Morphological basis of Parkinson disease-associated cognitive impairment: an updateJournal of Neural Transmission - Tập 129 - Trang 977-999 - 2022
Kurt A. Jellinger
Cognitive impairment is one of the most salient non-motor symptoms of Parkinson disease (PD) that poses a significant burden on the patients and carers as well as being a risk factor for early mortality. People with PD show a wide spectrum of cognitive dysfunctions ranging from subjective cognitive decline and mild cognitive impairment (MCI) to frank dementia. The mean frequency of PD with MCI (PD...... hiện toàn bộ
Long-term effects of chronic stress models in adult miceJournal of Neural Transmission - Tập 130 - Trang 1133-1151 - 2023
Inès Tran, Anne-Kathrin Gellner
Neuropsychiatric disorders, such as major depression, anxiety disorders, and post-traumatic stress disorder, tend to be long-term conditions in whose development and maintenance stress are central pathogenic factors. Translational mouse models are widely used in neuropsychiatric research, exploiting social and non-social stressors to investigate the mechanisms underlying their detrimental effects....... hiện toàn bộ
Family-based association studies of the TCP1 gene and schizophrenia in the Chinese Han populationJournal of Neural Transmission - Tập 113 - Trang 1537-1543 - 2006
W. Tang, Y. Shi, G. Feng, L. Yan, Y. Xing, S. Zhu, J. Liu, X. Zhao, R. Tang, J. Du, J. Zhang, G. He, P. Liang, L. He
A previous case-control study by Yang et al. indicated that the TCP1 gene in 6q25 was associated with schizophrenia in the Han population. To replicate this result, we selected eight SNPs (rs2273828, rs3818298, rs1547094, rs1547093, rs2295898, rs2295899, rs4832, rs15982) spanning the whole gene and performed a family-based study using 325 trios samples. Our transmission disequilibrium test showed ...... hiện toàn bộ