Journal of Orthopaedic Research

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Polyethylene wear rate and osteolysis: Critical threshold versus continuous dose-response relationship
Journal of Orthopaedic Research - Tập 23 - Trang 520-525 - 2005
J. Mark Wilkinson, Andrew J. Hamer, Ian Stockley, Richard Eastell
Role of miR-155 in the regulation of MMP-16 expression in intervertebral disc degeneration
Journal of Orthopaedic Research - Tập 35 Số 6 - Trang 1323-1334 - 2017
Weilin Zhang, Yufei Chen, Hong‐Zheng Meng, Junjie Du, Guan-Nan Luan, Hai‐Qiang Wang, Maowei Yang, Zhuojing Luo
Cellular basis for age-related changes in fracture repair
Journal of Orthopaedic Research - Tập 23 - Trang 1300-1307 - 2005
Chuanyong Lu, Theodore Miclau, Diane Hu, Erik Hansen, Kathy Tsui, Christian Puttlitz, Ralph S. Marcucio
Effects of hydroxyapatite participate debris on the production of cytokines and proteases in human fibroblasts
Journal of Orthopaedic Research - Tập 19 - Trang 621-628 - 2001
James T. Ninomiya, Janine A. Struve, Cary T. Stelloh, Jeffrey M. Toth, Kevin E. Crosby
AbstractCytokines and proteases are secreted by fibroblasts in response to particulate wear debris, and these proteins are felt to play an important role in the development of osteolysis and implant loosening. Although metallic and polyethlyene debris have been studied extensively, little is known about the cellular responses to hydroxyapatite, despite the wide cli...... hiện toàn bộ
Smad6 is induced by BMP‐2 and modulates chondrocyte differentiation
Journal of Orthopaedic Research - Tập 21 - Trang 908-913 - 2003
Xeufeng Li, Andreia M Ionescu, Edward M Schwarz, Xinping Zhang, Hicham Drissi, J.Edward Puzas, Randy N Rosier, Michael J Zuscik, Regis J O’Keefe
AbstractBMPs regulate cartilage differentiation and have been approved for clinical use as stimulators of bone repair. BMP signaling is complex and there are multiple potential points of regulation, including modulation of Smad signaling, which is inhibited by both Smad6 and Smad7. In the current manuscript we assessed the expression and biological function of Smad...... hiện toàn bộ
Early osteoblastic differentiation induced by dexamethasone enhances adenoviral gene delivery to marrow stromal cells
Journal of Orthopaedic Research - Tập 22 - Trang 411-416 - 2004
Jeremy S Blum, M Brandon Parrott, Antonios G Mikos, Michael A Barry
AbstractWe investigated the implications of induced osteogenic differentiation on gene delivery in multipotent rat marrow stromal cells (MSCs). Prior to genetic manipulation cells were cultured with or without osteogenic supplements (5 ± 10−8 M dexamethasone, 160 μM l‐ascorbic acid 2‐phosphate, and 10 mM β‐glycerophosphate). Comparison of lipos...... hiện toàn bộ
Molecular aspects of healing in stabilized and non‐stabilized fractures
Journal of Orthopaedic Research - Tập 19 - Trang 78-84 - 2001
A.X Le, T Miclau, D Hu, J.A Helms
AbstractBone formation is a continuous process that is initiated during fetal development and persists in adults in the form of bone regeneration and remodeling. These latter two aspects of bone formation are clearly influenced by the mechanical environment. In this study we tested the hypothesis that alterations in the mechanical environment regulate the program o...... hiện toàn bộ
Osteon pullout in the equine third metacarpal bone: Effects of ex vivo fatigue
Journal of Orthopaedic Research - Tập 21 - Trang 481-488 - 2003
L.P. Hiller, S.M. Stover, V.A. Gibson, J.C. Gibeling, C.S. Prater, S.J. Hazelwood, O.C. Yeh, R.B. Martin
AbstractAn important concept in bone mechanics is that osteons influence mechanical properties in several ways, including contributing to toughness and fatigue strength by debonding from the interstitial matrix so as to „bridge”︁ developing cracks. Observations of „pulled out„ osteons on fracture surfaces are thought to be indicative of such behavior. We tested the...... hiện toàn bộ
Differences in stability and bone remodeling between a customized uncemented hydroxyapatite coated and a standard cemented femoral stemA randomized study with use of radiostereometry and bone densitometry
Journal of Orthopaedic Research - Tập 23 - Trang 1280-1285 - 2005
Peter Grant, Arild Aamodt, Jan A. Falch, Lars Nordsletten
Electromyographic activity of the abdominal and low back musculature during the generation of isometric and dynamic axial trunk torque: Implications for lumbar mechanics
Journal of Orthopaedic Research - Tập 9 Số 1 - Trang 91-103 - 1991
Stuart M. McGill
AbstractThis study focused on the electromyographic activity of the trunk musculature, given the well‐documented link between occupational twisting and the increased incidence of low back pain. Ten men and 15 women volunteered for this study, in which several aspects of muscle activity were examined. The first aspect assessed the myoelectric relationships during is...... hiện toàn bộ
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