Journal of Cell Biology

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Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule.
Journal of Cell Biology - Tập 114 Số 5 - Trang 1059-1068 - 1991
Steven Μ. Albelda, William A. Müller, Clayton A. Buck, Peter J. Newman
PECAM-1 is a 130-120-kD integral membrane glycoprotein found on the surface of platelets, at endothelial intercellular junctions in culture, and on cells of myeloid lineage. Previous studies have shown that it is a member of the immunoglobulin gene superfamily and that antibodies against the bovine form of this protein (endoCAM) can inhibit endothelial cell-cell interactions. These data su...... hiện toàn bộ
Differential regulation of cell motility and invasion by FAK
Journal of Cell Biology - Tập 160 Số 5 - Trang 753-767 - 2003
Datsun A. Hsia, Satyajit K. Mitra, Christof R. Hauck, Daniel N. Streblow, Jay A. Nelson, Duško Ilić, Shuang Huang, Erguang Li, Glen R. Nemerow, Jixuan Leng, Kathryn Spencer, David A. Cheresh, David D. Schlaepfer
Cell migration and invasion are fundamental components of tumor cell metastasis. Increased focal adhesion kinase (FAK) expression and tyrosine phosphorylation are connected with elevated tumorigenesis. Null mutation of FAK results in embryonic lethality, and FAK−/− fibroblasts exhibit cell migration defects in culture. Here we show that viral Src (v-Src) transformation of FAK−/− cells prom...... hiện toàn bộ
Ripped Pocket and Pickpocket, Novel Drosophila DEG/ENaC Subunits Expressed in Early Development and in Mechanosensory Neurons
Journal of Cell Biology - Tập 140 Số 1 - Trang 143-152 - 1998
Christopher M. Adams, Michael G. Anderson, David G. Motto, Margaret P. Price, Wayne A. Johnson, Michael J. Welsh
Drosophila melanogaster has proven to be a good model for understanding the physiology of ion channels. We identified two novel Drosophila DEG/ ENaC proteins, Pickpocket (PPK) and Ripped Pocket (RPK). Both appear to be ion channel subunits. Expression of RPK generated multimeric Na+ channels that were dominantly activated by a mutation associated with neurodegeneration. Amiloride and gadol...... hiện toàn bộ
Endogenous HMGB1 regulates autophagy
Journal of Cell Biology - Tập 190 Số 5 - Trang 881-892 - 2010
Daolin Tang, Rui Kang, Kristen M. Livesey, Chun-Wei Cheh, Adam M. Farkas, Patricia Loughran, George Hoppe, Marco E. Bianchi, Kevin J. Tracey, Wei‐Guo Zhu, Michael T. Lotze
Autophagy clears long-lived proteins and dysfunctional organelles and generates substrates for adenosine triphosphate production during periods of starvation and other types of cellular stress. Here we show that high mobility group box 1 (HMGB1), a chromatin-associated nuclear protein and extracellular damage-associated molecular pattern molecule, is a critical regulator of autophagy. Stim...... hiện toàn bộ
Electron microscope evidence for the presence of globular structures in different sperm chromatins.
Journal of Cell Biology - Tập 87 Số 1 - Trang 280-284 - 1980
Michel Gusse, P Chevaillier
Dispersion of nuclear fibers of the spermatozoa of dogfish, man, and bull is made possible after treatment with a reducing and alkylating reagent coupled with an anionic detergent; the same detergent used at a low ionic strength dissociates the nuclear content of the rainbow trout sperm. Electron microscopy of such dispersed nuclear fibers has shown a beads-on-a-string configuration for th...... hiện toàn bộ
The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.
Journal of Cell Biology - Tập 134 Số 1 - Trang 165-179 - 1996
Inke Näthke, Cindy L. Adams, Paul Polakis, Joseph H. Sellin, W. James Nelson
Mutations in the adenomatous polyposis coli (APC) gene are linked to polyp formation in familial and sporadic colon cancer, but the functions of the protein are not known. We show that APC protein localizes mainly to clusters of puncta near the ends of microtubules that extend into actively migrating regions of epithelial cell membranes. This subcellular distribution of APC protein require...... hiện toàn bộ
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.
Journal of Cell Biology - Tập 127 Số 6 - Trang 2061-2069 - 1994
Jörg Hülsken, Walter Birchmeier, Jürgen Behrens
beta-Catenin is involved in the formation of adherens junctions of mammalian epithelia. It interacts with the cell adhesion molecule E-cadherin and also with the tumor suppressor gene product APC, and the Drosophila homologue of beta-catenin, armadillo, mediates morphogenetic signals. We demonstrate here that E-cadherin and APC directly compete for binding to the internal, armadillo-like r...... hiện toàn bộ
The role of microtubule dynamics in growth cone motility and axonal growth.
Journal of Cell Biology - Tập 128 Số 1 - Trang 139-155 - 1995
Elly M. Tanaka, Tiffany C. Ho, Marc W. Kirschner
The growth cone contains dynamic and relatively stable microtubule populations, whose function in motility and axonal growth is uncharacterized. We have used vinblastine at low doses to inhibit microtubule dynamics without appreciable depolymerization to probe the role of these dynamics in growth cone behavior. At doses of vinblastine that interfere only with dynamics, the forward and pers...... hiện toàn bộ
ISOLATION AND STRUCTURAL STUDIES ON SYNAPTIC COMPLEXES FROM RAT BRAIN
Journal of Cell Biology - Tập 55 Số 3 - Trang 696-711 - 1972
Carl W. Cotman, Dwan A. Taylor
A fraction enriched in synaptic complexes has been isolated from rat brain. The major structural elements of synaptic complexes after isolation are a sector of pre- and postsynaptic plasma membranes joined together by a synaptic cleft and a postsynaptic density (PSD) located on the inner surface of the postsynaptic membrane. On its outer surface, the postsynaptic membrane has a series of p...... hiện toàn bộ
ISOLATION OF POSTSYNAPTIC DENSITIES FROM RAT BRAIN
Journal of Cell Biology - Tập 63 Số 2 - Trang 441-455 - 1974
Carl W. Cotman, Gary Banker, Lynn Churchill, Dwan A. Taylor
Most synapses in the central nervous system exhibit a prominent electron-opaque specialization of the postsynaptic plasma membrane called the postsynaptic density (PSD). We have developed a procedure for the isolation of PSDs which is based on their buoyant density and their insolubility in N-lauroyl sarcosinate. Treatment of synaptic membranes with this detergent solubilizes most plasma m...... hiện toàn bộ
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