Journal of Cell Biology
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Molecular and cellular properties of PECAM-1 (endoCAM/CD31): a novel vascular cell-cell adhesion molecule.
Journal of Cell Biology - Tập 114 Số 5 - Trang 1059-1068 - 1991
PECAM-1 is a 130-120-kD integral membrane glycoprotein found on the surface of
platelets, at endothelial intercellular junctions in culture, and on cells of
myeloid lineage. Previous studies have shown that it is a member of the
immunoglobulin gene superfamily and that antibodies against the bovine form of
this protein (endoCAM) can inhibit endothelial cell-cell interactions. These
data suggest th...
Differential regulation of cell motility and invasion by FAK
Journal of Cell Biology - Tập 160 Số 5 - Trang 753-767 - 2003
Cell migration and invasion are fundamental components of tumor cell metastasis.
Increased focal adhesion kinase (FAK) expression and tyrosine phosphorylation
are connected with elevated tumorigenesis. Null mutation of FAK results in
embryonic lethality, and FAK−/− fibroblasts exhibit cell migration defects in
culture. Here we show that viral Src (v-Src) transformation of FAK−/− cells
promotes int...
Ripped Pocket and Pickpocket, Novel Drosophila DEG/ENaC Subunits Expressed in Early Development and in Mechanosensory Neurons
Journal of Cell Biology - Tập 140 Số 1 - Trang 143-152 - 1998
Drosophila melanogaster has proven to be a good model for understanding the
physiology of ion channels. We identified two novel Drosophila DEG/ ENaC
proteins, Pickpocket (PPK) and Ripped Pocket (RPK). Both appear to be ion
channel subunits. Expression of RPK generated multimeric Na+ channels that were
dominantly activated by a mutation associated with neurodegeneration. Amiloride
and gadolinium, w...
Endogenous HMGB1 regulates autophagy
Journal of Cell Biology - Tập 190 Số 5 - Trang 881-892 - 2010
Autophagy clears long-lived proteins and dysfunctional organelles and generates
substrates for adenosine triphosphate production during periods of starvation
and other types of cellular stress. Here we show that high mobility group box 1
(HMGB1), a chromatin-associated nuclear protein and extracellular
damage-associated molecular pattern molecule, is a critical regulator of
autophagy. Stimuli that...
Electron microscope evidence for the presence of globular structures in different sperm chromatins.
Journal of Cell Biology - Tập 87 Số 1 - Trang 280-284 - 1980
Dispersion of nuclear fibers of the spermatozoa of dogfish, man, and bull is
made possible after treatment with a reducing and alkylating reagent coupled
with an anionic detergent; the same detergent used at a low ionic strength
dissociates the nuclear content of the rainbow trout sperm. Electron microscopy
of such dispersed nuclear fibers has shown a beads-on-a-string configuration for
these four...
The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.
Journal of Cell Biology - Tập 134 Số 1 - Trang 165-179 - 1996
Mutations in the adenomatous polyposis coli (APC) gene are linked to polyp
formation in familial and sporadic colon cancer, but the functions of the
protein are not known. We show that APC protein localizes mainly to clusters of
puncta near the ends of microtubules that extend into actively migrating regions
of epithelial cell membranes. This subcellular distribution of APC protein
requires microt...
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.
Journal of Cell Biology - Tập 127 Số 6 - Trang 2061-2069 - 1994
beta-Catenin is involved in the formation of adherens junctions of mammalian
epithelia. It interacts with the cell adhesion molecule E-cadherin and also with
the tumor suppressor gene product APC, and the Drosophila homologue of
beta-catenin, armadillo, mediates morphogenetic signals. We demonstrate here
that E-cadherin and APC directly compete for binding to the internal,
armadillo-like repeats o...
The role of microtubule dynamics in growth cone motility and axonal growth.
Journal of Cell Biology - Tập 128 Số 1 - Trang 139-155 - 1995
The growth cone contains dynamic and relatively stable microtubule populations,
whose function in motility and axonal growth is uncharacterized. We have used
vinblastine at low doses to inhibit microtubule dynamics without appreciable
depolymerization to probe the role of these dynamics in growth cone behavior. At
doses of vinblastine that interfere only with dynamics, the forward and
persistent m...
ISOLATION AND STRUCTURAL STUDIES ON SYNAPTIC COMPLEXES FROM RAT BRAIN
Journal of Cell Biology - Tập 55 Số 3 - Trang 696-711 - 1972
A fraction enriched in synaptic complexes has been isolated from rat brain. The
major structural elements of synaptic complexes after isolation are a sector of
pre- and postsynaptic plasma membranes joined together by a synaptic cleft and a
postsynaptic density (PSD) located on the inner surface of the postsynaptic
membrane. On its outer surface, the postsynaptic membrane has a series of
projectio...
ISOLATION OF POSTSYNAPTIC DENSITIES FROM RAT BRAIN
Journal of Cell Biology - Tập 63 Số 2 - Trang 441-455 - 1974
Most synapses in the central nervous system exhibit a prominent electron-opaque
specialization of the postsynaptic plasma membrane called the postsynaptic
density (PSD). We have developed a procedure for the isolation of PSDs which is
based on their buoyant density and their insolubility in N-lauroyl sarcosinate.
Treatment of synaptic membranes with this detergent solubilizes most plasma
membranes...
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