetized cats intraventricular injections of 2·5‐10 μg nicotine produced blinking, narrowing of the palpebral fissures, retching, vomiting and asynchronous twitching of the ears. With larger doses (30‐100 μg) the ear twitching was interrupted for a short time by laying back of the ears. Respiration first became laboured and deep, then rapid and shallow following which panting ...... hiện toàn bộ
Temperature effects produced in dogs and monkeys by injections of monoamines and related substances into the third ventricle
Journal of Physiology - Tập 191 Số 3 - Trang 501-515 - 1967
W. Feldberg, R. F. Hellon, Victor J. Lotti
1. In dogs the effects on rectal temperature of noradrenaline, adrenaline, 5‐hydroxytryptamine (5‐HT) and of the monoamine oxidase inhibitor tranylcypromine were studied following their injection into the third ventricle through a chronically implanted cannula. Tranylcypromine was given also by the intraperitoneal route.2. The hypothermic effect of the catecholamines and t...... hiện toàn bộ
The calcium‐activated potassium conductance in guinea‐pig myenteric neurones
Journal of Physiology - Tập 329 Số 1 - Trang 341-354 - 1982
Kenichi Morita, Richard North, Takayuki Tokimasa
1. Intracellular recordings were made from guinea‐pig myenteric neurones in vitro.2. From one to sixty action potentials were followed by an afterhyperpolarization, the amplitude and duration of which increased with the number of preceding action potentials.3. The afterhyperpolarization reversed its polarity at a membrane potenti...... hiện toàn bộ
Calcium‐activated outward current in voltage‐clamped hippocampal neurones of the guinea‐pig.
Journal of Physiology - Tập 337 Số 1 - Trang 287-301 - 1983
David A. Brown, William H. Griffith
Slow clamp currents were recorded from CA1 and CA3 pyramidal neurones in slices of guinea‐pig hippocampus maintained in vitro, using a single micro‐electrode sample‐and‐hold technique. Depolarizing voltage commands evoked a time‐ and voltage‐dependent outward current which was suppressed by removing external Ca or by adding Cd (0.5 mM) or Mn (5 mM). This Ca‐dependent current (Ic) was not r...... hiện toàn bộ
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