Hypertension

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Quantitative Polymerase Chain Reaction–Based Analysis of Podocyturia Is a Feasible Diagnostic Tool in Preeclampsia
Hypertension - Tập 60 Số 6 - Trang 1538-1544 - 2012
Tim P. Kelder, Marlies E. Penning, Hae‐Won Uh, Daniëlle Cohen, Kitty W.M. Bloemenkamp, Jan A. Bruijn, Sicco A. Scherjon, Hans J. Baelde
Preeclampsia is a significant cause of maternal and fetal morbidity and mortality worldwide. A clinically useful screening test that can predict development of preeclampsia at an early stage is urgently needed. The detection of podocyturia by immunohistochemistry after cell culture has been noted as a reliable marker for preeclampsia. However, this method is laborious and carr...... hiện toàn bộ
Macrophage Mineralocorticoid Receptor Is a Pleiotropic Modulator of Myocardial Infarct Healing
Hypertension - Tập 73 Số 1 - Trang 102-111 - 2019
Daniela Fraccarollo, Svenja Thomas, Claus‐Jürgen Scholz, Denise Hilfiker‐Kleiner, Paolo Galuppo, Johann Bauersachs
Myocardial infarction (MI) is a major cause of death worldwide. Here, we identify the macrophage MR (mineralocorticoid receptor) as a crucial pathogenic player in cardiac wound repair after MI. Seven days after left coronary artery ligation, mice with myeloid cell–restricted MR deficiency compared with WT (wild type) controls displayed improved cardiac function and remodeling associated wi...... hiện toàn bộ
Prevalence, Awareness, Treatment, and Control of Hypertension in China
Hypertension - Tập 40 Số 6 - Trang 920-927 - 2002
Dongfeng Gu, Kristi Reynolds, Xigui Wu, Jing Chen, Xiufang Duan, Paul Muntner, Guanyong Huang, Robert F. Reynolds, Shaoyong Su, Paul K. Whelton, Jiang He
The objective of this study was to estimate the prevalence and distribution of hypertension and to determine the status of hypertension awareness, treatment, and control in the general adult population in China. The International Collaborative Study of Cardiovascular Disease in ASIA (InterASIA), conducted in 2000–2001, used a multistage cluster sampling method to select a nationally repres...... hiện toàn bộ
Arterial Calcifications, Arterial Stiffness, and Cardiovascular Risk in End-Stage Renal Disease
Hypertension - Tập 38 Số 4 - Trang 938-942 - 2001
Jacques Blacher, Alain P. Guérin, Bruno Pannier, Sylvain J. Marchais, Gérard M. London
To test the predictive values of and independent contributions to cardiovascular and all-cause mortality of various arterial parameters exploring characteristics of the arterial wall at different sites, we studied prospectively 110 stable end-stage renal disease patients on hemodialysis. These parameters involved carotid diameter, carotid intima-media thickness, carotid compli...... hiện toàn bộ
Crossover design to test antihypertensive drugs with self-recorded blood pressure.
Hypertension - Tập 11 Số 2 - Trang 153-159 - 1988
Joël Ménard, D Serrurier, P Bautier, P.-F. Plouin, Pierre Corvol
In a double-blind, within-patient study, blood pressure was measured at regular intervals at the clinic by the physician and each day at home by the patient. Both methods of blood pressure measurement demonstrated an antihypertensive effect of the diuretics chlorthalidone (25 mg) and triamterene (50 mg) and the beta-blocker oxprenolol (160 mg) and the greater efficacy of the combination of...... hiện toàn bộ
Angiotensin analogues that selectively augment the force of contraction of the isolated heart.
Hypertension - Tập 11 Số 2_pt_2 - 1988
M. C. Khosla, E Bachynsky, S Forgac, C Lakios-Cherpas, F. M. Bumpus
Angiotensin II (Ang II) produces a positive inotropic effect on the heart; however, its usefulness as an inotropic agent is limited because of its inherent vasoconstrictor action. We therefore designed Ang II analogues that are potent, positive inotropic agents with minimal myotropic properties. Replacement of the proline residue in position 7 with alanine reduced the pressor and vascular ...... hiện toàn bộ
Individual responses to converting enzyme inhibitors and calcium antagonists.
Hypertension - Tập 11 Số 2 - Trang 166-173 - 1988
J. Bidiville, J. Nussberger, Gérard Waeber, M Porchet, Bernard Waeber, Hans R. Brunner
This study was designed to assess whether the acute blood pressure response of an individual hypertensive patient to a calcium antagonist or an angiotensin converting enzyme (ACE) inhibitor is a good predictor of the long-term efficacy of these drug classes in this particular patient. The concept that good responses to ACE inhibitors and calcium antagonists may be mutually exclusive was al...... hiện toàn bộ
Mechanism of inhibition of human renin by monoclonal antibodies.
Hypertension - Tập 11 Số 3 - Trang 209-216 - 1988
M M de Gasparo, Jeanette M. Wood, C H Heusser
The mechanism by which monoclonal antibodies directed against human renin (R3-36-16 and R3-47-10) inhibit renin activity was investigated using various substrates. Both antibodies acted as potent inhibitors of human renin activity when human angiotensinogen was used as a substrate. However, their effects differed clearly in the presence of synthetic tetradecapeptide. When low concentration...... hiện toàn bộ
Reversal of Genetic Salt-Sensitive Hypertension by Targeted Sympathetic Ablation
Hypertension - Tập 61 Số 4 - Trang 806-811 - 2013
Jason D. Foss, Gregory D. Fink, John W. Osborn
The sympathetic nervous system plays an important role in some forms of human hypertension as well as the Dahl salt-sensitive rat model of hypertension; however, the sympathetic targets involved remain unclear. To address this, we examined the role of the renal and splanchnic sympathetic nerves in Dahl hypertension by performing sham surgery (n=10) or targeted sympathetic ablation of the r...... hiện toàn bộ
Sympathetic neural contribution to salt-induced hypertension in Dahl rats.
Hypertension - Tập 17 Số 1_supplement - 1991
Allyn L. Mark
The Dahl strain provides a model for examining mechanisms involved in the genetic sensitivity or resistance to salt-induced hypertension. Dahl salt-sensitive rats develop hypertension when fed a high salt diet; Dahl salt-resistant rats remain normotensive. Based on early experiments, it was thought that hypertension in Dahl salt-sensitive rats epitomized the overriding importance of renal ...... hiện toàn bộ
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