Journal of Computational Neuroscience
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Normal mode dynamics of voltage-gated K+ channels: gating principle, opening mechanism, and inhibition
Journal of Computational Neuroscience - Tập 38 - Trang 83-88 - 2014
Voltage-dependent potassium channels open in response to changes in membrane potential and become partially inactivated upon binding of inhibitors. Here we calculate normal mode motion of two voltage-dependent K+ channels, KvAP and Shaker, and their complexes with inhibitors and address the gating principle, opening mechanism, and inhibition. The normal modes indicate that pore expansion and chann......
Tuning Neocortical Pyramidal Neurons between Integrators and Coincidence Detectors
Journal of Computational Neuroscience - - 2003
Do cortical neurons operate as integrators or as coincidence detectors? Despite the importance of this question, no definite answer has been given yet, because each of these two views can find its own experimental support. Here we investigated this question using models of morphologically-reconstructed neocortical pyramidal neurons under in vivo like conditions. In agreement with experiments we fi......
Modeling the response of a population of olfactory receptor neurons to an odorant
Journal of Computational Neuroscience - - 2009
We modeled the firing rate of populations of olfactory receptor neurons (ORNs) responding to an odorant at different concentrations. Two cases were considered: a population of ORNs that all express the same olfactory receptor (OR), and a population that expresses many different ORs. To take into account ORN variability, we replaced single parameter values in a biophysical ORN model with values dra......
Intermittency in the Hodgkin-Huxley model
Journal of Computational Neuroscience - Tập 43 - Trang 115-125 - 2017
We show that action potentials in the Hodgkin-Huxley neuron model result from a type I intermittency phenomenon that occurs in the proximity of a saddle-node bifurcation of limit cycles. For the Hodgkin-Huxley spatially extended model, describing propagation of action potential along axons, we show the existence of type I intermittency and a new type of chaotic intermittency, as well as space prop......
Additional Efficient Computation of Branched Nerve Equations: Adaptive Time Step and Ideal Voltage Clamp
Journal of Computational Neuroscience - Tập 8 - Trang 209-226 - 2000
Various improvements are described for the simulation of biophysically and anatomically detailed compartmental models of single neurons and networks of neurons. These include adaptive time-step integration and a reordering of the circuit matrix to allow ideal voltage clamp of arbitrary nodes. We demonstrate how the adaptive time-step method can give equivalent accuracy as a fixed time-step method ......
Phương pháp phân tích dữ liệu khám phá để xác định các vùng não và tần số quan tâm từ các ghi chép thần kinh quy mô lớn Dịch bởi AI
Journal of Computational Neuroscience - Tập 46 - Trang 3-17 - 2018
Ghi chép não toàn diện với độ phân giải cao có tiềm năng phát hiện ra những chức năng chưa được biết đến, nhưng cũng đặt ra thách thức về cách tìm ra các mối liên hệ giữa não và hành vi khi phải đối mặt với một số lượng lớn các vùng và tần số quang phổ. Trong bài báo này, chúng tôi đề xuất một phương pháp phân tích dữ liệu khám phá, sàng lọc một khối lượng lớn các ghi chép thần kinh đa biến nhằm t......
Modeling cortical spreading depression induced by the hyperactivity of interneurons
Journal of Computational Neuroscience - Tập 47 - Trang 125-140 - 2019
Cortical spreading depression (CSD) is a wave of transient intense neuronal firing leading to a long lasting depolarizing block of neuronal activity. It is a proposed pathological mechanism of migraine with aura. Some forms of migraine are associated with a genetic mutation of the Nav1.1 channel, resulting in its gain of function and implying hyperexcitability of interneurons. This leads to the co......
Role of Calcium Electrogenesis in Apical Dendrites: Generation of Intrinsic Oscillations by an Axial Current
Journal of Computational Neuroscience - Tập 7 - Trang 41-53 - 1999
Dendrites are covered with conductances whose function is still mysterious. Using intracellular recording and calcium imaging, we describe an electrogenic band of calcium channels in distal apical dendrites of layer 5 pyramidal neurons (Yuste et al., 1994). We now explore the functional consequences of this distal electrogenic area with multicompartmental numerical simulations. A calcium imaging a......
A Predictive Reinforcement Model of Dopamine Neurons for Learning Approach Behavior
Journal of Computational Neuroscience - Tập 6 - Trang 191-214 - 1999
A neural network model of how dopamine and prefrontal cortex activity guides short- and long-term information processing within the cortico-striatal circuits during reward-related learning of approach behavior is proposed. The model predicts two types of reward-related neuronal responses generated during learning: (1) cell activity signaling errors in the prediction of the expected time of reward ......
Model of Familiarity Discrimination in the Perirhinal Cortex
Journal of Computational Neuroscience - Tập 10 - Trang 5-23 - 2001
Much evidence indicates that recognition memory involves two separable processes, recollection and familiarity discrimination, with familiarity discrimination being dependent on the perirhinal cortex of the temporal lobe. Here, we describe a new neural network model designed to mimic the response patterns of perirhinal neurons that signal information concerning the novelty or familiarity of stimul......
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