BMP-2 and CDMP-2: stimulation of chondrocyte production of proteoglycanJournal of Orthopaedic Science - Tập 8 - Trang 829-835 - 2003
Jun Li, Keun Su Kim, Jin Soo Park, William A. Elmer, William C. Hutton, S. Tim Yoon
A hallmark of intervertebral disc degeneration is loss of proteoglycans. Cytokines may be used to stimulate proteoglycan production in the disc to reverse or prevent disc degeneration. The effects of bone morphogenetic protein 2 (BMP-2) and cartilage-derived morphogenetic protein 2 (CDMP-2) (singly and jointly) on proteoglycan synthesis by a chondrocytic cell line (MC615) were studied. MC615 cells...... hiện toàn bộ