Journal of Molecular Signaling

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Estradiol effects on the dopamine transporter – protein levels, subcellular location, and function
Journal of Molecular Signaling - Tập 1 - Trang 1-14 - 2006
Cheryl S Watson, Rebecca A Alyea, Bridget E Hawkins, Mary L Thomas, Kathryn A Cunningham, Adrian A Jakubas
The effects of estrogens on dopamine (DA) transport may have important implications for the increased incidence of neurological disorders in women during life stages when hormonal fluctuations are prevalent, e.g. during menarche, reproductive cycling, pregnancy, and peri-menopause. The activity of the DA transporter (DAT) was measured by the specific uptake of 3H-DA. We found that low concentratio...... hiện toàn bộ
Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively
Journal of Molecular Signaling - Tập 4 - Trang 1-23 - 2009
Peter D Donnellan, B Therese Kinsella
The human prostacyclin receptor (hIP) undergoes agonist-induced phosphorylation, desensitisation and internalisation and may be recycled to the plasma membrane or targeted for degradation by, as yet, unknown mechanism(s). Herein it was sought to investigate the turnover of the hIP under basal conditions and in response to cicaprost stimulation. It was established that the hIP is subject to low-lev...... hiện toàn bộ
EGF regulates tyrosine phosphorylation and membrane-translocation of the scaffold protein Tks5
Journal of Molecular Signaling - Tập 8 - Trang 1-8 - 2013
Anna Fekete, Gábor Bőgel, Szabolcs Pesti, Zalán Péterfi, Miklós Geiszt, László Buday
Tks5/FISH is a scaffold protein comprising of five SH3 domains and one PX domain. Tks5 is a substrate of the tyrosine kinase Src and is required for the organization of podosomes/invadopodia implicated in invasion of tumor cells. Recent data have suggested that a close homologue of Tks5, Tks4, is implicated in the EGF signaling. Here, we report that Tks5 is a component of the EGF signaling pathway...... hiện toàn bộ
TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling
Journal of Molecular Signaling - Tập 5 - Trang 18
Paul M. Campbell, Nadia Boufaied, James J. Fiordalisi, Adrienne D. Cox, Pierre Falardeau, Channing J. Der, Henriette Gourdeau
Identification of endoglin-dependent BMP-2- induced genes in the murine periodontal ligament cell line PDL-L2
Journal of Molecular Signaling -
Osamu Ishibashi, Takashi Inui
Phosphoprotein phosphatase-2A docks to Dishevelled and counterregulates Wnt3a/β-catenin signaling
Journal of Molecular Signaling - Tập 2 - Trang 1-18 - 2007
Noriko Yokoyama, Craig C Malbon
Wnt3a stimulates cellular trafficking of key signaling elements (e.g., Axin, Dishevelled-2, β-catenin, and glycogen synthase kinase-3β) and primitive endoderm formation in mouse F9 embryonic teratocarcinoma cells. The role of phosphoprotein phosphatase-2A in signaling of the Wnt/β-catenin/Lef-Tcf-sensitive gene activation pathway was investigated. Wnt3a action attenuates phosphoprotein phosphatase...... hiện toàn bộ
Mutations on the Switch III region and the alpha3 helix of Galpha 16 differentially affect receptor coupling and regulation of downstream effectors
Journal of Molecular Signaling - Tập 3 - Trang 1-16 - 2008
May YM Yu, Maurice KC Ho, Andrew MF Liu, Yung H Wong
Gα16 can activate phospholipase Cβ (PLCβ) directly like Gαq. It also couples to tetratricopeptide repeat 1 (TPR1) which is linked to Ras activation. It is unknown whether PLCβ and TPR1 interact with the same regions on Gα16. Previous studies on Gαq have defined two minimal clusters of amino acids that are essential for the coupling to PLCβ. Cognate residues in Gα16 might also be essential for inte...... hiện toàn bộ
Brain-derived neurotrophic factor receptor TrkB exists as a preformed dimer in living cells
Journal of Molecular Signaling - Tập 7 - Trang 1-7 - 2012
Jianying Shen, Ichiro N Maruyama
Neurotrophins (NTs) and their receptors play crucial roles in the development, functions and maintenance of nervous systems. It is widely believed that NT-induced dimerization of the receptors initiates the transmembrane signaling. However, it is still controversial whether the receptor molecule has a monomeric or dimeric structure on the cell surface before its ligand binding. Using chemical cros...... hiện toàn bộ
Binding mode prediction of conformationally restricted anandamide analogs within the CB1 receptor
Journal of Molecular Signaling - Tập 3 - Trang 1-19 - 2008
Lea W Padgett, Allyn C Howlett, Joong-Youn Shim
CB1 cannabinoid receptors are G-protein coupled receptors for endocannabinoids including anandamide and 2-arachidonoylglycerol. Because these arachidonic acid metabolites possess a 20-carbon polyene chain as the alkyl terminal moiety, they are highly flexible with the potential to adopt multiple biologically relevant conformations, particularly those in a bent form. To better understand the molecu...... hiện toàn bộ
Ovarian cancer G protein coupled receptor 1 suppresses cell migration of MCF7 breast cancer cells via a Gα12/13-Rho-Rac1 pathway
Journal of Molecular Signaling - Tập 8 - Trang 1-8 - 2013
Jing Li, Bin Guo, Jing Wang, Xiaoyan Cheng, Yan Xu, Jianli Sang
Ovarian cancer G protein coupled receptor 1 (OGR1) mediates inhibitory effects on cell migration in human prostate and ovarian cancer cells. However, the mechanisms and signaling pathways that mediate these inhibitory effects are essentially unknown. MCF7 cell line was chosen as a model system to study the mechanisms by which OGR1 regulates cell migration, since it expresses very low levels of end...... hiện toàn bộ
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