Journal of Medical Microbiology

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The epidemiology of acinetobacter infections in Hong Kong
Journal of Medical Microbiology - Tập 44 Số 5 - Trang 340-347 - 1996
Hong Siau, Kwok‐Yung Yuen, Edmond S.K., Pak‐Leung Ho, Wing Hang Luk
Modulation of antibiotic resistance and induction of a stress response in Pseudomonas aeruginosa by silver nanoparticles
Journal of Medical Microbiology - Tập 63 Số 6 - Trang 849-854 - 2014
Katarzyna Markowska, Anna Grudniak, Krzysztof Krawczyk, Izabela Wróbel-Pawelczyk, Krystyna I. Wolska
The objective of this study was to characterize the effects of silver nanoparticles on Pseudomonas aeruginosa. Their interactions with several conventional antibiotics and ability to induce a stress response were examined. Interactions between silver nanoparticles (AgNPs) and antibiotics against free-living cells and biofilm of P. aeruginosa... hiện toàn bộ
Humoral Immunity in mice Mediated by Monoclonal Antibodies Against the A and M Antigens of Brucella
Journal of Medical Microbiology - Tập 30 Số 1 - Trang 37-43 - 1989
J. N. Limet, Nicole Bosseray, Bruno Garin‐Bastuji, G Dubray, M Plommet
Prospects for control of mosquito-borne diseases
Journal of Medical Microbiology - Tập 48 Số 10 - Trang 879-881 - 1999
A. W. Sweeney
Specific IgG and IgM Antibody Responses in Herpes-Simplex-Virus Infections
Journal of Medical Microbiology - Tập 7 Số 3 - Trang 333-341 - 1974
J. B. Kurtz
Pre-treatment with Concanavalin-A increases resistance of mice to peritoneal infection by Serratia marcescens
Journal of Medical Microbiology - Tập 46 Số 3 - Trang 251-255 - 1997
Adriana Andrade Arraes, Luis Carlos Jabur Gaziri, Marilda Carlos Vidotto, Halha Ostrensky Saridakis, Ionice Felipe
The effect of humoral and cell-mediated immunity in resistance to systemic serratia infection
Journal of Medical Microbiology - Tập 36 Số 4 - Trang 245-249 - 1992
Yukio Kumagai, K. Okada, Yoshinori Sawae
Genomic and vaccine preclinical studies reveal a novel mouse-adapted Helicobacter pylori model for the hpEastAsia genotype in Southeast Asia
Journal of Medical Microbiology - Tập 73 Số 1 - 2024
Thị Kim Cúc Nguyễn, Hoang Dang Khoa, Thi Lan Phuong Nguyen, Thu Thuy Pham, Bao Ngoc Mach, Thi Chinh Nguyen, Thi Lan Pham, Paidamoyo M. Katsande, Huynh A. Hong, Huu Thai Duong, Anh N. Phan, Simon M. Cutting, Minh Thiet Vu, Văn Duy Nguyễn
Introduction. Helicobacter pylori infection is a major global health concern, linked to the development of various gastrointestinal diseases, including gastric cancer. To study the pathogenesis of H. pylori and develop effective intervention strategies, appropriate animal pathogen models that closely mimic human infection are essential. Gap statement. This study focuses on the understudied hpEastAsia genotype in Southeast Asia, a region marked by a high H. pylori infection rate. No mouse-adapted model strains has been reported previously. Moreover, it recognizes the urgent requirement for vaccines in developing countries, where overuse of antimicrobials is fuelling the emergence of resistance. Aim. This study aims to establish a novel mouse-adapted H. pylori model specific to the hpEastAsia genotype prevalent in Southeast Asia, focusing on comparative genomic and histopathological analysis of pathogens coupled with vaccine preclinical studies. Methodology. We collected and sequenced the whole genome of clinical strains of H. pylori from infected patients in Vietnam and performed comparative genomic analyses of H. pylori strains in Southeast Asia. In parallel, we conducted preclinical studies to assess the pathogenicity of the mouse-adapted H. pylori strain and the protective effect of a new spore-vectored vaccine candidate on male Mlac:ICR mice and the host immune response in a female C57BL/6 mouse model. Results. Genome sequencing and comparison revealed unique and common genetic signatures, antimicrobial resistance genes and virulence factors in strains HP22 and HP34; and supported clarithromycin-resistant HP34 as a representation of the hpEastAsia genotype in Vietnam and Southeast Asia. HP34-infected mice exhibited gastric inflammation, epithelial erosion and dysplastic changes that closely resembled the pathology observed in human H. pylori infection. Furthermore, comprehensive immunological characterization demonstrated a robust host immune response, including both mucosal and systemic immune responses. Oral vaccination with candidate vaccine formulations elicited a significant reduction in bacterial colonization in the model. Conclusion. Our findings demonstrate the successful development of a novel mouse-adapted H. pylori model for the hpEastAsia genotype in Vietnam and Southeast Asia. Our research highlights the distinctive genotype and pathogenicity of clinical hiện toàn bộ
Lysogeny and bacteriophage host range within the Burkholderia cepacia complex
Journal of Medical Microbiology - Tập 52 Số 6 - Trang 483-490 - 2003
Ross Langley, D. Kenna, Peter Vandamme, Rebecca Ure, John R. W. Govan
The Burkholderia cepacia complex comprises a group of nine closely related species that have emerged as life-threatening pulmonary pathogens in immunocompromised patients, particularly individuals with cystic fibrosis or chronic granulomatous disease. Attempts to explain the genomic plasticity, adaptability and virulence of the complex have paid little attention ...... hiện toàn bộ
Normal and tumour cervical cells respond differently to vaginal lactobacilli, independent of pH and lactate
Journal of Medical Microbiology - Tập 62 Số 7 - Trang 1065-1072 - 2013
Elahe Motevaseli, ‪Mahdieh Shirzad, Seyed Mohammad Akrami, Azam Sadat Mousavi, Akbar Mirsalehian, Mohammad Hossein Modarressi
Cervical cancer is a human papilloma virus (HPV)-related cancer, but most HPV infections are transient or intermittent and resolve spontaneously. Thus, other factors, such as cervical microflora, which are dominated by lactobacilli, must be involved in invasive cervical carcinoma development after HPV infection. Previous studies have demonstrated that lactobacilli have antitumour effects, ...... hiện toàn bộ
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