Journal of Pharmaceutical Innovation

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Development and Pharmaceutical Evaluation of Azelaic Acid and Vitamin E Oil-Based Nanoemulgel of Tacrolimus for Topical Application in Plaque Psoriasis
Journal of Pharmaceutical Innovation - Tập 18 - Trang 1616-1625 - 2023
Vineet Kumar Rai, Ankita Roy, Alok Sharma, Goutam Rath, Biswakanth Kar, Goutam Ghosh, Deepak Pradhan, Jitu Halder
Psoriasis is characterized by moisture- and lipid-deficient skin with an elevated epidermal keratinocyte hyperproliferation rate due to diminished p53 levels. Topical therapy with available tacrolimus ointment in such cases is very limited, ensuing to its less penetrability (thickened skin) and availability (moisture and lipid deficiency), thereby restricting its use. Therefore, we developed and e...... hiện toàn bộ
Fast-Dissolving Films of Sumatriptan Succinate: Factorial Design to Optimize In Vitro Dispersion Time
Journal of Pharmaceutical Innovation - Tập 10 - Trang 166-174 - 2015
Govind Soni, Khushwant S. Yadav
Sumatriptan succinate, a serotonin 5-HT agonist, commonly used for migraine has erratic absorption from the gastrointestinal tract following oral administration and undergoes first-pass metabolism, resulting in a low bioavailability. The present study was undertaken to formulate fast-dissolving films of sumatriptan succinate meant to be quickly dispersed in the mouth. Films were prepared by solven...... hiện toàn bộ
Development of Tamoxifen In Situ Gel Nanoemulsion for Ocular Delivery in Photoreceptor Degeneration Disorder: In Vitro Characterization, 131I-Radiolabeling, and In Vivo Biodistribution Studies
Journal of Pharmaceutical Innovation - Tập 18 - Trang 369-380 - 2022
Mohamed H. Aboumanei, Ashgan Fouad Mahmoud
The aim of our work is to develop an in situ ocular gellan gum–based nanoemulsion (NE) of tamoxifen TAM as an alternative drug delivery system to the oral route for the treatment of photoreceptor degeneration disorder. Six pseudoternary phase diagrams were developed using oil (oleic acid), surfactants (Tween 80 or Tween 20), a co-surfactant (polyethylene glycol 400), and water. The particle size, ...... hiện toàn bộ
Characterization of Self-Emulsifying Drug Delivery Systems Using In Situ Raman Spectroscopy to Study the Precipitation Inhibition Mechanism of Poorly Water-Soluble Drugs
Journal of Pharmaceutical Innovation - - 2018
Shilpa Raut, Eman Atef
Best Practices for Drug Substance Stress and Stability Studies During Early Stage Development. Part III—How to Make Science- and Risk-based Stability Testing Decisions for Drug Substance Batches Produced after Manufacturing Process Changes
Journal of Pharmaceutical Innovation - Tập 8 Số 4 - Trang 229-239 - 2013
Q. Chan Li, Fenghe Qiu, W.H. McWilliams, Cheryl Pape, Jinhua J. Song, F. Swanek, Xiaojun Wang, Kenneth A. Cohen, Dennis O’Connor
Mucoadhesive Films of Docetaxel with Ceramide as an Adjuvant Monitoring Polymer-Drug Partitioning for Optimal Drug Release
Journal of Pharmaceutical Innovation - - Trang 1-18 - 2023
Poornima Agrawal, Vandana Soni
Millions of individuals worldwide are affected by cancer, with increasing instances by 1% annually and strikingly high mortality rates of 0.4% per year for cancers of the oral cavity and 2% for cancers of the tongue, tonsil, and oropharynx. Here we propose the administration of the water-insoluble anti-cancer drug docetaxel (DTX) along with an adjuvant C6 ceramide (Cer) through the buccal route to...... hiện toàn bộ
Quality KPIs in Pharmaceutical and Food Industry
Journal of Pharmaceutical Innovation - Tập 8 - Trang 205-211 - 2013
Marianne Torkko, Anu Linna, Nina Katajavuori, Anne Mari Juppo
This study aims to investigate what type of quality key performance indicators (KPIs) companies use and how they utilize the results of these KPIs. This e-mail survey is aimed at the personnel in the pharmaceutical and the food industries of Finland responsible for quality. Quality KPIs were similar for both the pharmaceutical and food industries with some differences existing in their usage and r...... hiện toàn bộ
Japanese Regulation on GMP/GQP and Its Challenges
Journal of Pharmaceutical Innovation - Tập 4 - Trang 198-200 - 2009
Kiyohito Nakai, Hirotada Nagai, Fumi Yamamoto
Good manufacturing practice (GMP; see first comment in article note) and good quality practice (GQP; see second comment in article note) defined in Pharmaceutical Affairs Law (PAL) are crucial regulations for assuming the quality, efficacy, and safety for pharmaceutical products in Japan. The revision of Pharmaceutical Affairs Law in 2002 which entered into force in April 2005 has brought signific...... hiện toàn bộ
An Integrated Real-time Monitoring and Statistical Process Control Approach for Coating Process and Product Quality via In-line Optical Coherence Tomography
Journal of Pharmaceutical Innovation - Tập 18 - Trang 1870-1878 - 2023
Stephan Sacher, Elisabeth Fink, Vanessa Herndler, Willibald Stumptner, Anna Peter, Manuel Zettl, Maxwell Korang-Yeboah, Xin Feng, Huiquan Wu, Johannes G. Khinast
The thickness and other quality aspects of pharmaceutical coatings can be significantly impacted by coating process conditions. Under certain circumstances, they can notably influence the drug product performance such as dissolution profiles. Typically, a target coating thickness range is defined in the coating process. The coating thickness is conventionally measured off-line via weight or diamet...... hiện toàn bộ
Systematic Development and Optimization of Teriparatide-Loaded Nanoliposomes Employing Quality by Design Approach for Osteoporosis
Journal of Pharmaceutical Innovation - Tập 18 - Trang 548-562 - 2022
Dhwani Rana, Sagar Salave, Sonali Jain, Ravi Shah, Derajram Benival
The present study is aimed at developing liposomal nanovesicular system of teriparatide employing the use of ethanol injection method for providing sustained release in the treatment of osteoporosis. Formulation development was carried out systematically by employing Quality by Design (QbD) approach. The developed system was evaluated for various physicochemical characterizations. The developed li...... hiện toàn bộ
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