Journal of Chromatographic Science

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Liquid Chromatographic Method Development for Quantification of Inorganic Nitrite and Nitrate Impurities from Nitroglycerin Drug Substance by Using Ion-Pair Reagents with Liquid–Liquid Extraction Technique
Journal of Chromatographic Science - Tập 58 Số 1 - Trang 22-30 - 2020
Pritesh R. Desai, Priti Mehta, Avani Chokshi
Abstract A large number of laboratory studies have reported Nitrite (NO2−) and Nitrate (NO3−) to be among the most common degradation products of the high-explosive Nitroglycerin drug substance. A novel, simple, robust and rapid reversed-phase high-performance liquid chromatography method has been developed for quantification of inorganic Nitrite and Nitrate impurities from Nitroglycerin drug substance. Successful separation was achieved in isocratic elution, using Inertsil C8-3, (250 × 4.6 mm, 5.0 μm) column, with mobile phase consisting of pH 7.0 tetrabutyl ammonium hydrogen sulfate buffer, methanol and acetonitrile (96:02:02, v/v/v). Flow rate was monitored at 2.0 mL min−1 and ultraviolet detection at 220 nm. The present work describes the role of an ion-pair reagent in the separation of polar compounds and liquid–liquid extraction technique for separation of polar and non-polar compounds. Nitroglycerin was subjected to various stress conditions to demonstrate the stability-indicating power of the method. The performance of the method was validated as per present International Council for Harmonisation (ICH) guidelines for specificity, linearity, accuracy, precision, ruggedness and robustness. The developed method can be a valuable alternative to the current ion-exchange chromatographic method mentioned in the literature. To the best of our knowledge, a rapid Liquid Chromatography (LC) method, which separates inorganic Nitrite and Nitrate impurities of Nitroglycerin, disclosed in this investigation was not published elsewhere.
Hydrocarbon Group Types in Gasoline-Range Materials by High Performance Liquid Chromatography
Journal of Chromatographic Science - Tập 13 Số 8 - Trang 367-371 - 1975
J. C. Suatoni, H. R. Garber, B. E. Davis
The Sorption Behavior of Alkyl Bonded Phases in Reverse-Phase, High Performance Liquid Chromatography
Journal of Chromatographic Science - Tập 17 Số 10 - Trang 574-579 - 1979
C. H. Lochmüller, D. R. WILDER
HPLC and GC Methods for Analysis of Water-Soluble Nitrosulfonic Acids
Journal of Chromatographic Science - Tập 32 Số 2 - Trang 57-60 - 1994
Thomas O. Crowley, Richard A. Larson
Determination of Selected Herbicides and Phenols in Water and Soils by Solid-Phase Extraction and High-Performance Liquid Chromatography
Journal of Chromatographic Science - Tập 38 Số 5 - Trang 211-218 - 2000
I Baranowska, Celina Pieszko
UV--Visible Absorption Derivatization in Liquid Chromatography
Journal of Chromatographic Science - Tập 17 Số 3 - Trang 160-167 - 1979
Thomas H. Jupille
A Review of Basic Concepts in Comprehensive Two-Dimensional Gas Chromatography
Journal of Chromatographic Science - Tập 40 Số 5 - Trang 276-291 - 2002
Ruby Ong, Philip J. Marriott
Calcium Alginate-Caged Multiwalled Carbon Nanotubes Dispersive Microsolid Phase Extraction Combined With Gas Chromatography-Flame Ionization Detection for the Determination of Polycyclic Aromatic Hydrocarbons in Water Samples
Journal of Chromatographic Science - Tập 56 Số 2 - Trang 177-186 - 2018
Ayad Sami Abboud, Mohd Marsin Sanagi, Wan Aini Wan Ibrahim, Aemi Syazwani Abdul Keyon, Hassan Y. Aboul‐Enein
An Exploration of Experimental Parameters in the Analysis of Epoxy Resin by Reverse Phase Liquid Chromatography
Journal of Chromatographic Science - Tập 17 Số 5 - Trang 259-263 - 1979
J. E. Twichell, John Q. Walker, J. Barry Maynard
Quantitation of Sodium Saccharin, Sodium Benzoate and Other Food Additives by High Speed Liquid Chromatography
Journal of Chromatographic Science - Tập 11 Số 1 - Trang 28-35 - 1973
J. J. Nelson
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