International Journal of Diabetes in Developing Countries

Mục đích của thông báo sửa lỗi này là để thừa nhận rằng phiên bản gốc của bài báo này chứa một lỗi trong nhóm tác giả. Các tên của nhiều tác giả đã bị bỏ sót, và thay vào đó được thêm vào dưới dạng thành viên của ủy ban chỉ đạo.

Predictive low-glucose suspend (PLGS) system helps prevent hypoglycemia. To evaluate the effect of PLGS therapy on GV and percentage of time in range (TIR), time below range (TBR), and time above range (TAR) in pediatric type 1 diabetic patients. HbA1c, coefficient of variation (CV), standard deviation (SD), and percentage of TIR, TBR, and TAR were evaluated in type 1 diabetic (T1D) pediatric patients followed up between Jan 2016 and Mar 2020 using PLGS system. Mean ages of diagnosis and duration of diabetes were 6.7 ± 4.1 and 8.2 ± 4.3 years, respectively. Nineteen of the patients were male (46.3%) and 22 were female (53.7%). Twenty-two (53.7%) of the patients were using low-glucose suspend system and 19 (46.3%) were on multiple daily injection therapy (MDI). On PLGS therapy, the 3rd, 6th, 9th, and 12th months’ HbA1c of patients were not different from previous years’ mean HbA1c in all participants. In the 3rd, 6th, 9th, and 12th months of PLGS therapy, % of TIR were 65.34 ± 14.75%, 65.80 ± 14.67%, 66.58 ± 11.21%, and 70.04 ± 10.16%, respectively (p = 0.01). Although statistically insignificant, CV decreased from 36.33 to 34.30% and SD decreased from 60.14 to 58.60 in the 1-year follow-up period (p = 0.062 and p = 0.246). With PLGS therapy, TIR was > 70% and the time spent in hypoglycemia was very low.

Nephropathy is among the most pervasive complications of diabetes; it frequently results in end-stage renal disease and even death. However, current biomarkers for diabetic nephropathy (DN) have limited diagnostic utility. Thus, this present study aims to examine the associations of estimated glomerular filtration rate (eGFR) with plasma concentrations of microRNA-192 (miR-192), pentraxin-3 (PTX-3), and transforming growth factor-beta1 (TGF-β1) to identify biomarkers able to distinguish late-stage from early-stage DN. In total, 50 healthy volunteers and 271 diabetes patients were enrolled in this study. Participants were stratified into seven groups according to eGFR and glycated hemoglobin (HbA1c), healthy controls, diabetes without DN (G1), diabetes with mild renal impairment (G2), and 4 DN grades (G3a, G3b, G4, and G5). DN groups exhibited increases in serum miR-192 (p < 0.05), PTX-3(p < 0.05), TGF-β1(p < 0.05), malondialdehyde (p < 0.05), and xanthine oxidase (p < 0.05) levels and reductions in glutathione-s-transferase (p < 0.05) and superoxide dismutase (p < 0.05) compared to healthy controls. Among patients, eGFR was negatively correlated with miR-192, PTX-3, and TGF-β1, and positively correlated with HbA1c. In receiver operating characteristic curve analysis, miR-192 and PTX-3 demonstrated good diagnostic performance in distinguishing early from advanced DN. Elevated serum miR-192 and PTX-3 are associated with lower eGFR in DN, suggesting their utility as diagnostic and prognostic biomarkers.

Health authorities in Thailand implemented a policy especially to cope with chronic diseases in that they transformed former health stations into sub-district health promoting hospitals (SHPH). The “top down” measure left the staff of the SHPH somewhat confused and uncertain how to manage their duties effectively. One of the weak points was the questionable outreach of care into the community. In an attempt to demonstrate how to enhance community participation, one SHPH was selected and assisted in improving the care of type 2 diabetes mellitus (T2DM) patients. Patients from another SHPH served as controls. The combined efforts of patients, their families, SHPH staff, and the community with the help of village health workers succeeded in improving the control of T2DM in that a steady decline in capillary blood glucose (CBG) could be observed and the results could also be verified by the determination of glycated hemoglobin (HbA1c).

This study aimed to assess the dietary patterns among adults with type 2 diabetes mellitus living in Tehran, Iran, and their association with socio-demographic and lifestyle factors. In a cross-sectional study, 400 male and female subjects aged between 40–60 years with type 2 diabetes mellitus were selected. Socio-demographic and lifestyle characteristics and dietary intake were assessed using a food frequency questionnaire. To determine the dietary patterns, factor analysis was carried out, and to assess the association between socio-demographic and lifestyle factors to dietary patterns, analysis of covariance was performed. Three dietary patterns were found. These patterns were labeled as “vegetable and poultry,” “Western” and “mixed.” In this study, the vegetable and poultry pattern was associated with being female, primary education, and hypertension. The Western pattern was associated with being male, non-smokers, and lower physical activity. The mixed pattern was associated with higher income and family history of diabetes. We found that socio-demographic and lifestyle factors of diabetic patients were different according to the dietary pattern type. Further studies are necessary to confirm the benefits of this pattern.