Journal of NeuroVirology

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The IL-18, IL-12, and IFN-γ expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patients, HTLV-1 carriers, and healthy subjects
Journal of NeuroVirology - Tập 26 - Trang 338-346 - 2020
Hamid Reza Bidkhori, Mohammad Reza Hedayati-Moghaddam, Arman Mosavat, Narges Valizadeh, Mohsen Tadayon, Sanaz Ahmadi Ghezeldasht, Houshang Rafatpanah, Seyed Abdolrahim Rezaee
Interleukin (IL)-12, IL-18, and interferon gamma (IFN-γ) can induce Th1-inflammatory responses in favor of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) manifestation. In this study, the gene expression and plasma levels of these cytokines were evaluated. The peripheral blood mononuclear cells (PBMCs) in 20 HAM/TSP patients, 21 asymptomatic carriers (ACs), and 21 healthy subj...... hiện toàn bộ
Inhibition of multiple sclerosis-associated retrovirus as biomarker of interferon therapy
Journal of NeuroVirology - Tập 14 - Trang 73-77 - 2008
Giuseppe Mameli, Caterina Serra, Vito Astone, Massimiliano Castellazzi, Luciana Poddighe, Enrico Fainardi, Walter Neri, Enrico Granieri, Antonina Dolei
The authors performed a longitudinal evaluation of multiple sclerosis (MS) patients, during 1 year of therapy with interferon-β (IFN-β), by clinical examination and detection of presence in the blood and viral load of MS-associated retrovirus (MSRV), by MSRVenv-specific, fully quantitative, real time reverse transcriptase-polymerase chain reaction (RT-PCR). MSRV load in the blood was directly rela...... hiện toàn bộ
VP16 serine 375 is a critical determinant of herpes simplex virus exit from latency in vivo
Journal of NeuroVirology - Tập 17 - Trang 546-551 - 2011
Nancy M. Sawtell, Steven J. Triezenberg, Richard L. Thompson
Development of novel prevention and treatment strategies for herpes simplex virus (HSV) mediated diseases is dependent upon an accurate understanding of the central molecular events underlying the regulation of latency and reactivation. We have recently shown that the transactivation function of the virion protein VP16 is a critical determinant in the exit from latency in vivo. HSV-1 strain SJO2 c...... hiện toàn bộ
Disseminated cutaneous herpes zoster and multiple cerebral infarcts in an adult with diabetes mellitus
Journal of NeuroVirology - Tập 26 Số 1 - Trang 130-132 - 2020
Ching-Fuh Lin, Chien-Tai Hong, Wei Hwa Lee, Dean Wu, Chaur Jong Hu, Chen-Chih Chung
Scrapie pathogenesis in brain and retina: Effects of prion protein expression in neurons and astrocytes
Journal of NeuroVirology - Tập 11 Số 5 - Trang 476-480 - 2005
Chesebro, Bruce, Race, Richard, Kercher, Lisa
Brain damage in the transmissible spongiform encephalopathies or prion diseases is associated with the conversion of normal host prion protein to an abnormal protease-resistant isoform, and expression of prion protein is required for susceptibility to these diseases. This article reviews the data on studies using transgenic mice expressing prion protein in specific individual cell types to study t...... hiện toàn bộ
Polymorphisms in CAMKK2 may predict sensory neuropathy in African HIV patients
Journal of NeuroVirology - Tập 22 - Trang 508-517 - 2016
Hayley Goullee, Antonia L. Wadley, Catherine L. Cherry, Richard J. N. Allcock, Michael Black, Peter R. Kamerman, Patricia Price
HIV-associated sensory neuropathy (HIV-SN) is the most common neurological condition associated with HIV. HIV-SN has characteristics of an inflammatory pathology caused by the virus itself and/or by antiretroviral treatment (ART). Here, we assess the impact of single-nucleotide polymorphisms (SNPs) in a cluster of three genes that affect inflammation and neuronal repair: P2X7R, P2X4R and CAMKK2. H...... hiện toàn bộ
Progressive multifocal leukoencephalopathy in Zambia is caused by JC virus with prototype regulatory region
Journal of NeuroVirology - Tập 25 - Trang 475-479 - 2019
Eugene Mubanga, Atiyah Patel, Omar K. Siddiqi, Barbara A. Hanson, Xin Dang, Shabir Lakhi, Gina Mulundu, Noemi Bender, Igor J. Koralnik
There are only few documented cases of progressive multifocal leukoencephalopathy (PML) in Africa. Whether this is caused by a lack of JC virus (JCV) spread or alteration in the JCV genome is unknown. We characterized the clinical presentation, laboratory findings, and JCV regulatory region (RR) pattern of the first documented PML cases in Zambia as well as JCV seroprevalence among HIV+ and HIV− Z...... hiện toàn bộ
14-3-3s are potential biomarkers for HIV-related neurodegeneration
Journal of NeuroVirology - Tập 18 - Trang 341-353 - 2012
Diana Morales, Efthimios C. M. Skoulakis, Summer F. Acevedo
Over the last decade, it has become evident that 14-3-3 proteins are essential for primary cell functions. These proteins are abundant throughout the body, including the central nervous system and interact with other proteins in both cell cycle and apoptotic pathways. Examination of cerebral spinal fluid in humans suggests that 14-3-3s including 14-3-3ε (YWHAE) are up-regulated in several neurolog...... hiện toàn bộ
Emerging zoonotic encephalitis viruses: Lessons from Southeast Asia and Oceania
Journal of NeuroVirology - Tập 11 - Trang 434-440 - 2005
John S. Mackenzie
The last decade of the 20th Century saw the introduction of an unprecedented number of encephalitic viruses emerge or spread in the Southeast Asian and Western Pacific regions (Mackenzie et al, 2001; Solomon, 2003a). Most of these viruses are zoonotic, either being arthropod-borne viruses or bat-borne viruses. Thus Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, has spread through ...... hiện toàn bộ
Robust gene expression changes in the ganglia following subclinical reactivation in rhesus macaques infected with simian varicella virus
Journal of NeuroVirology - Tập 23 - Trang 520-538 - 2017
Nicole Arnold, Christine Meyer, Flora Engelmann, Ilhem Messaoudi
Varicella zoster virus (VZV) causes varicella during acute infection and establishes latency in the sensory ganglia. Reactivation of VZV results in herpes zoster, a debilitating and painful disease. It is believed that VZV reactivates due to a decline in cell-mediated immunity; however, the roles that CD4 versus CD8 T cells play in the prevention of herpes zoster remain poorly understood. To addre...... hiện toàn bộ
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