Journal of Experimental & Clinical Cancer Research

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SRSF10 stabilizes CDC25A by triggering exon 6 skipping to promote hepatocarcinogenesis
Journal of Experimental & Clinical Cancer Research - Tập 41 - Trang 1-19 - 2022
Xiaoming Liu, Yongqiang Zheng, Mengqing Xiao, Xingyu Chen, Yuxing Zhu, Canxia Xu, Fen Wang, Zexian Liu, Ke Cao
Alternative splicing (AS) events are extensively involved in the progression of diverse tumors, but how serine/arginine-rich splicing Factor 10 (SRSF10) behaves in hepatocellular carcinoma (HCC) has not been sufficiently studied. We aimed to determine SRSF10 associated AS mechanisms and their effects on HCC progression. The expression of SRSF10 in HCC tissues was examined, and the in vitro and in ...... hiện toàn bộ
ARHGEF37 overexpression promotes extravasation and metastasis of hepatocellular carcinoma via directly activating Cdc42
Journal of Experimental & Clinical Cancer Research - - 2022
Xin Zhang, Ren Lang, Junhua Wu, Rongni Feng, Yunyang Chen, Ronggang Li, Meimei Wu, Mingzhu Zheng, Xing Gui Wu, Wei Luo, Hongle He, Yanming Huang, Miaoling Tang, Jun Li
Abstract Background The extravasation capability of hepatocellular carcinoma (HCC) cells plays a vital role in distant metastasis. However, the underlying mechanism of extravasation in HCC lung metastasis remains largely unclear. ... hiện toàn bộ
Along with its favorable prognostic role, CLCA2 inhibits growth and metastasis of nasopharyngeal carcinoma cells via inhibition of FAK/ERK signaling
Journal of Experimental & Clinical Cancer Research - Tập 37 - Trang 1-14 - 2018
Yuan-Yuan Qiang, Chang-Zhi Li, Rui Sun, Li-Sheng Zheng, Li-Xia Peng, Jun-Ping Yang, Dong-Fang Meng, Yan-Hong Lang, Yan Mei, Ping Xie, Liang Xu, Yun Cao, Wen-Wen Wei, Li Cao, Hao Hu, Qin Yang, Dong-Hua Luo, Ying-Ying Liang, Bi-Jun Huang, Chao-Nan Qian
CLCA2 was reported as a tumor suppressor and disregulated in breast cancer. However, its function in tumor growth and metastasis in NPC has rarely been reported. In this study, we investigated the functional and molecular mechanisms by which CLCA2 influences NPC. CLCA2 expression in human NPC cell lines and tissues was examined via real-time PCR (RT-PCR), Western blot and IHC. The biological roles...... hiện toàn bộ
AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma
Journal of Experimental & Clinical Cancer Research - Tập 41 - Trang 1-14 - 2022
Chunyan Gu, Yajun Wang, Lulin Zhang, Li Qiao, Shanliang Sun, Miaomiao Shao, Xiaozhu Tang, Pinggang Ding, Chao Tang, Yuhao Cao, Yanyan Zhou, Mengjie Guo, Rongfang Wei, Nianguang Li, Yibei Xiao, Jinao Duan, Ye Yang
Currently, multiple myeloma (MM) is still an incurable plasma cell malignancy in urgent need of novel therapeutic targets and drugs. Bufalin was known as a highly toxic but effective anti-cancer compound. We used Bufalin as a probe to screen its potential targets by proteome microarray, in which AHSA1 was the unique target of Bufalin. The effects of AHSA1 on cellular proliferation and drug resista...... hiện toàn bộ
The autocrine loop of ALK receptor and ALKAL2 ligand is an actionable target in consensus molecular subtype 1 colon cancer
Journal of Experimental & Clinical Cancer Research - Tập 41 Số 1 - 2022
Martina Mazzeschi, Michela Sgarzi, Donatella Romaniello, Valerio Gelfo, Carola Cavallo, Francesca Ambrosi, Alessandra Morselli, Carmen Miano, Noemi Laprovitera, Cinzia Girone, Manuela Ferracin, Spartaco Santi, Karim Rihawi, Andrea Ardizzoni, Michelangelo Fiorentino, Gabriele D’Uva, Balázs Györffy, Ruth H. Palmer, Mattia Lauriola
