Journal of Neural Transmission

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The adrenal medulla may mediate the increase in pineal melatonin synthesis induced by stress, but not that caused by exposure to darkness
Journal of Neural Transmission - Tập 40 - Trang 87-97 - 1977
H. J. Lynch, Maria Ho, R. J. Wurtman
As previously shown (Lynch et al.: Proc. Nat. Acad. Sci. [U.S.A.]70, 1704–1707 [1973]), the activity of the enzyme serotonin-N-acetyltransferase (NAT) in the rat pineal increases when the animal is placed in darkness or is subjected to the stress of physical immobilization; partial sympathetic denervation (i.e., pretreatment of the animal with intravenous 6-hydroxydopamine [6-OHDA]) does not block...... hiện toàn bộ
Antidepressant effects of pramipexole, a novel dopamine receptor agonist
Journal of Neural Transmission - Tập 104 - Trang 525-533 - 1997
J. Maj, Z. Rogóż, G. Skuza, K. Kołodziejczyk
Pramipexole (2-amino-4,5,6,7-tetrahydro-6-propyl-amino-benzthiazole-dihydrochloride), a new dopamine receptor agonist with preference for D3 compared to D2 and D4 receptors, was tested in rats in respect of its potential antidepressant activity. In the forced swimming test the drug under study, given three times in rats, reduced the immobility time. In the forced swimming test, joint treatment wit...... hiện toàn bộ
A new quantitative method for evaluating freezing of gait and dual-attention task deficits in Parkinson’s disease
Journal of Neural Transmission - Tập 122 Số 11 - Trang 1523-1531 - 2015
Taylor Chomiak, Fernando Vieira Pereira, Nicole L Meyer, Natalie de Bruin, Lorelei Derwent, Kailie Luan, Alexandra Cihal, Lesley A. Brown, Bin Hu
Vegetative peripheral vascular controls
Journal of Neural Transmission - Tập 14 - Trang 123-129 - 1956
U. S. von Euler
Morphological basis of Parkinson disease-associated cognitive impairment: an update
Journal of Neural Transmission - Tập 129 - Trang 977-999 - 2022
Kurt A. Jellinger
Cognitive impairment is one of the most salient non-motor symptoms of Parkinson disease (PD) that poses a significant burden on the patients and carers as well as being a risk factor for early mortality. People with PD show a wide spectrum of cognitive dysfunctions ranging from subjective cognitive decline and mild cognitive impairment (MCI) to frank dementia. The mean frequency of PD with MCI (PD...... hiện toàn bộ
Effects of subacute exposure to noise on the noradrenergic innervation of the cardiovascular system in young and aged rats: a morphofunctional study
Journal of Neural Transmission - Tập 88 - Trang 105-113 - 1992
A. Paparelli, P. Soldani, M. C. Breschi, E. Martinotti, R. Scatizzi, S. Berrettini, A. Pellegrini
The effects of subacute noise stress on the noradrenergic pattern and receptor-mediated responses were examined in aorta and atria of young and aged rats. Noise exposure increased the density of noradrenergic fibres and responses to the β-adrenergic agonist isoprenaline in the cardiac tissue of young animals. In aged rats, the stressing stimulus markedly increased the maximal response to the α-ago...... hiện toàn bộ
Basic cell physiological activities (cell adhesion, chemotaxis and proliferation) induced by selegiline and its derivatives in Mono Mac 6 human monocytes
Journal of Neural Transmission - Tập 119 - Trang 545-556 - 2011
Eszter Lajkó, Lívia Polgár, Orsolya Láng, József Lengyel, László Kőhidai, Kálmán Magyar
Selegiline (R-deprenyl), a monoamine oxidase-B (MAO-B) inhibitor, has complex pharmacological effect that contributes to treatment of neurodegenerative diseases such as Parkinson’s and presumably Alzheimer’s disease and might work as an inhibitor of tumor growth. In respect of tumorigenesis and metastasis formation, the controlled modifications of adhesion and migration have high therapeutic signi...... hiện toàn bộ
Long-term effects of chronic stress models in adult mice
Journal of Neural Transmission - Tập 130 - Trang 1133-1151 - 2023
Inès Tran, Anne-Kathrin Gellner
Neuropsychiatric disorders, such as major depression, anxiety disorders, and post-traumatic stress disorder, tend to be long-term conditions in whose development and maintenance stress are central pathogenic factors. Translational mouse models are widely used in neuropsychiatric research, exploiting social and non-social stressors to investigate the mechanisms underlying their detrimental effects....... hiện toàn bộ
In vivo occupation of dopamine D 1 , D 2 and serotonin 2A receptors by novel antipsychotic drug, SM-9018and its metabolite, in rat brain
Journal of Neural Transmission - Tập 105 Số 2-3 - Trang 181-191 - 1998
Yasuhiro Takahashi, Ichiro Kusumi, Т. Ишикане, Tsukasa Koyama
Rat models of dementia based on reductions in regional glucose metabolism, cerebral blood flow and cytochrome oxidase activity
Journal of Neural Transmission - Tập 111 - Trang 347-366 - 2003
M. Weinstock, S. Shoham
Three models are described in rats which attempt to mimic morphological and behavioural pathology of Alzheimer’s dementia; intracerebroventricular injection of streptozotocin (STZ), permanent bilateral carotid artery occlusion (2VO) and brain mitochondrial cytochrome oxidase inhibition by sodium azide. Learning and memory are impaired within 4 weeks in all models. This probably involves a reductio...... hiện toàn bộ
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