Infectious Disease Reports
2036-7449
2036-7430
Thụy Sĩ
Cơ quản chủ quản: Multidisciplinary Digital Publishing Institute (MDPI) , MDPI
Phân tích ảnh hưởng
Thông tin về tạp chí
Lĩnh vực:
Infectious Diseases
Infectious Disease Reports (ISSN 2036-7449) is an international, open access peer-reviewed journal that publishes scientific papers about infectious diseases. Manuscripts dealing with research, biology, epidemiology, and clinical aspects of all infection-related diseases are welcome. Infectious Disease Reports publishes original articles, reviews, brief reports and case reports. Please note, we suggest that authors include a literature review to summarize the development of the field to which their paper is related in brief reports and case reports. Scope:• Diagnosis, treatment, management, and prevention of infectious diseases • Severe infections • Multidrug resistant bacterial infections • Emerging viral infections • Infections in critically ill patients • Infections in the Compromised Host • Transplant and infection • Haematological/oncological opportunistic infections • Immunology and Infection • Epidemiology of Infectious Diseases • Healthcare associated infections • Infection Prevention & Control • Antimicrobial Stewardship • HIV/AIDS • Viral hepatites • Sexually transmitted diseases • Tropical medicine • Travel medicine • Vaccines • Anti-infective therapy • Pharmacokinetics/Pharmacodynamics of Antimicrobials
Current trends of HIV recombination worldwide One of the major characteristics of HIV-1 is its high genetic variability and extensive heterogeneity. This characteristic is due to its molecular traits, which in turn allows it to vary, recombine, and diversify at a high frequency. As such, it generates complex molecular forms, termed recombinants, which evade the human immune system and so survive. There is no sequence constraint to the recombination pattern as it appears to occur at inter-group (between groups M and O), as well as inter- and intra-subtype within group M. Rapid emergence and active global transmission of HIV-1 recombinants, known as circulating recombinant forms (CRFs) and unique recombinant forms (URFs), requires urgent attention. To date, 55 CRFs have been reported around the world. The first CRF01_AE originated from Central Africa but spread widely in Asia. The most recent CRF; CRF55_01B is a recombinant form of CRF01_AE and subtype B, although its origin is yet to be publicly disclosed. HIV-1 recombination is an ongoing event and plays an indispensable role in HIV epidemics in different regions. Africa, Asia and South America are identified as recombination hot-spots. They are affected by continual emergence and co-circulation of newly emerging CRFs and URFs, which are now responsible for almost 20% of HIV-1 infections worldwide. Better understanding of recombinants is necessary to determine their biological and molecular attributes.
Tập 5 Số 11 - Trang e4