Journal of Clinical Endocrinology and Metabolism
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Corticotropin and Cortisol Secretion after Central 5-Hydroxytryptamine-1A (5-HT<sub>1A</sub>) Receptor Activation: Effects of 5-HT Receptor and<i>β</i>-Adrenoceptor Antagonists
Journal of Clinical Endocrinology and Metabolism - Tập 70 Số 3 - Trang 670-674 - 1990
Regulation of Fas Ligand Expression by IL-8 in Human Endometrium Numerous cytokines and growth factors are synthesized in the endometrium. IL-8 is one of these cytokines regulating endometrial function. It is a neutrophil chemoattractant/ activating factor and a potent angiogenic agent. IL-8 is elevated in the peritoneal fluid of women with endometriosis. We have previously demonstrated a direct proliferative effect of IL-8 on endometrial stromal cells. We hypothesized that increased levels of IL-8 in the endometriotic environment could up- regulate Fas ligand (FasL) expression in endometrial cells and may be relevant for the development of a relative local immunotolerance in endometriosis by inducing apoptosis of cytotoxic T lymphocytes. To test our hypothesis, we studied the in vitro regulation of FasL expression and apoptosis by IL-8 in endometrial cells. Western blot analysis in endometrial stromal, glandular, and Ishikawa cells revealed that IL-8 up- regulated FasL protein expression in these cells. By semiquantitative RT-PCR analysis, IL-8 does not alter the expression of either Fas or FasL mRNA levels in these cells. Immunocytochemistry results from endometrial stromal cells treated with IL-8 demonstrated an up-regulation of FasL protein expression. IL-8 decreased apoptosis rate in endometrial stromal cells as evaluated by terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick end-labeling assay. We observed an increased apoptotic rate in Jurkat (T lymphocyte line) cells plated on endometrial stromal cells previously treated with IL-8. We speculate that increased FasL expression by IL-8 may induce apoptosis of T lymphocytes and thus produce a local immunotolerant environment for the development of ectopic implants.
Journal of Clinical Endocrinology and Metabolism - Tập 87 Số 8 - Trang 3921-3927 - 2002
ENDOCRINE AND OTHER CLINICAL MANIFESTATIONS OF HYPOTHALAMIC DISEASE A SURVEY OF 60 CASES, WITH AUTOPSIES*
Journal of Clinical Endocrinology and Metabolism - Tập 14 Số 1 - Trang 13-31 - 1954
BLOOD LEVELS OF 17-HYDROXYCORTICOSTEROIDS IN NORMAL PREGNANCY
Journal of Clinical Endocrinology and Metabolism - Tập 13 Số 8 - Trang 898-902 - 1953
The Effect of a Short Sprint on Postexercise Whole-Body Glucose Production and Utilization Rates in Individuals with Type 1 Diabetes Mellitus
Context:
Recently we showed that a 10-sec maximal sprint effort performed before or after moderate intensity exercise can prevent early hypoglycemia during recovery in individuals with type 1 diabetes mellitus (T1DM). However, the mechanisms underlying this protective effect of sprinting are still unknown.
Objective:
The objective of the study was to test the hypothesis that short duration sprinting increases blood glucose levels via a disproportionate increase in glucose rate of appearance (Ra) relative to glucose rate of disappearance (Rd).
Subjects and Experimental Design:
Eight T1DM participants were subjected to a euglycemic-euinsulinemic clamp and, together with nondiabetic participants, were infused with [6,6-2H]glucose before sprinting for 10 sec and allowed to recover for 2 h.
Results:
In response to sprinting, blood glucose levels increased by 1.2 ± 0.2 mmol/liter (P < 0.05) within 30 min of recovery in T1DM participants and remained stable afterward, whereas glycemia rose by only 0.40 ± 0.05 mmol/liter in the nondiabetic group. During recovery, glucose Ra did not change in both groups (P > 0.05), but glucose Rd in the nondiabetic and diabetic participants fell rapidly after exercise before returning within 30 min to preexercise levels. After sprinting, the levels of plasma epinephrine, norepinephrine, and GH rose transiently in both experimental groups (P < 0.05).
Conclusion:
A sprint as short as 10 sec can increase plasma glucose levels in nondiabetic and T1DM individuals, with this rise resulting from a transient decline in glucose Rd rather than from a disproportionate rise in glucose Ra relative to glucose Rd as reported with intense aerobic exercise.
Journal of Clinical Endocrinology and Metabolism - Tập 97 Số 11 - Trang 4193-4200 - 2012
Type II Estrogen-Binding Sites and 17<i>β</i>-Hydroxysteroid Dehydrogenase Activity in Human Peripheral Blood Mononuclear Cells*
Journal of Clinical Endocrinology and Metabolism - Tập 67 Số 5 - Trang 888-892 - 1988
Dehydroepiandrosterone (DHEA): a fountain of youth?
Journal of Clinical Endocrinology and Metabolism - Tập 81 Số 9 - Trang 3147-3151 - 1996
Dehydroepiandrosterone Sulfate Levels Are Associated with More Favorable Cognitive Function in Women
Journal of Clinical Endocrinology and Metabolism - Tập 93 Số 3 - Trang 801-808 - 2008
Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood
Journal of Clinical Endocrinology and Metabolism - Tập 59 Số 3 - Trang 551-555 - 1984
Increase in Urinary Cortisol Excretion and Memory Declines: MacArthur Studies of Successful Aging
Journal of Clinical Endocrinology and Metabolism - Tập 82 Số 8 - Trang 2458-2465 - 1997
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