Journal of Neuro-Oncology

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Pleiotrophin expression in astrocytic and oligodendroglial tumors and it’s correlation with histological diagnosis, microvascular density, cellular proliferation and overall survival
Journal of Neuro-Oncology - Tập 84 - Trang 255-261 - 2007
Fernanda M. Peria, Luciano Neder, Sueli K. N. Marie, Sergio Rosemberg, Sueli M. Oba-Shinjo, Benedicto O. Colli, Alberto A. Gabbai, Suzana M. F. Malheiros, Marco A. Zago, Rodrigo A. Panepucci, Carlos A. Moreira-Filho, Oswaldo K. Okamoto, Carlos G. Carlotti
Pleiotrophin (PTN) is a secreted cytokine with several properties related with tumor development, including differentiation, angiogenesis, invasion, apoptosis and metastasis. There is evidence that PTN has also a relevant role in primary brain neoplasms and its inactivation could be important to treatment response. Astrocytic and oligodendroglial tumors are the most frequent primary brain neoplasm...... hiện toàn bộ
Diffuse intrinsic pontine glioma cells are vulnerable to low intensity electric fields delivered by intratumoral modulation therapy
Journal of Neuro-Oncology - Tập 143 - Trang 49-56 - 2019
Andrew Deweyert, Erin Iredale, Hu Xu, Eugene Wong, Susanne Schmid, Matthew O. Hebb
Diffuse intrinsic pontine glioma (DIPG) is a high fatality pediatric brain cancer without effective treatment. The field of electrotherapeutics offers new potential for other forms of glioma but the efficacy of this strategy has not been reported for DIPG. This pilot study evaluated the susceptibility of patient-derived DIPG cells to low intensity electric fields delivered using a developing techn...... hiện toàn bộ
Two Different Mechanisms of Apoptosis Resistance Observed in Interferon- Induced Apoptosis of Human Glioma Cells
Journal of Neuro-Oncology - Tập 67 Số 3 - Trang 273-280 - 2004
Ryuta Saito, Masaaki Mizuno, Manabu Hatano, Toshihiro Kumabe, Takashi Yoshimoto, Jun Yoshida
Preoperative antiepileptic drug prophylaxis for early postoperative seizures in supratentorial meningioma: a single-center experience
Journal of Neuro-Oncology - Tập 158 - Trang 59-67 - 2022
Qing Cai, Yingxi Wu, Shoujie Wang, Tao Huang, Qilong Tian, Julei Wang, Huaizhou Qin, Dayun Feng
Perioperative antiepileptic drug (AED) prophylaxis for early postoperative seizures (EPSs) in patients with supratentorial meningiomas without preoperative seizures is controversial. This paper discusses the incidence, risk factors, control rate and AED withdrawal indications of EPS in patients undergoing supratentorial convexity and parasagittal/falx meningioma resection without preoperative seiz...... hiện toàn bộ
Intensive chemotherapy followed by reduced-dose radiotherapy for biopsy-proven CNS germinoma with elevated beta-human chorionic gonadotropin
Journal of Neuro-Oncology - Tập 117 Số 2 - Trang 279-285 - 2014
Do Hoon Lim, Keon Hee Yoo, Na Hee Lee, Soo Hyun Lee, Ki Woong Sung, Hong Hoe Koo, Ji Hye Kim, Yeon‐Lim Suh, Yoo Sook Joung, Hyung Jin Shin
VEGF in Brain Tumors
Journal of Neuro-Oncology - Tập 50 - Trang 109-120 - 2000
Marcia Regina Machein, Karl Heinz Plate
Vascular endothelial growth factor (VEGF) is a regulator of angiogenesis, vasculogenesis and vascular permeability. In this contribution, molecular and biological properties of VEGF are described. Furthermore, this article focuses on the evidence that angiogenesis in brain tumors is mediated by VEGF. Among the topics discussed are expression patterns of VEGF and its receptors in different brain tu...... hiện toàn bộ
Loss of methylthioadenosine phosphorylase immunoreactivity correlates with poor prognosis and elevated uptake of 11C-methionine in IDH-mutant astrocytoma
Journal of Neuro-Oncology - - 2024
Toshihiro Yamamura, Kaoru Tamura, Daisuke Kobayashi, Motoki Inaji, Yuka Toyama, Hiroaki Wakimoto, Juri Kiyokawa, Shoko Hara, Yoji Tanaka, Tadashi Nariai, Kazuhide Shimizu, Kenji Ishii, Taketoshi Maehara
The proximate localization of MTAP, which encodes methylthioadenosine phosphorylase, and CDKN2A/B on Chromosome 9q21 has allowed the loss of MTAP expression as a surrogate for homozygous deletion of CDKN2A/B. This study aimed to determine whether MTAP status correlates with clinical outcomes and 11C-methionine uptake in astrocytomas with IDH mutations. We conducted immunohistochemistry for MTAP in...... hiện toàn bộ
Intracranial Thermotherapy using Magnetic Nanoparticles Combined with External Beam Radiotherapy: Results of a Feasibility Study on Patients with Glioblastoma Multiforme
Journal of Neuro-Oncology - Tập 81 - Trang 53-60 - 2006
Klaus Maier-Hauff, Ronny Rothe, Regina Scholz, Uwe Gneveckow, Peter Wust, Burghard Thiesen, Annelie Feussner, Andreas von Deimling, Norbert Waldoefner, Roland Felix, Andreas Jordan
We aimed to evaluate the feasibility and tolerability of the newly developed thermotherapy using magnetic nanoparticles on recurrent glioblastoma multiforme. Fourteen patients received 3-dimensional image guided intratumoral injection of aminosilane coated iron oxide nanoparticles. The patients were then exposed to an alternating magnetic field to induce particle heating. The amount of fluid and t...... hiện toàn bộ
Triple-dose Contrast/magnetization Transfer Suppressed Imaging of ‘non-enhancing’ Brain Gliomas
Journal of Neuro-Oncology - Tập 60 - Trang 25-29 - 2002
Bradley J. Erickson, Norbert G. Campeau, Shawn A. Schreiner, Jan C. Buckner, Brian P. O'Neill, Judith R. O'Fallon
PURPOSE: Triple-dose (TD) gadolinium contrast administration and magnetization transfer suppression (MTS) in brain magnetic resonance imaging (MRI) have proven to be useful for demonstrating additional enhancing lesions in some diseases. The purpose of this study was to determine if there is a subset of brain tumors that demonstrate contrast enhancement with TD and MTS that do not enhance with sta...... hiện toàn bộ
Radiomic features predict Ki-67 expression level and survival in lower grade gliomas
Journal of Neuro-Oncology - Tập 135 - Trang 317-324 - 2017
Yiming Li, Zenghui Qian, Kaibin Xu, Kai Wang, Xing Fan, Shaowu Li, Xing Liu, Yinyan Wang, Tao Jiang
To investigate the radiomic features associated with Ki-67 expression in lower grade gliomas and assess the prognostic values of these features. Patients with lower grade gliomas (n = 117) were randomly assigned into the training (n = 78) and validation (n = 39) sets. A total of 431 radiological features were extracted from each patient. Differential radiological features between the low and high ...... hiện toàn bộ
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