Journal of Experimental & Clinical Cancer Research

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SRSF10 stabilizes CDC25A by triggering exon 6 skipping to promote hepatocarcinogenesis
Journal of Experimental & Clinical Cancer Research - Tập 41 - Trang 1-19 - 2022
Xiaoming Liu, Yongqiang Zheng, Mengqing Xiao, Xingyu Chen, Yuxing Zhu, Canxia Xu, Fen Wang, Zexian Liu, Ke Cao
Alternative splicing (AS) events are extensively involved in the progression of diverse tumors, but how serine/arginine-rich splicing Factor 10 (SRSF10) behaves in hepatocellular carcinoma (HCC) has not been sufficiently studied. We aimed to determine SRSF10 associated AS mechanisms and their effects on HCC progression. The expression of SRSF10 in HCC tissues was examined, and the in vitro and in ...... hiện toàn bộ
AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma
Journal of Experimental & Clinical Cancer Research - Tập 41 - Trang 1-14 - 2022
Chunyan Gu, Yajun Wang, Lulin Zhang, Li Qiao, Shanliang Sun, Miaomiao Shao, Xiaozhu Tang, Pinggang Ding, Chao Tang, Yuhao Cao, Yanyan Zhou, Mengjie Guo, Rongfang Wei, Nianguang Li, Yibei Xiao, Jinao Duan, Ye Yang
Currently, multiple myeloma (MM) is still an incurable plasma cell malignancy in urgent need of novel therapeutic targets and drugs. Bufalin was known as a highly toxic but effective anti-cancer compound. We used Bufalin as a probe to screen its potential targets by proteome microarray, in which AHSA1 was the unique target of Bufalin. The effects of AHSA1 on cellular proliferation and drug resista...... hiện toàn bộ
Elesclomol: a copper ionophore targeting mitochondrial metabolism for cancer therapy
Journal of Experimental & Clinical Cancer Research - Tập 41 - Trang 1-13 - 2022
Peijie Zheng, Chuntao Zhou, Liuyi Lu, Bin Liu, Yuemin Ding
Elesclomol is an anticancer drug that targets mitochondrial metabolism. In the past, elesclomol was recognized as an inducer of oxidative stress, but now it has also been found to suppress cancer by inducing cuproptosis. Elesclomol’s anticancer activity is determined by the dependence of cancer on mitochondrial metabolism. The mitochondrial metabolism of cancer stem cells, cancer cells resistant t...... hiện toàn bộ
RNAi-mediated silencing of CD147 inhibits tumor cell proliferation, invasion and increases chemosensitivity to cisplatin in SGC7901 cells in vitro
Journal of Experimental & Clinical Cancer Research - Tập 29 - Trang 1-8 - 2010
Bo Wang, Yong-Fei Xu, Bang-Shun He, Yu-Qin Pan, Li-Rong Zhang, Chan Zhu, Li-Li Qu, Shu-Kui Wang
CD147 is a widely distributed cell surface glycoprotein that belongs to the Ig superfamily. CD147 has been implicated in numerous physiological and pathological activities. Enriched on the surface of many tumor cells, CD147 promotes tumor growth, invasion, metastasis and angiogenesis and confers resistance to some chemotherapeutic drugs. In this study, we investigated the possible role of CD147 in...... hiện toàn bộ
Correction: The epigenetic downregulation of LncGHRLOS mediated by RNA m6A methylase ZCCHC4 promotes colorectal cancer tumorigenesis
Journal of Experimental & Clinical Cancer Research - - 2024
Ke Chen, Jingcheng Zhang, Lei Meng, Lingshang Kong, Ming Lu, Zhengguang Wang, Wenbin Wang
A SUMOylation-dependent HIF-1α/CLDN6 negative feedback mitigates hypoxia-induced breast cancer metastasis
Journal of Experimental & Clinical Cancer Research - Tập 39 - Trang 1-15 - 2020
Yiyang Jia, Yantong Guo, Qiu Jin, Huinan Qu, Da Qi, Peiye Song, Xiaoli Zhang, Xinqi Wang, Wenhong Xu, Yuan Dong, Yingying Liang, Chengshi Quan
We have previously described CLDN6 as a tumor suppressor gene in breast cancer. Here, a new finding is that CLDN6 was upregulated under hypoxia, a commonly recognized factor that promotes tumor metastasis. In this study, we aim to explain this confusing finding and delineate the role of CLDN6 in the breast cancer metastasis induced by hypoxia. RNAi and ChIP assays were used to confirm that CLDN6 i...... hiện toàn bộ
A positive feedback loop between gastric cancer cells and tumor-associated macrophage induces malignancy progression
Journal of Experimental & Clinical Cancer Research - Tập 41 - Trang 1-17 - 2022
Haiyan Piao, Lingfeng Fu, Yuxin Wang, Yang Liu, Yue Wang, Xiangyu Meng, Dong Yang, Xiang Xiao, Jun Zhang
Hypoxia and inflammation tumor microenvironment (TME) play a crucial role in tumor development and progression. Although increased understanding of TME contributed to gastric cancer (GC) progression and prognosis, the direct interaction between macrophage and GC cells was not fully understood. Hypoxia and normoxia macrophage microarrays of GEO database was analyzed. The peripheral blood mononuclea...... hiện toàn bộ
GABPA-activated TGFBR2 transcription inhibits aggressiveness but is epigenetically erased by oncometabolites in renal cell carcinoma
Journal of Experimental & Clinical Cancer Research - Tập 41 Số 1 - 2022
Zhiqing Fang, Ning Zhang, Xiaotian Yuan, Xiangling Xing, Xiaofeng Li, Qin Xin, Zhengfang Liu, Shiyong Neo, Cheng Liu, Feng Kong, Magnus Björkholm, Yi‐Ming Fan, Dawei Xu
Abstract Background The ETS transcription factor GABPA has long been thought of as an oncogenic factor and recently suggested as a target for cancer therapy due to its critical effect on telomerase activation, but the role of GABPA in clear cell renal cell carcinoma (ccRCC) is unclear. In addition, ...... hiện toàn bộ
Identification of a novel subpopulation of Caspase-4 positive non-small cell lung Cancer patients
Journal of Experimental & Clinical Cancer Research - Tập 39 - Trang 1-17 - 2020
Michela Terlizzi, Chiara Colarusso, Ilaria De Rosa, Pasquale Somma, Carlo Curcio, Rita P. Aquino, Luigi Panico, Rosario Salvi, Federica Zito Marino, Gerardo Botti, Aldo Pinto, Rosalinda Sorrentino
Therapy/prognosis of Non-Small Cell Lung Cancer (NSCLC) patients are strongly related to gene alteration/s or protein expression. However, more than 50% of NSCLC patients are negative to key drugable biomarkers. We used human samples of NSCLC and mouse models of lung adenocarcinoma. We showed that caspase-4 was highly present in the tumor mass compared to non-cancerous human tissues. Interestingly...... hiện toàn bộ
Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling
Journal of Experimental & Clinical Cancer Research - Tập 42 - Trang 1-22 - 2023
Zixian Huang, Xi Rui, Chen Yi, Yongju Chen, Rui Chen, Yancan Liang, Yan Wang, Weicheng Yao, Xiaoding Xu, Zhiquan Huang
EGFR is an important signal involved in tumor growth that can induce tumor metastasis and drug resistance. Exploring targets for effective EGFR regulation is an important topic in current research and drug development. Inhibiting EGFR can effectively inhibit the progression and lymph node metastasis of oral squamous cell carcinoma (OSCC) because OSCC is a type of cancer with high EGFR expression. ...... hiện toàn bộ
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