Journal of Experimental & Clinical Cancer Research
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Alpha6beta4 integrin crosslinking induces EGFR clustering and promotes EGF-mediated Rho activation in breast cancer
Journal of Experimental & Clinical Cancer Research - Tập 28 - Trang 1-10 - 2009
The α6β4 integrin is overexpressed in the basal subtype of breast cancer and plays an important role in tumor cell motility and invasion. EGFR is also overexpressed in the basal subtype of breast cancer, and crosstalk between α6β4 integrin and EGFR appears to be important in tumor progression. We evaluated the effects of α6β4 crosslinking on the distribution and function of EGFR in breast carcinom...... hiện toàn bộ
Limoniastrum guyonianum aqueous gall extract induces apoptosis in human cervical cancer cells involving p16INK4A re-expression related to UHRF1 and DNMT1 down-regulationAbstract
Several reports have described the potential effects of natural compounds as anti-cancer agents in vitro as well as in vivo . The aim of this study was to evaluate the anti-cancer effect of Limoniastrum guyonianum aqueous gall extract (G extract) and luteolin in the h... ... hiện toàn bộ
Journal of Experimental & Clinical Cancer Research - - 2013
Calycosin ức chế sự phát triển của tế bào ung thư vú in vitro và in vivo thông qua tín hiệu WDR7-7-GPR30 Dịch bởi AI
Journal of Experimental & Clinical Cancer Research - Tập 36 - Trang 1-13 - 2017
Về mặt lâm sàng, ung thư vú thường được phân loại thành hai kiểu phụ dựa trên sự hiện diện của thụ thể estrogen: thụ thể dương tính (ER+) hoặc thụ thể âm tính (ER−). Phytoestrogen calycosin đã được chứng minh là có khả năng ức chế sự phát triển của các tế bào ER+ có thể thông qua một vòng phản hồi liên quan đến miR-375, RAS dexamethasone-induced 1 (RASD1) và ERα. Tuy nhiên, cách mà calycosin tác đ...... hiện toàn bộ
#Calycosin; ung thư vú; WDR7-7; GPR30; tín hiệu không mã hóa
Actin-like protein 6A/MYC/CDK2 axis confers high proliferative activity in triple-negative breast cancer
Journal of Experimental & Clinical Cancer Research - Tập 40 - Trang 1-18 - 2021
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with high proliferative activity. TNBC tumors exhibit elevated MYC expression and altered expression of MYC regulatory genes, which are associated with tumor progression and poor prognosis; however, the underlying mechanisms by which MYC retains its high expression and mediates TNBC tumorigenesis require further explora...... hiện toàn bộ
Paclitaxel alters the expression and specific activity of deoxycytidine kinase and cytidine deaminase in non-small cell lung cancer cell lines
Journal of Experimental & Clinical Cancer Research - Tập 28 - Trang 1-11 - 2009
We observed that paclitaxel altered the pharmacokinetic properties of gemcitabine in patients with non-small cell lung cancer (NSCLC) and limited the accumulation of gemcitabine and its metabolites in various primary and immortalized human cells. Therefore, we classified the drug-drug interaction and the effects of paclitaxel on deoxycytidine kinase (dCK) and cytidine deaminase (CDA) in three NSCL...... hiện toàn bộ
Hedgehog-Gli1-derived exosomal circ-0011536 mediates peripheral neural remodeling in pancreatic cancer by modulating the miR-451a/VGF axis
Journal of Experimental & Clinical Cancer Research - Tập 42 - Trang 1-18 - 2023
Hedgehog-Gli1 signaling induces development of two common neurological features seen in pancreatic ductal adenocarcinoma (PDAC): peripheral neural invasion (PNI) and peripheral neural remodeling (PNR). However, the underlying molecular mechanisms in cancer cells and nerves within Gli1-derived PNR have not previously been comprehensively analyzed. In this study, RNA sequencing was used to screen me...... hiện toàn bộ
Identification of novel early pancreatic cancer biomarkers KIF5B and SFRP2 from “first contact” interactions in the tumor microenvironment
Journal of Experimental & Clinical Cancer Research - Tập 41 - Trang 1-22 - 2022
Pancreatic cancer is one of the most difficult cancers to detect early and most patients die from complications arising due to distant organ metastases. The lack of bona fide early biomarkers is one of the primary reasons for late diagnosis of pancreatic cancer. It is a multifactorial disease and warrants a novel approach to identify early biomarkers. In order to characterize the proteome, Extrace...... hiện toàn bộ
Long non-coding RNA CCDC183-AS1 acts AS a miR-589-5p sponge to promote the progression of hepatocellular carcinoma through regulating SKP1 expressionAbstract
Background
Hepatocellular carcinoma (HCC) is a common type of malignant human cancer with high morbidity and poor prognosis, causing numerous deaths per year worldwide. Growing evidence has been demonstrated that long non-coding RNAs (lncRNAs) are closely associated with hepatocarcinogenesi... ... hiện toàn bộ
Journal of Experimental & Clinical Cancer Research - Tập 40 Số 1 - 2021
Targeting metastatic breast cancer with peptide epitopes derived from autocatalytic loop of Prss14/ST14 membrane serine protease and with monoclonal antibodies
Journal of Experimental & Clinical Cancer Research - Tập 38 - Trang 1-17 - 2019
In order to develop a new immunotherapeutic agent targeting metastatic breast cancers, we chose to utilize autocatalytic feature of the membrane serine protease Prss14/ST14, a specific prognosis marker for ER negative breast cancer as a target molecule. The study was conducted using three mouse breast cancer models, 4 T1 and E0771 mouse breast cancer cells into their syngeneic hosts, and an MMTV-P...... hiện toàn bộ
Blockade of novel immune checkpoints and new therapeutic combinations to boost antitumor immunity
Journal of Experimental & Clinical Cancer Research - Tập 41 - Trang 1-24 - 2022
Immunotherapy has emerged as a promising strategy for boosting antitumoral immunity. Blockade of immune checkpoints (ICs), which regulate the activity of cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells has proven clinical benefits. Antibodies targeting CTLA-4, PD-1, and PD-L1 are IC-blockade drugs approved for the treatment of various solid and hematological malignancies. However, a l...... hiện toàn bộ
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