Hypertension
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Arterial Baroreflex Control of the Sinus Node During Dobutamine Exercise Stress Testing
Abstract
—The contributions of increases in circulating catecholamines, changes in central command, and muscle afferents on baroreflex control of the sinus node during exercise are unclear. We used a dobutamine infusion to induce hemodynamic changes comparable to those of moderate physical exercise in the absence of changes in central com... ... hiện toàn bộ
Hypertension - Tập 33 Số 4 - Trang 987-991 - 1999
Morning Blood Pressure Peak, QT Intervals, and Sympathetic Activity in Hypertensive Patients
We investigated the relation between morning blood pressure (BP) variations, sympathetic activity, and QT intervals in 156 never-treated subjects with essential hypertension and different patterns of morning BP increase. The morning BP peak (MP) was defined as a rise in systolic BP ≥50 mm Hg and/or diastolic BP ≥22 mm Hg during early morning (6:00 to 10:00
... hiện toàn bộ
Hypertension - Tập 41 Số 2 - Trang 237-243 - 2003
Flow-Induced Remodeling in Resistance Arteries From Obese Zucker Rats Is Associated With Endothelial Dysfunction
Chronic increases in blood flow increase arterial diameter and NO-dependent dilation in resistance arteries. Because endothelial dysfunction accompanies metabolic syndrome, we hypothesized that flow-mediated remodeling might be impaired in obese rat resistance arteries. Obese and lean Zucker rat mesenteric resistance arteries were exposed to chronic flow increases through arte... ... hiện toàn bộ
Hypertension - Tập 50 Số 1 - Trang 248-254 - 2007
Heme Oxygenase 1 Is Differentially Involved in Blood Flow–Dependent Arterial Remodeling
Heme oxygenase 1 is induced by hemodynamic forces in vascular smooth muscle and endothelial cells. We investigated the involvement of heme oxygenase 1 in flow (shear stress)-dependent remodeling. Two or 14 days after ligation of mesenteric resistance arteries, vessels were isolated. In rats, at 14 days, diameter increased by 23% in high-flow arteries and decreased by 22% in lo... ... hiện toàn bộ
Hypertension - Tập 58 Số 2 - Trang 225-231 - 2011
Role of Angiotensin II in the Remodeling Induced by a Chronic Increase in Flow in Rat Mesenteric Resistance Arteries
Angiotensin II is a potent growth factor involved in arterial wall homeostasis. In resistance arteries, chronic increases in blood flow induce a rise in diameter associated with arterial wall hypertrophy. Nevertheless, the role of angiotensin II in this remodeling is unknown. We investigated the effect of blocking angiotensin II production or receptor activation on flow-induce... ... hiện toàn bộ
Hypertension - Tập 55 Số 1 - Trang 109-115 - 2010
PGC-1α (Peroxisome Proliferator–Activated Receptor γ Coactivator 1-α) Overexpression in Coronary Artery Disease Recruits NO and Hydrogen Peroxide During Flow-Mediated Dilation and Protects Against Increased Intraluminal Pressure
Blood flow through healthy human vessels releases NO to produce vasodilation, whereas in patients with coronary artery disease (CAD), the mediator of dilation transitions to mitochondria-derived hydrogen peroxide (
mt
H
2
O
2
). Excessive
... ... hiện toàn bộ
Hypertension - Tập 70 Số 1 - Trang 166-173 - 2017
Characteristics of 9194 Patients With Left Ventricular Hypertrophy
Abstract
—Losartan was the first available orally administered selective antagonist of the angiotensin II type 1 receptor developed for the treatment of hypertension. The Losartan Intervention For Endpoint (LIFE) Reduction in Hypertension Study is a double-blind, prospective, parallel group study designed to compare the effects of losarta... ... hiện toàn bộ
Hypertension - Tập 32 Số 6 - Trang 989-997 - 1998
Maladaptive Remodeling of Cardiac Myocyte Shape Begins Long Before Failure in Hypertension
Abstract
—Progression to failure in hypertension is associated with ventricular dilation, excessive myocyte lengthening, and an increase in myocyte length/width ratio. The temporal development of these changes in relation to impaired pump performance is unknown. We examined isolated myocytes from 1- to 12-month-old spontaneously hypertens... ... hiện toàn bộ
Hypertension - Tập 32 Số 4 - Trang 753-757 - 1998
Thromboxane Prostanoid Receptors Enhance Contractions, Endothelin-1, and Oxidative Stress in Microvessels From Mice With Chronic Kidney Disease
Cardiovascular disease is frequent in chronic kidney disease and has been related to angiotensin II, endothelin-1 (ET-1), thromboxane A
2
, and reactive oxygen species (ROS). Because activation of thromboxane prostanoid receptors (TP-Rs) can generate ROS, which can generate ET-1, we tested the hypothesis that chronic kidney disease ... ... hiện toàn bộ
Hypertension - Tập 65 Số 5 - Trang 1055-1063 - 2015
Mechanisms of Mineralocorticoid ActionSodium transport in epithelial tissues is regulated by the physiological mineralocorticoid aldosterone. The response to aldosterone is mediated by the mineralocorticoid receptor (MR), for which the crystal structure of the ligand-binding domain has recently been established. The classical mode of action for this receptor involves the regulation of gene transcription. Several genes have now... ... hiện toàn bộ
Hypertension - Tập 46 Số 6 - Trang 1227-1235 - 2005
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