Journal of Cell Biology

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Endogenous HMGB1 regulates autophagy
Journal of Cell Biology - Tập 190 Số 5 - Trang 881-892 - 2010
Daolin Tang, Rui Kang, Kristen M. Livesey, Chun-Wei Cheh, Adam M. Farkas, Patricia Loughran, George Hoppe, Marco E. Bianchi, Kevin J. Tracey, Wei‐Guo Zhu, Michael T. Lotze
Autophagy clears long-lived proteins and dysfunctional organelles and generates substrates for adenosine triphosphate production during periods of starvation and other types of cellular stress. Here we show that high mobility group box 1 (HMGB1), a chromatin-associated nuclear protein and extracellular damage-associated molecular pattern molecule, is a critical regulator of autophagy. Stim...... hiện toàn bộ
The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.
Journal of Cell Biology - Tập 134 Số 1 - Trang 165-179 - 1996
Inke Näthke, Cindy L. Adams, Paul Polakis, Joseph H. Sellin, W. James Nelson
Mutations in the adenomatous polyposis coli (APC) gene are linked to polyp formation in familial and sporadic colon cancer, but the functions of the protein are not known. We show that APC protein localizes mainly to clusters of puncta near the ends of microtubules that extend into actively migrating regions of epithelial cell membranes. This subcellular distribution of APC protein require...... hiện toàn bộ
Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway
Journal of Cell Biology - Tập 183 Số 2 - Trang 241-252 - 2008
Annapaola Franchitto, Livia Maria Pirzio, Ennio Prosperi, O. Sapora, Margherita Bignami, Pietro Pichierri
Failure to stabilize and properly process stalled replication forks results in chromosome instability, which is a hallmark of cancer cells and several human genetic conditions that are characterized by cancer predisposition. Loss of WRN, a RecQ-like enzyme mutated in the cancer-prone disease Werner syndrome (WS), leads to rapid accumulation of double-strand breaks (DSBs) and proliferating ...... hiện toàn bộ
Tissue-specific splicing pattern of fibronectin messenger RNA precursor during development and aging in rat.
Journal of Cell Biology - Tập 113 Số 5 - Trang 1223-1229 - 1991
Franco Pagani, Laura Zagato, Carlo Vergani, Giorgio Casari, A Sidoli, Francisco E. Baralle
Fibronectin isoforms are generated by the alternative splicing of a primary transcript derived from a single gene. In rat at least three regions of the molecule are involved: EIIIA, EIIIB, and V. This study investigated the splicing patterns of these regions during development and aging, by means of ribonuclease protection analysis. Between fetal and adult rat, the extent of inclusion of t...... hiện toàn bộ
DETECTION OF COMPLEX CARBOHYDRATES IN THE GOLGI APPARATUS OF RAT CELLS
Journal of Cell Biology - Tập 40 Số 2 - Trang 395-414 - 1969
A. Rambourg, W. Hernandez, C. P. Leblond
Two methods used for the electron microscopic detection of glycoproteins were applied to a variety of cell types in the rat; one involved successive treatment of sections with periodic acid, chromic acid, and silver methenamine; and the other, a brief treatment with a chromic acid-phosphotungstic acid mixture. The results obtained with the two methods were identical and, whenever the compa...... hiện toàn bộ
Topographical differences in the distribution of surface coat components and intramembrane particles. A cytochemical and freeze-fracture study in culture forms of Trypanosoma cruzi.
Journal of Cell Biology - Tập 69 Số 2 - Trang 507-513 - 1976
Adolfo Martı́nez-Palomo, Wanderley de Souza, Arturo González‐Robles
A regional specialization of the cell surface of T. cruzi culture forms was found at the cytostome as a localized thick surface coat rich in carbohydrate-containing components. The prominent surface coat was located over a region of the plasma membrane where intramembranous particles were exceedingly low in number. In turn, the particle-poor region was related to specialized submembrane fi...... hiện toàn bộ
Effects of cytochalasin and phalloidin on actin.
Journal of Cell Biology - Tập 105 Số 4 - Trang 1473-1478 - 1987
John A. Cooper
ULTRASTRUCTURAL BASES FOR METABOLICALLY LINKED MECHANICAL ACTIVITY IN MITOCHONDRIA
Journal of Cell Biology - Tập 37 Số 2 - Trang 345-369 - 1968
Charles R. Hackenbrock
Isolated mitochondria are capable of undergoing dramatic reversible ultrastructural transformations between a condensed and an orthodox conformation. These two conformations are the extremes in ultrastructural organization between which structually and functionally intact mitochondria transform during reversible respiratory cycles. It has been found that electron transport is required for ...... hiện toàn bộ
Cortactin phosphorylation regulates cell invasion through a pH-dependent pathway
Journal of Cell Biology - Tập 195 Số 5 - Trang 903-920 - 2011
Marco Magalhaes, Daniel R. Larson, Christopher C. Mader, Jose Javier Bravo‐Cordero, Hava Gil-Henn, Matthew G. Oser, Xiaohong Chen, Anthony J. Koleske, John S. Condeelis
Invadopodia are invasive protrusions with proteolytic activity uniquely found in tumor cells. Cortactin phosphorylation is a key step during invadopodia maturation, regulating Nck1 binding and cofilin activity. The precise mechanism of cortactin-dependent cofilin regulation and the roles of this pathway in invadopodia maturation and cell invasion are not fully understood. We provide eviden...... hiện toàn bộ
Hic-5 promotes invadopodia formation and invasion during TGF-β–induced epithelial–mesenchymal transition
Journal of Cell Biology - Tập 197 Số 3 - Trang 421-437 - 2012
Jeanine Pignatelli, David A. Tumbarello, Ronald P. Schmidt, Christopher E. Turner
Transforming growth factor β (TGF-β)–stimulated epithelial–mesenchymal transition (EMT) is an important developmental process that has also been implicated in increased cell invasion and metastatic potential of cancer cells. Expression of the focal adhesion protein Hic-5 has been shown to be up-regulated in epithelial cells in response to TGF-β. Herein, we demonstrate that TGF-β–induced Hi...... hiện toàn bộ
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