International Journal of Molecular Sciences

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Arid1b Haploinsufficiency Causes Abnormal Brain Gene Expression and Autism-Related Behaviors in Mice
International Journal of Molecular Sciences - Tập 18 Số 9 - Trang 1872
Mihiro Shibutani, Takuro Horii, Hirotaka Shoji, Sumiyo Morita, Mika Kimura, Naomi Terawaki, Tsuyoshi Miyakawa, Izuho Hatada
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with core symptoms that include poor social communication, restricted interests, and repetitive behaviors. Several ASD mouse models exhibit impaired social interaction, anxiety-like behavior, and elevated perseveration. Large-scale whole exome sequencing studies identified many genes putatively associated with ASD. Like chromo...... hiện toàn bộ
Extracellular Hsp70 Reduces the Pro-Tumor Capacity of Monocytes/Macrophages Co-Cultivated with Cancer Cells
International Journal of Molecular Sciences - Tập 21 Số 1 - Trang 59
Elena Y. Komarova, Л. В. Марченко, A. Zhakhov, Alina D. Nikotina, Nikolay Aksenov, Роман В. Суезов, A. Ischenko, Boris A. Margulis, Irina V. Guzhova
Cancer cells are known to contain high levels of the heat shock protein 70 kDa (Hsp70), which mediates increased cell proliferation, escape from programmed cell death, enhanced invasion, and metastasis. A part of Hsp70 molecules may release from cancer cells and affect the behavior of adjacent stromal cells. To explore the effects of Hsp70 on the status of monocytes/macrophages in the tumo...... hiện toàn bộ
Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders
International Journal of Molecular Sciences - Tập 14 Số 4 - Trang 6863-6888
Thibaut Quillard, Béatrice Charreau
Notch signaling is a major pathway in cell fate decisions. Since the first reports showing the major role of Notch in embryonic development, a considerable and still growing literature further highlights its key contributions in various pathological processes during adult life. In particular, Notch is now considered as a major player in vascular homeostasis through the control of key cellu...... hiện toàn bộ
Clinical Implications of Discordant Early Molecular Responses in CML Patients Treated with Imatinib
International Journal of Molecular Sciences - Tập 20 Số 9 - Trang 2226
Stefania Stella, Valentina Zammit, Silvia Rita Vitale, Maria Stella Pennisi, Michele Massimino, Elena Tirrò, Stefano Forte, Antonio Spitaleri, Agostino Antolino, Sergio Siracusa, Vincenzo Accurso, Donato Mannina, Stefana Impera, Caterina Musolino, Sabina Russo, Alessandra Malato, Giuseppe Mineo, Maurizio Musso, Ferdinando Porretto, Bruno Martino, Francesco Di Raimondo, Livia Manzella, Paolo Vigneri, Fabio Stagno
A reduction in BCR-ABL1/ABL1IS transcript levels to <10% after 3 months or <1% after 6 months of tyrosine kinase inhibitor therapy are associated with superior clinical outcomes in chronic myeloid leukemia (CML) patients. In this study, we investigated the reliability of multiple BCR-ABL1 thresholds in predicting treatment outcomes for 184 subjects diagnosed with CML and treated with...... hiện toàn bộ
Serine Racemase Deletion Affects the Excitatory/Inhibitory Balance of the Hippocampal CA1 Network
International Journal of Molecular Sciences - Tập 21 Số 24 - Trang 9447
Eva Ploux, Valentine Bouët, Inna Radzishevsky, Herman Wolosker, Thomas Fréret, Jean‐Marie Billard
d-serine is the major co-agonist of N-methyl-D-aspartate receptors (NMDAR) at CA3/CA1 hippocampal synapses, the activation of which drives long-term potentiation (LTP). The use of mice with targeted deletion of the serine racemase (SR) enzyme has been an important tool to uncover the physiological and pathological roles of D-serine. To date, some uncertainties remain regarding the directio...... hiện toàn bộ
BMP3 Alone and Together with TGF-β Promote the Differentiation of Human Mesenchymal Stem Cells into a Nucleus Pulposus-Like Phenotype
International Journal of Molecular Sciences - Tập 16 Số 9 - Trang 20344-20359
Xiaopeng Zhou, Yiqing Tao, Chengzhen Liang, Yujie Zhang, Hao Li
Human mesenchymal stem cells (MSCs) have the potential to differentiate into nucleus pulposus (NP)-like cells under specific stimulatory conditions. Thus far, the effects of bone morphogenetic protein 3 (BMP3) and the cocktail effects of BMP3 and transforming growth factor (TGF)-β on MSC proliferation and differentiation remain obscure. Therefore, this study was designed to clarify these u...... hiện toàn bộ
Formation and Change of Chloroplast-Located Plant Metabolites in Response to Light Conditions
International Journal of Molecular Sciences - Tập 19 Số 3 - Trang 654
Yiyong Chen, Bo Zhou, Jianlong Li, Hao Tang, Jinchi Tang, Ziyin Yang
Photosynthesis is the central energy conversion process for plant metabolism and occurs within mature chloroplasts. Chloroplasts are also the site of various metabolic reactions involving amino acids, lipids, starch, and sulfur, as well as where the production of some hormones takes place. Light is one of the most important environmental factors, acting as an essential energy source for pl...... hiện toàn bộ
Non-Surgical Periodontal Treatment Impact on Subgingival Microbiome and Intra-Oral Halitosis
International Journal of Molecular Sciences - Tập 24 Số 3 - Trang 2518
Catarina Izidoro, João Botelho, Vanessa Machado, Ana Mafalda Reis, Luís Proença, Helena Barroso, Ricardo Alves, José João Mendes
The purpose of this study was to characterize and compare subgingival microbiome before and after periodontal treatment to learn if any changes of the subgingival microbiome were reflected in intra-oral halitosis. We tested the hypothesis that intra-oral halitosis (Volatile sulfur compounds levels) correlates with corresponding subgingival bacterial levels before and after periodontal trea...... hiện toàn bộ
Functional Characterization of a Putative RNA Demethylase ALKBH6 in Arabidopsis Growth and Abiotic Stress Responses
International Journal of Molecular Sciences - Tập 21 Số 18 - Trang 6707 - 2020
Huong, Trinh Thi, Ngoc, Le Nguyen Tieu, Kang, Hunseung
RNA methylation and demethylation, which is mediated by RNA methyltransferases (referred to as “writers”) and demethylases (referred to as “erasers”), respectively, are emerging as a key regulatory process in plant development and stress responses. Although several studies have shown that AlkB homolog (ALKBH) proteins are potential RNA demethylases, the function of most ALKBHs is yet to be determi...... hiện toàn bộ
Structural Perspective on Revealing and Altering Molecular Functions of Genetic Variants Linked with Diseases
International Journal of Molecular Sciences - Tập 20 Số 3 - Trang 548
Yunhui Peng, Emil Alexov, Sankar Basu
Structural information of biological macromolecules is crucial and necessary to deliver predictions about the effects of mutations—whether polymorphic or deleterious (i.e., disease causing), wherein, thermodynamic parameters, namely, folding and binding free energies potentially serve as effective biomarkers. It may be emphasized that the effect of a mutation depends on various factors, in...... hiện toàn bộ
Tổng số: 657   
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