International Journal of Molecular Sciences

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Emodin Sensitizes Hepatocellular Carcinoma Cells to the Anti-Cancer Effect of Sorafenib through Suppression of Cholesterol Metabolism
International Journal of Molecular Sciences - Tập 19 Số 10 - Trang 3127
Young Seon Kim, Yoon-Mi Lee, Taek-In Oh, Dong Hoon Shin, Geon-Hee Kim, Sang-Yeon Kan, Hyeji Kang, Ji Hyung Kim, Byeong Mo Kim, Woo Jong Yim, Ji‐Hong Lim
Reduced therapeutic efficacy of sorafenib, a first-generation multikinase inhibitor, is often observed during the treatment of advanced hepatocellular carcinoma (HCC). Emodin is an active component of Chinese herbs, and is effective against leukemia, lung cancer, colon cancer, pancreatic cancer, and HCC; however, the sensitizing effect of emodin on sorafenib-based HCC therapy has not been ...... hiện toàn bộ
Biological Mechanisms Underlying the Ultraviolet Radiation-Induced Formation of Skin Wrinkling and Sagging II: Over-Expression of Neprilysin Plays an Essential Role
International Journal of Molecular Sciences - Tập 16 Số 4 - Trang 7776-7795
Genji Imokawa, Hiroaki Nakajima, Koichi Ishida
Our previous studies strongly indicated that the up-regulated activity of skin fibroblast-derived elastase plays a pivotal role in wrinkling and/or sagging of the skin via the impairment of elastic fiber configuration and the subsequent loss of skin elasticity. Fortunately, we succeeded in identifying human skin fibroblast-derived elastase as a previously known enzyme, neprilysin or neutr...... hiện toàn bộ
Arid1b Haploinsufficiency Causes Abnormal Brain Gene Expression and Autism-Related Behaviors in Mice
International Journal of Molecular Sciences - Tập 18 Số 9 - Trang 1872
Mihiro Shibutani, Takuro Horii, Hirotaka Shoji, Sumiyo Morita, Mika Kimura, Naomi Terawaki, Tsuyoshi Miyakawa, Izuho Hatada
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with core symptoms that include poor social communication, restricted interests, and repetitive behaviors. Several ASD mouse models exhibit impaired social interaction, anxiety-like behavior, and elevated perseveration. Large-scale whole exome sequencing studies identified many genes putatively associated with ASD. Like chromo...... hiện toàn bộ
Extracellular Hsp70 Reduces the Pro-Tumor Capacity of Monocytes/Macrophages Co-Cultivated with Cancer Cells
International Journal of Molecular Sciences - Tập 21 Số 1 - Trang 59
Elena Y. Komarova, Л. В. Марченко, A. Zhakhov, Alina D. Nikotina, Nikolay Aksenov, Роман В. Суезов, A. Ischenko, Boris A. Margulis, Irina V. Guzhova
Cancer cells are known to contain high levels of the heat shock protein 70 kDa (Hsp70), which mediates increased cell proliferation, escape from programmed cell death, enhanced invasion, and metastasis. A part of Hsp70 molecules may release from cancer cells and affect the behavior of adjacent stromal cells. To explore the effects of Hsp70 on the status of monocytes/macrophages in the tumo...... hiện toàn bộ
Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis
International Journal of Molecular Sciences - Tập 21 Số 15 - Trang 5378
Effi Haque, Md. Rezaul Karim, Aamir Salam Teeli, Magdalena Śmiech, Paweł Leszczyński, Dawid Winiarczyk, Emil D. Parvanov, Atanas G. Atanasov, Hiroaki Taniguchi
NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master regulator of redox homeostasis regulating a variety of genes for antioxidant and detoxification enzymes. NRF2 was, therefore, initially thought to protect the liver from oxidative stress. Recent studies, however, have revealed that mutations in NRF2 cause aberrant accumulation of NRF2 in the nucleus and ...... hiện toàn bộ
