Journal of Experimental & Clinical Cancer Research
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SRSF10 stabilizes CDC25A by triggering exon 6 skipping to promote hepatocarcinogenesis
Journal of Experimental & Clinical Cancer Research - Tập 41 - Trang 1-19 - 2022
Alternative splicing (AS) events are extensively involved in the progression of
diverse tumors, but how serine/arginine-rich splicing Factor 10 (SRSF10) behaves
in hepatocellular carcinoma (HCC) has not been sufficiently studied. We aimed to
determine SRSF10 associated AS mechanisms and their effects on HCC progression.
The expression of SRSF10 in HCC tissues was examined, and the in vitro and in
...
ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42
Journal of Experimental & Clinical Cancer Research - - 2022
Abstract Background The extravasation capability of hepatocellular carcinoma
(HCC) cells plays a vital role in distant metastasis. However, the underlying
mechanism of extravasation in HCC lung metastasis remains largely unclear.
Methods The expression of ARHGEF37 in human HCC specimens and HCC cell lines was
examined by quantitative RT-PCR, western blot, and immunohistochemistry (IHC)
analyses. T...
Along with its favorable prognostic role, CLCA2 inhibits growth and metastasis of nasopharyngeal carcinoma cells via inhibition of FAK/ERK signaling
Journal of Experimental & Clinical Cancer Research - Tập 37 - Trang 1-14 - 2018
CLCA2 was reported as a tumor suppressor and disregulated in breast cancer.
However, its function in tumor growth and metastasis in NPC has rarely been
reported. In this study, we investigated the functional and molecular mechanisms
by which CLCA2 influences NPC. CLCA2 expression in human NPC cell lines and
tissues was examined via real-time PCR (RT-PCR), Western blot and IHC. The
biological roles...
AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma
Journal of Experimental & Clinical Cancer Research - Tập 41 - Trang 1-14 - 2022
Currently, multiple myeloma (MM) is still an incurable plasma cell malignancy in
urgent need of novel therapeutic targets and drugs. Bufalin was known as a
highly toxic but effective anti-cancer compound. We used Bufalin as a probe to
screen its potential targets by proteome microarray, in which AHSA1 was the
unique target of Bufalin. The effects of AHSA1 on cellular proliferation and
drug resista...
The autocrine loop of ALK receptor and ALKAL2 ligand is an actionable target in consensus molecular subtype 1 colon cancer
Journal of Experimental & Clinical Cancer Research - Tập 41 Số 1 - 2022
Abstract Background In the last years, several efforts have been made to
classify colorectal cancer (CRC) into well-defined molecular subgroups,
representing the intrinsic inter-patient heterogeneity, known as Consensus
Molecular Subtypes (CMSs). Methods In this work, we performed a meta-analysis of
CRC patients stratified into four CMSs. We identified a negative correlation
between a high level o...
YAP promotes autophagy and progression of gliomas via upregulating HMGB1
Journal of Experimental & Clinical Cancer Research - Tập 40 Số 1 - 2021
Abstract Background Due to the hypoxia and nutrient deficiency microenvironment,
glioblastoma (GBM) exhibits high autophagy activity and autophagy plays an
important role in the progression of GBM. However, the molecular mechanism of
autophagy in GBM progression remains unclear. The aim of this study is to delve
out the role and mechanism of yes-associated protein (YAP) in GBM autophagy and
progre...
HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis
Journal of Experimental & Clinical Cancer Research - Tập 43 Số 1
Abstract Background Metastasis is the leading cause of cancer-related death in
non-small cell lung cancer (NSCLC) patients. We previously showed that low HERC5
expression predicts early tumor dissemination and a dismal prognosis in NSCLC
patients. Here, we performed functional studies to unravel the mechanism
underlying the “metastasis-suppressor” effect of HERC5, with a focus on
mitochondrial met...
Constructing the HBV-human protein interaction network to understand the relationship between HBV and hepatocellular carcinoma
Journal of Experimental & Clinical Cancer Research - Tập 29 - Trang 1-10 - 2010
Epidemiological studies have clearly validated the association between hepatitis
B virus (HBV) infection and hepatocellular carcinoma (HCC). Patients with
chronic HBV infection are at increased risk of HCC, in particular those with
active liver disease and cirrhosis. We catalogued all published interactions
between HBV and human proteins, identifying 250 descriptions of HBV and human
protein inter...
A modified sentinel node and occult lesion localization (SNOLL) technique in non-palpable breast cancer: a pilot study
Journal of Experimental & Clinical Cancer Research - Tập 34 Số 1 - 2015
RNF8 promotes epithelial-mesenchymal transition of breast cancer cells
Journal of Experimental & Clinical Cancer Research - Tập 35 - Trang 1-14 - 2016
Epithelial-mesenchymal transition (EMT) is a crucial step for solid tumor
progression and plays an important role in cancer invasion and metastasis. RNF8
is an ubiquitin E3 ligase with RING domain, and plays essential roles in DNA
damage response and cell cycle regulation. However the role of RNF8 in the
pathogenesis of breast cancer is still unclear. The expression of RNF8 was
examined in differe...
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