Infection and Immunity

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Bacteriophage Therapy Rescues Mice Bacteremic from a Clinical Isolate of Vancomycin-Resistant Enterococcus faecium
Infection and Immunity - Tập 70 Số 1 - Trang 204-210 - 2002
Biswajit Biswas, Sankar Adhya, Paul Washart, Paul Brian, Andrei Trostel, Bradford S. Powell, Richard M. Carlton, Carl R. Merril
ABSTRACT Colonization of the gastrointestinal tract with vancomycin-resistant Enterococcus faecium (VRE) has become endemic in many hospitals and nursing homes in the United States. Such colonization predisposes the individual to VRE bacteremia and/or endocarditis, and immunocompromised patie...... hiện toàn bộ
Bactericidal activity of human lysozyme, muramidase-inactive lysozyme, and cationic polypeptides against Streptococcus sanguis and Streptococcus faecalis: inhibition by chitin oligosaccharides
Infection and Immunity - Tập 48 Số 3 - Trang 720-728 - 1985
Nancy J. Laible, G R Germaine
The basis of the bactericidal activity of human lysozyme against Streptococcus sanguis was studied. Experiments were designed to evaluate the role of lysozyme muramidase activity in its bactericidal potency. Inactivation of the muramidase activity of lysozyme was achieved by reduction of essential disulfides with dithiothreitol (DTT) or by incubation with the chitin oligosaccharides chitot...... hiện toàn bộ
Generation of Helicobacter pylori Ghosts by PhiX Protein E-Mediated Inactivation and Their Evaluation as Vaccine Candidates
Infection and Immunity - Tập 71 Số 1 - Trang 109-116 - 2003
Klaus Panthel, Wolfgang Jechlinger, Alexander Matis, Manfred Rohde, Michael P. Szostak, Werner Lubitz, Rainer Haas
ABSTRACT Bacterial ghosts are empty cell envelopes, which may be generated by the controlled expression of the PhiX174 lysis gene E in gram-negative bacteria to obtain vaccine candidates. We describe here the application of this technology to Helicobacter pylori... hiện toàn bộ
Major outer membrane proteins of Vibrio cholerae and their role in induction of protective immunity through inhibition of intestinal colonization
Infection and Immunity - Tập 60 Số 11 - Trang 4848-4855 - 1992
Dilip K. Sengupta, Tanusree Sengupta, Asoke C. Ghose
Vibrio cholerae O1 organisms belonging to different biotypes and serotypes were shown to express major outer membrane proteins (MOMPs) with subunit molecular masses of 48 to 50, 40 to 43, 35 to 36, 27 to 28, and 20 kDa. Antisera raised against individual MOMPs of a V. cholerae O1 strain recognized MOMPs of corresponding molecular masses in other O1 and non-O1 strains. Serological data also...... hiện toàn bộ
A conserved Aeromonas salmonicida porin provides protective immunity to rainbow trout
Infection and Immunity - Tập 63 Số 8 - Trang 3137-3142 - 1995
Peter Lutwyche, Maurice M. Exner, Robert E. W. Hancock, T J Trust
A protein with an apparent M(r) of 28,000 was isolated from outer membrane preparations of Aeromonas salmonicida A440. The protein was tested for the ability to form pores, using a planar lipid bilayer model membrane system. The protein appeared to be a monomer with a single-channel conductance in 1.0 M KCl of 1.96 nS and a cation/anion permeability ratio of 2.91 +/- 0.68. These data show ...... hiện toàn bộ
Stimulation of nonspecific resistance to infection induced by muramyl dipeptide analogs substituted in the gamma-carboxyl group and evaluation of N alpha-muramyl dipeptide-N epsilon-stearoyllysine
Infection and Immunity - Tập 39 Số 3 - Trang 1029-1040 - 1983
Kensuke Matsumoto, Tomoyuki Otani, T Une, Y Osada, Haruko Ogawa, Ichiro Azuma
Stimulation of resistance to infection induced by the analogs of muramyl dipeptide (MDP) having substituted functions in the gamma-carboxyl group of D-isoglutamyl residue was examined in experimental Escherichia coli infections in mice. An MDP analog which is an efficient strengthener of resistance to infection, N alpha-MDP-N epsilon-stearoyllysine [MDP-Lys(L18)], was selected through the ...... hiện toàn bộ
Adjuvant Activity of N -Acetyl Muramyl Dipeptides for the Induction of Delayed-Type Hypersensitivity to Azobenzenearsonate- N -Acetyl- l -Tyrosine in Guinea Pigs
Infection and Immunity - Tập 29 Số 3 - Trang 1193-1196 - 1980
Ichiro Azuma, Keiichi Kamisango, Ikuo Saiki, Yoshiro Tanio, Shigeru Kobayashi, Yuichi Yamamura
The adjuvant activity of 23 kinds of synthetic N -acetyl muramyl dipeptide analogs on the induction of delayed-type hypersensitivity to azobenzenearsonate- N -acetyl- l -tyrosine was examined in guinea pigs.
Passive Immunization with Antibodies against Three Distinct Epitopes onPlasmodium yoeliiMerozoite Surface Protein 1 Suppresses Parasitemia
Infection and Immunity - Tập 66 Số 8 - Trang 3925-3930 - 1998
Lilian Spencer, Solabomi A. Ogun, Suzanne L. Fleck, Irene T. Ling, Terry J. Scott-Finnigan, Michael J. Blackman, Anthony A. Holder
ABSTRACTWe have produced monoclonal antibodies againstPlasmodium yoeliimerozoite surface protein 1 (MSP-1) and have assessed their ability to suppress blood stage parasitemia by passive immunization. Six immunoglobulin G antibodies were characterized in detail: three (B6, D3, and F5) were effective in suppressing a lethal blood stage chal...... hiện toàn bộ
A recombinant 15-kilodalton carboxyl-terminal fragment of Plasmodium yoelii yoelii 17XL merozoite surface protein 1 induces a protective immune response in mice
Infection and Immunity - Tập 61 Số 6 - Trang 2462-2467 - 1993
T M Daly, Carole A. Long
Since the developmental stages of malarial parasites which replicate within erythrocytes are responsible for the morbidity and mortality associated with this disease, antigens produced by these stages have been proposed as candidates for a vaccine. One surface protein of merozoites (MSP-1) has been shown to immunize both rodents and primates against virulent challenge infection in experime...... hiện toàn bộ
Immunization with a recombinant C-terminal fragment of Plasmodium yoelii merozoite surface protein 1 protects mice against homologous but not heterologous P. yoelii sporozoite challenge
Infection and Immunity - Tập 65 Số 11 - Trang 4419-4423 - 1997
Laurent Rénia, Irene T. Ling, Myriam Marussig, F. Miltgen, Anthony A. Holder, Dominique Mazier
It has been reported previously that immunization with recombinant protein containing the two epidermal growth factor (EGF)-like modules from merozoite surface protein 1 (MSP-1) of Plasmodium yoelii (strain YM) protects mice against a lethal blood-stage challenge with the same parasite strain. Since MSP-1 is expressed in both liver- and blood-stage schizonts and on the surface of merozoite...... hiện toàn bộ
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