Delivery of MiRNA-92a Inhibitor Using RP1-Linked Peptide Elicits Anti-Inflammatory Effects in an Acute Lung Injury ModelJournal of Biomedical Nanotechnology - Tập 17 Số 7 - Trang 1273-1283 - 2021
Chuanyu Zhuang, Chunxian Piao, Myoungjee Choi, Junkyu Ha, Minhyung Lee
Acute lung injury (ALI) is an inflammatory lung disease. miRNA-92a (miR92a) is
induced in the lungs of ALI patients and mediates inflammatory reactions. In
this study, a RP1-linked R3V6 (RP1R3V6) peptide was synthesized and evaluated as
a carrier of anti-microRNA-92a oligonucleotide (AMO92a) into the lungs of an ALI
animal model. In addition to the carrier function, the RP1-linked peptide can
have... hiện toàn bộ
Delivery of High Mobility Group Box-1 siRNA Using Brain-Targeting Exosomes for Ischemic Stroke TherapyJournal of Biomedical Nanotechnology - Tập 15 Số 12 - Trang 2401-2412 - 2019
Minkyung Kim, Gyeungyun Kim, Do Won Hwang, Minhyung Lee
Ischemic strokes are caused by decreased blood flow into the brain, due to
narrowed cerebral arteries. In the ischemic brain, high-mobility group box 1
(HMGB1) is released into extracellular spaces and induces inflammatory
reactions. In this study, HMGB1 small interfering RNA (siRNA) was delivered into
ischemic brains by intravenous administration using rabies virus glycoprotein
(RVG) peptide-deco... hiện toàn bộ
Interferon Regulatory Factor 5 siRNA-Loaded Folate-Modified Cationic Liposomes for Acute Lung Injury TherapyJournal of Biomedical Nanotechnology - Tập 17 Số 3 - Trang 466-476 - 2021
Qin Xu, Mengran Guo, Xiaodong Jin, Quansheng Jin, Zhongshan He, Wen Xiao, Wei Zou, Ruiling Xu, Cheng Li-zhi, Siyan He, Lili Cao, Mostafa A. Elbahnasawy, Wentao Peng, Chunling Jiang, Xiangrong Song
Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is an
overwhelming pulmonary inflammation with limited clinical treatment strategies.
Interferon regulatory factor 5 (IRF5) is a crucial regulator of inflammation
factors, which can be upregulated under an inflammatory state and related to the
efferocytosis of macrophages. Herein, IRF5 was knockdown by small interfering
RNA (siIRF5) ... hiện toàn bộ
<I>In Vitro</I> and <I>In Vivo</I> Therapeutic Evaluation of Camptothecin-Encapsulated <I>β</I>-Cyclodextrin Nanosponges in Prostate CancerJournal of Biomedical Nanotechnology - Tập 12 Số 1 - Trang 114-127 - 2016
Casimiro Luca Gigliotti, Rosalba Minelli, Roberta Cavalli, Sergio Occhipinti, Giuseppina Barrera, Stefania Pizzimenti, Giuseppe Cappellano, Elena Boggio, Laura Conti, Roberto Fantozzi, Mirella Giovarelli, Francesco Trotta, Umberto Dianzani, Chiara Dianzani