Hypertension

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Role of Nitric Oxide in Cyclosporine A–Induced Hypertension
Hypertension - Tập 32 Số 5 - Trang 849-855 - 1998
G.K. Oriji, Harry R. Keiser
Abstract —Cyclosporine A (CsA) is an immunosuppressive agent that also causes hypertension. The effect of CsA on vascular responses was determined in Sprague-Dawley rats and isolated rat aortic rings. Male rats weighing 250 to 300 g were given either CsA (25 mg · kg −1 · d ... hiện toàn bộ
Inducible Nitric Oxide Synthase and Blood Pressure
Hypertension - Tập 31 Số 1 - Trang 15-20 - 1998
David L. Mattson, Celso Y. Maeda, Timothy D. Bachman, Allen W. Cowley
Abstract —In the present studies, the influence of inducible nitric oxide synthase (NOS) inhibition with aminoguanidine on renal function and blood pressure was examined in rats. Intravenous aminoguanidine infusion (60 mg · kg −1 · hr −1 ) for 40 min...... hiện toàn bộ
Oxidative Stress Mediates the Stimulation of Sympathetic Nerve Activity in the Phenol Renal Injury Model of Hypertension
Hypertension - Tập 48 Số 2 - Trang 309-315 - 2006
Shaohua Ye, Huiquin Zhong, Vito M. Campese
Renal injury caused by the injection of phenol in the lower pole of one kidney increases blood pressure (BP), norepinephrine secretion from the posterior hypothalamic nuclei (PH), and renal sympathetic nerve activity in the rat. Renal denervation prevents these effects of phenol. We have also demonstrated that noradrenergic traffic in the brain is modulated by NO and interleukin-1β. In thi...... hiện toàn bộ
Oxidative Stress Mediates Angiotensin II–Dependent Stimulation of Sympathetic Nerve Activity
Hypertension - Tập 46 Số 3 - Trang 533-539 - 2005
Vito M. Campese, Shaohua Ye, Huiquin Zhong
Evidence indicates that angiotensin II (Ang II) enhances sympathetic nervous system (SNS) activity centrally and peripherally, but the exact mechanisms of this activation are not well established. We have previously shown that infusion of Ang II in the lateral cerebral ventricle raises blood pressure (BP), renal sympathetic nervous system activity (RSNA), and norepinephrine (N...... hiện toàn bộ
Characteristics of 9194 Patients With Left Ventricular Hypertrophy
Hypertension - Tập 32 Số 6 - Trang 989-997 - 1998
Björn Dahlöf, Richard B. Devereux, Stevo Julius, Sverre E. Kjeldsen, Gareth Beevers, Ulf dé Fairé, Frej Fyhrquist, Thomas Hedner, Hans Ibsen, Krister Kristianson, Ole Lederballe‐Pedersen, Lars Lindholm, Markku S. Nieminen, Per Omvik, Suzanne Oparil, Hans Wedel
Abstract —Losartan was the first available orally administered selective antagonist of the angiotensin II type 1 receptor developed for the treatment of hypertension. The Losartan Intervention For Endpoint (LIFE) Reduction in Hypertension Study is a double-blind, prospective, parallel group study designed to compare the effects of losarta...... hiện toàn bộ
Early Pregnancy Prediction of Preeclampsia in Nulliparous Women, Combining Clinical Risk and Biomarkers
Hypertension - Tập 64 Số 3 - Trang 644-652 - 2014
Louise C. Kenny, Michael A. Black, Lucilla Poston, Rennae S. Taylor, Jenny Myers, Philip N. Baker, Lesley McCowan, Nigel Simpson, Gus Dekker, Claire T. Roberts, Kelline Rodems, B.W. Noland, Michael Raymundo, James J. Walker, Robyn A. North
More than half of all cases of preeclampsia occur in healthy first-time pregnant women. Our aim was to develop a method to predict those at risk by combining clinical factors and measurements of biomarkers in women recruited to the Screening for Pregnancy Endpoints (SCOPE) study of low-risk nulliparous women. Forty-seven biomarkers identified on the basis of (1) association with preeclamps...... hiện toàn bộ
Quantitative Polymerase Chain Reaction–Based Analysis of Podocyturia Is a Feasible Diagnostic Tool in Preeclampsia
Hypertension - Tập 60 Số 6 - Trang 1538-1544 - 2012
Tim P. Kelder, Marlies E. Penning, Hae‐Won Uh, Daniëlle Cohen, Kitty W.M. Bloemenkamp, Jan A. Bruijn, Sicco A. Scherjon, Hans J. Baelde
Preeclampsia is a significant cause of maternal and fetal morbidity and mortality worldwide. A clinically useful screening test that can predict development of preeclampsia at an early stage is urgently needed. The detection of podocyturia by immunohistochemistry after cell culture has been noted as a reliable marker for preeclampsia. However, this method is laborious and carr...... hiện toàn bộ
Podocyturia Predates Proteinuria and Clinical Features of Preeclampsia
Hypertension - Tập 61 Số 6 - Trang 1289-1296 - 2013
Iasmina Craici, Steven J. Wagner, Kent R. Bailey, Patrick D. Fitz‐Gibbon, Christina M. Wood‐Wentz, Stephen T. Turner, Suzanne R. Hayman, Wendy White, Brian Brost, Carl H. Rose, Joseph P. Grande, Vesna D. Garovic
Podocyturia, the shedding of live podocytes, is present at delivery in women with preeclampsia. The aim of this study was to test whether podocyturia is present earlier in pregnancy and predicts for preeclampsia. We also aimed to compare test characteristics of podocyturia with those of angiogenic factors previously implicated in the pathogenesis of this disorder. We prospectively enrolled...... hiện toàn bộ
Macrophage Mineralocorticoid Receptor Is a Pleiotropic Modulator of Myocardial Infarct Healing
Hypertension - Tập 73 Số 1 - Trang 102-111 - 2019
Daniela Fraccarollo, Svenja Thomas, Claus‐Jürgen Scholz, Denise Hilfiker‐Kleiner, Paolo Galuppo, Johann Bauersachs
Myocardial infarction (MI) is a major cause of death worldwide. Here, we identify the macrophage MR (mineralocorticoid receptor) as a crucial pathogenic player in cardiac wound repair after MI. Seven days after left coronary artery ligation, mice with myeloid cell–restricted MR deficiency compared with WT (wild type) controls displayed improved cardiac function and remodeling associated wi...... hiện toàn bộ
Effects of Smoking Cessation on Blood Pressure and Heart Rate Variability in Habitual Smokers
Hypertension - Tập 33 Số 1 - Trang 586-590 - 1999
Junichi Minami, Toshihiko Ishimitsu, Hiroaki Matsuoka
Abstract —We investigated the effects of 1-week of smoking cessation on ambulatory blood pressure, heart rate, and heart rate variability in 39 normotensive male habitual smokers (mean±SEM, 32.5±1.0 years). The ambulatory blood pressure, heart rate, and ECG R-R intervals were measured during a 24-hour period with a portable recorder (TM-2...... hiện toàn bộ
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