Antidepressant effects of pramipexole, a novel dopamine receptor agonistJournal of Neural Transmission - Tập 104 - Trang 525-533 - 1997
J. Maj, Z. Rogóż, G. Skuza, K. Kołodziejczyk
Pramipexole (2-amino-4,5,6,7-tetrahydro-6-propyl-amino-benzthiazole-dihydrochloride), a new dopamine receptor agonist with preference for D3 compared to D2 and D4 receptors, was tested in rats in respect of its potential antidepressant activity. In the forced swimming test the drug under study, given three times in rats, reduced the immobility time. In the forced swimming test, joint treatment wit...... hiện toàn bộ
Morphological basis of Parkinson disease-associated cognitive impairment: an updateJournal of Neural Transmission - Tập 129 - Trang 977-999 - 2022
Kurt A. Jellinger
Cognitive impairment is one of the most salient non-motor symptoms of Parkinson disease (PD) that poses a significant burden on the patients and carers as well as being a risk factor for early mortality. People with PD show a wide spectrum of cognitive dysfunctions ranging from subjective cognitive decline and mild cognitive impairment (MCI) to frank dementia. The mean frequency of PD with MCI (PD...... hiện toàn bộ
Long-term effects of chronic stress models in adult miceJournal of Neural Transmission - Tập 130 - Trang 1133-1151 - 2023
Inès Tran, Anne-Kathrin Gellner
Neuropsychiatric disorders, such as major depression, anxiety disorders, and post-traumatic stress disorder, tend to be long-term conditions in whose development and maintenance stress are central pathogenic factors. Translational mouse models are widely used in neuropsychiatric research, exploiting social and non-social stressors to investigate the mechanisms underlying their detrimental effects....... hiện toàn bộ
Rat models of dementia based on reductions in regional glucose metabolism, cerebral blood flow and cytochrome oxidase activityJournal of Neural Transmission - Tập 111 - Trang 347-366 - 2003
M. Weinstock, S. Shoham
Three models are described in rats which attempt to mimic morphological and behavioural pathology of Alzheimer’s dementia; intracerebroventricular injection of streptozotocin (STZ), permanent bilateral carotid artery occlusion (2VO) and brain mitochondrial cytochrome oxidase inhibition by sodium azide. Learning and memory are impaired within 4 weeks in all models. This probably involves a reductio...... hiện toàn bộ