Journal of Molecular Signaling

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Retinoic acid decreases ATF-2 phosphorylation and sensitizes melanoma cells to taxol-mediated growth inhibition
Journal of Molecular Signaling - Tập 3 - Trang 3
Ying Huang, Jennifer Minigh, Sarah Miles, Richard M. Niles
Src homology 2 (SH2) domain containing protein tyrosine phosphatase-1 (SHP-1) dephosphorylates VEGF Receptor-2 and attenuates endothelial DNA synthesis, but not migration*
Journal of Molecular Signaling - Tập 3 - Trang 1-13 - 2008
Resham Bhattacharya, Junhye Kwon, Enfeng Wang, Priyabrata Mukherjee, Debabrata Mukhopadhyay
Vascular endothelial growth factor receptor-2 (VEGFR-2, KDR), a receptor tyrosine kinase, regulates mitogenic, chemotactic, hyperpermeability, and survival signals in vascular endothelial cells in response to its ligand vascular permeability factor/ vascular endothelial growth factor (VPF/VEGF). SHP-1 is a protein tyrosine phosphatase known to negatively regulate signaling from receptors such as E...... hiện toàn bộ
Multiple paxillin binding sites regulate FAK function
Journal of Molecular Signaling - Tập 3 - Trang 1-11 - 2008
Danielle M Scheswohl, Jessica R Harrell, Zenon Rajfur, Guanghua Gao, Sharon L Campbell, Michael D Schaller
FAK localization to focal adhesions is essential for its activation and function. Localization of FAK is mediated through the C-terminal focal adhesion targeting (FAT) domain. Recent structural analyses have revealed two paxillin-binding sites in the FAT domain of FAK. To define the role of paxillin binding to each site on FAK, point mutations have been engineered to specifically disrupt paxillin ...... hiện toàn bộ
AKAP12 and AKAP5 form higher-order hetero-oligomers
Journal of Molecular Signaling - Tập 6 - Trang 1-12 - 2011
Shujuan Gao, Hsien-yu Wang, Craig C Malbon
The family of A-kinase-anchoring proteins, AKAPs, constitutes a group of molecular scaffolds that act to catalyze dynamic interactions of protein kinase A, protein kinase C, tyrosine kinases, G-protein-coupled receptors and ion channels. AKAP5 (MW ~47 kDa) and AKAP12 (MW ~191 kDa) homo-oligomerize, but whether or not such AKAPs can hetero-oligomerize into supermolecular scaffolds of increased comp...... hiện toàn bộ
Rad6B acts downstream of Wnt signaling to stabilize β-catenin: Implications for a novel Wnt/β-catenin target
Journal of Molecular Signaling - Tập 6 - Trang 6
Brigitte Gèrard, Larry Tait, Pratima Nangia‐Makker, Malathy P.V. Shekhar
Estradiol effects on the dopamine transporter – protein levels, subcellular location, and function
Journal of Molecular Signaling - Tập 1 - Trang 1-14 - 2006
Cheryl S Watson, Rebecca A Alyea, Bridget E Hawkins, Mary L Thomas, Kathryn A Cunningham, Adrian A Jakubas
The effects of estrogens on dopamine (DA) transport may have important implications for the increased incidence of neurological disorders in women during life stages when hormonal fluctuations are prevalent, e.g. during menarche, reproductive cycling, pregnancy, and peri-menopause. The activity of the DA transporter (DAT) was measured by the specific uptake of 3H-DA. We found that low concentratio...... hiện toàn bộ
Immature and mature species of the human Prostacyclin Receptor are ubiquitinated and targeted to the 26S proteasomal or lysosomal degradation pathways, respectively
Journal of Molecular Signaling - Tập 4 - Trang 1-23 - 2009
Peter D Donnellan, B Therese Kinsella
The human prostacyclin receptor (hIP) undergoes agonist-induced phosphorylation, desensitisation and internalisation and may be recycled to the plasma membrane or targeted for degradation by, as yet, unknown mechanism(s). Herein it was sought to investigate the turnover of the hIP under basal conditions and in response to cicaprost stimulation. It was established that the hIP is subject to low-lev...... hiện toàn bộ
EGF regulates tyrosine phosphorylation and membrane-translocation of the scaffold protein Tks5
Journal of Molecular Signaling - Tập 8 - Trang 1-8 - 2013
Anna Fekete, Gábor Bőgel, Szabolcs Pesti, Zalán Péterfi, Miklós Geiszt, László Buday
Tks5/FISH is a scaffold protein comprising of five SH3 domains and one PX domain. Tks5 is a substrate of the tyrosine kinase Src and is required for the organization of podosomes/invadopodia implicated in invasion of tumor cells. Recent data have suggested that a close homologue of Tks5, Tks4, is implicated in the EGF signaling. Here, we report that Tks5 is a component of the EGF signaling pathway...... hiện toàn bộ
TLN-4601 suppresses growth and induces apoptosis of pancreatic carcinoma cells through inhibition of Ras-ERK MAPK signaling
Journal of Molecular Signaling - Tập 5 - Trang 18
Paul M. Campbell, Nadia Boufaied, James J. Fiordalisi, Adrienne D. Cox, Pierre Falardeau, Channing J. Der, Henriette Gourdeau
Identification of endoglin-dependent BMP-2- induced genes in the murine periodontal ligament cell line PDL-L2
Journal of Molecular Signaling -
Osamu Ishibashi, Takashi Inui
Tổng số: 77   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 8