Infection and Immunity

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Adjuvant Activity of N -Acetyl Muramyl Dipeptides for the Induction of Delayed-Type Hypersensitivity to Azobenzenearsonate- N -Acetyl- l -Tyrosine in Guinea Pigs
Infection and Immunity - Tập 29 Số 3 - Trang 1193-1196 - 1980
Ichiro Azuma, Keiichi Kamisango, Ikuo Saiki, Yoshiro Tanio, Shigeru Kobayashi, Yuichi Yamamura
The adjuvant activity of 23 kinds of synthetic N -acetyl muramyl dipeptide analogs on the induction of delayed-type hypersensitivity to azobenzenearsonate- N -acetyl- l -tyrosine was examined in guinea pigs.
A recombinant 15-kilodalton carboxyl-terminal fragment of Plasmodium yoelii yoelii 17XL merozoite surface protein 1 induces a protective immune response in mice
Infection and Immunity - Tập 61 Số 6 - Trang 2462-2467 - 1993
T M Daly, Carole A. Long
Since the developmental stages of malarial parasites which replicate within erythrocytes are responsible for the morbidity and mortality associated with this disease, antigens produced by these stages have been proposed as candidates for a vaccine. One surface protein of merozoites (MSP-1) has been shown to immunize both rodents and primates against virulent challenge infection in experime...... hiện toàn bộ
Immunization with a recombinant C-terminal fragment of Plasmodium yoelii merozoite surface protein 1 protects mice against homologous but not heterologous P. yoelii sporozoite challenge
Infection and Immunity - Tập 65 Số 11 - Trang 4419-4423 - 1997
Laurent Rénia, Irene T. Ling, Myriam Marussig, F. Miltgen, Anthony A. Holder, Dominique Mazier
It has been reported previously that immunization with recombinant protein containing the two epidermal growth factor (EGF)-like modules from merozoite surface protein 1 (MSP-1) of Plasmodium yoelii (strain YM) protects mice against a lethal blood-stage challenge with the same parasite strain. Since MSP-1 is expressed in both liver- and blood-stage schizonts and on the surface of merozoite...... hiện toàn bộ
CD4+T Cells and Toll-Like Receptors RecognizeSalmonellaAntigens Expressed in Bacterial Surface Organelles
Infection and Immunity - Tập 73 Số 3 - Trang 1350-1356 - 2005
Molly A. Bergman, Lisa A. Cummings, Sara L. Rassoulian Barrett, Kelly D. Smith, J C Lara, Alan Aderem, Brad T. Cookson
ABSTRACTA better understanding of immunity to infection is revealed from the characteristics of microbial ligands recognized by host immune responses. Murine infection with the intracellular bacteriumSalmonellagenerates CD4+T cells that specifically recognizeSalmonellaproteins expressed in b...... hiện toàn bộ
Toll-Like Receptor 2-Dependent Protection against Pneumococcal Carriage by Immunization with Lipidated Pneumococcal Proteins
Infection and Immunity - Tập 82 Số 5 - Trang 2079-2086 - 2014
Kristin Moffitt, Mojca Škoberne, A. Howard, L. Cristina Gavrilescu, Todd M. Gierahn, Scott Munzer, Bharat L. Dixit, Paul J. Giannasca, Jessica B. Flechtner, Richard Malley
ABSTRACTInfections withStreptococcus pneumoniaecause substantial morbidity and mortality, particularly in children in developing nations. Polysaccharide-conjugate vaccines provide protection against both invasive disease and colonization, but their use in developing countries is limited by restri...... hiện toàn bộ
Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae
Infection and Immunity - Tập 62 Số 12 - Trang 5683-5688 - 1994
Janet E. Alexander, R.A.C. Lock, C C Peeters, Jan Poolman, Peter W. Andrew, Timothy J. Mitchell, David Hansman, James C. Paton
Pneumolysin is the thiol-activated cytolysin produced by Streptococcus pneumoniae. Mice were immunized with a genetically engineered toxoid version of pneumolysin, which was derived from a serotype 2 pneumococcus. The toxoid carried the mutation Trp-433-->Phe. Alum was used as the adjuvant. Immunized mice had significantly increased levels of anti-pneumolysin antibodies, principally imm...... hiện toàn bộ
Comparative Virulence of Streptococcus pneumoniae Strains with Insertion-Duplication, Point, and Deletion Mutations in the Pneumolysin Gene
Infection and Immunity - Tập 67 Số 2 - Trang 981-985 - 1999
Anne M. Berry, Abiodun D. Ogunniyi, D. Craig Miller, James C. Paton
ABSTRACT Pneumolysin is a 471-amino-acid toxin produced by Streptococcus pneumoniae which has both cytolytic and complement activation properties. We have constructed a derivative of the type 2 S. pneumoniae strain D39 in which the portion of...... hiện toàn bộ
Two DHH Subfamily 1 Proteins Contribute to Pneumococcal Virulence and Confer Protection against Pneumococcal Disease
Infection and Immunity - Tập 79 Số 9 - Trang 3697-3710 - 2011
L. E. Cron, Kim Stol, Peter Burghout, Saskia van Selm, Elles Simonetti, Hester J. Bootsma, Peter W. M. Hermans
ABSTRACT hiện toàn bộ
Role of Streptococcus gordonii Amylase-Binding Protein A in Adhesion to Hydroxyapatite, Starch Metabolism, and Biofilm Formation
Infection and Immunity - Tập 69 Số 11 - Trang 7046-7056 - 2001
Jeffrey Rogers, Robert Palmer, Paul E. Kolenbrander, Frank A. Scannapieco
ABSTRACT Interactions between bacteria and salivary components are thought to be important in the establishment and ecology of the oral microflora. α-Amylase, the predominant salivary enzyme in humans, binds to Streptococcus gordonii , a primary colonizer of the tooth. Previous studies have i...... hiện toàn bộ
Characterization of an amylase-binding component of Streptococcus gordonii G9B
Infection and Immunity - Tập 60 Số 11 - Trang 4726-4733 - 1992
Frank A. Scannapieco, G G Haraszthy, M I Cho, Michael J. Levine
The goal of the present study was to begin characterizing the amylase-binding component(s) on the surface of Streptococcus gordonii G9B. Alkali extracts but not phenol-water extracts of this bacterium inhibited 125I-amylase binding to S. gordonii G9B. To identify the bacterial components involved in amylase binding, the alkali extract was subjected to affinity chromatography on amylase-Sep...... hiện toàn bộ
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