International Journal of Molecular Sciences
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Eyeing the Extracellular Matrix in Vascular Development and Microvascular Diseases and Bridging the Divide between Vascular Mechanics and FunctionThe extracellular matrix (ECM) is critical in all aspects of vascular development and health: supporting cell anchorage, providing structure, organization and mechanical stability, and serving as a sink for growth factors and sustained survival signals. Abnormal changes in ECM protein expression, organization, and/or properties, and the ensuing changes in vascular compliance affect vasodil... ... hiện toàn bộ
International Journal of Molecular Sciences - Tập 21 Số 10 - Trang 3487
Long Non-Coding RNAs as Mediators of Tumor Microenvironment and Liver Cancer Cell CommunicationThe tumor microenvironment is an important concept that defines cancer development not only through tumor cells themselves but also the surrounding cellular and non-cellular components, including stromal cells, blood vessels, infiltrating inflammatory cells, cancer stem cells (CSC), cytokines, and growth factors, which act in concert to promote tumor cell survival and metastasis. Hepatocel... ... hiện toàn bộ
International Journal of Molecular Sciences - Tập 19 Số 12 - Trang 3742
De Novo Transcriptome Assembly and Analysis of Longevity Genes Using Subterranean Termite (Reticulitermes chinensis) Castes
International Journal of Molecular Sciences - - 2022
The longevity phenomenon is entirely controlled by the insulin signaling pathway (IIS-pathway). Both vertebrates and invertebrates have IIS-pathways that are comparable to one another, though no one has previously described de novo transcriptome assembly of IIS-pathway-associated genes in termites. In this research, we analyzed the transcriptomes of both reproductive (primary kings “PK” and queens...... hiện toàn bộ
The Complex Interplay between Endocannabinoid System and the Estrogen System in Central Nervous System and PeripheryThe endocannabinoid system (ECS) is a lipid cell signaling system involved in the physiology and homeostasis of the brain and peripheral tissues. Synaptic plasticity, neuroendocrine functions, reproduction, and immune response among others all require the activity of functional ECS, with the onset of disease in case of ECS impairment. Estrogens, classically considered as female steroid hor... ... hiện toàn bộ
International Journal of Molecular Sciences - Tập 22 Số 2 - Trang 972
Modified Fluoroquinolones as Antimicrobial Compounds Targeting Chlamydia trachomatis
International Journal of Molecular Sciences - Tập 23 Số 12 - Trang 6741 - 2022
Chlamydia trachomatis causes the most common sexually transmitted bacterial infection and trachoma, an eye infection. Untreated infections can lead to sequelae, such as infertility and ectopic pregnancy in women and blindness. We previously enhanced the antichlamydial activity of the fluoroquinolone ciprofloxacin by grafting a metal chelating moiety onto it. In the present study, we pursued this p...... hiện toàn bộ
Cbx2, a PcG Family Gene, Plays a Regulatory Role in Medaka Gonadal DevelopmentChromobox homolog 2 (CBX2), a key member of the polycomb group (PcG) family, is essential for gonadal development in mammals. A functional deficiency or genetic mutation in cbx2 can lead to sex reversal in mice and humans. However, little is known about the function of cbx2 in gonadal development in fish. In this study, the cbx2 gene was identified in medaka, which is a model species for t... ... hiện toàn bộ
International Journal of Molecular Sciences - Tập 21 Số 4 - Trang 1288
Protein Folding and Mechanisms of ProteostasisHighly sophisticated mechanisms that modulate protein structure and function, which involve synthesis and degradation, have evolved to maintain cellular homeostasis. Perturbations in these mechanisms can lead to protein dysfunction as well as deleterious cell processes. Therefore in recent years the etiology of a great number of diseases has been attributed to failures in mechanisms that m... ... hiện toàn bộ
International Journal of Molecular Sciences - Tập 16 Số 8 - Trang 17193-17230
Synergistic Antiviral Activity of Pamapimod and Pioglitazone against SARS-CoV-2 and Its Variants of ConcernThe SARS-CoV-2 pandemic remains a major public health threat, especially due to newly emerging SARS-CoV-2 Variants of Concern (VoCs), which are more efficiently transmitted, more virulent, and more able to escape naturally acquired and vaccine-induced immunity. Recently, the protease inhibitor Paxlovid® and the polymerase inhibitor molnupiravir, both targeting mutant-prone viral components... ... hiện toàn bộ
International Journal of Molecular Sciences - Tập 23 Số 12 - Trang 6830
Mitochondrial Oxidative Stress, Mitochondrial DNA Damage and Their Role in Age-Related Vascular DysfunctionThe prevalence of cardiovascular diseases is significantly increased in the older population. Risk factors and predictors of future cardiovascular events such as hypertension, atherosclerosis, or diabetes are observed with higher frequency in elderly individuals. A major determinant of vascular aging is endothelial dysfunction, characterized by impaired endothelium-dependent signaling pro... ... hiện toàn bộ
International Journal of Molecular Sciences - Tập 16 Số 7 - Trang 15918-15953
Estrogen, Angiogenesis, Immunity and Cell Metabolism: Solving the PuzzleEstrogen plays an important role in the regulation of cardiovascular physiology and the immune system by inducing direct effects on multiple cell types including immune and vascular cells. Sex steroid hormones are implicated in cardiovascular protection, including endothelial healing in case of arterial injury and collateral vessel formation in ischemic tissue. Estrogen can exert potent mo... ... hiện toàn bộ
International Journal of Molecular Sciences - Tập 19 Số 3 - Trang 859
Tổng số: 657
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