Journal of Computational Neuroscience
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Transfer entropy—a model-free measure of effective connectivity for the neurosciences
Journal of Computational Neuroscience - - 2011
Ring models of binocular rivalry and fusion
Journal of Computational Neuroscience - Tập 48 - Trang 193-211 - 2020
When similar visual stimuli are presented binocularly to both eyes, one perceives a fused single image. However, when the two stimuli are distinct, one does not perceive a single image; instead, one perceives binocular rivalry. That is, one perceives one of the stimulated patterns for a few seconds, then the other for few seconds, and so on – with random transitions between the two percepts. Most ......
Systems-level modeling of neuronal circuits for leech swimming
Journal of Computational Neuroscience - Tập 22 - Trang 21-38 - 2006
This paper describes a mathematical model of the neuronal central pattern generator (CPG) that controls the rhythmic body motion of the swimming leech. The systems approach is employed to capture the neuronal dynamics essential for generating coordinated oscillations of cell membrane potentials by a simple CPG architecture with a minimal number of parameters. Based on input/output data from physio......
Encoding certainty in bump attractors
Journal of Computational Neuroscience - Tập 37 - Trang 29-48 - 2013
Persistent activity in neuronal populations has been shown to represent the spatial position of remembered stimuli. Networks that support bump attractors are often used to model such persistent activity. Such models usually exhibit translational symmetry. Thus activity bumps are neutrally stable, and perturbations in position do not decay away. We extend previous work on bump attractors by constru......
An integrate-and-fire model for synchronized bursting in a network of cultured cortical neurons
Journal of Computational Neuroscience - Tập 21 - Trang 227-241 - 2006
It has been suggested that spontaneous synchronous neuronal activity is an essential step in the formation of functional networks in the central nervous system. The key features of this type of activity consist of bursts of action potentials with associated spikes of elevated cytoplasmic calcium. These features are also observed in networks of rat cortical neurons that have been formed in culture.......
Normal mode dynamics of voltage-gated K+ channels: gating principle, opening mechanism, and inhibition
Journal of Computational Neuroscience - Tập 38 - Trang 83-88 - 2014
Voltage-dependent potassium channels open in response to changes in membrane potential and become partially inactivated upon binding of inhibitors. Here we calculate normal mode motion of two voltage-dependent K+ channels, KvAP and Shaker, and their complexes with inhibitors and address the gating principle, opening mechanism, and inhibition. The normal modes indicate that pore expansion and chann......
Control of firing patterns by two transient potassium currents: leading spike, latency, bistability
Journal of Computational Neuroscience - Tập 31 - Trang 117-136 - 2010
Transient potassium currents distinctively affect firing properties, particularly in regulating the latency before repetitive firing. Pyramidal cells of the dorsal cochlear nucleus (DCN) have two transient potassium currents, I
Kif and I
Kis, fast and slowly inactivating, respectively, and they exhibit firing patterns with dramatically variable laten......
Tuning Neocortical Pyramidal Neurons between Integrators and Coincidence Detectors
Journal of Computational Neuroscience - - 2003
Do cortical neurons operate as integrators or as coincidence detectors? Despite the importance of this question, no definite answer has been given yet, because each of these two views can find its own experimental support. Here we investigated this question using models of morphologically-reconstructed neocortical pyramidal neurons under in vivo like conditions. In agreement with experiments we fi......
Frontotemporal dementia patients exhibit deficits in predictive saccades
Journal of Computational Neuroscience - Tập 49 - Trang 357-369 - 2020
Prediction and time estimation are all but required for motor function in everyday life. In the context of eye movements, for instance, they allow predictive saccades and eye re-acceleration in anticipation of a target re-appearance. While the neural pathways involved are not fully understood, it is known that the frontal lobe plays an important role. As such, neurological disorders that affect it......
Cross-trial correlation analysis of evoked potentials reveals arousal-related attenuation of thalamo-cortical coupling
Journal of Computational Neuroscience - - 2010
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