Journal of Pharmaceutical Innovation
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Knowledge Transfers in the US Biopharmaceutical Market During a Time of Transition
Journal of Pharmaceutical Innovation - Tập 15 - Trang 445-454 - 2019
The purpose of the paper is to examine the effects that firm factors, multinational corporations, and location have on explicit and tacit knowledge transfers originating in US biopharmaceutical firms during a time of transition. Examination of all known biopharmaceutical formal tacit and explicit knowledge transfers was done. The study performs logistic regression to test its hypotheses. The study...... hiện toàn bộ
A Novel Method for Preparing Uniform-Sized PLGA Microspheres and the Application in Anti-tubercular Drug Delivery
Journal of Pharmaceutical Innovation - Tập 16 - Trang 620-629 - 2020
The size was a key factor influencing the drug loading, release, and delivery efficacies of poly (lactic-co-glycolic) acid (PLGA) microspheres (MS). The purpose of the study was to explore a novel and simple method to prepare uniform-sized PLGA MS for drug delivery. Different from routine homogenizer, a vortex shaker was employed for emulsification during the preparation of PLGA MS. To enhance the...... hiện toàn bộ
Does Firm’s Alliances Increase New Drug Development Time? A Multiple Regression Analysis of Clinical Development Time
Journal of Pharmaceutical Innovation - Tập 18 - Trang 2066-2074 - 2023
Alliances between firms are becoming more common for drug development; however, it is not clear how these alliances affect the time spent on drug development. This study analyzes the effect of firm’s alliances on the clinical development time of new drugs by clinical phase. Datasets of the new drug development program in which the Phase 1 trials were started between 2000 and 2015 were constructed ...... hiện toàn bộ
Optimization of Unidirectional Mucoadhesive Buccal Patches Based on Chitosan and Pluronic® F-127 for Metoprolol Controlled Release: In Vitro and Ex Vivo Evaluations
Journal of Pharmaceutical Innovation - Tập 15 - Trang 556-568 - 2019
The aim of this work was to optimize unidirectional buccal patches loaded with metoprolol (MT-MBPs) to provide adequate mucoadhesive and water uptake properties as well as controlled drug release for the effective treatment of different cardiovascular diseases. The patches were prepared layer-by-layer using the solvent casting method. A central composite design was employed to statistically optimi...... hiện toàn bộ
QbD Enabled Formulation Development of Nanoemulsion of Nimodipine for Improved Biopharmaceutical Performance
Journal of Pharmaceutical Innovation - Tập 18 - Trang 1279-1297 - 2023
The objective of the current research is to formulate a nanoemulsion (NE) of nimodipine (ND) to improve its oral bioavailability and stability by adopting a scientific and systematic quality-by-design (QbD) approach. Triacetin (oil), Cremophor RH40 (surfactant), and PEG600 (co-surfactant) were selected to formulate NE. Factors affecting critical quality attributes (CQA) were screened by Taguchi de...... hiện toàn bộ
Enhancement of Valsartan Dissolution Rate by the Increased Porosity of Pellets Using Supercritical CO2: Optimization via Central Composite Design
Journal of Pharmaceutical Innovation - Tập 18 - Trang 861-873 - 2022
The aim of this research was to optimize the enhancement the porosity of pellet containing valsartan (VAL) using carbon dioxide at supercritical pressure (scCO2) via central composite design (CCD) to increase the release at simulated gastrointestinal fluids (pH 1.2 and 6.8). To prepare the pellet, an extrusion/spheronization apparatus was used. Central composite design was applied to reach the opt...... hiện toàn bộ
Use of Commercial Data Loggers to Develop Process Understanding in Pharmaceutical Unit Operations
Journal of Pharmaceutical Innovation - Tập 5 - Trang 169-180 - 2010
Due to the growing emphasis on quality by design during pharmaceutical development, accurate process data collection has become even more crucial. While process analytical technology has emphasized complex spectroscopic techniques, univariate measurements can provide data to develop further process understanding, such as assessing the impact of operating conditions on downstream product attributes...... hiện toàn bộ
Advanced Model Predictive Feedforward/Feedback Control of a Tablet Press
Journal of Pharmaceutical Innovation - Tập 12 - Trang 110-123 - 2017
In continuous pharmaceutical manufacturing, real-time precise control of critical quality attributes (CQAs) is necessary for quality by design (QbD)-based manufacturing and real-time release (RTR) with minimum consumption of time, space, and resources. Pharmaceutical tablets can be produced through different routes with a common tablet press unit operation always placed at the end of the manufactu...... hiện toàn bộ
PQLI Engineering Controls and Automation Strategy
Journal of Pharmaceutical Innovation - Tập 3 Số 2 - Trang 88-94 - 2008
Dissolving Microneedle Formulation of Ceftriaxone: Effect of Polymer Concentrations on Characterisation and Ex Vivo Permeation Study
Journal of Pharmaceutical Innovation - Tập 17 - Trang 1176-1188 - 2021
This study aimed to develop dissolving microneedle preparations containing ceftriaxone and evaluate the effect of polymer concentrations on characterisation and ex vivo permeation study. The microneedles were prepared using centrifugation method with different ratios of PVP40% and PVA15%, namely FB1 (50:50), FB2 (60:40), and FB3 (70:30). The microneedles were also prepared with various concentrati...... hiện toàn bộ
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