Hypertension
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Role of Nitric Oxide in Cyclosporine A–Induced Hypertension
Hypertension - Tập 32 Số 5 - Trang 849-855 - 1998
Abstract —Cyclosporine A (CsA) is an immunosuppressive agent that also causes
hypertension. The effect of CsA on vascular responses was determined in
Sprague-Dawley rats and isolated rat aortic rings. Male rats weighing 250 to 300
g were given either CsA (25 mg · kg −1 · d −1 ) in olive oil or vehicle by
intraperitoneal injection for 7 days. CsA administration produced a 42% increase
( P <0.001) i...
Inducible Nitric Oxide Synthase and Blood Pressure
Hypertension - Tập 31 Số 1 - Trang 15-20 - 1998
Abstract —In the present studies, the influence of inducible nitric oxide
synthase (NOS) inhibition with aminoguanidine on renal function and blood
pressure was examined in rats. Intravenous aminoguanidine infusion (60 mg · kg
−1 · hr −1 ) for 40 minutes to anesthetized Sprague-Dawley rats (n=7) resulted
in no significant changes in mean arterial pressure or renal cortical blood
flow, while medull...
Oxidative Stress Mediates the Stimulation of Sympathetic Nerve Activity in the Phenol Renal Injury Model of Hypertension
Hypertension - Tập 48 Số 2 - Trang 309-315 - 2006
Renal injury caused by the injection of phenol in the lower pole of one kidney
increases blood pressure (BP), norepinephrine secretion from the posterior
hypothalamic nuclei (PH), and renal sympathetic nerve activity in the rat. Renal
denervation prevents these effects of phenol. We have also demonstrated that
noradrenergic traffic in the brain is modulated by NO and interleukin-1β. In
this study,...
Oxidative Stress Mediates Angiotensin II–Dependent Stimulation of Sympathetic Nerve Activity
Hypertension - Tập 46 Số 3 - Trang 533-539 - 2005
Evidence indicates that angiotensin II (Ang II) enhances sympathetic nervous
system (SNS) activity centrally and peripherally, but the exact mechanisms of
this activation are not well established. We have previously shown that infusion
of Ang II in the lateral cerebral ventricle raises blood pressure (BP), renal
sympathetic nervous system activity (RSNA), and norepinephrine (NE) secretion
from the...
Characteristics of 9194 Patients With Left Ventricular Hypertrophy
Hypertension - Tập 32 Số 6 - Trang 989-997 - 1998
Abstract —Losartan was the first available orally administered selective
antagonist of the angiotensin II type 1 receptor developed for the treatment of
hypertension. The Losartan Intervention For Endpoint (LIFE) Reduction in
Hypertension Study is a double-blind, prospective, parallel group study designed
to compare the effects of losartan with those of the β-blocker atenolol on the
reduction of c...
Early Pregnancy Prediction of Preeclampsia in Nulliparous Women, Combining Clinical Risk and Biomarkers
Hypertension - Tập 64 Số 3 - Trang 644-652 - 2014
More than half of all cases of preeclampsia occur in healthy first-time pregnant
women. Our aim was to develop a method to predict those at risk by combining
clinical factors and measurements of biomarkers in women recruited to the
Screening for Pregnancy Endpoints (SCOPE) study of low-risk nulliparous women.
Forty-seven biomarkers identified on the basis of (1) association with
preeclampsia, (2) ...
Quantitative Polymerase Chain Reaction–Based Analysis of Podocyturia Is a Feasible Diagnostic Tool in Preeclampsia
Hypertension - Tập 60 Số 6 - Trang 1538-1544 - 2012
Preeclampsia is a significant cause of maternal and fetal morbidity and
mortality worldwide. A clinically useful screening test that can predict
development of preeclampsia at an early stage is urgently needed. The detection
of podocyturia by immunohistochemistry after cell culture has been noted as a
reliable marker for preeclampsia. However, this method is laborious and carries
the risk of cell ...
Podocyturia Predates Proteinuria and Clinical Features of Preeclampsia
Hypertension - Tập 61 Số 6 - Trang 1289-1296 - 2013
Podocyturia, the shedding of live podocytes, is present at delivery in women
with preeclampsia. The aim of this study was to test whether podocyturia is
present earlier in pregnancy and predicts for preeclampsia. We also aimed to
compare test characteristics of podocyturia with those of angiogenic factors
previously implicated in the pathogenesis of this disorder. We prospectively
enrolled 315 wom...
Macrophage Mineralocorticoid Receptor Is a Pleiotropic Modulator of Myocardial Infarct Healing
Hypertension - Tập 73 Số 1 - Trang 102-111 - 2019
Myocardial infarction (MI) is a major cause of death worldwide. Here, we
identify the macrophage MR (mineralocorticoid receptor) as a crucial pathogenic
player in cardiac wound repair after MI. Seven days after left coronary artery
ligation, mice with myeloid cell–restricted MR deficiency compared with WT (wild
type) controls displayed improved cardiac function and remodeling associated
with enhan...
Effects of Smoking Cessation on Blood Pressure and Heart Rate Variability in Habitual Smokers
Hypertension - Tập 33 Số 1 - Trang 586-590 - 1999
Abstract —We investigated the effects of 1-week of smoking cessation on
ambulatory blood pressure, heart rate, and heart rate variability in 39
normotensive male habitual smokers (mean±SEM, 32.5±1.0 years). The ambulatory
blood pressure, heart rate, and ECG R-R intervals were measured during a 24-hour
period with a portable recorder (TM-2425) on the last day of 1-week smoking and
nonsmoking period...
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