Journal of Orthopaedic Research

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Molecular aspects of healing in stabilized and non‐stabilized fractures
Journal of Orthopaedic Research - Tập 19 - Trang 78-84 - 2001
A.X Le, T Miclau, D Hu, J.A Helms
AbstractBone formation is a continuous process that is initiated during fetal development and persists in adults in the form of bone regeneration and remodeling. These latter two aspects of bone formation are clearly influenced by the mechanical environment. In this study we tested the hypothesis that alterations in the mechanical environment regulate the program o...... hiện toàn bộ
Osteon pullout in the equine third metacarpal bone: Effects of ex vivo fatigue
Journal of Orthopaedic Research - Tập 21 - Trang 481-488 - 2003
L.P. Hiller, S.M. Stover, V.A. Gibson, J.C. Gibeling, C.S. Prater, S.J. Hazelwood, O.C. Yeh, R.B. Martin
AbstractAn important concept in bone mechanics is that osteons influence mechanical properties in several ways, including contributing to toughness and fatigue strength by debonding from the interstitial matrix so as to „bridge”︁ developing cracks. Observations of „pulled out„ osteons on fracture surfaces are thought to be indicative of such behavior. We tested the...... hiện toàn bộ
Differences in stability and bone remodeling between a customized uncemented hydroxyapatite coated and a standard cemented femoral stemA randomized study with use of radiostereometry and bone densitometry
Journal of Orthopaedic Research - Tập 23 - Trang 1280-1285 - 2005
Peter Grant, Arild Aamodt, Jan A. Falch, Lars Nordsletten
Electromyographic activity of the abdominal and low back musculature during the generation of isometric and dynamic axial trunk torque: Implications for lumbar mechanics
Journal of Orthopaedic Research - Tập 9 Số 1 - Trang 91-103 - 1991
Stuart M. McGill
AbstractThis study focused on the electromyographic activity of the trunk musculature, given the well‐documented link between occupational twisting and the increased incidence of low back pain. Ten men and 15 women volunteered for this study, in which several aspects of muscle activity were examined. The first aspect assessed the myoelectric relationships during is...... hiện toàn bộ
A cumulative damage model for bone fracture
Journal of Orthopaedic Research - Tập 3 Số 1 - Trang 84-90 - 1985
D. R. Carter, William E. Caler
AbstractA mathematical model is presented to describe the combined time‐dependent and cycle‐dependent fracture characteristics of devitalized cortical bone. Failure is interpreted based on a linear‐life fraction rule, which accounts for cumulative creep and fatigue damage under arbitrary loading histories. The model is successful in describing the influence of load...... hiện toàn bộ
Neuronal regeneration after application of radiofrequency energy to collagenous tissue is affected by limb immobilization: An in vivo animal study
Journal of Orthopaedic Research - Tập 22 - Trang 1345-1350 - 2004
W. Pötzl, P. Kümpers, T. Szuwart, T. Filler, B. Marquardt, J. Steinbeck
AbstractDespite widespread use of radiofrequency (RF)‐shrinkage, there have been no studies on the influence of RF‐energy on neural elements of collagenous tissue. The purpose of this study was to examine the effect of RF‐shrinkage on neural structures of capsuloligamentous tissue and the recovery of neural elements under different postoperative treatment protocols...... hiện toàn bộ
rhBMP‐2 injected in a calcium phosphate paste (α‐BSM) accelerates healing in the rabbit ulnar osteotomy model
Journal of Orthopaedic Research - Tập 21 - Trang 997-1004 - 2003
R.H Li, M.L Bouxsein, C.A Blake, D D’Augusta, H Kim, X.J Li, J.M Wozney, H.J Seeherman
AbstractThis study evaluated the ability of recombinant human bone morphogenetic protein‐2 (rhBMP‐2) delivered in an injectable calcium phosphate carrier (α‐BSM) to accelerate healing in a rabbit ulna osteotomy model compared to untreated surgical controls. Healing was assessed by radiography, histology and biomechanics. Bilateral mid‐ulnar osteotomies were created...... hiện toàn bộ
The C‐terminal domain of focal adhesion kinase reduces the tumor cell invasiveness in chondrosarcoma cell lines
Journal of Orthopaedic Research - Tập 21 - Trang 1071-1080 - 2003
Jin Woo Lee, Yun Hee Kim, Hee Boong Park, Li-Hui Xu, William G Cance, Joel A Block, Sean P Scully
AbstractHuman chondrosarcoma is a malignancy that has no effective systemic therapy, making the interruption of the metastatic cascade critical to enhance patient survival. The processes of local invasion and metastases share similar mechanisms at a cellular level. Focal adhesion kinase (FAK) has been implicated in local invasion of malignant tumor cells. In the cu...... hiện toàn bộ
Intramembranous ossification mechanism for bone bridge formation at the growth plate cartilage injury site
Journal of Orthopaedic Research - Tập 22 - Trang 417-426 - 2004
Cory J Xian, Fiona H Zhou, Rosa C McCarty, Bruce K Foster
AbstractSalter's type III and type IV growth plate injuries often induce bone bridge formation at the injury site. To understand the cellular mechanisms, this study characterized proximal tibial transphyseal injury in rats. Histologically, bony bridge trabeculae appeared on day 7, increased on day 10, and became well‐constructed on day 14 with marrow. Prior to and ...... hiện toàn bộ
Centrifugal characterization of proteoglycans from various depth layers and weight‐bearing areas of normal and abnormal human articular cartilage
Journal of Orthopaedic Research - Tập 7 Số 3 - Trang 326-334 - 1989
Francisco J. Müller, Julio C. Pita, Daniel Manicourt, Theodore I. Malinin, John M. Schoonbeck, Van C. Mow
AbstractUltracentrifugal polydispersity differential [g(S)] distributions were determined for the proteoglycans of various postmortem human articular cartilage samples extracted from six lateral patellar grooves in nondissociative conditions after mild collagenase digestion of the tissue. The samples consisted o...... hiện toàn bộ
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