CD4+T Cells and Toll-Like Receptors RecognizeSalmonellaAntigens Expressed in Bacterial Surface OrganellesInfection and Immunity - Tập 73 Số 3 - Trang 1350-1356 - 2005
Molly A. Bergman, Lisa A. Cummings, Sara L. Rassoulian Barrett, Kelly D. Smith, J C Lara, Alan Aderem, Brad T. Cookson
ABSTRACTA better understanding of immunity to infection is revealed from the characteristics of microbial ligands recognized by host immune responses. Murine infection with the intracellular bacteriumSalmonellagenerates CD4+T cells that specifically recognizeSalmonellaproteins expressed in b...... hiện toàn bộ
Toll-Like Receptor 2-Dependent Protection against Pneumococcal Carriage by Immunization with Lipidated Pneumococcal ProteinsInfection and Immunity - Tập 82 Số 5 - Trang 2079-2086 - 2014
Kristin Moffitt, Mojca Škoberne, A. Howard, L. Cristina Gavrilescu, Todd M. Gierahn, Scott Munzer, Bharat L. Dixit, Paul J. Giannasca, Jessica B. Flechtner, Richard Malley
ABSTRACTInfections withStreptococcus pneumoniaecause substantial morbidity and mortality, particularly in children in developing nations. Polysaccharide-conjugate vaccines provide protection against both invasive disease and colonization, but their use in developing countries is limited by restri...... hiện toàn bộ
Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniaeInfection and Immunity - Tập 62 Số 12 - Trang 5683-5688 - 1994
Janet E. Alexander, R.A.C. Lock, C C Peeters, Jan Poolman, Peter W. Andrew, Timothy J. Mitchell, David Hansman, James C. Paton
Pneumolysin is the thiol-activated cytolysin produced by Streptococcus pneumoniae. Mice were immunized with a genetically engineered toxoid version of pneumolysin, which was derived from a serotype 2 pneumococcus. The toxoid carried the mutation Trp-433-->Phe. Alum was used as the adjuvant. Immunized mice had significantly increased levels of anti-pneumolysin antibodies, principally imm...... hiện toàn bộ
Characterization of an amylase-binding component of Streptococcus gordonii G9BInfection and Immunity - Tập 60 Số 11 - Trang 4726-4733 - 1992
Frank A. Scannapieco, G G Haraszthy, M I Cho, Michael J. Levine
The goal of the present study was to begin characterizing the amylase-binding component(s) on the surface of Streptococcus gordonii G9B. Alkali extracts but not phenol-water extracts of this bacterium inhibited 125I-amylase binding to S. gordonii G9B. To identify the bacterial components involved in amylase binding, the alkali extract was subjected to affinity chromatography on amylase-Sep...... hiện toàn bộ