Determination and Analysis of Ustiloxins A and B by LC-ESI-MS and HPLC in False Smut Balls of Rice
International Journal of Molecular Sciences - Tập 13 Số 9 - Trang 11275-11287
Tijiang Shan, Weibo Sun, Hao Liu, Shan Gao, Shiqiong Lu, Mingan Wang, Wenxian Sun, Zhiyi Chen, Zonghua Wang, Ligang Zhou
Ustiloxins are cyclopeptide mycotoxins produced by the pathogenic fungus Villosiclava virens of rice false smut. Ustiloxins A and B as two main mycotoxins were determined conveniently by LC-ESI-MS in the water extract from rice false smut balls which were mostly composed of the chlamydospores and mycelia of the pathogen. Both ustiloxins A and B in the water extract were also quantitatively...... hiện toàn bộ
Impact of Notch Signaling on Inflammatory Responses in Cardiovascular Disorders
International Journal of Molecular Sciences - Tập 14 Số 4 - Trang 6863-6888
Thibaut Quillard, Béatrice Charreau
Notch signaling is a major pathway in cell fate decisions. Since the first reports showing the major role of Notch in embryonic development, a considerable and still growing literature further highlights its key contributions in various pathological processes during adult life. In particular, Notch is now considered as a major player in vascular homeostasis through the control of key cellu...... hiện toàn bộ
Clinical Implications of Discordant Early Molecular Responses in CML Patients Treated with Imatinib
International Journal of Molecular Sciences - Tập 20 Số 9 - Trang 2226
Stefania Stella, Valentina Zammit, Silvia Rita Vitale, Maria Stella Pennisi, Michele Massimino, Elena Tirrò, Stefano Forte, Antonio Spitaleri, Agostino Antolino, Sergio Siracusa, Vincenzo Accurso, Donato Mannina, Stefana Impera, Caterina Musolino, Sabina Russo, Alessandra Malato, Giuseppe Mineo, Maurizio Musso, Ferdinando Porretto, Bruno Martino, Francesco Di Raimondo, Livia Manzella, Paolo Vigneri, Fabio Stagno
A reduction in BCR-ABL1/ABL1IS transcript levels to <10% after 3 months or <1% after 6 months of tyrosine kinase inhibitor therapy are associated with superior clinical outcomes in chronic myeloid leukemia (CML) patients. In this study, we investigated the reliability of multiple BCR-ABL1 thresholds in predicting treatment outcomes for 184 subjects diagnosed with CML and treated with...... hiện toàn bộ
Enzymatic Synthesis of Glucose Monodecanoate in a Hydrophobic Deep Eutectic Solvent
International Journal of Molecular Sciences - Tập 21 Số 12 - Trang 4342
Rebecca Hollenbach, Katrin Ochsenreither, Christoph Syldatk
Environmentally friendly and biodegradable reaction media are an important part of a sustainable glycolipid production in the transition to green chemistry. Deep eutectic solvents (DESs) are an ecofriendly alternative to organic solvents. So far, only hydrophilic DESs were considered for enzymatic glycolipid synthesis. In this study, a hydrophobic DES consisting of (-)-menthol and decanoic...... hiện toàn bộ
Early Pregnancy Biomarkers in Pre-Eclampsia: A Systematic Review and Meta-Analysis
International Journal of Molecular Sciences - Tập 16 Số 9 - Trang 23035-23056
Pensée Wu, Caroline van den Berg, Žarko Alfirević, Shaughn O’Brien, Maria Röthlisberger, Philip N. Baker, Louise C. Kenny, Karolina Kublickiene, Johannes J. Duvekot
Pre-eclampsia (PE) complicates 2%–8% of all pregnancies and is an important cause of perinatal morbidity and mortality worldwide. In order to reduce these complications and to develop possible treatment modalities, it is important to identify women at risk of developing PE. The use of biomarkers in early pregnancy would allow appropriate stratification into high and low risk pregnancies fo...... hiện toàn bộ
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