Infection and Immunity
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Bacteriophage Therapy Rescues Mice Bacteremic from a Clinical Isolate of Vancomycin-Resistant Enterococcus faecium
Infection and Immunity - Tập 70 Số 1 - Trang 204-210 - 2002
ABSTRACT Colonization of the gastrointestinal tract with vancomycin-resistant
Enterococcus faecium (VRE) has become endemic in many hospitals and nursing
homes in the United States. Such colonization predisposes the individual to VRE
bacteremia and/or endocarditis, and immunocompromised patients are at particular
risk for these conditions. The emergence of antibiotic-resistant bacterial
strains re...
Bactericidal activity of human lysozyme, muramidase-inactive lysozyme, and cationic polypeptides against Streptococcus sanguis and Streptococcus faecalis: inhibition by chitin oligosaccharides
Infection and Immunity - Tập 48 Số 3 - Trang 720-728 - 1985
The basis of the bactericidal activity of human lysozyme against Streptococcus
sanguis was studied. Experiments were designed to evaluate the role of lysozyme
muramidase activity in its bactericidal potency. Inactivation of the muramidase
activity of lysozyme was achieved by reduction of essential disulfides with
dithiothreitol (DTT) or by incubation with the chitin oligosaccharides
chitotriose an...
Generation of Helicobacter pylori Ghosts by PhiX Protein E-Mediated Inactivation and Their Evaluation as Vaccine Candidates
Infection and Immunity - Tập 71 Số 1 - Trang 109-116 - 2003
ABSTRACT Bacterial ghosts are empty cell envelopes, which may be generated by
the controlled expression of the PhiX174 lysis gene E in gram-negative bacteria
to obtain vaccine candidates. We describe here the application of this
technology to Helicobacter pylori . The lysis gene cassette was cloned into an
Escherichia coli-Helicobacter pylori shuttle vector and introduced into an H.
pylori recipie...
A conserved Aeromonas salmonicida porin provides protective immunity to rainbow trout
Infection and Immunity - Tập 63 Số 8 - Trang 3137-3142 - 1995
A protein with an apparent M(r) of 28,000 was isolated from outer membrane
preparations of Aeromonas salmonicida A440. The protein was tested for the
ability to form pores, using a planar lipid bilayer model membrane system. The
protein appeared to be a monomer with a single-channel conductance in 1.0 M KCl
of 1.96 nS and a cation/anion permeability ratio of 2.91 +/- 0.68. These data
show that the...
Major outer membrane proteins of Vibrio cholerae and their role in induction of protective immunity through inhibition of intestinal colonization
Infection and Immunity - Tập 60 Số 11 - Trang 4848-4855 - 1992
Vibrio cholerae O1 organisms belonging to different biotypes and serotypes were
shown to express major outer membrane proteins (MOMPs) with subunit molecular
masses of 48 to 50, 40 to 43, 35 to 36, 27 to 28, and 20 kDa. Antisera raised
against individual MOMPs of a V. cholerae O1 strain recognized MOMPs of
corresponding molecular masses in other O1 and non-O1 strains. Serological data
also suggest...
Stimulation of nonspecific resistance to infection induced by muramyl dipeptide analogs substituted in the gamma-carboxyl group and evaluation of N alpha-muramyl dipeptide-N epsilon-stearoyllysine
Infection and Immunity - Tập 39 Số 3 - Trang 1029-1040 - 1983
Stimulation of resistance to infection induced by the analogs of muramyl
dipeptide (MDP) having substituted functions in the gamma-carboxyl group of
D-isoglutamyl residue was examined in experimental Escherichia coli infections
in mice. An MDP analog which is an efficient strengthener of resistance to
infection, N alpha-MDP-N epsilon-stearoyllysine [MDP-Lys(L18)], was selected
through the comparat...
Adjuvant Activity of N -Acetyl Muramyl Dipeptides for the Induction of Delayed-Type Hypersensitivity to Azobenzenearsonate- N -Acetyl- l -Tyrosine in Guinea Pigs
Infection and Immunity - Tập 29 Số 3 - Trang 1193-1196 - 1980
The adjuvant activity of 23 kinds of synthetic N -acetyl muramyl dipeptide
analogs on the induction of delayed-type hypersensitivity to azobenzenearsonate-
N -acetyl- l -tyrosine was examined in guinea pigs.
Passive Immunization with Antibodies against Three Distinct Epitopes onPlasmodium yoeliiMerozoite Surface Protein 1 Suppresses Parasitemia
Infection and Immunity - Tập 66 Số 8 - Trang 3925-3930 - 1998
ABSTRACTWe have produced monoclonal antibodies againstPlasmodium yoeliimerozoite
surface protein 1 (MSP-1) and have assessed their ability to suppress blood
stage parasitemia by passive immunization. Six immunoglobulin G antibodies were
characterized in detail: three (B6, D3, and F5) were effective in suppressing a
lethal blood stage challenge infection, two (B10 and G3) were partially
effective, ...
A recombinant 15-kilodalton carboxyl-terminal fragment of Plasmodium yoelii yoelii 17XL merozoite surface protein 1 induces a protective immune response in mice
Infection and Immunity - Tập 61 Số 6 - Trang 2462-2467 - 1993
Since the developmental stages of malarial parasites which replicate within
erythrocytes are responsible for the morbidity and mortality associated with
this disease, antigens produced by these stages have been proposed as candidates
for a vaccine. One surface protein of merozoites (MSP-1) has been shown to
immunize both rodents and primates against virulent challenge infection in
experimental sys...
Immunization with a recombinant C-terminal fragment of Plasmodium yoelii merozoite surface protein 1 protects mice against homologous but not heterologous P. yoelii sporozoite challenge
Infection and Immunity - Tập 65 Số 11 - Trang 4419-4423 - 1997
It has been reported previously that immunization with recombinant protein
containing the two epidermal growth factor (EGF)-like modules from merozoite
surface protein 1 (MSP-1) of Plasmodium yoelii (strain YM) protects mice against
a lethal blood-stage challenge with the same parasite strain. Since MSP-1 is
expressed in both liver- and blood-stage schizonts and on the surface of
merozoites, we ev...
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