The IL-18, IL-12, and IFN-γ expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, HTLV-1 carriers, and healthy subjectsJournal of NeuroVirology - Tập 26 - Trang 338-346 - 2020
Hamid Reza Bidkhori, Mohammad Reza Hedayati-Moghaddam, Arman Mosavat, Narges Valizadeh, Mohsen Tadayon, Sanaz Ahmadi Ghezeldasht, Houshang Rafatpanah, Seyed Abdolrahim Rezaee
Interleukin (IL)-12, IL-18, and interferon gamma (IFN-γ) can induce Th1-inflammatory responses in favor of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) manifestation. In this study, the gene expression and plasma levels of these cytokines were evaluated. The peripheral blood mononuclear cells (PBMCs) in 20 HAM/TSP patients, 21 asymptomatic carriers (ACs), and 21 healthy subj...... hiện toàn bộ
Inhibition of multiple sclerosis-associated retrovirus as biomarker of interferon therapyJournal of NeuroVirology - Tập 14 - Trang 73-77 - 2008
Giuseppe Mameli, Caterina Serra, Vito Astone, Massimiliano Castellazzi, Luciana Poddighe, Enrico Fainardi, Walter Neri, Enrico Granieri, Antonina Dolei
The authors performed a longitudinal evaluation of multiple sclerosis (MS) patients, during 1 year of therapy with interferon-β (IFN-β), by clinical examination and detection of presence in the blood and viral load of MS-associated retrovirus (MSRV), by MSRVenv-specific, fully quantitative, real time reverse transcriptase-polymerase chain reaction (RT-PCR). MSRV load in the blood was directly rela...... hiện toàn bộ
VP16 serine 375 is a critical determinant of herpes simplex virus exit from latency in vivoJournal of NeuroVirology - Tập 17 - Trang 546-551 - 2011
Nancy M. Sawtell, Steven J. Triezenberg, Richard L. Thompson
Development of novel prevention and treatment strategies for herpes simplex virus (HSV) mediated diseases is dependent upon an accurate understanding of the central molecular events underlying the regulation of latency and reactivation. We have recently shown that the transactivation function of the virion protein VP16 is a critical determinant in the exit from latency in vivo. HSV-1 strain SJO2 c...... hiện toàn bộ
Defective NF-κB activation in virus-infected neuronal cells is restored by genetic complementationJournal of NeuroVirology - Tập 8 - Trang 459-463 - 2002
Yu-Yan Fang, Zan-Min Song, Tao Wu, Abhijit Raha, Dhananjaya V. Kalvakolanu, Suhayl Dhib-Jalbut
The interferon-beta (IFNβ) gene is not inducible in neuronal cells in response to measles virus (MV) due to lack of nuclear factor kappa B (NF-κB) activation. NF-κB is normally sequestered in the cytoplasm by an inhibitor (IκBα). Previously, the authors demonstrated that the failure to activate neuronal NF-κB by MV was due to the inability to phosphorylate and degrade its inhibitor, IκBα. Here the...... hiện toàn bộ
Scrapie pathogenesis in brain and retina: Effects of prion protein expression in neurons and astrocytesJournal of NeuroVirology - Tập 11 Số 5 - Trang 476-480 - 2005
Chesebro, Bruce, Race, Richard, Kercher, Lisa
Brain damage in the transmissible spongiform encephalopathies or prion diseases is associated with the conversion of normal host prion protein to an abnormal protease-resistant isoform, and expression of prion protein is required for susceptibility to these diseases. This article reviews the data on studies using transgenic mice expressing prion protein in specific individual cell types to study t...... hiện toàn bộ
Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patientsJournal of NeuroVirology - Tập 22 - Trang 508-517 - 2016
Hayley Goullee, Antonia L. Wadley, Catherine L. Cherry, Richard J. N. Allcock, Michael Black, Peter R. Kamerman, Patricia Price
HIV-associated sensory neuropathy (HIV-SN) is the most common neurological condition associated with HIV. HIV-SN has characteristics of an inflammatory pathology caused by the virus itself and/or by antiretroviral treatment (ART). Here, we assess the impact of single-nucleotide polymorphisms (SNPs) in a cluster of three genes that affect inflammation and neuronal repair: P2X7R, P2X4R and CAMKK2. H...... hiện toàn bộ