Journal of Orthopaedic Research

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Polyethylene wear rate and osteolysis: Critical threshold versus continuous dose-response relationship
Journal of Orthopaedic Research - Tập 23 - Trang 520-525 - 2005
J. Mark Wilkinson, Andrew J. Hamer, Ian Stockley, Richard Eastell
Role of miR-155 in the regulation of MMP-16 expression in intervertebral disc degeneration
Journal of Orthopaedic Research - Tập 35 Số 6 - Trang 1323-1334 - 2017
Weilin Zhang, Yufei Chen, Hong‐Zheng Meng, Junjie Du, Guan-Nan Luan, Hai‐Qiang Wang, Maowei Yang, Zhuojing Luo
Cellular basis for age-related changes in fracture repair
Journal of Orthopaedic Research - Tập 23 - Trang 1300-1307 - 2005
Chuanyong Lu, Theodore Miclau, Diane Hu, Erik Hansen, Kathy Tsui, Christian Puttlitz, Ralph S. Marcucio
Effects of hydroxyapatite participate debris on the production of cytokines and proteases in human fibroblasts
Journal of Orthopaedic Research - Tập 19 - Trang 621-628 - 2001
James T. Ninomiya, Janine A. Struve, Cary T. Stelloh, Jeffrey M. Toth, Kevin E. Crosby
AbstractCytokines and proteases are secreted by fibroblasts in response to particulate wear debris, and these proteins are felt to play an important role in the development of osteolysis and implant loosening. Although metallic and polyethlyene debris have been studied extensively, little is known about the cellular responses to hydroxyapatite, despite the wide clinical use of these materials. The... hiện toàn bộ
Smad6 is induced by BMP‐2 and modulates chondrocyte differentiation
Journal of Orthopaedic Research - Tập 21 - Trang 908-913 - 2003
Xeufeng Li, Andreia M Ionescu, Edward M Schwarz, Xinping Zhang, Hicham Drissi, J.Edward Puzas, Randy N Rosier, Michael J Zuscik, Regis J O’Keefe
AbstractBMPs regulate cartilage differentiation and have been approved for clinical use as stimulators of bone repair. BMP signaling is complex and there are multiple potential points of regulation, including modulation of Smad signaling, which is inhibited by both Smad6 and Smad7. In the current manuscript we assessed the expression and biological function of Smad6 during chondrocyte differentiat... hiện toàn bộ
A quantitative method to measure maximal workspace of the trapeziometacarpal joint—normal model development
Journal of Orthopaedic Research - Tập 22 - Trang 600-606 - 2004
Li-Chieh Kuo, William P Cooney, Kenton R Kaufman, Qing-Shan Chen, Fong-Chin Su, Kai-Nan An
AbstractIntroduction: A reliable and quantitative method for measuring motion of the thumb is lacking. In particular, review of the previous methods of motion analysis of the thumb joints shows that there is no objective method for clinicians to assess the impairment of the thumb trapeziometacarpal (TMC) joint. Based on the concept of the three‐dimensional (3‐D) space within which the first metaca... hiện toàn bộ
Early osteoblastic differentiation induced by dexamethasone enhances adenoviral gene delivery to marrow stromal cells
Journal of Orthopaedic Research - Tập 22 - Trang 411-416 - 2004
Jeremy S Blum, M Brandon Parrott, Antonios G Mikos, Michael A Barry
AbstractWe investigated the implications of induced osteogenic differentiation on gene delivery in multipotent rat marrow stromal cells (MSCs). Prior to genetic manipulation cells were cultured with or without osteogenic supplements (5 ± 10−8 M dexamethasone, 160 μM l‐ascorbic acid 2‐phosphate, and 10 mM β‐glycerophosphate). Comparison of liposome, retroviral, and adenoviral vectors demonstrated t... hiện toàn bộ
In situ strain and stress of nerve conduction blocking in the brachial plexus
Journal of Orthopaedic Research - Tập 20 - Trang 1311-1314 - 2002
Shinro Takai, Hidefumi Dohno, Yoshinobu Watanabe, Nobuyuki Yoshino, Taku Ogura, Yasusuke Hirasawa
AbstractThe objective of the present study was to determine the in situ strain and stress of nerve conduction blocking in the brachial plexus. The measurement of the in situ tension stress inducing functional failure of the brachial plexus consisted of two steps. Step I (in vivo): The brachial plexus of the rabbit was stretched laterally until electrophysiological conduction blocking occurred. The... hiện toàn bộ
Molecular aspects of healing in stabilized and non‐stabilized fractures
Journal of Orthopaedic Research - Tập 19 - Trang 78-84 - 2001
A.X Le, T Miclau, D Hu, J.A Helms
AbstractBone formation is a continuous process that is initiated during fetal development and persists in adults in the form of bone regeneration and remodeling. These latter two aspects of bone formation are clearly influenced by the mechanical environment. In this study we tested the hypothesis that alterations in the mechanical environment regulate the program of mesenchymal cell differentiatio... hiện toàn bộ
Osteon pullout in the equine third metacarpal bone: Effects of ex vivo fatigue
Journal of Orthopaedic Research - Tập 21 - Trang 481-488 - 2003
L.P. Hiller, S.M. Stover, V.A. Gibson, J.C. Gibeling, C.S. Prater, S.J. Hazelwood, O.C. Yeh, R.B. Martin
AbstractAn important concept in bone mechanics is that osteons influence mechanical properties in several ways, including contributing to toughness and fatigue strength by debonding from the interstitial matrix so as to „bridge”︁ developing cracks. Observations of „pulled out„ osteons on fracture surfaces are thought to be indicative of such behavior. We tested the hypothesis that osteon pullout v... hiện toàn bộ
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