Abstract Background In the last years, several efforts have been made to classify colorectal cancer (CRC) into well-defined molecular subgroups, representing the intrinsic inter-patient heterogeneity, known as Consensus Molecular Subtypes (CMSs). ...... hiện toàn bộ
YAP promotes autophagy and progression of gliomas via upregulating HMGB1
Journal of Experimental & Clinical Cancer Research - Tập 40 Số 1 - 2021
Min Zhao, Yu Zhang, Yang Jiang, Kai Wang, Xiang Wang, Ding Zhou, Xiaogang Wang, Rutong Yu, Xiuping Zhou
Abstract Background Due to the hypoxia and nutrient deficiency microenvironment, glioblastoma (GBM) exhibits high autophagy activity and autophagy plays an important role in the progression of GBM. However, the molecular mechanism of autophagy in GBM progression remains unclear. The aim of this stud...... hiện toàn bộ
HERC5 downregulation in non-small cell lung cancer is associated with altered energy metabolism and metastasis
Journal of Experimental & Clinical Cancer Research - Tập 43 Số 1
Svenja Schneegans, Jana Löptien, Angelika Mojzisch, Desirée Loreth, Oliver Kretz, Christoph Raschdorf, Annkathrin Hanssen, Antonia Gocke, Bente Siebels, K. Gunasekaran, Yi Ding, Leticia Oliveira‐Ferrer, Laura Brylka, Thorsten Schinke, Hartmut Schlüter, Ilkka Paatero, Hannah Voß, Stefan Werner, Klaus Pantel, Harriet Wikman
Abstract Background Metastasis is the leading cause of cancer-related death in non-small cell lung cancer (NSCLC) patients. We previously showed that low HERC5 expression predicts early tumor dissemination and a dismal prognosis in NSCLC patients. Here, we performed functional studies to unravel the...... hiện toàn bộ
Constructing the HBV-human protein interaction network to understand the relationship between HBV and hepatocellular carcinoma
Journal of Experimental & Clinical Cancer Research - Tập 29 - Trang 1-10 - 2010
Zhong-Jun Wu, Yu Zhu, De-Rong Huang, Zhi-Qiang Wang
Epidemiological studies have clearly validated the association between hepatitis B virus (HBV) infection and hepatocellular carcinoma (HCC). Patients with chronic HBV infection are at increased risk of HCC, in particular those with active liver disease and cirrhosis. We catalogued all published interactions between HBV and human proteins, identifying 250 descriptions of HBV and human protein inter...... hiện toàn bộ
RNF8 promotes epithelial-mesenchymal transition of breast cancer cells
Journal of Experimental & Clinical Cancer Research - Tập 35 - Trang 1-14 - 2016
Jingyu Kuang, Li Li, Limei Guo, Yanrong Su, Yuxuan Wang, Yongjie Xu, Xiaozhen Wang, Shucong Meng, Liandi Lei, Luzheng Xu, Genze Shao
Epithelial-mesenchymal transition (EMT) is a crucial step for solid tumor progression and plays an important role in cancer invasion and metastasis. RNF8 is an ubiquitin E3 ligase with RING domain, and plays essential roles in DNA damage response and cell cycle regulation. However the role of RNF8 in the pathogenesis of breast cancer is still unclear. The expression of RNF8 was examined in differe...... hiện toàn bộ
A modified sentinel node and occult lesion localization (SNOLL) technique in non-palpable breast cancer: a pilot study
Journal of Experimental & Clinical Cancer Research - Tập 34 Số 1 - 2015
Giulia Anna Follacchio, Francesco Monteleone, Paolo Anibaldi, Giuseppe De Vincentis, Silvia Iacobelli, Raffaele Merola, Valerio D’Orazi, Massimo Monti, Vittorio Pasta
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